DUF659 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0S7_LEIMA

TriTrypDb:

LmjF.36.4860 , LMJLV39_360060300 , LMJSD75_360060000

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 7
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0S7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.514
CLV_NRD_NRD_1	51	53	PF00675	0.568
CLV_NRD_NRD_1	86	88	PF00675	0.552
CLV_PCSK_SKI1_1	155	159	PF00082	0.394
CLV_PCSK_SKI1_1	88	92	PF00082	0.537
CLV_Separin_Metazoa	77	81	PF03568	0.462
DEG_SPOP_SBC_1	21	25	PF00917	0.524
DOC_MAPK_DCC_7	115	124	PF00069	0.495
DOC_MAPK_gen_1	115	124	PF00069	0.495
DOC_MAPK_MEF2A_6	115	124	PF00069	0.495
DOC_PP2B_PxIxI_1	119	125	PF00149	0.364
DOC_USP7_MATH_1	21	25	PF00917	0.524
DOC_WW_Pin1_4	124	129	PF00397	0.478
DOC_WW_Pin1_4	167	172	PF00397	0.551
DOC_WW_Pin1_4	184	189	PF00397	0.267
LIG_14-3-3_CanoR_1	217	226	PF00244	0.411
LIG_BIR_II_1	1	5	PF00653	0.415
LIG_BRCT_BRCA1_1	11	15	PF00533	0.337
LIG_CaM_IQ_9	60	75	PF13499	0.438
LIG_deltaCOP1_diTrp_1	172	177	PF00928	0.478
LIG_deltaCOP1_diTrp_1	81	86	PF00928	0.422
LIG_FHA_1	185	191	PF00498	0.393
LIG_FHA_2	108	114	PF00498	0.545
LIG_FHA_2	167	173	PF00498	0.474
LIG_LIR_Gen_1	12	22	PF02991	0.480
LIG_LIR_Gen_1	228	234	PF02991	0.504
LIG_LIR_Gen_1	81	91	PF02991	0.415
LIG_LIR_LC3C_4	215	220	PF02991	0.364
LIG_LIR_Nem_3	12	18	PF02991	0.474
LIG_LIR_Nem_3	228	233	PF02991	0.440
LIG_LIR_Nem_3	81	86	PF02991	0.487
LIG_Pex14_1	173	177	PF04695	0.354
LIG_Pex14_2	158	162	PF04695	0.453
LIG_Pex14_2	226	230	PF04695	0.448
LIG_SH2_STAT5	186	189	PF00017	0.366
LIG_SH3_3	114	120	PF00018	0.433
LIG_SH3_3	15	21	PF00018	0.492
LIG_SUMO_SIM_par_1	27	34	PF11976	0.568
LIG_SxIP_EBH_1	204	214	PF03271	0.414
LIG_TRFH_1	42	46	PF08558	0.557
LIG_UBA3_1	174	180	PF00899	0.460
LIG_WRC_WIRS_1	174	179	PF05994	0.478
MOD_CK1_1	176	182	PF00069	0.459
MOD_CK1_1	93	99	PF00069	0.495
MOD_CK2_1	166	172	PF00069	0.486
MOD_CK2_1	225	231	PF00069	0.380
MOD_Cter_Amidation	50	53	PF01082	0.485
MOD_GlcNHglycan	155	158	PF01048	0.523
MOD_GSK3_1	120	127	PF00069	0.492
MOD_GSK3_1	184	191	PF00069	0.361
MOD_GSK3_1	93	100	PF00069	0.552
MOD_LATS_1	145	151	PF00433	0.435
MOD_N-GLC_1	120	125	PF02516	0.438
MOD_N-GLC_1	166	171	PF02516	0.509
MOD_N-GLC_1	184	189	PF02516	0.469
MOD_N-GLC_2	225	227	PF02516	0.366
MOD_N-GLC_2	7	9	PF02516	0.298
MOD_NEK2_1	10	15	PF00069	0.420
MOD_NEK2_1	133	138	PF00069	0.409
MOD_NEK2_1	218	223	PF00069	0.428
MOD_NEK2_1	22	27	PF00069	0.377
MOD_NEK2_1	97	102	PF00069	0.431
MOD_PKA_2	79	85	PF00069	0.399
MOD_Plk_1	120	126	PF00069	0.441
MOD_Plk_1	35	41	PF00069	0.527
MOD_Plk_4	133	139	PF00069	0.411
MOD_Plk_4	173	179	PF00069	0.469
MOD_Plk_4	58	64	PF00069	0.460
MOD_Plk_4	79	85	PF00069	0.486
MOD_Plk_4	93	99	PF00069	0.365
MOD_ProDKin_1	124	130	PF00069	0.472
MOD_ProDKin_1	167	173	PF00069	0.549
MOD_ProDKin_1	184	190	PF00069	0.264
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB92	Leptomonas seymouri	70%	100%
A0A1X0P0Q7	Trypanosomatidae	48%	100%
A0A3Q8IPJ6	Leishmania donovani	97%	100%
A0A3R7NWI3	Trypanosoma rangeli	46%	91%
A4HQ03	Leishmania braziliensis	90%	100%
A4IDR4	Leishmania infantum	97%	100%
E9ATS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BQ42	Trypanosoma cruzi	46%	100%