Small monomeric GTPase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0T0_LEIMA

TriTrypDb:

LmjF.36.4830 , LMJLV39_360060000 , LMJSD75_360059700

Length:

472

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0T0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0T0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.551
CLV_NRD_NRD_1	182	184	PF00675	0.616
CLV_NRD_NRD_1	223	225	PF00675	0.423
CLV_NRD_NRD_1	330	332	PF00675	0.603
CLV_NRD_NRD_1	342	344	PF00675	0.525
CLV_NRD_NRD_1	37	39	PF00675	0.412
CLV_PCSK_KEX2_1	182	184	PF00082	0.567
CLV_PCSK_KEX2_1	223	225	PF00082	0.423
CLV_PCSK_KEX2_1	330	332	PF00082	0.688
CLV_PCSK_KEX2_1	342	344	PF00082	0.518
CLV_PCSK_KEX2_1	37	39	PF00082	0.412
CLV_PCSK_KEX2_1	89	91	PF00082	0.499
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.499
CLV_PCSK_SKI1_1	206	210	PF00082	0.613
CLV_PCSK_SKI1_1	224	228	PF00082	0.336
CLV_PCSK_SKI1_1	240	244	PF00082	0.521
CLV_PCSK_SKI1_1	259	263	PF00082	0.702
CLV_PCSK_SKI1_1	269	273	PF00082	0.509
CLV_PCSK_SKI1_1	32	36	PF00082	0.385
CLV_PCSK_SKI1_1	334	338	PF00082	0.639
DEG_APCC_DBOX_1	205	213	PF00400	0.424
DEG_APCC_DBOX_1	333	341	PF00400	0.543
DEG_SCF_FBW7_1	106	112	PF00400	0.597
DEG_SCF_FBW7_1	138	145	PF00400	0.597
DEG_SPOP_SBC_1	142	146	PF00917	0.591
DOC_CKS1_1	106	111	PF01111	0.635
DOC_CKS1_1	139	144	PF01111	0.597
DOC_CYCLIN_yClb5_NLxxxL_5	309	318	PF00134	0.668
DOC_CYCLIN_yCln2_LP_2	344	350	PF00134	0.472
DOC_MAPK_gen_1	265	273	PF00069	0.382
DOC_MAPK_RevD_3	316	331	PF00069	0.593
DOC_PP1_RVXF_1	340	347	PF00149	0.528
DOC_USP7_MATH_1	121	125	PF00917	0.548
DOC_USP7_MATH_1	134	138	PF00917	0.577
DOC_USP7_MATH_1	377	381	PF00917	0.490
DOC_USP7_MATH_1	61	65	PF00917	0.629
DOC_USP7_MATH_1	9	13	PF00917	0.569
DOC_USP7_UBL2_3	258	262	PF12436	0.501
DOC_WW_Pin1_4	105	110	PF00397	0.716
DOC_WW_Pin1_4	138	143	PF00397	0.598
DOC_WW_Pin1_4	176	181	PF00397	0.687
DOC_WW_Pin1_4	243	248	PF00397	0.516
DOC_WW_Pin1_4	320	325	PF00397	0.567
DOC_WW_Pin1_4	57	62	PF00397	0.649
LIG_14-3-3_CanoR_1	117	121	PF00244	0.593
LIG_14-3-3_CanoR_1	150	155	PF00244	0.540
LIG_14-3-3_CanoR_1	182	187	PF00244	0.530
LIG_14-3-3_CanoR_1	223	232	PF00244	0.402
LIG_14-3-3_CanoR_1	237	243	PF00244	0.454
LIG_14-3-3_CanoR_1	419	425	PF00244	0.528
LIG_14-3-3_CanoR_1	90	95	PF00244	0.519
LIG_APCC_ABBA_1	406	411	PF00400	0.460
LIG_BRCT_BRCA1_1	337	341	PF00533	0.488
LIG_BRCT_BRCA1_1	354	358	PF00533	0.423
LIG_deltaCOP1_diTrp_1	234	238	PF00928	0.374
LIG_EH1_1	398	406	PF00400	0.518
LIG_FHA_1	110	116	PF00498	0.557
LIG_FHA_1	18	24	PF00498	0.451
LIG_FHA_1	225	231	PF00498	0.437
LIG_FHA_1	31	37	PF00498	0.431
LIG_FHA_1	78	84	PF00498	0.536
LIG_FHA_1	90	96	PF00498	0.511
LIG_FHA_2	106	112	PF00498	0.485
LIG_FHA_2	306	312	PF00498	0.537
LIG_FHA_2	421	427	PF00498	0.431
LIG_FHA_2	48	54	PF00498	0.595
LIG_FHA_2	91	97	PF00498	0.604
LIG_LIR_Apic_2	137	142	PF02991	0.604
LIG_LIR_Gen_1	167	175	PF02991	0.513
LIG_LIR_Gen_1	17	25	PF02991	0.345
LIG_LIR_Gen_1	384	393	PF02991	0.440
LIG_LIR_LC3C_4	20	25	PF02991	0.416
LIG_LIR_Nem_3	167	172	PF02991	0.510
LIG_LIR_Nem_3	17	22	PF02991	0.365
LIG_LIR_Nem_3	189	195	PF02991	0.403
LIG_LIR_Nem_3	198	204	PF02991	0.474
LIG_LIR_Nem_3	2	8	PF02991	0.638
LIG_LIR_Nem_3	234	239	PF02991	0.352
LIG_LIR_Nem_3	338	344	PF02991	0.473
LIG_LIR_Nem_3	355	361	PF02991	0.423
LIG_LIR_Nem_3	384	389	PF02991	0.433
LIG_Pex14_2	386	390	PF04695	0.363
LIG_PTB_Apo_2	208	215	PF02174	0.404
LIG_PTB_Phospho_1	208	214	PF10480	0.408
LIG_SH2_CRK	118	122	PF00017	0.596
LIG_SH2_CRK	139	143	PF00017	0.633
LIG_SH2_CRK	214	218	PF00017	0.350
LIG_SH2_NCK_1	110	114	PF00017	0.658
LIG_SH2_NCK_1	118	122	PF00017	0.591
LIG_SH2_SRC	409	412	PF00017	0.476
LIG_SH2_STAP1	110	114	PF00017	0.578
LIG_SH2_STAP1	5	9	PF00017	0.521
LIG_SH2_STAT3	157	160	PF00017	0.656
LIG_SH2_STAT3	62	65	PF00017	0.636
LIG_SH2_STAT5	118	121	PF00017	0.693
LIG_SH2_STAT5	231	234	PF00017	0.377
LIG_SH2_STAT5	399	402	PF00017	0.473
LIG_SH3_3	351	357	PF00018	0.459
LIG_SH3_3	55	61	PF00018	0.640
LIG_SH3_3	96	102	PF00018	0.637
LIG_SUMO_SIM_anti_2	20	27	PF11976	0.389
LIG_SUMO_SIM_par_1	20	27	PF11976	0.389
LIG_TRAF2_1	408	411	PF00917	0.483
LIG_TRAF2_1	423	426	PF00917	0.482
LIG_TYR_ITIM	212	217	PF00017	0.371
LIG_WW_3	179	183	PF00397	0.555
MOD_CDC14_SPxK_1	179	182	PF00782	0.558
MOD_CDK_SPxK_1	176	182	PF00069	0.614
MOD_CDK_SPxxK_3	176	183	PF00069	0.567
MOD_CK1_1	124	130	PF00069	0.647
MOD_CK1_1	165	171	PF00069	0.659
MOD_CK1_1	225	231	PF00069	0.570
MOD_CK1_1	241	247	PF00069	0.319
MOD_CK1_1	3	9	PF00069	0.630
MOD_CK1_1	305	311	PF00069	0.690
MOD_CK1_1	323	329	PF00069	0.471
MOD_CK1_1	444	450	PF00069	0.516
MOD_CK1_1	48	54	PF00069	0.579
MOD_CK2_1	11	17	PF00069	0.573
MOD_CK2_1	420	426	PF00069	0.443
MOD_CK2_1	48	54	PF00069	0.597
MOD_CK2_1	90	96	PF00069	0.443
MOD_CMANNOS	235	238	PF00535	0.367
MOD_GlcNHglycan	11	14	PF01048	0.571
MOD_GlcNHglycan	126	129	PF01048	0.750
MOD_GlcNHglycan	145	148	PF01048	0.612
MOD_GlcNHglycan	176	179	PF01048	0.607
MOD_GlcNHglycan	2	5	PF01048	0.668
MOD_GlcNHglycan	243	246	PF01048	0.464
MOD_GlcNHglycan	300	303	PF01048	0.563
MOD_GlcNHglycan	53	58	PF01048	0.672
MOD_GlcNHglycan	65	68	PF01048	0.628
MOD_GSK3_1	105	112	PF00069	0.762
MOD_GSK3_1	134	141	PF00069	0.587
MOD_GSK3_1	182	189	PF00069	0.521
MOD_GSK3_1	222	229	PF00069	0.464
MOD_GSK3_1	26	33	PF00069	0.571
MOD_GSK3_1	298	305	PF00069	0.577
MOD_GSK3_1	44	51	PF00069	0.434
MOD_GSK3_1	444	451	PF00069	0.448
MOD_GSK3_1	53	60	PF00069	0.639
MOD_LATS_1	222	228	PF00433	0.410
MOD_N-GLC_1	165	170	PF02516	0.689
MOD_N-GLC_1	444	449	PF02516	0.515
MOD_NEK2_1	104	109	PF00069	0.686
MOD_NEK2_1	162	167	PF00069	0.717
MOD_NEK2_1	195	200	PF00069	0.449
MOD_NEK2_1	226	231	PF00069	0.428
MOD_NEK2_1	272	277	PF00069	0.382
MOD_NEK2_1	359	364	PF00069	0.676
MOD_NEK2_1	415	420	PF00069	0.516
MOD_NEK2_1	432	437	PF00069	0.382
MOD_NEK2_1	44	49	PF00069	0.525
MOD_NEK2_1	88	93	PF00069	0.518
MOD_NEK2_1	95	100	PF00069	0.632
MOD_NEK2_2	121	126	PF00069	0.584
MOD_NEK2_2	134	139	PF00069	0.663
MOD_NEK2_2	238	243	PF00069	0.373
MOD_NEK2_2	293	298	PF00069	0.514
MOD_PIKK_1	272	278	PF00454	0.473
MOD_PIKK_1	325	331	PF00454	0.660
MOD_PIKK_1	432	438	PF00454	0.451
MOD_PIKK_1	61	67	PF00454	0.683
MOD_PK_1	150	156	PF00069	0.522
MOD_PKA_1	182	188	PF00069	0.527
MOD_PKA_1	89	95	PF00069	0.502
MOD_PKA_2	116	122	PF00069	0.593
MOD_PKA_2	17	23	PF00069	0.425
MOD_PKA_2	182	188	PF00069	0.499
MOD_PKA_2	222	228	PF00069	0.486
MOD_PKA_2	89	95	PF00069	0.502
MOD_Plk_1	165	171	PF00069	0.649
MOD_Plk_1	26	32	PF00069	0.595
MOD_Plk_1	305	311	PF00069	0.637
MOD_Plk_1	444	450	PF00069	0.484
MOD_Plk_1	45	51	PF00069	0.443
MOD_Plk_1	95	101	PF00069	0.654
MOD_Plk_4	134	140	PF00069	0.582
MOD_Plk_4	150	156	PF00069	0.643
MOD_Plk_4	182	188	PF00069	0.615
MOD_Plk_4	226	232	PF00069	0.394
MOD_Plk_4	30	36	PF00069	0.384
MOD_Plk_4	305	311	PF00069	0.596
MOD_Plk_4	90	96	PF00069	0.511
MOD_ProDKin_1	105	111	PF00069	0.715
MOD_ProDKin_1	138	144	PF00069	0.597
MOD_ProDKin_1	176	182	PF00069	0.686
MOD_ProDKin_1	243	249	PF00069	0.528
MOD_ProDKin_1	320	326	PF00069	0.569
MOD_ProDKin_1	57	63	PF00069	0.649
MOD_SUMO_for_1	428	431	PF00179	0.512
MOD_SUMO_rev_2	251	260	PF00179	0.493
MOD_SUMO_rev_2	311	318	PF00179	0.527
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.408
TRG_ENDOCYTIC_2	201	204	PF00928	0.465
TRG_ENDOCYTIC_2	214	217	PF00928	0.352
TRG_ENDOCYTIC_2	236	239	PF00928	0.345
TRG_ER_diArg_1	181	183	PF00400	0.573
TRG_ER_diArg_1	341	343	PF00400	0.532
TRG_ER_diArg_1	36	38	PF00400	0.411
TRG_ER_diArg_1	371	374	PF00400	0.649
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I895	Leptomonas seymouri	56%	95%
A0A3Q8IRK5	Leishmania donovani	91%	100%
A4HQ00	Leishmania braziliensis	71%	99%
A4IDR1	Leishmania infantum	90%	100%
E9ATR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%