Sugar transporter SWEET

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sugar efflux transporter for intercellular exchange, putative

Species:

Leishmania major

UniProt:

Q4Q0S5_LEIMA

TriTrypDb:

LmjF.36.4870 , LMJLV39_360060400 , LMJSD75_360060100

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

Q4Q0S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0S5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	17
GO:0008643	carbohydrate transport	5	17
GO:0051179	localization	1	17
GO:0051234	establishment of localization	2	17
GO:0071702	organic substance transport	4	17

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	3
GO:0015144	carbohydrate transmembrane transporter activity	3	3
GO:0022857	transmembrane transporter activity	2	3
GO:0051119	sugar transmembrane transporter activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	31	35	PF00082	0.329
DOC_CYCLIN_yCln2_LP_2	152	158	PF00134	0.358
DOC_CYCLIN_yCln2_LP_2	62	68	PF00134	0.251
DOC_MAPK_gen_1	31	41	PF00069	0.529
DOC_MAPK_MEF2A_6	34	43	PF00069	0.529
DOC_PP2B_LxvP_1	62	65	PF13499	0.251
DOC_USP7_MATH_1	32	36	PF00917	0.465
DOC_WW_Pin1_4	151	156	PF00397	0.316
LIG_14-3-3_CanoR_1	31	37	PF00244	0.465
LIG_Actin_WH2_2	83	101	PF00022	0.459
LIG_BRCT_BRCA1_1	131	135	PF00533	0.358
LIG_Clathr_ClatBox_1	191	195	PF01394	0.265
LIG_EH1_1	114	122	PF00400	0.353
LIG_FHA_1	107	113	PF00498	0.297
LIG_FHA_1	228	234	PF00498	0.649
LIG_FHA_1	5	11	PF00498	0.234
LIG_FHA_1	59	65	PF00498	0.336
LIG_FHA_1	99	105	PF00498	0.538
LIG_GBD_Chelix_1	117	125	PF00786	0.359
LIG_LIR_Gen_1	175	185	PF02991	0.344
LIG_LIR_Gen_1	195	204	PF02991	0.241
LIG_LIR_Nem_3	175	181	PF02991	0.343
LIG_LIR_Nem_3	183	189	PF02991	0.335
LIG_LIR_Nem_3	195	200	PF02991	0.232
LIG_NRBOX	115	121	PF00104	0.292
LIG_NRBOX	187	193	PF00104	0.412
LIG_Pex3_1	119	130	PF04882	0.278
LIG_SH2_CRK	189	193	PF00017	0.328
LIG_SH2_CRK	79	83	PF00017	0.323
LIG_SH2_PTP2	197	200	PF00017	0.362
LIG_SH2_STAT3	57	60	PF00017	0.381
LIG_SH2_STAT5	103	106	PF00017	0.513
LIG_SH2_STAT5	126	129	PF00017	0.383
LIG_SH2_STAT5	197	200	PF00017	0.362
LIG_SH2_STAT5	79	82	PF00017	0.313
LIG_SUMO_SIM_par_1	190	195	PF11976	0.296
LIG_SUMO_SIM_par_1	22	29	PF11976	0.407
LIG_WRC_WIRS_1	127	132	PF05994	0.402
MOD_CK1_1	106	112	PF00069	0.335
MOD_CK1_1	129	135	PF00069	0.304
MOD_CK1_1	23	29	PF00069	0.437
MOD_CK1_1	35	41	PF00069	0.553
MOD_GlcNHglycan	73	76	PF01048	0.385
MOD_GSK3_1	126	133	PF00069	0.489
MOD_GSK3_1	180	187	PF00069	0.311
MOD_GSK3_1	19	26	PF00069	0.316
MOD_GSK3_1	35	42	PF00069	0.509
MOD_GSK3_1	6	13	PF00069	0.292
MOD_GSK3_1	99	106	PF00069	0.518
MOD_NEK2_1	128	133	PF00069	0.344
MOD_NEK2_1	150	155	PF00069	0.345
MOD_NEK2_1	158	163	PF00069	0.311
MOD_NEK2_1	177	182	PF00069	0.389
MOD_NEK2_1	19	24	PF00069	0.362
MOD_NEK2_1	196	201	PF00069	0.287
MOD_NEK2_1	39	44	PF00069	0.357
MOD_NEK2_1	4	9	PF00069	0.319
MOD_NEK2_1	98	103	PF00069	0.542
MOD_NEK2_2	110	115	PF00069	0.381
MOD_NEK2_2	145	150	PF00069	0.334
MOD_Plk_4	110	116	PF00069	0.361
MOD_Plk_4	145	151	PF00069	0.294
MOD_Plk_4	158	164	PF00069	0.273
MOD_Plk_4	172	178	PF00069	0.360
MOD_Plk_4	180	186	PF00069	0.335
MOD_Plk_4	20	26	PF00069	0.401
MOD_Plk_4	99	105	PF00069	0.564
MOD_ProDKin_1	151	157	PF00069	0.316
TRG_ENDOCYTIC_2	189	192	PF00928	0.302
TRG_ENDOCYTIC_2	197	200	PF00928	0.267
TRG_ENDOCYTIC_2	79	82	PF00928	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVB3	Leptomonas seymouri	66%	100%
A0A0N1HZ27	Leptomonas seymouri	43%	99%
A0A0S4JK63	Bodo saltans	30%	100%
A0A0S4JP06	Bodo saltans	33%	83%
A0A1X0NHK1	Trypanosomatidae	49%	100%
A0A3Q8IJU9	Leishmania donovani	90%	100%
A0A3R7RTY4	Trypanosoma rangeli	47%	100%
A0A3S7X189	Leishmania donovani	41%	99%
A2WSD3	Oryza sativa subsp. indica	24%	94%
A2WSD8	Oryza sativa subsp. indica	25%	92%
A2X3S3	Oryza sativa subsp. indica	28%	92%
A2X5B4	Oryza sativa subsp. indica	26%	75%
A2YZ24	Oryza sativa subsp. indica	27%	90%
A3BWJ9	Oryza sativa subsp. japonica	28%	93%
A4HG76	Leishmania braziliensis	42%	99%
A4HQ04	Leishmania braziliensis	70%	100%
A4I3B9	Leishmania infantum	41%	99%
A4IDR5	Leishmania infantum	90%	100%
B9G2E6	Oryza sativa subsp. japonica	26%	87%
D3ZH22	Rattus norvegicus	26%	100%
E9ATS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AZJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	99%
P0DKJ5	Vitis vinifera	26%	83%
Q0J349	Oryza sativa subsp. japonica	27%	90%
Q10LN5	Oryza sativa subsp. japonica	23%	73%
Q19VE6	Oryza sativa subsp. indica	25%	78%
Q290X1	Drosophila pseudoobscura pseudoobscura	27%	100%
Q4Q8N5	Leishmania major	41%	99%
Q54JW5	Dictyostelium discoideum	24%	100%
Q5EAL3	Xenopus tropicalis	26%	100%
Q5EB14	Danio rerio	28%	100%
Q5NAZ9	Oryza sativa subsp. japonica	25%	95%
Q6K4V2	Oryza sativa subsp. japonica	28%	92%
Q6K602	Oryza sativa subsp. japonica	26%	75%
Q6NQN5	Arabidopsis thaliana	25%	91%
Q6NTJ7	Xenopus laevis	24%	100%
Q6YZF3	Oryza sativa subsp. japonica	25%	78%
Q7JVE7	Drosophila melanogaster	25%	100%
Q84WN3	Arabidopsis thaliana	23%	99%
Q8LBF7	Arabidopsis thaliana	28%	93%
Q8LR09	Oryza sativa subsp. japonica	25%	92%
Q8W0K2	Oryza sativa subsp. japonica	23%	94%
Q944M5	Arabidopsis thaliana	24%	95%
Q9C9M9	Arabidopsis thaliana	23%	92%
Q9CXK4	Mus musculus	25%	100%
Q9FGQ2	Arabidopsis thaliana	24%	81%
Q9FM10	Arabidopsis thaliana	24%	100%
Q9FY94	Arabidopsis thaliana	23%	82%
Q9LUE3	Arabidopsis thaliana	28%	83%
Q9SMM5	Arabidopsis thaliana	27%	83%
Q9SW25	Arabidopsis thaliana	22%	85%
Q9ZV02	Arabidopsis thaliana	26%	93%