Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0S1_LEIMA

TriTrypDb:

LmjF.36.4910 , LMJLV39_360060800 , LMJSD75_360060600

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0030990	intraciliary transport particle	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0S1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0S1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.587
CLV_NRD_NRD_1	15	17	PF00675	0.516
CLV_NRD_NRD_1	157	159	PF00675	0.487
CLV_NRD_NRD_1	188	190	PF00675	0.553
CLV_NRD_NRD_1	220	222	PF00675	0.440
CLV_NRD_NRD_1	263	265	PF00675	0.479
CLV_NRD_NRD_1	274	276	PF00675	0.448
CLV_NRD_NRD_1	295	297	PF00675	0.539
CLV_NRD_NRD_1	33	35	PF00675	0.499
CLV_NRD_NRD_1	332	334	PF00675	0.452
CLV_NRD_NRD_1	336	338	PF00675	0.445
CLV_NRD_NRD_1	63	65	PF00675	0.666
CLV_PCSK_FUR_1	261	265	PF00082	0.501
CLV_PCSK_KEX2_1	113	115	PF00082	0.546
CLV_PCSK_KEX2_1	15	17	PF00082	0.516
CLV_PCSK_KEX2_1	183	185	PF00082	0.516
CLV_PCSK_KEX2_1	220	222	PF00082	0.440
CLV_PCSK_KEX2_1	263	265	PF00082	0.501
CLV_PCSK_KEX2_1	295	297	PF00082	0.641
CLV_PCSK_KEX2_1	332	334	PF00082	0.493
CLV_PCSK_KEX2_1	52	54	PF00082	0.656
CLV_PCSK_KEX2_1	63	65	PF00082	0.511
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.546
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.546
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.507
CLV_PCSK_PC7_1	48	54	PF00082	0.573
CLV_PCSK_SKI1_1	131	135	PF00082	0.586
CLV_PCSK_SKI1_1	16	20	PF00082	0.468
CLV_PCSK_SKI1_1	220	224	PF00082	0.465
CLV_PCSK_SKI1_1	263	267	PF00082	0.513
CLV_PCSK_SKI1_1	319	323	PF00082	0.550
CLV_PCSK_SKI1_1	43	47	PF00082	0.584
CLV_PCSK_SKI1_1	52	56	PF00082	0.529
DEG_APCC_DBOX_1	15	23	PF00400	0.587
DOC_CYCLIN_RxL_1	221	234	PF00134	0.469
DOC_USP7_MATH_1	240	244	PF00917	0.373
DOC_USP7_MATH_1	314	318	PF00917	0.454
DOC_USP7_MATH_1	5	9	PF00917	0.709
DOC_USP7_MATH_1	66	70	PF00917	0.707
DOC_USP7_UBL2_3	179	183	PF12436	0.610
LIG_14-3-3_CanoR_1	131	136	PF00244	0.644
LIG_14-3-3_CanoR_1	24	32	PF00244	0.584
LIG_14-3-3_CanoR_1	295	303	PF00244	0.542
LIG_FHA_1	224	230	PF00498	0.491
LIG_FHA_1	99	105	PF00498	0.606
LIG_FHA_2	264	270	PF00498	0.513
LIG_FHA_2	351	357	PF00498	0.552
LIG_LIR_Apic_2	297	303	PF02991	0.479
LIG_LIR_Gen_1	115	124	PF02991	0.593
LIG_LIR_Nem_3	115	119	PF02991	0.607
LIG_LIR_Nem_3	317	321	PF02991	0.492
LIG_Pex14_2	280	284	PF04695	0.460
LIG_PTB_Apo_2	230	237	PF02174	0.489
LIG_SH2_CRK	116	120	PF00017	0.598
LIG_SH2_CRK	318	322	PF00017	0.489
LIG_SH2_NCK_1	252	256	PF00017	0.509
LIG_SH2_NCK_1	70	74	PF00017	0.578
LIG_SH2_SRC	252	255	PF00017	0.512
LIG_SH2_SRC	300	303	PF00017	0.499
LIG_SH2_STAP1	120	124	PF00017	0.573
LIG_SH2_STAP1	252	256	PF00017	0.613
LIG_TRAF2_1	167	170	PF00917	0.573
LIG_TRAF2_1	257	260	PF00917	0.499
LIG_TRAF2_1	266	269	PF00917	0.507
LIG_UBA3_1	340	347	PF00899	0.430
MOD_CK2_1	263	269	PF00069	0.514
MOD_GlcNHglycan	7	10	PF01048	0.597
MOD_GlcNHglycan	76	79	PF01048	0.751
MOD_GlcNHglycan	91	94	PF01048	0.561
MOD_GSK3_1	240	247	PF00069	0.372
MOD_GSK3_1	346	353	PF00069	0.601
MOD_GSK3_1	81	88	PF00069	0.721
MOD_N-GLC_1	223	228	PF02516	0.581
MOD_NEK2_1	178	183	PF00069	0.474
MOD_NEK2_1	25	30	PF00069	0.589
MOD_NEK2_1	294	299	PF00069	0.483
MOD_NEK2_1	304	309	PF00069	0.587
MOD_NEK2_1	89	94	PF00069	0.724
MOD_PIKK_1	25	31	PF00454	0.594
MOD_PKA_1	244	250	PF00069	0.441
MOD_PKA_1	263	269	PF00069	0.589
MOD_PKA_2	25	31	PF00069	0.584
MOD_PKA_2	263	269	PF00069	0.448
MOD_PKA_2	294	300	PF00069	0.548
MOD_PKA_2	350	356	PF00069	0.542
MOD_PKA_2	89	95	PF00069	0.677
MOD_PKB_1	261	269	PF00069	0.652
MOD_Plk_1	223	229	PF00069	0.580
MOD_Plk_1	98	104	PF00069	0.580
MOD_SUMO_rev_2	154	161	PF00179	0.563
TRG_ENDOCYTIC_2	116	119	PF00928	0.610
TRG_ENDOCYTIC_2	252	255	PF00928	0.512
TRG_ENDOCYTIC_2	318	321	PF00928	0.494
TRG_ER_diArg_1	220	222	PF00400	0.481
TRG_ER_diArg_1	24	27	PF00400	0.500
TRG_ER_diArg_1	261	264	PF00400	0.580
TRG_ER_diArg_1	294	296	PF00400	0.517
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	227	232	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	263	268	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBM7	Leptomonas seymouri	68%	100%
A0A1X0P2Z9	Trypanosomatidae	40%	100%
A0A3Q8ILH7	Leishmania donovani	98%	100%
A0A3R7KX10	Trypanosoma rangeli	37%	100%
A4HQ08	Leishmania braziliensis	81%	100%
A4IDR9	Leishmania infantum	98%	100%
D0A8W4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ATS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5B8Z3	Trypanosoma cruzi	40%	100%