Bacterial transferase hexapeptide repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0Q8_LEIMA

TriTrypDb:

LmjF.36.5040 , LMJLV39_360062400 , LMJSD75_360062100

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Q8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.419
CLV_NRD_NRD_1	3	5	PF00675	0.548
CLV_NRD_NRD_1	7	9	PF00675	0.536
CLV_PCSK_KEX2_1	3	5	PF00082	0.548
CLV_PCSK_KEX2_1	303	305	PF00082	0.446
CLV_PCSK_KEX2_1	7	9	PF00082	0.536
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.442
CLV_PCSK_PC7_1	3	9	PF00082	0.655
CLV_PCSK_SKI1_1	255	259	PF00082	0.338
DEG_APCC_DBOX_1	2	10	PF00400	0.654
DEG_APCC_DBOX_1	72	80	PF00400	0.525
DEG_Nend_Nbox_1	1	3	PF02207	0.576
DOC_CYCLIN_RxL_1	38	47	PF00134	0.540
DOC_MAPK_gen_1	101	111	PF00069	0.571
DOC_PP4_FxxP_1	66	69	PF00568	0.620
DOC_PP4_MxPP_1	393	396	PF00568	0.692
DOC_USP7_MATH_1	103	107	PF00917	0.563
DOC_USP7_MATH_1	14	18	PF00917	0.574
DOC_USP7_UBL2_3	299	303	PF12436	0.421
DOC_WW_Pin1_4	349	354	PF00397	0.476
DOC_WW_Pin1_4	378	383	PF00397	0.544
DOC_WW_Pin1_4	408	413	PF00397	0.771
LIG_14-3-3_CanoR_1	3	7	PF00244	0.528
LIG_APCC_ABBA_1	343	348	PF00400	0.449
LIG_APCC_ABBA_1	400	405	PF00400	0.599
LIG_BIR_III_4	13	17	PF00653	0.628
LIG_eIF4E_1	206	212	PF01652	0.575
LIG_FHA_1	151	157	PF00498	0.367
LIG_FHA_1	176	182	PF00498	0.354
LIG_FHA_1	199	205	PF00498	0.467
LIG_FHA_1	259	265	PF00498	0.435
LIG_FHA_1	340	346	PF00498	0.480
LIG_FHA_1	350	356	PF00498	0.337
LIG_FHA_2	229	235	PF00498	0.341
LIG_FHA_2	63	69	PF00498	0.564
LIG_IBAR_NPY_1	213	215	PF08397	0.431
LIG_LIR_Apic_2	114	119	PF02991	0.456
LIG_LIR_Apic_2	301	305	PF02991	0.437
LIG_LIR_Apic_2	65	69	PF02991	0.621
LIG_LIR_Gen_1	418	426	PF02991	0.531
LIG_LIR_Gen_1	88	99	PF02991	0.524
LIG_LIR_Nem_3	246	250	PF02991	0.460
LIG_LIR_Nem_3	328	333	PF02991	0.614
LIG_LIR_Nem_3	418	422	PF02991	0.580
LIG_LIR_Nem_3	423	429	PF02991	0.553
LIG_LIR_Nem_3	88	94	PF02991	0.500
LIG_LIR_Nem_3	98	102	PF02991	0.490
LIG_Pex14_1	415	419	PF04695	0.641
LIG_SH2_CRK	132	136	PF00017	0.519
LIG_SH2_CRK	302	306	PF00017	0.471
LIG_SH2_CRK	307	311	PF00017	0.439
LIG_SH2_CRK	31	35	PF00017	0.489
LIG_SH2_CRK	419	423	PF00017	0.615
LIG_SH2_GRB2like	113	116	PF00017	0.467
LIG_SH2_GRB2like	333	336	PF00017	0.446
LIG_SH2_GRB2like	419	422	PF00017	0.583
LIG_SH2_NCK_1	419	423	PF00017	0.601
LIG_SH2_SRC	116	119	PF00017	0.456
LIG_SH2_SRC	238	241	PF00017	0.442
LIG_SH2_SRC	347	350	PF00017	0.555
LIG_SH2_SRC	419	422	PF00017	0.673
LIG_SH2_STAP1	113	117	PF00017	0.453
LIG_SH2_STAP1	307	311	PF00017	0.515
LIG_SH2_STAP1	347	351	PF00017	0.463
LIG_SH2_STAT3	130	133	PF00017	0.501
LIG_SH2_STAT3	149	152	PF00017	0.290
LIG_SH2_STAT3	326	329	PF00017	0.478
LIG_SH2_STAT5	116	119	PF00017	0.456
LIG_SH2_STAT5	130	133	PF00017	0.484
LIG_SH2_STAT5	149	152	PF00017	0.290
LIG_SH2_STAT5	182	185	PF00017	0.334
LIG_SH2_STAT5	238	241	PF00017	0.442
LIG_SH3_3	392	398	PF00018	0.573
LIG_SH3_3	66	72	PF00018	0.499
LIG_TRAF2_2	214	219	PF00917	0.424
LIG_WRC_WIRS_1	244	249	PF05994	0.454
MOD_CDK_SPxxK_3	349	356	PF00069	0.481
MOD_CDK_SPxxK_3	378	385	PF00069	0.549
MOD_CK1_1	243	249	PF00069	0.451
MOD_CK1_1	272	278	PF00069	0.378
MOD_CK1_1	410	416	PF00069	0.600
MOD_CK2_1	228	234	PF00069	0.321
MOD_CK2_1	295	301	PF00069	0.393
MOD_CK2_1	312	318	PF00069	0.583
MOD_CK2_1	408	414	PF00069	0.629
MOD_GSK3_1	139	146	PF00069	0.487
MOD_GSK3_1	190	197	PF00069	0.327
MOD_GSK3_1	228	235	PF00069	0.435
MOD_GSK3_1	312	319	PF00069	0.526
MOD_N-GLC_1	321	326	PF02516	0.465
MOD_N-GLC_1	415	420	PF02516	0.604
MOD_N-GLC_2	192	194	PF02516	0.330
MOD_NEK2_1	190	195	PF00069	0.324
MOD_NEK2_1	2	7	PF00069	0.549
MOD_NEK2_1	369	374	PF00069	0.585
MOD_NEK2_1	39	44	PF00069	0.530
MOD_NEK2_1	87	92	PF00069	0.519
MOD_NEK2_2	14	19	PF00069	0.572
MOD_PKA_2	2	8	PF00069	0.524
MOD_PKA_2	312	318	PF00069	0.503
MOD_Plk_1	190	196	PF00069	0.327
MOD_Plk_1	321	327	PF00069	0.456
MOD_Plk_4	152	158	PF00069	0.367
MOD_Plk_4	228	234	PF00069	0.321
MOD_Plk_4	269	275	PF00069	0.416
MOD_Plk_4	306	312	PF00069	0.448
MOD_Plk_4	339	345	PF00069	0.452
MOD_Plk_4	62	68	PF00069	0.609
MOD_ProDKin_1	349	355	PF00069	0.479
MOD_ProDKin_1	378	384	PF00069	0.547
MOD_ProDKin_1	408	414	PF00069	0.775
MOD_SUMO_rev_2	272	280	PF00179	0.373
MOD_SUMO_rev_2	296	305	PF00179	0.405
MOD_SUMO_rev_2	381	391	PF00179	0.689
TRG_ENDOCYTIC_2	132	135	PF00928	0.515
TRG_ENDOCYTIC_2	307	310	PF00928	0.479
TRG_ENDOCYTIC_2	320	323	PF00928	0.460
TRG_ENDOCYTIC_2	419	422	PF00928	0.573
TRG_ENDOCYTIC_2	96	99	PF00928	0.533
TRG_ER_diArg_1	2	4	PF00400	0.551
TRG_ER_diArg_1	6	8	PF00400	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P359	Leptomonas seymouri	87%	100%
A0A0S4JP99	Bodo saltans	64%	100%
A0A1X0NE18	Trypanosomatidae	74%	100%
A0A3Q8IKZ8	Leishmania donovani	98%	100%
A4HQ20	Leishmania braziliensis	97%	100%
A4IDS7	Leishmania infantum	98%	100%
D0A8U9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	92%
E9ATT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5ATD4	Trypanosoma cruzi	75%	100%