Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania major

UniProt:

Q4Q0R7_LEIMA

TriTrypDb:

LmjF.36.4950 , LMJLV39_360061300 , LMJSD75_360061100

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0R7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0R7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.572
CLV_C14_Caspase3-7	231	235	PF00656	0.521
CLV_C14_Caspase3-7	608	612	PF00656	0.636
CLV_C14_Caspase3-7	71	75	PF00656	0.524
CLV_NRD_NRD_1	10	12	PF00675	0.655
CLV_NRD_NRD_1	198	200	PF00675	0.446
CLV_NRD_NRD_1	30	32	PF00675	0.761
CLV_NRD_NRD_1	478	480	PF00675	0.605
CLV_NRD_NRD_1	526	528	PF00675	0.510
CLV_NRD_NRD_1	709	711	PF00675	0.628
CLV_PCSK_KEX2_1	179	181	PF00082	0.414
CLV_PCSK_KEX2_1	198	200	PF00082	0.302
CLV_PCSK_KEX2_1	30	32	PF00082	0.776
CLV_PCSK_KEX2_1	363	365	PF00082	0.358
CLV_PCSK_KEX2_1	478	480	PF00082	0.605
CLV_PCSK_KEX2_1	526	528	PF00082	0.518
CLV_PCSK_KEX2_1	566	568	PF00082	0.321
CLV_PCSK_KEX2_1	620	622	PF00082	0.661
CLV_PCSK_KEX2_1	709	711	PF00082	0.696
CLV_PCSK_KEX2_1	9	11	PF00082	0.632
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.416
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.358
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.321
CLV_PCSK_PC1ET2_1	620	622	PF00082	0.661
CLV_PCSK_PC1ET2_1	709	711	PF00082	0.690
CLV_PCSK_PC7_1	5	11	PF00082	0.617
CLV_PCSK_PC7_1	616	622	PF00082	0.512
CLV_PCSK_SKI1_1	179	183	PF00082	0.487
CLV_PCSK_SKI1_1	490	494	PF00082	0.332
CLV_PCSK_SKI1_1	526	530	PF00082	0.390
DEG_APCC_DBOX_1	478	486	PF00400	0.500
DOC_CDC14_PxL_1	582	590	PF14671	0.598
DOC_CKS1_1	403	408	PF01111	0.323
DOC_CKS1_1	514	519	PF01111	0.417
DOC_CKS1_1	581	586	PF01111	0.467
DOC_MAPK_MEF2A_6	312	320	PF00069	0.445
DOC_MAPK_MEF2A_6	663	672	PF00069	0.505
DOC_MAPK_MEF2A_6	97	106	PF00069	0.334
DOC_PP2B_LxvP_1	575	578	PF13499	0.468
DOC_PP2B_LxvP_1	668	671	PF13499	0.528
DOC_USP7_MATH_1	183	187	PF00917	0.548
DOC_USP7_MATH_1	294	298	PF00917	0.593
DOC_USP7_MATH_1	43	47	PF00917	0.640
DOC_USP7_MATH_1	481	485	PF00917	0.389
DOC_USP7_MATH_1	576	580	PF00917	0.547
DOC_USP7_MATH_1	596	600	PF00917	0.643
DOC_USP7_MATH_1	76	80	PF00917	0.620
DOC_USP7_MATH_2	242	248	PF00917	0.613
DOC_USP7_MATH_2	354	360	PF00917	0.476
DOC_WW_Pin1_4	226	231	PF00397	0.754
DOC_WW_Pin1_4	253	258	PF00397	0.436
DOC_WW_Pin1_4	297	302	PF00397	0.598
DOC_WW_Pin1_4	34	39	PF00397	0.675
DOC_WW_Pin1_4	350	355	PF00397	0.382
DOC_WW_Pin1_4	402	407	PF00397	0.309
DOC_WW_Pin1_4	513	518	PF00397	0.494
DOC_WW_Pin1_4	580	585	PF00397	0.443
DOC_WW_Pin1_4	61	66	PF00397	0.474
DOC_WW_Pin1_4	614	619	PF00397	0.761
LIG_14-3-3_CanoR_1	16	23	PF00244	0.606
LIG_14-3-3_CanoR_1	180	188	PF00244	0.521
LIG_14-3-3_CanoR_1	214	221	PF00244	0.770
LIG_14-3-3_CanoR_1	31	41	PF00244	0.649
LIG_14-3-3_CanoR_1	542	551	PF00244	0.361
LIG_APCC_ABBA_1	424	429	PF00400	0.393
LIG_BRCT_BRCA1_1	246	250	PF00533	0.444
LIG_BRCT_BRCA1_1	578	582	PF00533	0.470
LIG_Clathr_ClatBox_1	315	319	PF01394	0.418
LIG_EH1_1	171	179	PF00400	0.483
LIG_eIF4E_1	188	194	PF01652	0.341
LIG_FHA_1	105	111	PF00498	0.377
LIG_FHA_1	148	154	PF00498	0.388
LIG_FHA_1	159	165	PF00498	0.444
LIG_FHA_1	169	175	PF00498	0.386
LIG_FHA_1	188	194	PF00498	0.244
LIG_FHA_1	323	329	PF00498	0.374
LIG_FHA_1	46	52	PF00498	0.626
LIG_FHA_1	514	520	PF00498	0.505
LIG_FHA_1	545	551	PF00498	0.356
LIG_FHA_1	632	638	PF00498	0.650
LIG_FHA_1	678	684	PF00498	0.508
LIG_FHA_2	351	357	PF00498	0.398
LIG_FHA_2	363	369	PF00498	0.373
LIG_FHA_2	370	376	PF00498	0.443
LIG_LIR_Apic_2	498	504	PF02991	0.366
LIG_LIR_Gen_1	190	196	PF02991	0.343
LIG_LIR_Gen_1	275	285	PF02991	0.542
LIG_LIR_Gen_1	336	344	PF02991	0.437
LIG_LIR_Gen_1	39	47	PF02991	0.565
LIG_LIR_Gen_1	393	400	PF02991	0.371
LIG_LIR_Nem_3	119	124	PF02991	0.435
LIG_LIR_Nem_3	185	191	PF02991	0.382
LIG_LIR_Nem_3	275	280	PF02991	0.546
LIG_LIR_Nem_3	336	340	PF02991	0.436
LIG_LIR_Nem_3	39	44	PF02991	0.566
LIG_LIR_Nem_3	498	503	PF02991	0.392
LIG_MYND_1	207	211	PF01753	0.612
LIG_PAM2_1	258	270	PF00658	0.482
LIG_PCNA_PIPBox_1	619	628	PF02747	0.504
LIG_PCNA_yPIPBox_3	265	277	PF02747	0.463
LIG_PCNA_yPIPBox_3	616	626	PF02747	0.508
LIG_Pex14_1	390	394	PF04695	0.350
LIG_Pex14_2	277	281	PF04695	0.377
LIG_PTB_Apo_2	522	529	PF02174	0.499
LIG_SH2_CRK	400	404	PF00017	0.409
LIG_SH2_CRK	501	505	PF00017	0.477
LIG_SH2_GRB2like	457	460	PF00017	0.614
LIG_SH2_PTP2	337	340	PF00017	0.360
LIG_SH2_SRC	457	460	PF00017	0.531
LIG_SH2_STAP1	41	45	PF00017	0.544
LIG_SH2_STAP1	646	650	PF00017	0.493
LIG_SH2_STAT3	156	159	PF00017	0.514
LIG_SH2_STAT3	451	454	PF00017	0.483
LIG_SH2_STAT5	333	336	PF00017	0.321
LIG_SH2_STAT5	337	340	PF00017	0.320
LIG_SH2_STAT5	433	436	PF00017	0.323
LIG_SH2_STAT5	570	573	PF00017	0.364
LIG_SH3_1	254	260	PF00018	0.442
LIG_SH3_3	254	260	PF00018	0.469
LIG_SH3_3	263	269	PF00018	0.474
LIG_SH3_3	449	455	PF00018	0.428
LIG_SH3_3	483	489	PF00018	0.341
LIG_SH3_3	511	517	PF00018	0.539
LIG_SH3_3	583	589	PF00018	0.478
LIG_SUMO_SIM_par_1	435	441	PF11976	0.299
LIG_SUMO_SIM_par_1	633	640	PF11976	0.511
LIG_SUMO_SIM_par_1	664	669	PF11976	0.497
LIG_TRAF2_1	353	356	PF00917	0.449
LIG_TRAF2_1	365	368	PF00917	0.304
LIG_TRAF2_1	650	653	PF00917	0.601
LIG_WRC_WIRS_1	188	193	PF05994	0.360
LIG_WRC_WIRS_1	346	351	PF05994	0.348
LIG_WRC_WIRS_1	447	452	PF05994	0.454
LIG_WRC_WIRS_1	622	627	PF05994	0.502
MOD_CDC14_SPxK_1	617	620	PF00782	0.782
MOD_CDK_SPxK_1	614	620	PF00069	0.791
MOD_CDK_SPxxK_3	297	304	PF00069	0.388
MOD_CDK_SPxxK_3	614	621	PF00069	0.595
MOD_CK1_1	212	218	PF00069	0.708
MOD_CK1_1	229	235	PF00069	0.690
MOD_CK1_1	275	281	PF00069	0.337
MOD_CK1_1	297	303	PF00069	0.571
MOD_CK1_1	32	38	PF00069	0.629
MOD_CK1_1	359	365	PF00069	0.479
MOD_CK1_1	380	386	PF00069	0.341
MOD_CK1_1	441	447	PF00069	0.337
MOD_CK1_1	46	52	PF00069	0.605
MOD_CK1_1	544	550	PF00069	0.357
MOD_CK1_1	603	609	PF00069	0.652
MOD_CK1_1	610	616	PF00069	0.702
MOD_CK2_1	336	342	PF00069	0.328
MOD_CK2_1	350	356	PF00069	0.375
MOD_CK2_1	362	368	PF00069	0.395
MOD_CK2_1	369	375	PF00069	0.473
MOD_Cter_Amidation	476	479	PF01082	0.493
MOD_GlcNHglycan	224	227	PF01048	0.711
MOD_GlcNHglycan	246	249	PF01048	0.482
MOD_GlcNHglycan	45	48	PF01048	0.683
MOD_GlcNHglycan	495	498	PF01048	0.479
MOD_GlcNHglycan	598	601	PF01048	0.704
MOD_GlcNHglycan	603	606	PF01048	0.702
MOD_GlcNHglycan	611	615	PF01048	0.727
MOD_GlcNHglycan	706	709	PF01048	0.518
MOD_GlcNHglycan	88	91	PF01048	0.509
MOD_GSK3_1	154	161	PF00069	0.391
MOD_GSK3_1	168	175	PF00069	0.370
MOD_GSK3_1	179	186	PF00069	0.363
MOD_GSK3_1	209	216	PF00069	0.689
MOD_GSK3_1	222	229	PF00069	0.511
MOD_GSK3_1	29	36	PF00069	0.669
MOD_GSK3_1	369	376	PF00069	0.445
MOD_GSK3_1	405	412	PF00069	0.359
MOD_GSK3_1	438	445	PF00069	0.414
MOD_GSK3_1	533	540	PF00069	0.541
MOD_GSK3_1	576	583	PF00069	0.494
MOD_GSK3_1	596	603	PF00069	0.480
MOD_GSK3_1	606	613	PF00069	0.640
MOD_GSK3_1	66	73	PF00069	0.610
MOD_GSK3_1	671	678	PF00069	0.664
MOD_GSK3_1	709	716	PF00069	0.629
MOD_N-GLC_1	465	470	PF02516	0.463
MOD_NEK2_1	172	177	PF00069	0.358
MOD_NEK2_1	373	378	PF00069	0.507
MOD_NEK2_1	442	447	PF00069	0.353
MOD_NEK2_1	60	65	PF00069	0.512
MOD_NEK2_1	687	692	PF00069	0.490
MOD_NEK2_2	446	451	PF00069	0.442
MOD_NEK2_2	465	470	PF00069	0.334
MOD_OFUCOSY	371	377	PF10250	0.450
MOD_PIKK_1	209	215	PF00454	0.739
MOD_PIKK_1	275	281	PF00454	0.402
MOD_PKA_1	179	185	PF00069	0.506
MOD_PKA_1	709	715	PF00069	0.607
MOD_PKA_2	179	185	PF00069	0.506
MOD_PKA_2	197	203	PF00069	0.337
MOD_PKA_2	213	219	PF00069	0.454
MOD_PKA_2	29	35	PF00069	0.697
MOD_PKA_2	541	547	PF00069	0.356
MOD_PKA_2	552	558	PF00069	0.414
MOD_PKA_2	606	612	PF00069	0.704
MOD_PKA_2	709	715	PF00069	0.607
MOD_PKB_1	284	292	PF00069	0.471
MOD_Plk_1	465	471	PF00069	0.458
MOD_Plk_2-3	336	342	PF00069	0.367
MOD_Plk_4	160	166	PF00069	0.534
MOD_Plk_4	272	278	PF00069	0.421
MOD_Plk_4	311	317	PF00069	0.480
MOD_Plk_4	345	351	PF00069	0.550
MOD_Plk_4	377	383	PF00069	0.360
MOD_Plk_4	435	441	PF00069	0.295
MOD_Plk_4	446	452	PF00069	0.307
MOD_Plk_4	481	487	PF00069	0.381
MOD_Plk_4	621	627	PF00069	0.533
MOD_Plk_4	679	685	PF00069	0.475
MOD_Plk_4	687	693	PF00069	0.458
MOD_ProDKin_1	226	232	PF00069	0.755
MOD_ProDKin_1	253	259	PF00069	0.439
MOD_ProDKin_1	297	303	PF00069	0.595
MOD_ProDKin_1	34	40	PF00069	0.669
MOD_ProDKin_1	350	356	PF00069	0.390
MOD_ProDKin_1	402	408	PF00069	0.310
MOD_ProDKin_1	513	519	PF00069	0.496
MOD_ProDKin_1	580	586	PF00069	0.451
MOD_ProDKin_1	61	67	PF00069	0.467
MOD_ProDKin_1	614	620	PF00069	0.762
MOD_SUMO_rev_2	185	191	PF00179	0.312
MOD_SUMO_rev_2	355	359	PF00179	0.413
MOD_SUMO_rev_2	49	57	PF00179	0.426
MOD_SUMO_rev_2	660	665	PF00179	0.503
MOD_SUMO_rev_2	689	698	PF00179	0.488
TRG_DiLeu_BaEn_1	488	493	PF01217	0.302
TRG_DiLeu_BaEn_1	661	666	PF01217	0.544
TRG_DiLeu_BaEn_4	342	348	PF01217	0.366
TRG_ENDOCYTIC_2	188	191	PF00928	0.358
TRG_ENDOCYTIC_2	337	340	PF00928	0.419
TRG_ENDOCYTIC_2	400	403	PF00928	0.392
TRG_ENDOCYTIC_2	41	44	PF00928	0.568
TRG_ENDOCYTIC_2	433	436	PF00928	0.370
TRG_ENDOCYTIC_2	572	575	PF00928	0.369
TRG_ER_diArg_1	197	199	PF00400	0.507
TRG_ER_diArg_1	478	480	PF00400	0.617
TRG_ER_diArg_1	526	528	PF00400	0.518
TRG_ER_diArg_1	648	651	PF00400	0.426
TRG_ER_diArg_1	9	11	PF00400	0.604
TRG_NES_CRM1_1	660	673	PF08389	0.551
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL8	Leptomonas seymouri	65%	100%
A0A0S4JGT6	Bodo saltans	43%	100%
A0A1X0P422	Trypanosomatidae	45%	100%
A0A3S7XBU8	Leishmania donovani	93%	100%
A0A422NC22	Trypanosoma rangeli	48%	100%
A4HQ12	Leishmania braziliensis	79%	100%
A4ICE7	Leishmania infantum	93%	100%
D0A8V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ATS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5AP55	Trypanosoma cruzi	46%	100%