J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q0R5_LEIMA

TriTrypDb:

LmjF.36.4970 , LMJLV39_360061600 , LMJSD75_360061400

Length:

345

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0R5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.646
CLV_NRD_NRD_1	118	120	PF00675	0.567
CLV_NRD_NRD_1	203	205	PF00675	0.429
CLV_NRD_NRD_1	222	224	PF00675	0.565
CLV_NRD_NRD_1	253	255	PF00675	0.736
CLV_NRD_NRD_1	257	259	PF00675	0.737
CLV_NRD_NRD_1	270	272	PF00675	0.601
CLV_NRD_NRD_1	324	326	PF00675	0.773
CLV_NRD_NRD_1	43	45	PF00675	0.574
CLV_PCSK_FUR_1	116	120	PF00082	0.605
CLV_PCSK_KEX2_1	116	118	PF00082	0.610
CLV_PCSK_KEX2_1	203	205	PF00082	0.429
CLV_PCSK_KEX2_1	222	224	PF00082	0.519
CLV_PCSK_KEX2_1	253	255	PF00082	0.703
CLV_PCSK_KEX2_1	257	259	PF00082	0.705
CLV_PCSK_KEX2_1	272	274	PF00082	0.641
CLV_PCSK_KEX2_1	324	326	PF00082	0.776
CLV_PCSK_KEX2_1	339	341	PF00082	0.577
CLV_PCSK_KEX2_1	43	45	PF00082	0.574
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.538
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.704
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.708
CLV_PCSK_PC7_1	253	259	PF00082	0.723
CLV_PCSK_SKI1_1	167	171	PF00082	0.526
CLV_PCSK_SKI1_1	196	200	PF00082	0.494
CLV_PCSK_SKI1_1	253	257	PF00082	0.738
DEG_Nend_Nbox_1	1	3	PF02207	0.586
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.527
DOC_MAPK_gen_1	283	293	PF00069	0.658
DOC_USP7_MATH_1	227	231	PF00917	0.694
DOC_USP7_MATH_1	233	237	PF00917	0.679
DOC_USP7_MATH_1	264	268	PF00917	0.738
DOC_USP7_MATH_1	313	317	PF00917	0.733
DOC_USP7_MATH_1	32	36	PF00917	0.629
DOC_USP7_MATH_1	323	327	PF00917	0.698
DOC_WW_Pin1_4	256	261	PF00397	0.761
DOC_WW_Pin1_4	303	308	PF00397	0.704
LIG_14-3-3_CanoR_1	30	39	PF00244	0.595
LIG_14-3-3_CanoR_1	324	331	PF00244	0.599
LIG_BRCT_BRCA1_1	165	169	PF00533	0.475
LIG_deltaCOP1_diTrp_1	274	282	PF00928	0.660
LIG_FHA_1	145	151	PF00498	0.632
LIG_FHA_2	134	140	PF00498	0.652
LIG_FHA_2	147	153	PF00498	0.682
LIG_FHA_2	168	174	PF00498	0.498
LIG_FHA_2	197	203	PF00498	0.451
LIG_FHA_2	244	250	PF00498	0.548
LIG_FHA_2	290	296	PF00498	0.548
LIG_FHA_2	68	74	PF00498	0.409
LIG_LIR_Apic_2	281	285	PF02991	0.699
LIG_LIR_Gen_1	137	144	PF02991	0.566
LIG_LIR_Gen_1	70	80	PF02991	0.449
LIG_LIR_Nem_3	137	143	PF02991	0.574
LIG_LIR_Nem_3	166	171	PF02991	0.455
LIG_LIR_Nem_3	176	181	PF02991	0.408
LIG_LIR_Nem_3	334	338	PF02991	0.572
LIG_LIR_Nem_3	70	75	PF02991	0.417
LIG_MAD2	21	29	PF02301	0.550
LIG_MLH1_MIPbox_1	165	169	PF16413	0.482
LIG_NRBOX	298	304	PF00104	0.654
LIG_PCNA_yPIPBox_3	296	308	PF02747	0.662
LIG_Pex14_1	275	279	PF04695	0.701
LIG_PTB_Apo_2	204	211	PF02174	0.426
LIG_PTB_Apo_2	66	73	PF02174	0.434
LIG_PTB_Phospho_1	66	72	PF10480	0.432
LIG_SH2_CRK	178	182	PF00017	0.427
LIG_SH2_CRK	338	342	PF00017	0.710
LIG_SH2_CRK	85	89	PF00017	0.700
LIG_SH2_GRB2like	335	338	PF00017	0.564
LIG_SH2_NCK_1	72	76	PF00017	0.529
LIG_SH2_NCK_1	85	89	PF00017	0.706
LIG_SH2_SRC	261	264	PF00017	0.684
LIG_SH2_STAT3	287	290	PF00017	0.657
LIG_SH2_STAT5	216	219	PF00017	0.464
LIG_SH2_STAT5	46	49	PF00017	0.446
LIG_SH3_3	26	32	PF00018	0.613
LIG_SH3_3	274	280	PF00018	0.627
LIG_TRAF2_1	151	154	PF00917	0.591
LIG_TRAF2_1	292	295	PF00917	0.507
LIG_TYR_ITSM	174	181	PF00017	0.473
LIG_TYR_ITSM	68	75	PF00017	0.530
LIG_WRC_WIRS_1	168	173	PF05994	0.419
MOD_CDK_SPK_2	303	308	PF00069	0.704
MOD_CK1_1	130	136	PF00069	0.587
MOD_CK1_1	146	152	PF00069	0.600
MOD_CK1_1	235	241	PF00069	0.785
MOD_CK1_1	316	322	PF00069	0.757
MOD_CK1_1	326	332	PF00069	0.692
MOD_CK2_1	148	154	PF00069	0.560
MOD_CK2_1	196	202	PF00069	0.438
MOD_CK2_1	243	249	PF00069	0.774
MOD_CK2_1	256	262	PF00069	0.695
MOD_CK2_1	275	281	PF00069	0.644
MOD_CK2_1	289	295	PF00069	0.434
MOD_CK2_1	67	73	PF00069	0.430
MOD_GlcNHglycan	125	128	PF01048	0.688
MOD_GlcNHglycan	235	238	PF01048	0.638
MOD_GlcNHglycan	321	324	PF01048	0.755
MOD_GlcNHglycan	325	328	PF01048	0.712
MOD_GlcNHglycan	58	61	PF01048	0.509
MOD_GlcNHglycan	77	80	PF01048	0.333
MOD_GSK3_1	123	130	PF00069	0.629
MOD_GSK3_1	144	151	PF00069	0.619
MOD_GSK3_1	163	170	PF00069	0.483
MOD_GSK3_1	222	229	PF00069	0.621
MOD_GSK3_1	235	242	PF00069	0.692
MOD_GSK3_1	245	252	PF00069	0.685
MOD_GSK3_1	315	322	PF00069	0.624
MOD_LATS_1	165	171	PF00433	0.469
MOD_N-GLC_1	144	149	PF02516	0.630
MOD_NEK2_1	163	168	PF00069	0.503
MOD_NEK2_1	2	7	PF00069	0.593
MOD_NEK2_1	239	244	PF00069	0.795
MOD_NEK2_1	74	79	PF00069	0.439
MOD_NEK2_2	183	188	PF00069	0.473
MOD_PKA_1	222	228	PF00069	0.680
MOD_PKA_2	222	228	PF00069	0.643
MOD_PKA_2	323	329	PF00069	0.724
MOD_Plk_1	127	133	PF00069	0.684
MOD_Plk_1	173	179	PF00069	0.391
MOD_Plk_2-3	148	154	PF00069	0.679
MOD_Plk_2-3	289	295	PF00069	0.631
MOD_Plk_4	173	179	PF00069	0.417
MOD_Plk_4	196	202	PF00069	0.444
MOD_ProDKin_1	256	262	PF00069	0.760
MOD_ProDKin_1	303	309	PF00069	0.706
MOD_SUMO_rev_2	148	158	PF00179	0.644
TRG_DiLeu_BaEn_4	294	300	PF01217	0.614
TRG_ENDOCYTIC_2	178	181	PF00928	0.419
TRG_ENDOCYTIC_2	338	341	PF00928	0.566
TRG_ENDOCYTIC_2	46	49	PF00928	0.449
TRG_ENDOCYTIC_2	72	75	PF00928	0.411
TRG_ER_diArg_1	116	119	PF00400	0.611
TRG_ER_diArg_1	203	205	PF00400	0.429
TRG_ER_diArg_1	256	258	PF00400	0.737
TRG_ER_diArg_1	270	273	PF00400	0.706
TRG_ER_diArg_1	340	343	PF00400	0.652
TRG_ER_diArg_1	42	44	PF00400	0.562
TRG_NLS_Bipartite_1	324	343	PF00514	0.574
TRG_NLS_MonoExtC_3	338	343	PF00514	0.592
TRG_PTS1	342	345	PF00515	0.715

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P554	Leptomonas seymouri	65%	92%
A0A1X0P394	Trypanosomatidae	39%	87%
A0A3Q8IRL6	Leishmania donovani	90%	100%
A0A3R7NA51	Trypanosoma rangeli	50%	97%
A4HQ14	Leishmania braziliensis	82%	98%
A4ICE4	Leishmania infantum	90%	100%
D0A8V6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ATT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
V5BDN3	Trypanosoma cruzi	50%	100%