START domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0R2_LEIMA

TriTrypDb:

LmjF.36.5000 , LMJLV39_360062000 , LMJSD75_360061700

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 6
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0R2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0R2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.741
CLV_NRD_NRD_1	172	174	PF00675	0.732
CLV_NRD_NRD_1	208	210	PF00675	0.589
CLV_NRD_NRD_1	291	293	PF00675	0.671
CLV_NRD_NRD_1	294	296	PF00675	0.669
CLV_NRD_NRD_1	30	32	PF00675	0.401
CLV_NRD_NRD_1	350	352	PF00675	0.750
CLV_PCSK_FUR_1	292	296	PF00082	0.666
CLV_PCSK_FUR_1	348	352	PF00082	0.761
CLV_PCSK_KEX2_1	169	171	PF00082	0.733
CLV_PCSK_KEX2_1	208	210	PF00082	0.589
CLV_PCSK_KEX2_1	291	293	PF00082	0.671
CLV_PCSK_KEX2_1	294	296	PF00082	0.669
CLV_PCSK_KEX2_1	30	32	PF00082	0.401
CLV_PCSK_KEX2_1	348	350	PF00082	0.683
CLV_PCSK_PC7_1	345	351	PF00082	0.760
CLV_PCSK_SKI1_1	123	127	PF00082	0.481
CLV_PCSK_SKI1_1	209	213	PF00082	0.637
CLV_PCSK_SKI1_1	249	253	PF00082	0.639
DEG_APCC_DBOX_1	257	265	PF00400	0.379
DEG_MDM2_SWIB_1	135	142	PF02201	0.543
DEG_SPOP_SBC_1	301	305	PF00917	0.720
DOC_CKS1_1	45	50	PF01111	0.560
DOC_MAPK_FxFP_2	218	221	PF00069	0.481
DOC_MAPK_gen_1	113	121	PF00069	0.464
DOC_MAPK_gen_1	208	214	PF00069	0.536
DOC_MAPK_gen_1	345	355	PF00069	0.741
DOC_MAPK_JIP1_4	247	253	PF00069	0.560
DOC_MAPK_MEF2A_6	12	21	PF00069	0.485
DOC_MAPK_MEF2A_6	243	252	PF00069	0.510
DOC_MAPK_MEF2A_6	258	266	PF00069	0.381
DOC_MAPK_RevD_3	15	31	PF00069	0.391
DOC_PP1_RVXF_1	116	122	PF00149	0.506
DOC_PP1_RVXF_1	247	253	PF00149	0.582
DOC_PP1_RVXF_1	77	83	PF00149	0.473
DOC_PP4_FxxP_1	218	221	PF00568	0.481
DOC_SPAK_OSR1_1	239	243	PF12202	0.474
DOC_USP7_MATH_1	196	200	PF00917	0.531
DOC_USP7_MATH_1	321	325	PF00917	0.679
DOC_USP7_MATH_1	33	37	PF00917	0.587
DOC_WW_Pin1_4	44	49	PF00397	0.578
DOC_WW_Pin1_4	80	85	PF00397	0.705
LIG_14-3-3_CanoR_1	12	18	PF00244	0.412
LIG_14-3-3_CanoR_1	226	230	PF00244	0.507
LIG_14-3-3_CanoR_1	280	289	PF00244	0.656
LIG_APCC_ABBA_1	212	217	PF00400	0.512
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_BIR_III_4	88	92	PF00653	0.623
LIG_Clathr_ClatBox_1	261	265	PF01394	0.371
LIG_EH_1	73	77	PF12763	0.641
LIG_EH1_1	272	280	PF00400	0.606
LIG_FHA_1	14	20	PF00498	0.569
LIG_FHA_1	153	159	PF00498	0.522
LIG_FHA_1	186	192	PF00498	0.611
LIG_FHA_1	22	28	PF00498	0.518
LIG_FHA_1	258	264	PF00498	0.501
LIG_FHA_2	45	51	PF00498	0.546
LIG_GBD_Chelix_1	17	25	PF00786	0.439
LIG_LIR_Apic_2	217	221	PF02991	0.492
LIG_LIR_Gen_1	40	48	PF02991	0.576
LIG_LIR_LC3C_4	260	263	PF02991	0.533
LIG_LIR_Nem_3	228	233	PF02991	0.473
LIG_LIR_Nem_3	40	46	PF02991	0.570
LIG_NRBOX	22	28	PF00104	0.393
LIG_PCNA_PIPBox_1	234	243	PF02747	0.582
LIG_PCNA_yPIPBox_3	232	241	PF02747	0.575
LIG_PCNA_yPIPBox_3	5	18	PF02747	0.406
LIG_Pex14_2	135	139	PF04695	0.542
LIG_SH2_SRC	184	187	PF00017	0.641
LIG_SH2_STAT5	146	149	PF00017	0.492
LIG_SH2_STAT5	157	160	PF00017	0.380
LIG_SH2_STAT5	241	244	PF00017	0.478
LIG_SH2_STAT5	41	44	PF00017	0.510
LIG_SH3_3	180	186	PF00018	0.684
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.579
LIG_SUMO_SIM_anti_2	210	215	PF11976	0.523
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.568
LIG_SUMO_SIM_anti_2	260	265	PF11976	0.481
LIG_SUMO_SIM_anti_2	63	69	PF11976	0.502
LIG_SUMO_SIM_par_1	16	22	PF11976	0.606
LIG_SUMO_SIM_par_1	23	28	PF11976	0.533
LIG_SUMO_SIM_par_1	259	265	PF11976	0.610
LIG_TRAF2_1	37	40	PF00917	0.567
LIG_ULM_U2AF65_1	348	353	PF00076	0.758
MOD_CK1_1	187	193	PF00069	0.606
MOD_CK1_1	199	205	PF00069	0.559
MOD_CK1_1	302	308	PF00069	0.757
MOD_CK1_1	44	50	PF00069	0.539
MOD_CK2_1	138	144	PF00069	0.504
MOD_Cter_Amidation	167	170	PF01082	0.669
MOD_Cter_Amidation	346	349	PF01082	0.651
MOD_GlcNHglycan	285	288	PF01048	0.691
MOD_GlcNHglycan	307	310	PF01048	0.626
MOD_GlcNHglycan	311	314	PF01048	0.602
MOD_GlcNHglycan	324	327	PF01048	0.657
MOD_GlcNHglycan	328	331	PF01048	0.657
MOD_GlcNHglycan	34	38	PF01048	0.456
MOD_GlcNHglycan	6	9	PF01048	0.424
MOD_GSK3_1	158	165	PF00069	0.582
MOD_GSK3_1	281	288	PF00069	0.715
MOD_GSK3_1	297	304	PF00069	0.706
MOD_GSK3_1	305	312	PF00069	0.682
MOD_GSK3_1	322	329	PF00069	0.698
MOD_GSK3_1	6	13	PF00069	0.629
MOD_N-GLC_1	10	15	PF02516	0.611
MOD_N-GLC_2	56	58	PF02516	0.429
MOD_NEK2_1	19	24	PF00069	0.452
MOD_NEK2_1	283	288	PF00069	0.671
MOD_NEK2_1	4	9	PF00069	0.587
MOD_NEK2_2	225	230	PF00069	0.570
MOD_PIKK_1	158	164	PF00454	0.614
MOD_PKA_2	225	231	PF00069	0.543
MOD_PKA_2	257	263	PF00069	0.616
MOD_PKA_2	4	10	PF00069	0.649
MOD_Plk_1	10	16	PF00069	0.637
MOD_Plk_1	162	168	PF00069	0.630
MOD_Plk_1	316	322	PF00069	0.522
MOD_Plk_4	106	112	PF00069	0.586
MOD_Plk_4	196	202	PF00069	0.527
MOD_Plk_4	21	27	PF00069	0.524
MOD_Plk_4	225	231	PF00069	0.532
MOD_Plk_4	257	263	PF00069	0.546
MOD_ProDKin_1	44	50	PF00069	0.574
MOD_ProDKin_1	80	86	PF00069	0.706
TRG_DiLeu_BaEn_1	63	68	PF01217	0.464
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.582
TRG_ER_diArg_1	207	209	PF00400	0.564
TRG_ER_diArg_1	29	31	PF00400	0.397
TRG_ER_diArg_1	291	294	PF00400	0.646
TRG_ER_diArg_1	348	351	PF00400	0.723
TRG_NES_CRM1_1	265	276	PF08389	0.611
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVC1	Leptomonas seymouri	53%	100%
A0A1X0P309	Trypanosomatidae	28%	100%
A0A3Q8IJW1	Leishmania donovani	90%	100%
A0A3R7KTI3	Trypanosoma rangeli	25%	100%
A4HQ17	Leishmania braziliensis	70%	100%
A4IDS3	Leishmania infantum	90%	100%
E9ATT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5D4Y6	Trypanosoma cruzi	24%	100%