Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

32 kDa ER-associated protein, putative

Species:

Leishmania major

UniProt:

Q4Q0Q7_LEIMA

TriTrypDb:

LmjF.36.5050 , LMJLV39_360062500 , LMJSD75_360062200

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q0Q7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Q7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.382
CLV_NRD_NRD_1	137	139	PF00675	0.537
CLV_NRD_NRD_1	222	224	PF00675	0.557
CLV_NRD_NRD_1	243	245	PF00675	0.687
CLV_NRD_NRD_1	50	52	PF00675	0.699
CLV_PCSK_KEX2_1	137	139	PF00082	0.554
CLV_PCSK_KEX2_1	222	224	PF00082	0.557
CLV_PCSK_KEX2_1	242	244	PF00082	0.482
CLV_PCSK_KEX2_1	52	54	PF00082	0.713
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.686
CLV_PCSK_SKI1_1	243	247	PF00082	0.683
CLV_PCSK_SKI1_1	61	65	PF00082	0.709
DEG_SPOP_SBC_1	22	26	PF00917	0.472
DOC_MAPK_FxFP_2	169	172	PF00069	0.411
DOC_MAPK_gen_1	11	21	PF00069	0.459
DOC_MAPK_gen_1	150	159	PF00069	0.375
DOC_MAPK_gen_1	71	81	PF00069	0.434
DOC_MAPK_HePTP_8	147	159	PF00069	0.398
DOC_MAPK_MEF2A_6	14	23	PF00069	0.252
DOC_MAPK_MEF2A_6	150	159	PF00069	0.371
DOC_MAPK_MEF2A_6	74	83	PF00069	0.401
DOC_MAPK_NFAT4_5	152	160	PF00069	0.407
DOC_PP1_RVXF_1	2	8	PF00149	0.663
DOC_PP2B_LxvP_1	157	160	PF13499	0.420
DOC_PP4_FxxP_1	169	172	PF00568	0.387
DOC_PP4_FxxP_1	64	67	PF00568	0.482
DOC_USP7_MATH_1	160	164	PF00917	0.460
DOC_USP7_MATH_1	22	26	PF00917	0.442
DOC_WW_Pin1_4	209	214	PF00397	0.423
DOC_WW_Pin1_4	63	68	PF00397	0.419
DOC_WW_Pin1_4	85	90	PF00397	0.406
DOC_WW_Pin1_4	94	99	PF00397	0.376
LIG_14-3-3_CanoR_1	4	10	PF00244	0.665
LIG_14-3-3_CanoR_1	51	60	PF00244	0.504
LIG_14-3-3_CterR_2	263	267	PF00244	0.480
LIG_Actin_WH2_2	102	118	PF00022	0.422
LIG_BRCT_BRCA1_1	23	27	PF00533	0.445
LIG_BRCT_BRCA1_1	87	91	PF00533	0.468
LIG_deltaCOP1_diTrp_1	58	64	PF00928	0.503
LIG_FHA_1	174	180	PF00498	0.355
LIG_FHA_1	205	211	PF00498	0.484
LIG_FHA_1	232	238	PF00498	0.478
LIG_FHA_1	91	97	PF00498	0.415
LIG_FHA_2	149	155	PF00498	0.346
LIG_FHA_2	189	195	PF00498	0.369
LIG_LIR_Apic_2	162	167	PF02991	0.426
LIG_LIR_Apic_2	62	67	PF02991	0.409
LIG_LIR_Gen_1	153	164	PF02991	0.410
LIG_LIR_Gen_1	78	86	PF02991	0.401
LIG_LIR_Gen_1	88	98	PF02991	0.437
LIG_LIR_Nem_3	153	159	PF02991	0.392
LIG_LIR_Nem_3	212	217	PF02991	0.418
LIG_LIR_Nem_3	54	59	PF02991	0.454
LIG_LIR_Nem_3	62	68	PF02991	0.478
LIG_LIR_Nem_3	78	83	PF02991	0.240
LIG_LIR_Nem_3	88	94	PF02991	0.414
LIG_MLH1_MIPbox_1	24	28	PF16413	0.252
LIG_PALB2_WD40_1	193	201	PF16756	0.406
LIG_Pex14_1	60	64	PF04695	0.481
LIG_Pex14_2	171	175	PF04695	0.424
LIG_Pex14_2	39	43	PF04695	0.400
LIG_SH2_CRK	164	168	PF00017	0.448
LIG_SH2_CRK	45	49	PF00017	0.398
LIG_SH2_CRK	65	69	PF00017	0.252
LIG_SH2_NCK_1	45	49	PF00017	0.451
LIG_SH2_STAT5	120	123	PF00017	0.376
LIG_SH2_STAT5	132	135	PF00017	0.314
LIG_SH2_STAT5	156	159	PF00017	0.415
LIG_SH2_STAT5	56	59	PF00017	0.463
LIG_SH3_3	207	213	PF00018	0.453
LIG_SH3_3	83	89	PF00018	0.399
LIG_SUMO_SIM_par_1	82	88	PF11976	0.437
LIG_TRAF2_1	70	73	PF00917	0.415
MOD_CK1_1	204	210	PF00069	0.402
MOD_CK1_1	46	52	PF00069	0.457
MOD_CK2_1	188	194	PF00069	0.371
MOD_CK2_1	235	241	PF00069	0.452
MOD_CK2_1	67	73	PF00069	0.369
MOD_GlcNHglycan	198	201	PF01048	0.653
MOD_GlcNHglycan	30	33	PF01048	0.485
MOD_GlcNHglycan	61	64	PF01048	0.640
MOD_GSK3_1	155	162	PF00069	0.410
MOD_GSK3_1	227	234	PF00069	0.443
MOD_GSK3_1	59	66	PF00069	0.434
MOD_GSK3_1	90	97	PF00069	0.399
MOD_LATS_1	148	154	PF00433	0.323
MOD_N-GLC_1	43	48	PF02516	0.643
MOD_NEK2_1	102	107	PF00069	0.304
MOD_NEK2_1	179	184	PF00069	0.419
MOD_NEK2_1	188	193	PF00069	0.381
MOD_NEK2_1	201	206	PF00069	0.349
MOD_NEK2_1	21	26	PF00069	0.394
MOD_NEK2_1	227	232	PF00069	0.387
MOD_NEK2_1	28	33	PF00069	0.363
MOD_NEK2_1	5	10	PF00069	0.679
MOD_NEK2_1	59	64	PF00069	0.436
MOD_NEK2_1	90	95	PF00069	0.413
MOD_PKA_1	235	241	PF00069	0.492
MOD_PKA_1	51	57	PF00069	0.450
MOD_Plk_4	23	29	PF00069	0.394
MOD_Plk_4	79	85	PF00069	0.418
MOD_ProDKin_1	209	215	PF00069	0.414
MOD_ProDKin_1	63	69	PF00069	0.409
MOD_ProDKin_1	85	91	PF00069	0.414
MOD_ProDKin_1	94	100	PF00069	0.372
TRG_DiLeu_BaEn_4	72	78	PF01217	0.402
TRG_ENDOCYTIC_2	156	159	PF00928	0.437
TRG_ENDOCYTIC_2	224	227	PF00928	0.411
TRG_ENDOCYTIC_2	45	48	PF00928	0.423
TRG_ENDOCYTIC_2	56	59	PF00928	0.447
TRG_ENDOCYTIC_2	65	68	PF00928	0.458
TRG_ER_diArg_1	136	138	PF00400	0.348
TRG_ER_diArg_1	222	224	PF00400	0.359
TRG_ER_diArg_1	242	244	PF00400	0.282
TRG_ER_diArg_1	50	53	PF00400	0.477
TRG_NES_CRM1_1	110	123	PF08389	0.393
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZW1	Leptomonas seymouri	67%	100%
A0A0S4JNP4	Bodo saltans	28%	100%
A0A1X0NDW5	Trypanosomatidae	34%	100%
A0A3S7XBV9	Leishmania donovani	93%	100%
A4HQ21	Leishmania braziliensis	85%	100%
A4IDS8	Leishmania infantum	95%	100%
D0A8U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ATT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%