Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0R4_LEIMA

TriTrypDb:

LmjF.36.4980 , LMJLV39_360061800 , LMJSD75_360061500

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0R4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0R4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.609
CLV_MEL_PAP_1	174	180	PF00089	0.575
CLV_NRD_NRD_1	259	261	PF00675	0.620
CLV_NRD_NRD_1	269	271	PF00675	0.592
CLV_NRD_NRD_1	69	71	PF00675	0.714
CLV_NRD_NRD_1	74	76	PF00675	0.753
CLV_PCSK_KEX2_1	259	261	PF00082	0.610
CLV_PCSK_KEX2_1	69	71	PF00082	0.678
CLV_PCSK_KEX2_1	74	76	PF00082	0.820
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.636
CLV_PCSK_PC7_1	70	76	PF00082	0.762
CLV_PCSK_SKI1_1	130	134	PF00082	0.792
CLV_PCSK_SKI1_1	188	192	PF00082	0.666
CLV_PCSK_SKI1_1	217	221	PF00082	0.543
DEG_APCC_DBOX_1	259	267	PF00400	0.537
DEG_Nend_UBRbox_2	1	3	PF02207	0.700
DOC_CDC14_PxL_1	237	245	PF14671	0.580
DOC_MAPK_FxFP_2	324	327	PF00069	0.543
DOC_PP1_RVXF_1	215	222	PF00149	0.574
DOC_PP2B_LxvP_1	13	16	PF13499	0.709
DOC_PP4_FxxP_1	183	186	PF00568	0.503
DOC_PP4_FxxP_1	276	279	PF00568	0.366
DOC_PP4_FxxP_1	324	327	PF00568	0.504
DOC_USP7_MATH_1	108	112	PF00917	0.671
DOC_USP7_MATH_1	164	168	PF00917	0.716
DOC_USP7_MATH_1	327	331	PF00917	0.530
DOC_USP7_MATH_1	45	49	PF00917	0.602
DOC_USP7_MATH_1	97	101	PF00917	0.743
DOC_USP7_UBL2_3	81	85	PF12436	0.769
DOC_WW_Pin1_4	230	235	PF00397	0.548
DOC_WW_Pin1_4	6	11	PF00397	0.680
DOC_WW_Pin1_4	60	65	PF00397	0.705
LIG_14-3-3_CanoR_1	170	175	PF00244	0.509
LIG_BRCT_BRCA1_1	172	176	PF00533	0.516
LIG_BRCT_BRCA1_1	179	183	PF00533	0.552
LIG_FHA_1	293	299	PF00498	0.456
LIG_FHA_1	323	329	PF00498	0.562
LIG_FHA_2	118	124	PF00498	0.648
LIG_FHA_2	252	258	PF00498	0.643
LIG_GBD_Chelix_1	306	314	PF00786	0.513
LIG_IBAR_NPY_1	30	32	PF08397	0.616
LIG_LIR_Apic_2	180	186	PF02991	0.527
LIG_LIR_Apic_2	228	234	PF02991	0.576
LIG_LIR_Apic_2	275	279	PF02991	0.370
LIG_LIR_Apic_2	321	327	PF02991	0.482
LIG_LIR_Gen_1	47	56	PF02991	0.520
LIG_LIR_Nem_3	47	52	PF02991	0.620
LIG_Pex14_2	178	182	PF04695	0.576
LIG_Pex14_2	183	187	PF04695	0.515
LIG_SH2_CRK	171	175	PF00017	0.498
LIG_SH2_CRK	53	57	PF00017	0.739
LIG_SH2_NCK_1	171	175	PF00017	0.509
LIG_SH2_SRC	51	54	PF00017	0.721
LIG_SH2_STAP1	128	132	PF00017	0.759
LIG_SH2_STAP1	32	36	PF00017	0.663
LIG_SH2_STAT5	222	225	PF00017	0.611
LIG_SH2_STAT5	231	234	PF00017	0.560
LIG_SH2_STAT5	51	54	PF00017	0.721
LIG_SH3_1	61	67	PF00018	0.741
LIG_SH3_2	64	69	PF14604	0.598
LIG_SH3_3	194	200	PF00018	0.578
LIG_SH3_3	61	67	PF00018	0.741
LIG_SUMO_SIM_par_1	286	292	PF11976	0.526
LIG_TRAF2_1	233	236	PF00917	0.572
LIG_TRAF2_1	315	318	PF00917	0.515
LIG_TRAF2_2	279	284	PF00917	0.516
LIG_TYR_ITIM	169	174	PF00017	0.503
LIG_WRC_WIRS_1	187	192	PF05994	0.564
MOD_CK1_1	118	124	PF00069	0.704
MOD_CK1_1	141	147	PF00069	0.796
MOD_CK1_1	152	158	PF00069	0.655
MOD_CK1_1	211	217	PF00069	0.549
MOD_CK1_1	292	298	PF00069	0.474
MOD_CK1_1	54	60	PF00069	0.744
MOD_CK2_1	230	236	PF00069	0.567
MOD_GlcNHglycan	10	13	PF01048	0.708
MOD_GlcNHglycan	104	107	PF01048	0.684
MOD_GlcNHglycan	123	126	PF01048	0.575
MOD_GlcNHglycan	152	155	PF01048	0.639
MOD_GlcNHglycan	179	182	PF01048	0.547
MOD_GlcNHglycan	210	213	PF01048	0.638
MOD_GlcNHglycan	22	25	PF01048	0.761
MOD_GlcNHglycan	290	294	PF01048	0.501
MOD_GlcNHglycan	329	332	PF01048	0.652
MOD_GSK3_1	115	122	PF00069	0.705
MOD_GSK3_1	138	145	PF00069	0.679
MOD_GSK3_1	148	155	PF00069	0.634
MOD_GSK3_1	18	25	PF00069	0.514
MOD_GSK3_1	208	215	PF00069	0.548
MOD_GSK3_1	322	329	PF00069	0.518
MOD_GSK3_1	4	11	PF00069	0.711
MOD_GSK3_1	47	54	PF00069	0.487
MOD_GSK3_1	81	88	PF00069	0.732
MOD_N-GLC_1	201	206	PF02516	0.588
MOD_NEK2_1	102	107	PF00069	0.713
MOD_NEK2_1	140	145	PF00069	0.672
MOD_NEK2_1	149	154	PF00069	0.698
MOD_NEK2_1	22	27	PF00069	0.642
MOD_NEK2_1	289	294	PF00069	0.522
MOD_NEK2_1	301	306	PF00069	0.461
MOD_NEK2_1	4	9	PF00069	0.614
MOD_NEK2_2	201	206	PF00069	0.629
MOD_NEK2_2	86	91	PF00069	0.733
MOD_NEK2_2	97	102	PF00069	0.578
MOD_PIKK_1	142	148	PF00454	0.716
MOD_PK_1	170	176	PF00069	0.512
MOD_Plk_1	201	207	PF00069	0.588
MOD_Plk_1	261	267	PF00069	0.610
MOD_Plk_1	289	295	PF00069	0.499
MOD_Plk_4	164	170	PF00069	0.539
MOD_Plk_4	292	298	PF00069	0.496
MOD_Plk_4	51	57	PF00069	0.614
MOD_Plk_4	97	103	PF00069	0.670
MOD_ProDKin_1	230	236	PF00069	0.546
MOD_ProDKin_1	6	12	PF00069	0.681
MOD_ProDKin_1	60	66	PF00069	0.707
MOD_SUMO_rev_2	249	256	PF00179	0.557
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.579
TRG_ENDOCYTIC_2	171	174	PF00928	0.480
TRG_ENDOCYTIC_2	53	56	PF00928	0.735
TRG_ER_diArg_1	258	260	PF00400	0.556
TRG_NLS_MonoCore_2	68	73	PF00514	0.608
TRG_NLS_MonoExtC_3	69	74	PF00514	0.740
TRG_NLS_MonoExtN_4	66	73	PF00514	0.724
TRG_Pf-PMV_PEXEL_1	270	275	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBG8	Leptomonas seymouri	60%	100%
A0A3Q8IJQ3	Leishmania donovani	93%	100%
A4HQ15	Leishmania braziliensis	76%	100%
A4IDS1	Leishmania infantum	93%	100%
E9ATT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%