RWD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterized protein family UPF0029, putative

Species:

Leishmania major

UniProt:

Q4Q0R8_LEIMA

TriTrypDb:

LmjF.36.4940 , LMJLV39_360061200 , LMJSD75_360061000

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q0R8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0R8

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	8
GO:0006446	regulation of translational initiation	7	2
GO:0009889	regulation of biosynthetic process	4	8
GO:0010468	regulation of gene expression	5	8
GO:0010556	regulation of macromolecule biosynthetic process	5	8
GO:0010608	post-transcriptional regulation of gene expression	6	8
GO:0019222	regulation of metabolic process	3	8
GO:0031323	regulation of cellular metabolic process	4	8
GO:0031326	regulation of cellular biosynthetic process	5	8
GO:0034248	regulation of amide metabolic process	5	8
GO:0050789	regulation of biological process	2	8
GO:0050794	regulation of cellular process	3	8
GO:0051171	regulation of nitrogen compound metabolic process	4	8
GO:0051246	regulation of protein metabolic process	5	8
GO:0060255	regulation of macromolecule metabolic process	4	8
GO:0065007	biological regulation	1	8
GO:0080090	regulation of primary metabolic process	4	8
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.580
CLV_NRD_NRD_1	132	134	PF00675	0.621
CLV_NRD_NRD_1	148	150	PF00675	0.242
CLV_NRD_NRD_1	270	272	PF00675	0.598
CLV_NRD_NRD_1	76	78	PF00675	0.531
CLV_PCSK_KEX2_1	132	134	PF00082	0.627
CLV_PCSK_KEX2_1	148	150	PF00082	0.331
CLV_PCSK_KEX2_1	270	272	PF00082	0.626
CLV_PCSK_KEX2_1	76	78	PF00082	0.480
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.590
CLV_PCSK_SKI1_1	104	108	PF00082	0.578
CLV_PCSK_SKI1_1	173	177	PF00082	0.309
CLV_PCSK_SKI1_1	213	217	PF00082	0.264
CLV_PCSK_SKI1_1	252	256	PF00082	0.281
DOC_CYCLIN_RxL_1	246	260	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	84	90	PF00134	0.390
DOC_MAPK_gen_1	132	139	PF00069	0.555
DOC_MAPK_gen_1	243	250	PF00069	0.451
DOC_MAPK_gen_1	76	86	PF00069	0.404
DOC_MAPK_HePTP_8	74	86	PF00069	0.493
DOC_MAPK_MEF2A_6	77	86	PF00069	0.493
DOC_MAPK_NFAT4_5	79	87	PF00069	0.502
DOC_PP2B_LxvP_1	256	259	PF13499	0.389
DOC_PP2B_LxvP_1	84	87	PF13499	0.464
DOC_PP2B_LxvP_1	91	94	PF13499	0.428
DOC_USP7_MATH_1	49	53	PF00917	0.445
DOC_WW_Pin1_4	58	63	PF00397	0.493
LIG_14-3-3_CanoR_1	158	163	PF00244	0.514
LIG_14-3-3_CanoR_1	190	198	PF00244	0.481
LIG_14-3-3_CanoR_1	271	275	PF00244	0.468
LIG_APCC_ABBA_1	12	17	PF00400	0.480
LIG_BIR_II_1	1	5	PF00653	0.544
LIG_BIR_III_4	193	197	PF00653	0.514
LIG_eIF4E_1	53	59	PF01652	0.533
LIG_FHA_1	249	255	PF00498	0.503
LIG_FHA_2	255	261	PF00498	0.505
LIG_LIR_Gen_1	224	230	PF02991	0.481
LIG_LIR_Nem_3	224	229	PF02991	0.460
LIG_LIR_Nem_3	231	237	PF02991	0.439
LIG_LIR_Nem_3	242	247	PF02991	0.398
LIG_LIR_Nem_3	50	56	PF02991	0.465
LIG_LYPXL_yS_3	53	56	PF13949	0.435
LIG_NRP_CendR_1	272	275	PF00754	0.577
LIG_SH2_PTP2	226	229	PF00017	0.447
LIG_SH2_STAP1	187	191	PF00017	0.451
LIG_SH2_STAT5	226	229	PF00017	0.447
LIG_SH2_STAT5	57	60	PF00017	0.508
LIG_SH3_3	28	34	PF00018	0.416
LIG_SH3_3	38	44	PF00018	0.330
LIG_SUMO_SIM_par_1	226	231	PF11976	0.447
LIG_SUMO_SIM_par_1	254	260	PF11976	0.481
LIG_TRAF2_1	3	6	PF00917	0.422
LIG_UBA3_1	254	263	PF00899	0.449
MOD_CK1_1	13	19	PF00069	0.528
MOD_CK1_1	174	180	PF00069	0.555
MOD_CK1_1	208	214	PF00069	0.531
MOD_CK1_1	68	74	PF00069	0.476
MOD_CK2_1	158	164	PF00069	0.559
MOD_CK2_1	254	260	PF00069	0.468
MOD_CK2_1	95	101	PF00069	0.430
MOD_GlcNHglycan	1	4	PF01048	0.468
MOD_GlcNHglycan	140	143	PF01048	0.476
MOD_GlcNHglycan	207	210	PF01048	0.331
MOD_GlcNHglycan	267	270	PF01048	0.618
MOD_GlcNHglycan	67	70	PF01048	0.465
MOD_NEK2_1	10	15	PF00069	0.446
MOD_NEK2_1	248	253	PF00069	0.486
MOD_NEK2_1	254	259	PF00069	0.413
MOD_NEK2_1	265	270	PF00069	0.575
MOD_NEK2_1	39	44	PF00069	0.375
MOD_NEK2_1	95	100	PF00069	0.423
MOD_PIKK_1	68	74	PF00454	0.425
MOD_PKA_1	132	138	PF00069	0.528
MOD_PKA_2	120	126	PF00069	0.611
MOD_PKA_2	132	138	PF00069	0.547
MOD_PKA_2	147	153	PF00069	0.304
MOD_PKA_2	189	195	PF00069	0.481
MOD_Plk_1	49	55	PF00069	0.501
MOD_Plk_1	80	86	PF00069	0.385
MOD_Plk_4	10	16	PF00069	0.471
MOD_Plk_4	182	188	PF00069	0.456
MOD_Plk_4	25	31	PF00069	0.278
MOD_ProDKin_1	58	64	PF00069	0.499
MOD_SUMO_rev_2	98	106	PF00179	0.508
TRG_DiLeu_BaEn_3	5	11	PF01217	0.461
TRG_DiLeu_BaEn_4	101	107	PF01217	0.505
TRG_ENDOCYTIC_2	226	229	PF00928	0.451
TRG_ENDOCYTIC_2	53	56	PF00928	0.409
TRG_ENDOCYTIC_2	75	78	PF00928	0.285
TRG_ER_diArg_1	148	151	PF00400	0.531
TRG_ER_diArg_1	75	77	PF00400	0.522
TRG_ER_diLys_1	270	275	PF00400	0.582
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWZ9	Leptomonas seymouri	76%	100%
A0A0S4JCX3	Bodo saltans	47%	92%
A0A1X0P3C9	Trypanosomatidae	49%	100%
A0A3Q8IHS6	Leishmania donovani	93%	100%
A0A422NC53	Trypanosoma rangeli	52%	99%
A4HQ11	Leishmania braziliensis	83%	100%
A4ICE6	Leishmania infantum	93%	100%
E9ATS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O13997	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	98%
Q5GFD8	Oryctolagus cuniculus	31%	87%
Q5M8G6	Xenopus tropicalis	33%	86%
Q9W625	Xenopus laevis	34%	88%
Q9XWF4	Caenorhabditis elegans	35%	100%
V5B4H2	Trypanosoma cruzi	52%	88%