Cilia- and flagella-associated protein 58

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0R0_LEIMA

TriTrypDb:

LmjF.36.5020 , LMJLV39_360062200 , LMJSD75_360061900

Length:

845

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005856	cytoskeleton	5	2
GO:0005930	axoneme	2	2
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

Q4Q0R0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0R0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.446
CLV_C14_Caspase3-7	287	291	PF00656	0.679
CLV_NRD_NRD_1	196	198	PF00675	0.506
CLV_NRD_NRD_1	266	268	PF00675	0.504
CLV_NRD_NRD_1	348	350	PF00675	0.478
CLV_NRD_NRD_1	361	363	PF00675	0.420
CLV_NRD_NRD_1	429	431	PF00675	0.517
CLV_NRD_NRD_1	474	476	PF00675	0.540
CLV_NRD_NRD_1	482	484	PF00675	0.571
CLV_NRD_NRD_1	537	539	PF00675	0.663
CLV_NRD_NRD_1	619	621	PF00675	0.389
CLV_NRD_NRD_1	714	716	PF00675	0.631
CLV_PCSK_FUR_1	712	716	PF00082	0.646
CLV_PCSK_KEX2_1	156	158	PF00082	0.473
CLV_PCSK_KEX2_1	265	267	PF00082	0.506
CLV_PCSK_KEX2_1	348	350	PF00082	0.401
CLV_PCSK_KEX2_1	363	365	PF00082	0.440
CLV_PCSK_KEX2_1	372	374	PF00082	0.420
CLV_PCSK_KEX2_1	429	431	PF00082	0.489
CLV_PCSK_KEX2_1	482	484	PF00082	0.571
CLV_PCSK_KEX2_1	503	505	PF00082	0.590
CLV_PCSK_KEX2_1	583	585	PF00082	0.504
CLV_PCSK_KEX2_1	619	621	PF00082	0.389
CLV_PCSK_KEX2_1	714	716	PF00082	0.663
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.473
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.431
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.420
CLV_PCSK_PC1ET2_1	503	505	PF00082	0.575
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.504
CLV_PCSK_SKI1_1	121	125	PF00082	0.505
CLV_PCSK_SKI1_1	156	160	PF00082	0.539
CLV_PCSK_SKI1_1	179	183	PF00082	0.548
CLV_PCSK_SKI1_1	197	201	PF00082	0.326
CLV_PCSK_SKI1_1	267	271	PF00082	0.498
CLV_PCSK_SKI1_1	314	318	PF00082	0.542
CLV_PCSK_SKI1_1	432	436	PF00082	0.400
CLV_PCSK_SKI1_1	48	52	PF00082	0.434
CLV_PCSK_SKI1_1	482	486	PF00082	0.619
CLV_PCSK_SKI1_1	553	557	PF00082	0.542
CLV_PCSK_SKI1_1	583	587	PF00082	0.520
CLV_PCSK_SKI1_1	6	10	PF00082	0.562
CLV_PCSK_SKI1_1	601	605	PF00082	0.316
CLV_PCSK_SKI1_1	688	692	PF00082	0.511
CLV_PCSK_SKI1_1	735	739	PF00082	0.484
CLV_Separin_Metazoa	205	209	PF03568	0.556
DEG_APCC_DBOX_1	431	439	PF00400	0.522
DEG_APCC_DBOX_1	645	653	PF00400	0.468
DOC_CYCLIN_RxL_1	194	202	PF00134	0.506
DOC_CYCLIN_RxL_1	729	742	PF00134	0.535
DOC_MAPK_gen_1	619	626	PF00069	0.376
DOC_MAPK_gen_1	646	654	PF00069	0.405
DOC_MAPK_gen_1	684	692	PF00069	0.536
DOC_MAPK_gen_1	823	831	PF00069	0.550
DOC_USP7_MATH_1	177	181	PF00917	0.366
DOC_USP7_MATH_1	7	11	PF00917	0.647
DOC_USP7_UBL2_3	152	156	PF12436	0.478
DOC_USP7_UBL2_3	233	237	PF12436	0.532
DOC_USP7_UBL2_3	544	548	PF12436	0.609
DOC_USP7_UBL2_3	583	587	PF12436	0.394
DOC_USP7_UBL2_3	782	786	PF12436	0.579
DOC_USP7_UBL2_3	97	101	PF12436	0.427
LIG_14-3-3_CanoR_1	157	165	PF00244	0.539
LIG_14-3-3_CanoR_1	179	184	PF00244	0.623
LIG_14-3-3_CanoR_1	245	249	PF00244	0.566
LIG_14-3-3_CanoR_1	482	491	PF00244	0.578
LIG_14-3-3_CanoR_1	538	547	PF00244	0.641
LIG_Actin_WH2_2	645	662	PF00022	0.513
LIG_BIR_II_1	1	5	PF00653	0.642
LIG_CaM_IQ_9	586	602	PF13499	0.506
LIG_DLG_GKlike_1	395	403	PF00625	0.458
LIG_eIF4E_1	223	229	PF01652	0.549
LIG_eIF4E_1	628	634	PF01652	0.507
LIG_FHA_1	293	299	PF00498	0.543
LIG_FHA_1	401	407	PF00498	0.527
LIG_FHA_1	66	72	PF00498	0.423
LIG_FHA_2	158	164	PF00498	0.561
LIG_FHA_2	256	262	PF00498	0.481
LIG_FHA_2	292	298	PF00498	0.668
LIG_FHA_2	317	323	PF00498	0.534
LIG_FHA_2	325	331	PF00498	0.592
LIG_FHA_2	372	378	PF00498	0.343
LIG_FHA_2	569	575	PF00498	0.544
LIG_FHA_2	676	682	PF00498	0.375
LIG_FHA_2	737	743	PF00498	0.566
LIG_LIR_Gen_1	336	344	PF02991	0.546
LIG_LIR_Gen_1	42	50	PF02991	0.391
LIG_LIR_Gen_1	602	609	PF02991	0.452
LIG_LIR_Nem_3	100	106	PF02991	0.430
LIG_LIR_Nem_3	13	19	PF02991	0.517
LIG_LIR_Nem_3	331	337	PF02991	0.428
LIG_LIR_Nem_3	42	46	PF02991	0.405
LIG_LIR_Nem_3	710	716	PF02991	0.545
LIG_LYPXL_yS_3	720	723	PF13949	0.594
LIG_PTB_Apo_2	830	837	PF02174	0.483
LIG_SH2_CRK	43	47	PF00017	0.416
LIG_SH2_CRK	628	632	PF00017	0.509
LIG_SH2_STAP1	172	176	PF00017	0.501
LIG_SH2_STAP1	43	47	PF00017	0.426
LIG_SH2_STAP1	827	831	PF00017	0.429
LIG_SH2_STAT5	172	175	PF00017	0.501
LIG_SH3_3	1	7	PF00018	0.677
LIG_SUMO_SIM_anti_2	202	208	PF11976	0.596
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.609
LIG_SUMO_SIM_anti_2	377	383	PF11976	0.429
LIG_SUMO_SIM_anti_2	622	628	PF11976	0.364
LIG_SUMO_SIM_par_1	227	234	PF11976	0.544
LIG_SUMO_SIM_par_1	293	300	PF11976	0.639
LIG_TRAF2_1	189	192	PF00917	0.566
LIG_TRAF2_1	193	196	PF00917	0.565
LIG_TRAF2_1	238	241	PF00917	0.531
LIG_TRAF2_1	355	358	PF00917	0.542
LIG_TRAF2_1	374	377	PF00917	0.577
LIG_TRAF2_1	394	397	PF00917	0.290
LIG_TRAF2_1	459	462	PF00917	0.449
LIG_TRAF2_1	750	753	PF00917	0.547
LIG_TYR_ITIM	626	631	PF00017	0.372
LIG_UBA3_1	228	237	PF00899	0.549
LIG_UBA3_1	585	594	PF00899	0.312
LIG_UBA3_1	654	658	PF00899	0.379
MOD_CDC14_SPxK_1	3	6	PF00782	0.612
MOD_CK1_1	129	135	PF00069	0.637
MOD_CK1_1	139	145	PF00069	0.448
MOD_CK1_1	291	297	PF00069	0.660
MOD_CK1_1	398	404	PF00069	0.525
MOD_CK1_1	422	428	PF00069	0.446
MOD_CK1_1	447	453	PF00069	0.449
MOD_CK1_1	53	59	PF00069	0.420
MOD_CK1_1	542	548	PF00069	0.574
MOD_CK1_1	564	570	PF00069	0.565
MOD_CK2_1	143	149	PF00069	0.535
MOD_CK2_1	157	163	PF00069	0.452
MOD_CK2_1	186	192	PF00069	0.516
MOD_CK2_1	199	205	PF00069	0.377
MOD_CK2_1	255	261	PF00069	0.478
MOD_CK2_1	291	297	PF00069	0.668
MOD_CK2_1	316	322	PF00069	0.508
MOD_CK2_1	324	330	PF00069	0.521
MOD_CK2_1	371	377	PF00069	0.520
MOD_CK2_1	384	390	PF00069	0.463
MOD_CK2_1	455	461	PF00069	0.587
MOD_CK2_1	53	59	PF00069	0.534
MOD_CK2_1	568	574	PF00069	0.583
MOD_CK2_1	675	681	PF00069	0.343
MOD_CK2_1	719	725	PF00069	0.482
MOD_CK2_1	736	742	PF00069	0.419
MOD_CK2_1	87	93	PF00069	0.445
MOD_Cter_Amidation	427	430	PF01082	0.505
MOD_GlcNHglycan	178	182	PF01048	0.486
MOD_GlcNHglycan	385	389	PF01048	0.586
MOD_GlcNHglycan	452	455	PF01048	0.556
MOD_GlcNHglycan	457	460	PF01048	0.550
MOD_GlcNHglycan	9	12	PF01048	0.581
MOD_GSK3_1	135	142	PF00069	0.587
MOD_GSK3_1	159	166	PF00069	0.639
MOD_GSK3_1	182	189	PF00069	0.510
MOD_GSK3_1	284	291	PF00069	0.653
MOD_GSK3_1	564	571	PF00069	0.549
MOD_GSK3_1	87	94	PF00069	0.545
MOD_N-GLC_1	288	293	PF02516	0.671
MOD_N-GLC_1	561	566	PF02516	0.556
MOD_N-GLC_1	708	713	PF02516	0.557
MOD_N-GLC_1	798	803	PF02516	0.439
MOD_N-GLC_1	832	837	PF02516	0.537
MOD_NEK2_1	119	124	PF00069	0.537
MOD_NEK2_1	199	204	PF00069	0.502
MOD_NEK2_1	228	233	PF00069	0.545
MOD_NEK2_1	281	286	PF00069	0.516
MOD_NEK2_1	50	55	PF00069	0.541
MOD_NEK2_1	568	573	PF00069	0.420
MOD_NEK2_1	798	803	PF00069	0.443
MOD_PIKK_1	400	406	PF00454	0.546
MOD_PIKK_1	419	425	PF00454	0.484
MOD_PIKK_1	447	453	PF00454	0.462
MOD_PIKK_1	482	488	PF00454	0.512
MOD_PIKK_1	542	548	PF00454	0.641
MOD_PIKK_1	59	65	PF00454	0.478
MOD_PKA_1	482	488	PF00069	0.576
MOD_PKA_2	244	250	PF00069	0.497
MOD_PKA_2	324	330	PF00069	0.553
MOD_PKA_2	482	488	PF00069	0.566
MOD_PKA_2	609	615	PF00069	0.539
MOD_Plk_1	288	294	PF00069	0.670
MOD_Plk_1	32	38	PF00069	0.565
MOD_Plk_1	357	363	PF00069	0.546
MOD_Plk_1	384	390	PF00069	0.591
MOD_Plk_1	395	401	PF00069	0.442
MOD_Plk_1	447	453	PF00069	0.443
MOD_Plk_1	542	548	PF00069	0.616
MOD_Plk_1	568	574	PF00069	0.453
MOD_Plk_1	708	714	PF00069	0.585
MOD_Plk_1	832	838	PF00069	0.549
MOD_Plk_1	87	93	PF00069	0.416
MOD_Plk_2-3	371	377	PF00069	0.539
MOD_Plk_2-3	88	94	PF00069	0.417
MOD_Plk_4	129	135	PF00069	0.627
MOD_Plk_4	244	250	PF00069	0.626
MOD_Plk_4	663	669	PF00069	0.452
MOD_Plk_4	832	838	PF00069	0.459
MOD_SUMO_for_1	123	126	PF00179	0.475
MOD_SUMO_for_1	368	371	PF00179	0.548
MOD_SUMO_for_1	489	492	PF00179	0.584
MOD_SUMO_for_1	529	532	PF00179	0.544
MOD_SUMO_for_1	745	748	PF00179	0.569
MOD_SUMO_for_1	831	834	PF00179	0.378
MOD_SUMO_for_1	95	98	PF00179	0.415
MOD_SUMO_rev_2	149	158	PF00179	0.469
MOD_SUMO_rev_2	191	200	PF00179	0.524
MOD_SUMO_rev_2	385	394	PF00179	0.531
MOD_SUMO_rev_2	456	466	PF00179	0.430
MOD_SUMO_rev_2	576	585	PF00179	0.492
MOD_SUMO_rev_2	722	730	PF00179	0.513
TRG_DiLeu_BaEn_1	244	249	PF01217	0.600
TRG_DiLeu_BaEn_1	377	382	PF01217	0.511
TRG_DiLeu_BaEn_1	581	586	PF01217	0.533
TRG_DiLeu_BaEn_1	753	758	PF01217	0.446
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.592
TRG_DiLeu_BaLyEn_6	650	655	PF01217	0.509
TRG_DiLeu_LyEn_5	581	586	PF01217	0.325
TRG_ENDOCYTIC_2	43	46	PF00928	0.369
TRG_ENDOCYTIC_2	47	50	PF00928	0.374
TRG_ENDOCYTIC_2	491	494	PF00928	0.462
TRG_ENDOCYTIC_2	628	631	PF00928	0.373
TRG_ENDOCYTIC_2	720	723	PF00928	0.594
TRG_ENDOCYTIC_2	826	829	PF00928	0.433
TRG_ER_diArg_1	265	267	PF00400	0.594
TRG_ER_diArg_1	347	349	PF00400	0.405
TRG_ER_diArg_1	361	364	PF00400	0.491
TRG_ER_diArg_1	429	432	PF00400	0.525
TRG_ER_diArg_1	482	484	PF00400	0.571
TRG_ER_diArg_1	515	518	PF00400	0.574
TRG_ER_diArg_1	713	715	PF00400	0.652
TRG_NES_CRM1_1	143	154	PF08389	0.423
TRG_NES_CRM1_1	622	636	PF08389	0.462
TRG_NES_CRM1_1	647	661	PF08389	0.468
TRG_NLS_Bipartite_1	348	366	PF00514	0.529
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	558	563	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J7	Leptomonas seymouri	73%	99%
A0A0N1IC41	Leptomonas seymouri	24%	72%
A0A0S4JDB4	Bodo saltans	38%	99%
A0A0S4JNC8	Bodo saltans	22%	86%
A0A0S4KGN1	Bodo saltans	28%	89%
A0A1X0NE93	Trypanosomatidae	47%	99%
A0A3Q8IGJ9	Leishmania donovani	96%	100%
A0A3R7L4Y2	Trypanosoma rangeli	26%	88%
A0A3R7NDH9	Trypanosoma rangeli	46%	99%
A4HQ18	Leishmania braziliensis	83%	100%
A4IDS5	Leishmania infantum	96%	100%
A8HUA1	Chlamydomonas reinhardtii	31%	98%
B2RW38	Mus musculus	32%	97%
D0A8V1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ATT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q2U9	Leishmania major	23%	79%
V5A873	Trypanosoma cruzi	46%	99%