Putative delta tubulin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin delta chain

Species:

Leishmania major

UniProt:

Q4Q0R3_LEIMA

TriTrypDb:

LmjF.36.4990 , LMJLV39_360061900 , LMJSD75_360061600

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005874	microtubule	6	9
GO:0099080	supramolecular complex	2	9
GO:0099081	supramolecular polymer	3	9
GO:0099512	supramolecular fiber	4	9
GO:0099513	polymeric cytoskeletal fiber	5	9
GO:0110165	cellular anatomical entity	1	9
GO:0005634	nucleus	5	2
GO:0005814	centriole	5	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q0R3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0R3

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0000278	mitotic cell cycle	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	9
GO:0007049	cell cycle	2	2
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	4
GO:0071840	cellular component organization or biogenesis	2	4
GO:0030030	cell projection organization	4	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0005198	structural molecule activity	1	4
GO:0005200	structural constituent of cytoskeleton	2	4
GO:0005488	binding	1	9
GO:0005525	GTP binding	5	9
GO:0017076	purine nucleotide binding	4	9
GO:0019001	guanyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032561	guanyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.521
CLV_C14_Caspase3-7	512	516	PF00656	0.454
CLV_C14_Caspase3-7	542	546	PF00656	0.365
CLV_NRD_NRD_1	145	147	PF00675	0.499
CLV_NRD_NRD_1	177	179	PF00675	0.275
CLV_NRD_NRD_1	186	188	PF00675	0.226
CLV_NRD_NRD_1	355	357	PF00675	0.551
CLV_NRD_NRD_1	54	56	PF00675	0.617
CLV_NRD_NRD_1	73	75	PF00675	0.722
CLV_PCSK_KEX2_1	145	147	PF00082	0.499
CLV_PCSK_KEX2_1	177	179	PF00082	0.288
CLV_PCSK_KEX2_1	186	188	PF00082	0.216
CLV_PCSK_KEX2_1	355	357	PF00082	0.551
CLV_PCSK_KEX2_1	54	56	PF00082	0.620
CLV_PCSK_KEX2_1	73	75	PF00082	0.639
CLV_PCSK_SKI1_1	103	107	PF00082	0.449
CLV_PCSK_SKI1_1	222	226	PF00082	0.263
CLV_PCSK_SKI1_1	283	287	PF00082	0.581
CLV_PCSK_SKI1_1	337	341	PF00082	0.745
CLV_PCSK_SKI1_1	356	360	PF00082	0.364
CLV_PCSK_SKI1_1	374	378	PF00082	0.420
CLV_PCSK_SKI1_1	426	430	PF00082	0.575
CLV_PCSK_SKI1_1	45	49	PF00082	0.586
CLV_PCSK_SKI1_1	59	63	PF00082	0.532
DEG_APCC_DBOX_1	102	110	PF00400	0.405
DEG_APCC_DBOX_1	442	450	PF00400	0.356
DEG_SPOP_SBC_1	132	136	PF00917	0.797
DOC_MAPK_DCC_7	299	309	PF00069	0.420
DOC_MAPK_gen_1	283	293	PF00069	0.548
DOC_PIKK_1	269	276	PF02985	0.507
DOC_PP2B_LxvP_1	307	310	PF13499	0.357
DOC_PP2B_LxvP_1	48	51	PF13499	0.656
DOC_PP4_FxxP_1	406	409	PF00568	0.576
DOC_PP4_FxxP_1	480	483	PF00568	0.446
DOC_USP7_MATH_1	132	136	PF00917	0.735
DOC_USP7_MATH_1	27	31	PF00917	0.416
DOC_USP7_MATH_1	358	362	PF00917	0.496
DOC_USP7_MATH_1	402	406	PF00917	0.477
DOC_USP7_MATH_1	433	437	PF00917	0.606
DOC_USP7_MATH_1	475	479	PF00917	0.441
DOC_USP7_MATH_1	489	493	PF00917	0.618
DOC_USP7_MATH_1	496	500	PF00917	0.416
DOC_USP7_UBL2_3	321	325	PF12436	0.587
DOC_WW_Pin1_4	128	133	PF00397	0.698
DOC_WW_Pin1_4	134	139	PF00397	0.619
DOC_WW_Pin1_4	315	320	PF00397	0.501
DOC_WW_Pin1_4	469	474	PF00397	0.495
DOC_WW_Pin1_4	479	484	PF00397	0.418
DOC_WW_Pin1_4	487	492	PF00397	0.514
DOC_WW_Pin1_4	503	508	PF00397	0.408
LIG_14-3-3_CanoR_1	145	151	PF00244	0.509
LIG_14-3-3_CanoR_1	227	231	PF00244	0.433
LIG_14-3-3_CanoR_1	355	364	PF00244	0.426
LIG_14-3-3_CanoR_1	38	46	PF00244	0.497
LIG_14-3-3_CanoR_1	78	84	PF00244	0.413
LIG_BIR_II_1	1	5	PF00653	0.343
LIG_BIR_III_4	515	519	PF00653	0.410
LIG_BRCT_BRCA1_1	470	474	PF00533	0.542
LIG_Clathr_ClatBox_1	106	110	PF01394	0.406
LIG_FHA_1	1	7	PF00498	0.385
LIG_FHA_1	15	21	PF00498	0.324
LIG_FHA_1	196	202	PF00498	0.515
LIG_FHA_1	343	349	PF00498	0.562
LIG_FHA_1	375	381	PF00498	0.522
LIG_FHA_1	427	433	PF00498	0.708
LIG_FHA_1	454	460	PF00498	0.468
LIG_FHA_1	504	510	PF00498	0.371
LIG_FHA_2	155	161	PF00498	0.452
LIG_FHA_2	357	363	PF00498	0.482
LIG_FHA_2	492	498	PF00498	0.561
LIG_LIR_Apic_2	405	409	PF02991	0.565
LIG_LIR_Apic_2	477	483	PF02991	0.440
LIG_LIR_Apic_2	490	496	PF02991	0.557
LIG_LIR_Gen_1	197	206	PF02991	0.453
LIG_LIR_Gen_1	245	254	PF02991	0.434
LIG_LIR_Gen_1	290	300	PF02991	0.413
LIG_LIR_Gen_1	388	399	PF02991	0.398
LIG_LIR_Nem_3	197	202	PF02991	0.453
LIG_LIR_Nem_3	245	251	PF02991	0.434
LIG_LIR_Nem_3	262	268	PF02991	0.434
LIG_LIR_Nem_3	290	296	PF02991	0.364
LIG_LIR_Nem_3	388	394	PF02991	0.390
LIG_MYND_1	46	50	PF01753	0.604
LIG_PDZ_Class_2	554	559	PF00595	0.533
LIG_Pex14_1	166	170	PF04695	0.434
LIG_Pex14_2	529	533	PF04695	0.447
LIG_SH2_CRK	248	252	PF00017	0.434
LIG_SH2_CRK	314	318	PF00017	0.506
LIG_SH2_NCK_1	148	152	PF00017	0.389
LIG_SH2_NCK_1	314	318	PF00017	0.502
LIG_SH2_NCK_1	357	361	PF00017	0.481
LIG_SH2_NCK_1	493	497	PF00017	0.533
LIG_SH2_NCK_1	551	555	PF00017	0.454
LIG_SH2_STAP1	551	555	PF00017	0.454
LIG_SH2_STAP1	81	85	PF00017	0.532
LIG_SH2_STAT3	170	173	PF00017	0.434
LIG_SH2_STAT3	85	88	PF00017	0.556
LIG_SH2_STAT5	314	317	PF00017	0.511
LIG_SH2_STAT5	493	496	PF00017	0.542
LIG_SH3_3	231	237	PF00018	0.443
LIG_SH3_3	300	306	PF00018	0.461
LIG_TRAF2_1	483	486	PF00917	0.509
LIG_TRFH_1	148	152	PF08558	0.389
LIG_UBA3_1	312	321	PF00899	0.537
LIG_WRC_WIRS_1	196	201	PF05994	0.515
MOD_CDC14_SPxK_1	318	321	PF00782	0.553
MOD_CDK_SPxK_1	315	321	PF00069	0.532
MOD_CK1_1	130	136	PF00069	0.772
MOD_CK1_1	139	145	PF00069	0.554
MOD_CK1_1	211	217	PF00069	0.515
MOD_CK1_1	342	348	PF00069	0.615
MOD_CK1_1	415	421	PF00069	0.634
MOD_CK2_1	154	160	PF00069	0.434
MOD_CK2_1	22	28	PF00069	0.486
MOD_CK2_1	418	424	PF00069	0.660
MOD_CK2_1	479	485	PF00069	0.462
MOD_CK2_1	536	542	PF00069	0.456
MOD_GlcNHglycan	141	144	PF01048	0.661
MOD_GlcNHglycan	160	164	PF01048	0.149
MOD_GlcNHglycan	210	213	PF01048	0.246
MOD_GlcNHglycan	300	303	PF01048	0.468
MOD_GlcNHglycan	332	335	PF01048	0.632
MOD_GlcNHglycan	341	344	PF01048	0.608
MOD_GlcNHglycan	39	42	PF01048	0.403
MOD_GlcNHglycan	409	412	PF01048	0.692
MOD_GlcNHglycan	414	417	PF01048	0.660
MOD_GlcNHglycan	434	438	PF01048	0.581
MOD_GlcNHglycan	59	62	PF01048	0.458
MOD_GSK3_1	127	134	PF00069	0.802
MOD_GSK3_1	191	198	PF00069	0.497
MOD_GSK3_1	226	233	PF00069	0.485
MOD_GSK3_1	383	390	PF00069	0.475
MOD_GSK3_1	398	405	PF00069	0.502
MOD_GSK3_1	475	482	PF00069	0.512
MOD_GSK3_1	487	494	PF00069	0.397
MOD_GSK3_1	62	69	PF00069	0.695
MOD_LATS_1	57	63	PF00433	0.548
MOD_NEK2_1	19	24	PF00069	0.391
MOD_NEK2_1	230	235	PF00069	0.452
MOD_NEK2_1	252	257	PF00069	0.434
MOD_NEK2_1	312	317	PF00069	0.517
MOD_NEK2_1	37	42	PF00069	0.492
MOD_NEK2_1	376	381	PF00069	0.406
MOD_NEK2_1	550	555	PF00069	0.362
MOD_NEK2_1	95	100	PF00069	0.657
MOD_NEK2_2	475	480	PF00069	0.460
MOD_PIKK_1	242	248	PF00454	0.434
MOD_PKA_1	186	192	PF00069	0.515
MOD_PKA_2	186	192	PF00069	0.492
MOD_PKA_2	226	232	PF00069	0.433
MOD_PKA_2	298	304	PF00069	0.485
MOD_PKA_2	37	43	PF00069	0.477
MOD_Plk_1	27	33	PF00069	0.506
MOD_Plk_1	289	295	PF00069	0.410
MOD_Plk_1	433	439	PF00069	0.611
MOD_Plk_1	496	502	PF00069	0.526
MOD_Plk_1	95	101	PF00069	0.657
MOD_Plk_2-3	365	371	PF00069	0.478
MOD_Plk_4	191	197	PF00069	0.512
MOD_Plk_4	220	226	PF00069	0.485
MOD_Plk_4	230	236	PF00069	0.417
MOD_Plk_4	475	481	PF00069	0.432
MOD_Plk_4	498	504	PF00069	0.374
MOD_Plk_4	81	87	PF00069	0.616
MOD_ProDKin_1	128	134	PF00069	0.698
MOD_ProDKin_1	136	142	PF00069	0.588
MOD_ProDKin_1	315	321	PF00069	0.507
MOD_ProDKin_1	469	475	PF00069	0.484
MOD_ProDKin_1	479	485	PF00069	0.433
MOD_ProDKin_1	487	493	PF00069	0.521
MOD_ProDKin_1	503	509	PF00069	0.406
MOD_SUMO_rev_2	108	114	PF00179	0.375
MOD_SUMO_rev_2	214	224	PF00179	0.515
MOD_SUMO_rev_2	270	279	PF00179	0.570
MOD_SUMO_rev_2	421	428	PF00179	0.653
TRG_DiLeu_BaEn_1	461	466	PF01217	0.466
TRG_ENDOCYTIC_2	248	251	PF00928	0.434
TRG_ENDOCYTIC_2	80	83	PF00928	0.525
TRG_ER_diArg_1	145	147	PF00400	0.550
TRG_ER_diArg_1	185	187	PF00400	0.452
TRG_ER_diArg_1	354	356	PF00400	0.409
TRG_ER_diArg_1	73	75	PF00400	0.635
TRG_Pf-PMV_PEXEL_1	463	468	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4R4	Leptomonas seymouri	66%	99%
A0A0S4JK93	Bodo saltans	35%	97%
A0A3Q8IPL1	Leishmania donovani	95%	99%
A0A422NC27	Trypanosoma rangeli	38%	100%
A4IDS2	Leishmania infantum	95%	99%
D0A8V4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ATT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
Q4R7T7	Macaca fascicularis	21%	100%
Q6FNU9	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	24%	100%
Q8HZV4	Canis lupus familiaris	23%	100%
Q8WZE0	Microbotryum violaceum	22%	100%
Q9R1K7	Mus musculus	22%	100%
Q9UJT1	Homo sapiens	22%	100%