Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0S8_LEIMA

TriTrypDb:

LmjF.36.4850 , LMJLV39_360060200 , LMJSD75_360059900

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0S8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.563
CLV_C14_Caspase3-7	292	296	PF00656	0.588
CLV_NRD_NRD_1	220	222	PF00675	0.536
CLV_NRD_NRD_1	395	397	PF00675	0.444
CLV_NRD_NRD_1	435	437	PF00675	0.387
CLV_NRD_NRD_1	440	442	PF00675	0.412
CLV_NRD_NRD_1	444	446	PF00675	0.450
CLV_NRD_NRD_1	549	551	PF00675	0.495
CLV_PCSK_KEX2_1	434	436	PF00082	0.421
CLV_PCSK_KEX2_1	440	442	PF00082	0.410
CLV_PCSK_KEX2_1	444	446	PF00082	0.447
CLV_PCSK_KEX2_1	549	551	PF00082	0.495
CLV_PCSK_PC7_1	436	442	PF00082	0.405
CLV_PCSK_SKI1_1	222	226	PF00082	0.581
CLV_PCSK_SKI1_1	227	231	PF00082	0.506
CLV_PCSK_SKI1_1	322	326	PF00082	0.502
CLV_PCSK_SKI1_1	380	384	PF00082	0.405
CLV_PCSK_SKI1_1	424	428	PF00082	0.421
CLV_PCSK_SKI1_1	436	440	PF00082	0.458
CLV_PCSK_SKI1_1	445	449	PF00082	0.517
CLV_PCSK_SKI1_1	532	536	PF00082	0.547
DEG_APCC_DBOX_1	414	422	PF00400	0.454
DEG_APCC_DBOX_1	483	491	PF00400	0.522
DEG_SCF_FBW7_1	263	269	PF00400	0.519
DOC_AGCK_PIF_2	119	124	PF00069	0.416
DOC_CKS1_1	263	268	PF01111	0.601
DOC_CYCLIN_RxL_1	216	228	PF00134	0.566
DOC_CYCLIN_RxL_1	325	337	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	209	215	PF00134	0.477
DOC_CYCLIN_yCln2_LP_2	302	308	PF00134	0.425
DOC_MAPK_gen_1	401	408	PF00069	0.455
DOC_MAPK_gen_1	440	450	PF00069	0.470
DOC_MAPK_JIP1_4	211	217	PF00069	0.444
DOC_MAPK_MEF2A_6	137	145	PF00069	0.297
DOC_MAPK_MEF2A_6	211	219	PF00069	0.448
DOC_PP1_RVXF_1	476	482	PF00149	0.491
DOC_PP2B_LxvP_1	302	305	PF13499	0.438
DOC_PP2B_LxvP_1	483	486	PF13499	0.497
DOC_PP2B_LxvP_1	581	584	PF13499	0.554
DOC_PP4_FxxP_1	113	116	PF00568	0.558
DOC_USP7_MATH_1	255	259	PF00917	0.621
DOC_USP7_MATH_1	289	293	PF00917	0.499
DOC_USP7_MATH_1	315	319	PF00917	0.477
DOC_USP7_MATH_1	486	490	PF00917	0.512
DOC_USP7_MATH_1	525	529	PF00917	0.601
DOC_USP7_MATH_1	554	558	PF00917	0.511
DOC_USP7_UBL2_3	325	329	PF12436	0.447
DOC_USP7_UBL2_3	397	401	PF12436	0.313
DOC_WW_Pin1_4	103	108	PF00397	0.734
DOC_WW_Pin1_4	178	183	PF00397	0.583
DOC_WW_Pin1_4	262	267	PF00397	0.654
DOC_WW_Pin1_4	27	32	PF00397	0.583
DOC_WW_Pin1_4	57	62	PF00397	0.631
DOC_WW_Pin1_4	579	584	PF00397	0.589
DOC_WW_Pin1_4	590	595	PF00397	0.555
LIG_14-3-3_CanoR_1	175	184	PF00244	0.673
LIG_14-3-3_CanoR_1	242	251	PF00244	0.454
LIG_14-3-3_CanoR_1	271	276	PF00244	0.589
LIG_14-3-3_CanoR_1	338	344	PF00244	0.475
LIG_14-3-3_CanoR_1	415	425	PF00244	0.510
LIG_14-3-3_CanoR_1	521	530	PF00244	0.618
LIG_14-3-3_CanoR_1	555	561	PF00244	0.495
LIG_BIR_II_1	1	5	PF00653	0.503
LIG_BRCT_BRCA1_1	40	44	PF00533	0.624
LIG_Clathr_ClatBox_1	278	282	PF01394	0.511
LIG_Clathr_ClatBox_1	541	545	PF01394	0.549
LIG_FHA_1	106	112	PF00498	0.687
LIG_FHA_1	149	155	PF00498	0.465
LIG_FHA_1	263	269	PF00498	0.661
LIG_FHA_1	3	9	PF00498	0.379
LIG_FHA_1	326	332	PF00498	0.355
LIG_FHA_1	377	383	PF00498	0.462
LIG_FHA_1	451	457	PF00498	0.468
LIG_FHA_1	536	542	PF00498	0.524
LIG_FHA_1	62	68	PF00498	0.549
LIG_FHA_2	192	198	PF00498	0.482
LIG_FHA_2	358	364	PF00498	0.532
LIG_FHA_2	497	503	PF00498	0.603
LIG_GBD_Chelix_1	408	416	PF00786	0.423
LIG_GBD_Chelix_1	497	505	PF00786	0.606
LIG_LIR_Gen_1	123	130	PF02991	0.423
LIG_LIR_Gen_1	161	169	PF02991	0.510
LIG_LIR_Gen_1	452	462	PF02991	0.457
LIG_LIR_Nem_3	123	127	PF02991	0.400
LIG_LIR_Nem_3	161	165	PF02991	0.528
LIG_LIR_Nem_3	274	278	PF02991	0.538
LIG_LIR_Nem_3	452	458	PF02991	0.485
LIG_MYND_1	488	492	PF01753	0.503
LIG_MYND_1	61	65	PF01753	0.581
LIG_Pex14_1	162	166	PF04695	0.527
LIG_PTAP_UEV_1	106	111	PF05743	0.502
LIG_Rb_pABgroove_1	116	124	PF01858	0.402
LIG_SH2_CRK	166	170	PF00017	0.524
LIG_SH2_NCK_1	575	579	PF00017	0.547
LIG_SH2_SRC	356	359	PF00017	0.390
LIG_SH2_STAT3	391	394	PF00017	0.423
LIG_SH2_STAT5	19	22	PF00017	0.458
LIG_SH2_STAT5	356	359	PF00017	0.554
LIG_SH2_STAT5	391	394	PF00017	0.492
LIG_SH2_STAT5	482	485	PF00017	0.484
LIG_SH2_STAT5	523	526	PF00017	0.490
LIG_SH3_1	62	68	PF00018	0.483
LIG_SH3_3	104	110	PF00018	0.711
LIG_SH3_3	166	172	PF00018	0.479
LIG_SH3_3	248	254	PF00018	0.524
LIG_SH3_3	588	594	PF00018	0.796
LIG_SH3_3	62	68	PF00018	0.667
LIG_SUMO_SIM_anti_2	138	145	PF11976	0.449
LIG_SUMO_SIM_par_1	141	147	PF11976	0.473
LIG_SUMO_SIM_par_1	274	280	PF11976	0.628
LIG_SUMO_SIM_par_1	303	310	PF11976	0.604
LIG_SUMO_SIM_par_1	446	454	PF11976	0.502
LIG_TRAF2_1	194	197	PF00917	0.528
LIG_TRAF2_1	339	342	PF00917	0.533
LIG_TRAF2_1	605	608	PF00917	0.588
LIG_UBA3_1	388	397	PF00899	0.294
LIG_UBA3_1	77	83	PF00899	0.437
LIG_WRC_WIRS_1	462	467	PF05994	0.439
MOD_CDC14_SPxK_1	30	33	PF00782	0.630
MOD_CDK_SPK_2	57	62	PF00069	0.500
MOD_CDK_SPxK_1	27	33	PF00069	0.625
MOD_CK1_1	178	184	PF00069	0.651
MOD_CK1_1	2	8	PF00069	0.429
MOD_CK1_1	243	249	PF00069	0.623
MOD_CK1_1	284	290	PF00069	0.578
MOD_CK1_1	40	46	PF00069	0.669
MOD_CK1_1	414	420	PF00069	0.568
MOD_CK1_1	56	62	PF00069	0.573
MOD_CK1_1	593	599	PF00069	0.740
MOD_CK2_1	177	183	PF00069	0.618
MOD_CK2_1	191	197	PF00069	0.468
MOD_CK2_1	362	368	PF00069	0.503
MOD_CK2_1	525	531	PF00069	0.451
MOD_CK2_1	560	566	PF00069	0.544
MOD_CK2_1	602	608	PF00069	0.696
MOD_GlcNHglycan	1	4	PF01048	0.491
MOD_GlcNHglycan	101	104	PF01048	0.636
MOD_GlcNHglycan	131	135	PF01048	0.429
MOD_GlcNHglycan	166	169	PF01048	0.569
MOD_GlcNHglycan	177	180	PF01048	0.685
MOD_GlcNHglycan	23	26	PF01048	0.503
MOD_GlcNHglycan	257	260	PF01048	0.752
MOD_GlcNHglycan	268	271	PF01048	0.558
MOD_GlcNHglycan	291	294	PF01048	0.588
MOD_GlcNHglycan	363	367	PF01048	0.508
MOD_GlcNHglycan	55	58	PF01048	0.713
MOD_GlcNHglycan	556	559	PF01048	0.463
MOD_GlcNHglycan	588	591	PF01048	0.541
MOD_GSK3_1	173	180	PF00069	0.603
MOD_GSK3_1	223	230	PF00069	0.446
MOD_GSK3_1	23	30	PF00069	0.565
MOD_GSK3_1	242	249	PF00069	0.607
MOD_GSK3_1	253	260	PF00069	0.655
MOD_GSK3_1	262	269	PF00069	0.782
MOD_GSK3_1	333	340	PF00069	0.478
MOD_GSK3_1	517	524	PF00069	0.503
MOD_GSK3_1	53	60	PF00069	0.771
MOD_GSK3_1	586	593	PF00069	0.690
MOD_GSK3_1	66	73	PF00069	0.567
MOD_GSK3_1	99	106	PF00069	0.653
MOD_LATS_1	173	179	PF00433	0.621
MOD_N-GLC_1	347	352	PF02516	0.568
MOD_N-GLC_1	37	42	PF02516	0.640
MOD_NEK2_1	12	17	PF00069	0.407
MOD_NEK2_1	130	135	PF00069	0.481
MOD_NEK2_1	215	220	PF00069	0.498
MOD_NEK2_1	411	416	PF00069	0.541
MOD_NEK2_1	586	591	PF00069	0.656
MOD_PIKK_1	390	396	PF00454	0.422
MOD_PIKK_1	463	469	PF00454	0.483
MOD_PKA_2	337	343	PF00069	0.598
MOD_PKA_2	414	420	PF00069	0.481
MOD_PKA_2	554	560	PF00069	0.493
MOD_Plk_1	227	233	PF00069	0.438
MOD_Plk_1	294	300	PF00069	0.579
MOD_Plk_1	37	43	PF00069	0.582
MOD_Plk_1	517	523	PF00069	0.581
MOD_Plk_2-3	123	129	PF00069	0.402
MOD_Plk_2-3	337	343	PF00069	0.474
MOD_Plk_4	215	221	PF00069	0.525
MOD_Plk_4	315	321	PF00069	0.508
MOD_Plk_4	486	492	PF00069	0.518
MOD_Plk_4	496	502	PF00069	0.517
MOD_ProDKin_1	103	109	PF00069	0.733
MOD_ProDKin_1	178	184	PF00069	0.578
MOD_ProDKin_1	262	268	PF00069	0.654
MOD_ProDKin_1	27	33	PF00069	0.586
MOD_ProDKin_1	57	63	PF00069	0.631
MOD_ProDKin_1	579	585	PF00069	0.595
MOD_ProDKin_1	590	596	PF00069	0.556
MOD_SUMO_for_1	402	405	PF00179	0.378
TRG_DiLeu_BaEn_1	139	144	PF01217	0.387
TRG_DiLeu_BaEn_1	428	433	PF01217	0.497
TRG_DiLeu_BaEn_1	512	517	PF01217	0.596
TRG_DiLeu_BaEn_4	569	575	PF01217	0.383
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.586
TRG_ENDOCYTIC_2	124	127	PF00928	0.387
TRG_ENDOCYTIC_2	166	169	PF00928	0.514
TRG_ER_diArg_1	421	424	PF00400	0.502
TRG_ER_diArg_1	433	436	PF00400	0.327
TRG_ER_diArg_1	439	441	PF00400	0.306
TRG_ER_diArg_1	549	551	PF00400	0.497
TRG_NES_CRM1_1	207	223	PF08389	0.490
TRG_NES_CRM1_1	461	472	PF08389	0.404
TRG_Pf-PMV_PEXEL_1	473	477	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	549	553	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N7	Leptomonas seymouri	50%	98%
A0A1X0P1Y3	Trypanosomatidae	26%	100%
A0A3Q8IJM8	Leishmania donovani	93%	100%
A4HQ02	Leishmania braziliensis	78%	100%
A4IDR3	Leishmania infantum	93%	100%
D0A4F5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ATR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%