Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0S0_LEIMA

TriTrypDb:

LmjF.36.4920 , LMJLV39_360060900 , LMJSD75_360060700

Length:

710

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	2
GO:0005938	cell cortex	3	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q0S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0S0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.415
CLV_C14_Caspase3-7	287	291	PF00656	0.296
CLV_C14_Caspase3-7	550	554	PF00656	0.654
CLV_C14_Caspase3-7	565	569	PF00656	0.506
CLV_C14_Caspase3-7	93	97	PF00656	0.436
CLV_NRD_NRD_1	102	104	PF00675	0.439
CLV_NRD_NRD_1	462	464	PF00675	0.614
CLV_NRD_NRD_1	560	562	PF00675	0.652
CLV_NRD_NRD_1	66	68	PF00675	0.472
CLV_NRD_NRD_1	672	674	PF00675	0.462
CLV_PCSK_KEX2_1	112	114	PF00082	0.565
CLV_PCSK_KEX2_1	253	255	PF00082	0.308
CLV_PCSK_KEX2_1	441	443	PF00082	0.555
CLV_PCSK_KEX2_1	462	464	PF00082	0.581
CLV_PCSK_KEX2_1	559	561	PF00082	0.667
CLV_PCSK_KEX2_1	66	68	PF00082	0.451
CLV_PCSK_KEX2_1	672	674	PF00082	0.398
CLV_PCSK_KEX2_1	682	684	PF00082	0.395
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.502
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.304
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.555
CLV_PCSK_PC1ET2_1	682	684	PF00082	0.431
CLV_PCSK_PC7_1	678	684	PF00082	0.422
CLV_PCSK_SKI1_1	112	116	PF00082	0.480
CLV_PCSK_SKI1_1	14	18	PF00082	0.359
CLV_PCSK_SKI1_1	653	657	PF00082	0.469
CLV_PCSK_SKI1_1	673	677	PF00082	0.308
CLV_PCSK_SKI1_1	682	686	PF00082	0.337
CLV_PCSK_SKI1_1	90	94	PF00082	0.520
CLV_PCSK_SKI1_1	95	99	PF00082	0.447
DEG_APCC_DBOX_1	188	196	PF00400	0.518
DEG_APCC_DBOX_1	335	343	PF00400	0.550
DEG_APCC_DBOX_1	94	102	PF00400	0.486
DEG_SCF_FBW7_1	515	520	PF00400	0.616
DEG_SCF_FBW7_2	586	591	PF00400	0.588
DEG_SPOP_SBC_1	391	395	PF00917	0.524
DEG_SPOP_SBC_1	473	477	PF00917	0.529
DOC_AGCK_PIF_2	17	22	PF00069	0.380
DOC_CKS1_1	488	493	PF01111	0.544
DOC_CKS1_1	514	519	PF01111	0.620
DOC_MAPK_gen_1	24	34	PF00069	0.474
DOC_MAPK_gen_1	672	679	PF00069	0.377
DOC_MAPK_MEF2A_6	168	176	PF00069	0.521
DOC_MAPK_MEF2A_6	227	236	PF00069	0.304
DOC_MAPK_MEF2A_6	315	322	PF00069	0.389
DOC_MAPK_MEF2A_6	625	634	PF00069	0.428
DOC_MAPK_MEF2A_6	672	679	PF00069	0.377
DOC_PP1_RVXF_1	602	608	PF00149	0.595
DOC_PP1_RVXF_1	670	677	PF00149	0.444
DOC_PP2B_LxvP_1	249	252	PF13499	0.321
DOC_PP2B_PxIxI_1	317	323	PF00149	0.428
DOC_PP4_FxxP_1	176	179	PF00568	0.513
DOC_PP4_MxPP_1	471	474	PF00568	0.557
DOC_USP7_MATH_1	139	143	PF00917	0.624
DOC_USP7_MATH_1	225	229	PF00917	0.397
DOC_USP7_MATH_1	391	395	PF00917	0.691
DOC_USP7_MATH_1	422	426	PF00917	0.567
DOC_USP7_MATH_1	450	454	PF00917	0.678
DOC_USP7_MATH_1	474	478	PF00917	0.532
DOC_USP7_MATH_1	483	487	PF00917	0.579
DOC_USP7_MATH_1	517	521	PF00917	0.641
DOC_USP7_MATH_1	554	558	PF00917	0.654
DOC_USP7_MATH_1	97	101	PF00917	0.430
DOC_USP7_MATH_2	362	368	PF00917	0.604
DOC_USP7_UBL2_3	437	441	PF12436	0.579
DOC_WW_Pin1_4	121	126	PF00397	0.625
DOC_WW_Pin1_4	154	159	PF00397	0.594
DOC_WW_Pin1_4	238	243	PF00397	0.325
DOC_WW_Pin1_4	375	380	PF00397	0.631
DOC_WW_Pin1_4	38	43	PF00397	0.422
DOC_WW_Pin1_4	410	415	PF00397	0.528
DOC_WW_Pin1_4	457	462	PF00397	0.645
DOC_WW_Pin1_4	464	469	PF00397	0.581
DOC_WW_Pin1_4	487	492	PF00397	0.756
DOC_WW_Pin1_4	506	511	PF00397	0.584
DOC_WW_Pin1_4	513	518	PF00397	0.638
DOC_WW_Pin1_4	584	589	PF00397	0.565
DOC_WW_Pin1_4	609	614	PF00397	0.592
DOC_WW_Pin1_4	645	650	PF00397	0.418
LIG_14-3-3_CanoR_1	103	108	PF00244	0.381
LIG_14-3-3_CanoR_1	119	125	PF00244	0.514
LIG_14-3-3_CanoR_1	295	304	PF00244	0.304
LIG_14-3-3_CanoR_1	306	314	PF00244	0.381
LIG_14-3-3_CanoR_1	423	427	PF00244	0.580
LIG_14-3-3_CanoR_1	651	656	PF00244	0.488
LIG_14-3-3_CanoR_1	85	92	PF00244	0.488
LIG_Actin_WH2_1	672	689	PF00022	0.448
LIG_Actin_WH2_2	212	229	PF00022	0.304
LIG_BIR_II_1	1	5	PF00653	0.515
LIG_BIR_III_2	553	557	PF00653	0.651
LIG_BRCT_BRCA1_1	1	5	PF00533	0.515
LIG_BRCT_BRCA1_1	172	176	PF00533	0.521
LIG_deltaCOP1_diTrp_1	215	222	PF00928	0.237
LIG_EH1_1	282	290	PF00400	0.325
LIG_FHA_1	427	433	PF00498	0.609
LIG_FHA_1	474	480	PF00498	0.786
LIG_FHA_2	186	192	PF00498	0.488
LIG_FHA_2	282	288	PF00498	0.304
LIG_FHA_2	333	339	PF00498	0.487
LIG_FHA_2	39	45	PF00498	0.474
LIG_FHA_2	4	10	PF00498	0.438
LIG_FHA_2	405	411	PF00498	0.610
LIG_FHA_2	488	494	PF00498	0.611
LIG_FHA_2	537	543	PF00498	0.704
LIG_FHA_2	585	591	PF00498	0.569
LIG_FHA_2	610	616	PF00498	0.626
LIG_FHA_2	656	662	PF00498	0.431
LIG_FHA_2	74	80	PF00498	0.445
LIG_FHA_2	91	97	PF00498	0.540
LIG_LIR_Apic_2	173	179	PF02991	0.515
LIG_LIR_Apic_2	215	220	PF02991	0.237
LIG_LIR_Gen_1	21	28	PF02991	0.378
LIG_LIR_Gen_1	273	283	PF02991	0.237
LIG_LIR_Gen_1	44	53	PF02991	0.394
LIG_LIR_Nem_3	15	20	PF02991	0.387
LIG_LIR_Nem_3	21	25	PF02991	0.396
LIG_LIR_Nem_3	273	278	PF02991	0.237
LIG_LIR_Nem_3	44	49	PF02991	0.390
LIG_LIR_Nem_3	624	630	PF02991	0.501
LIG_LIR_Nem_3	659	665	PF02991	0.452
LIG_NRBOX	231	237	PF00104	0.304
LIG_PDZ_Class_2	705	710	PF00595	0.513
LIG_REV1ctd_RIR_1	256	265	PF16727	0.304
LIG_RPA_C_Fungi	662	674	PF08784	0.387
LIG_SH2_CRK	665	669	PF00017	0.375
LIG_SH2_NCK_1	275	279	PF00017	0.369
LIG_SH2_STAP1	323	327	PF00017	0.423
LIG_SH2_STAT3	105	108	PF00017	0.539
LIG_SH2_STAT5	575	578	PF00017	0.583
LIG_SH2_STAT5	662	665	PF00017	0.371
LIG_SH3_1	462	468	PF00018	0.568
LIG_SH3_3	462	468	PF00018	0.577
LIG_SH3_3	530	536	PF00018	0.576
LIG_SUMO_SIM_anti_2	170	177	PF11976	0.520
LIG_SUMO_SIM_anti_2	628	634	PF11976	0.333
LIG_TRAF2_1	129	132	PF00917	0.557
LIG_TRAF2_1	394	397	PF00917	0.606
LIG_TRAF2_1	539	542	PF00917	0.783
LIG_TRAF2_1	562	565	PF00917	0.648
LIG_TRAF2_1	588	591	PF00917	0.597
LIG_TYR_ITIM	663	668	PF00017	0.453
LIG_UBA3_1	16	24	PF00899	0.396
LIG_UBA3_1	231	238	PF00899	0.294
LIG_UBA3_1	45	54	PF00899	0.461
LIG_UBA3_1	580	585	PF00899	0.507
LIG_WRC_WIRS_1	264	269	PF05994	0.324
LIG_WW_1	619	622	PF00397	0.468
LIG_WW_3	618	622	PF00397	0.483
MOD_CDC14_SPxK_1	648	651	PF00782	0.389
MOD_CDK_SPK_2	457	462	PF00069	0.557
MOD_CDK_SPxK_1	457	463	PF00069	0.614
MOD_CDK_SPxK_1	513	519	PF00069	0.643
MOD_CDK_SPxK_1	645	651	PF00069	0.415
MOD_CDK_SPxxK_3	121	128	PF00069	0.632
MOD_CDK_SPxxK_3	375	382	PF00069	0.622
MOD_CK1_1	118	124	PF00069	0.625
MOD_CK1_1	149	155	PF00069	0.591
MOD_CK1_1	170	176	PF00069	0.645
MOD_CK1_1	181	187	PF00069	0.511
MOD_CK1_1	404	410	PF00069	0.643
MOD_CK1_1	443	449	PF00069	0.576
MOD_CK1_1	457	463	PF00069	0.590
MOD_CK1_1	486	492	PF00069	0.608
MOD_CK1_1	509	515	PF00069	0.591
MOD_CK1_1	567	573	PF00069	0.535
MOD_CK1_1	598	604	PF00069	0.524
MOD_CK1_1	609	615	PF00069	0.591
MOD_CK2_1	38	44	PF00069	0.595
MOD_CK2_1	380	386	PF00069	0.711
MOD_CK2_1	390	396	PF00069	0.642
MOD_CK2_1	404	410	PF00069	0.607
MOD_CK2_1	474	480	PF00069	0.544
MOD_CK2_1	536	542	PF00069	0.775
MOD_CK2_1	559	565	PF00069	0.646
MOD_CK2_1	584	590	PF00069	0.587
MOD_CK2_1	609	615	PF00069	0.634
MOD_CK2_1	655	661	PF00069	0.445
MOD_GlcNHglycan	1	4	PF01048	0.565
MOD_GlcNHglycan	161	164	PF01048	0.686
MOD_GlcNHglycan	169	172	PF01048	0.579
MOD_GlcNHglycan	183	186	PF01048	0.574
MOD_GlcNHglycan	227	230	PF01048	0.369
MOD_GlcNHglycan	309	312	PF01048	0.402
MOD_GlcNHglycan	403	406	PF01048	0.654
MOD_GlcNHglycan	452	455	PF01048	0.699
MOD_GlcNHglycan	476	479	PF01048	0.622
MOD_GlcNHglycan	511	514	PF01048	0.724
MOD_GlcNHglycan	544	547	PF01048	0.620
MOD_GlcNHglycan	561	564	PF01048	0.594
MOD_GlcNHglycan	568	572	PF01048	0.509
MOD_GlcNHglycan	658	661	PF01048	0.434
MOD_GSK3_1	148	155	PF00069	0.578
MOD_GSK3_1	159	166	PF00069	0.540
MOD_GSK3_1	170	177	PF00069	0.529
MOD_GSK3_1	181	188	PF00069	0.522
MOD_GSK3_1	238	245	PF00069	0.325
MOD_GSK3_1	263	270	PF00069	0.325
MOD_GSK3_1	296	303	PF00069	0.369
MOD_GSK3_1	373	380	PF00069	0.612
MOD_GSK3_1	391	398	PF00069	0.492
MOD_GSK3_1	410	417	PF00069	0.537
MOD_GSK3_1	422	429	PF00069	0.684
MOD_GSK3_1	450	457	PF00069	0.614
MOD_GSK3_1	483	490	PF00069	0.651
MOD_GSK3_1	509	516	PF00069	0.619
MOD_GSK3_1	537	544	PF00069	0.728
MOD_GSK3_1	651	658	PF00069	0.505
MOD_N-GLC_1	501	506	PF02516	0.634
MOD_N-GLC_1	668	673	PF02516	0.388
MOD_N-GLC_1	73	78	PF02516	0.522
MOD_NEK2_1	115	120	PF00069	0.588
MOD_NEK2_1	153	158	PF00069	0.724
MOD_NEK2_1	174	179	PF00069	0.514
MOD_NEK2_1	267	272	PF00069	0.325
MOD_NEK2_1	390	395	PF00069	0.520
MOD_NEK2_1	614	619	PF00069	0.611
MOD_NEK2_1	668	673	PF00069	0.514
MOD_NEK2_2	139	144	PF00069	0.656
MOD_PIKK_1	404	410	PF00454	0.535
MOD_PIKK_1	614	620	PF00454	0.554
MOD_PK_1	103	109	PF00069	0.497
MOD_PKA_1	103	109	PF00069	0.478
MOD_PKA_1	253	259	PF00069	0.304
MOD_PKA_1	559	565	PF00069	0.654
MOD_PKA_2	118	124	PF00069	0.648
MOD_PKA_2	253	259	PF00069	0.304
MOD_PKA_2	332	338	PF00069	0.546
MOD_PKA_2	422	428	PF00069	0.581
MOD_PKA_2	546	552	PF00069	0.718
MOD_PKA_2	559	565	PF00069	0.597
MOD_PKA_2	60	66	PF00069	0.504
MOD_PKA_2	84	90	PF00069	0.469
MOD_PKB_1	651	659	PF00069	0.463
MOD_Plk_1	149	155	PF00069	0.651
MOD_Plk_1	28	34	PF00069	0.476
MOD_Plk_1	395	401	PF00069	0.526
MOD_Plk_1	414	420	PF00069	0.590
MOD_Plk_1	495	501	PF00069	0.641
MOD_Plk_2-3	440	446	PF00069	0.530
MOD_Plk_4	170	176	PF00069	0.587
MOD_Plk_4	263	269	PF00069	0.304
MOD_Plk_4	483	489	PF00069	0.538
MOD_Plk_4	79	85	PF00069	0.418
MOD_ProDKin_1	121	127	PF00069	0.628
MOD_ProDKin_1	154	160	PF00069	0.597
MOD_ProDKin_1	238	244	PF00069	0.325
MOD_ProDKin_1	375	381	PF00069	0.630
MOD_ProDKin_1	38	44	PF00069	0.422
MOD_ProDKin_1	410	416	PF00069	0.531
MOD_ProDKin_1	457	463	PF00069	0.650
MOD_ProDKin_1	464	470	PF00069	0.581
MOD_ProDKin_1	487	493	PF00069	0.759
MOD_ProDKin_1	506	512	PF00069	0.585
MOD_ProDKin_1	513	519	PF00069	0.638
MOD_ProDKin_1	584	590	PF00069	0.567
MOD_ProDKin_1	609	615	PF00069	0.593
MOD_ProDKin_1	645	651	PF00069	0.415
MOD_SUMO_rev_2	245	252	PF00179	0.497
MOD_SUMO_rev_2	538	545	PF00179	0.658
MOD_SUMO_rev_2	82	92	PF00179	0.414
MOD_SUMO_rev_2	96	106	PF00179	0.427
TRG_DiLeu_BaEn_4	131	137	PF01217	0.600
TRG_ENDOCYTIC_2	275	278	PF00928	0.369
TRG_ENDOCYTIC_2	50	53	PF00928	0.465
TRG_ENDOCYTIC_2	665	668	PF00928	0.460
TRG_ER_diArg_1	461	463	PF00400	0.571
TRG_ER_diArg_1	559	561	PF00400	0.688
TRG_ER_diArg_1	66	69	PF00400	0.477
TRG_ER_diArg_1	672	674	PF00400	0.462
TRG_NES_CRM1_1	224	240	PF08389	0.304
TRG_NES_CRM1_1	44	56	PF08389	0.466
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJX5	Leptomonas seymouri	47%	99%
A0A3S7XBQ1	Leishmania donovani	87%	100%
A4HQ09	Leishmania braziliensis	65%	99%
A4IDS0	Leishmania infantum	87%	100%
E9ATS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%