Leucine-rich repeat-containing protein 61

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0S4_LEIMA

TriTrypDb:

LmjF.36.4890 , LMJLV39_360060500 , LMJSD75_360060300

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

Q4Q0S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0S4

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0036158	outer dynein arm assembly	7	10
GO:0036159	inner dynein arm assembly	7	10
GO:0043933	protein-containing complex organization	4	10
GO:0065003	protein-containing complex assembly	5	10
GO:0070286	axonemal dynein complex assembly	6	10
GO:0071840	cellular component organization or biogenesis	2	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0044877	protein-containing complex binding	2	10
GO:0070840	dynein complex binding	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.494
CLV_C14_Caspase3-7	66	70	PF00656	0.546
CLV_NRD_NRD_1	253	255	PF00675	0.318
CLV_NRD_NRD_1	325	327	PF00675	0.574
CLV_NRD_NRD_1	48	50	PF00675	0.660
CLV_NRD_NRD_1	87	89	PF00675	0.472
CLV_PCSK_FUR_1	46	50	PF00082	0.459
CLV_PCSK_KEX2_1	255	257	PF00082	0.405
CLV_PCSK_KEX2_1	324	326	PF00082	0.561
CLV_PCSK_KEX2_1	48	50	PF00082	0.660
CLV_PCSK_KEX2_1	59	61	PF00082	0.436
CLV_PCSK_KEX2_1	87	89	PF00082	0.514
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.419
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.413
CLV_PCSK_PC7_1	321	327	PF00082	0.514
CLV_PCSK_SKI1_1	222	226	PF00082	0.376
CLV_PCSK_SKI1_1	237	241	PF00082	0.345
DEG_APCC_DBOX_1	232	240	PF00400	0.441
DOC_CDC14_PxL_1	158	166	PF14671	0.417
DOC_CKS1_1	332	337	PF01111	0.448
DOC_CKS1_1	92	97	PF01111	0.356
DOC_PP4_FxxP_1	11	14	PF00568	0.362
DOC_PP4_FxxP_1	28	31	PF00568	0.383
DOC_USP7_MATH_1	19	23	PF00917	0.370
DOC_USP7_MATH_1	37	41	PF00917	0.441
DOC_WW_Pin1_4	27	32	PF00397	0.386
DOC_WW_Pin1_4	331	336	PF00397	0.591
DOC_WW_Pin1_4	338	343	PF00397	0.581
DOC_WW_Pin1_4	39	44	PF00397	0.449
DOC_WW_Pin1_4	91	96	PF00397	0.418
LIG_14-3-3_CanoR_1	233	237	PF00244	0.431
LIG_APCC_ABBA_1	121	126	PF00400	0.336
LIG_BRCT_BRCA1_1	79	83	PF00533	0.311
LIG_Clathr_ClatBox_1	209	213	PF01394	0.417
LIG_FHA_1	116	122	PF00498	0.398
LIG_FHA_1	164	170	PF00498	0.450
LIG_FHA_1	236	242	PF00498	0.338
LIG_FHA_1	27	33	PF00498	0.389
LIG_FHA_1	339	345	PF00498	0.606
LIG_FHA_1	51	57	PF00498	0.438
LIG_FHA_1	76	82	PF00498	0.404
LIG_FHA_2	138	144	PF00498	0.460
LIG_LIR_Nem_3	268	273	PF02991	0.402
LIG_LIR_Nem_3	308	313	PF02991	0.418
LIG_NRBOX	186	192	PF00104	0.417
LIG_NRBOX	205	211	PF00104	0.417
LIG_NRBOX	235	241	PF00104	0.427
LIG_Pex14_1	257	261	PF04695	0.396
LIG_Pex14_2	11	15	PF04695	0.364
LIG_SH2_NCK_1	92	96	PF00017	0.373
LIG_SH2_SRC	102	105	PF00017	0.389
LIG_SH2_SRC	124	127	PF00017	0.347
LIG_SH2_SRC	358	361	PF00017	0.602
LIG_SH2_STAT5	102	105	PF00017	0.311
LIG_SH2_STAT5	124	127	PF00017	0.301
LIG_SH2_STAT5	146	149	PF00017	0.417
LIG_SH2_STAT5	336	339	PF00017	0.489
LIG_SH2_STAT5	358	361	PF00017	0.485
LIG_SH3_3	156	162	PF00018	0.417
LIG_SUMO_SIM_par_1	207	213	PF11976	0.440
MOD_CDK_SPxxK_3	27	34	PF00069	0.394
MOD_CDK_SPxxK_3	39	46	PF00069	0.449
MOD_CK1_1	30	36	PF00069	0.410
MOD_CK1_1	39	45	PF00069	0.449
MOD_CK2_1	90	96	PF00069	0.381
MOD_Cter_Amidation	46	49	PF01082	0.461
MOD_GlcNHglycan	17	20	PF01048	0.369
MOD_GlcNHglycan	206	209	PF01048	0.219
MOD_GlcNHglycan	225	228	PF01048	0.267
MOD_GlcNHglycan	229	232	PF01048	0.444
MOD_GSK3_1	137	144	PF00069	0.466
MOD_GSK3_1	15	22	PF00069	0.368
MOD_GSK3_1	150	157	PF00069	0.480
MOD_GSK3_1	204	211	PF00069	0.489
MOD_GSK3_1	223	230	PF00069	0.303
MOD_GSK3_1	26	33	PF00069	0.382
MOD_GSK3_1	37	44	PF00069	0.446
MOD_NEK2_1	106	111	PF00069	0.326
MOD_NEK2_1	145	150	PF00069	0.433
MOD_NEK2_1	15	20	PF00069	0.369
MOD_NEK2_1	212	217	PF00069	0.465
MOD_NEK2_1	77	82	PF00069	0.482
MOD_OFUCOSY	16	23	PF10250	0.369
MOD_PIKK_1	106	112	PF00454	0.327
MOD_PIKK_1	328	334	PF00454	0.652
MOD_PKA_1	48	54	PF00069	0.453
MOD_PKA_2	232	238	PF00069	0.444
MOD_PKA_2	48	54	PF00069	0.453
MOD_PKB_1	46	54	PF00069	0.456
MOD_Plk_4	141	147	PF00069	0.435
MOD_Plk_4	186	192	PF00069	0.417
MOD_Plk_4	77	83	PF00069	0.395
MOD_ProDKin_1	27	33	PF00069	0.389
MOD_ProDKin_1	331	337	PF00069	0.590
MOD_ProDKin_1	338	344	PF00069	0.585
MOD_ProDKin_1	39	45	PF00069	0.447
MOD_ProDKin_1	91	97	PF00069	0.419
MOD_SUMO_rev_2	215	224	PF00179	0.424
TRG_ENDOCYTIC_2	270	273	PF00928	0.447
TRG_ENDOCYTIC_2	313	316	PF00928	0.473
TRG_ER_diArg_1	254	257	PF00400	0.422
TRG_ER_diArg_1	324	326	PF00400	0.577
TRG_ER_diArg_1	46	49	PF00400	0.715
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJD4	Leptomonas seymouri	60%	100%
A0A0S4JHJ7	Bodo saltans	36%	97%
A0A0S4KIJ3	Bodo saltans	31%	73%
A0A1X0P4D9	Trypanosomatidae	43%	100%
A0A3Q8IWC9	Leishmania donovani	91%	100%
A0A3R7KFT3	Trypanosoma rangeli	32%	82%
A0A422NC68	Trypanosoma rangeli	43%	100%
A4HQ05	Leishmania braziliensis	75%	100%
A4IDR6	Leishmania infantum	91%	100%
D0A8W7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ATS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q09JZ4	Chlamydomonas reinhardtii	33%	87%
Q7ZV84	Danio rerio	32%	67%
V5D6Q2	Trypanosoma cruzi	32%	73%