Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0Q5_LEIMA

TriTrypDb:

LmjF.36.5070 , LMJLV39_360062700 , LMJSD75_360062400

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Q5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	329	331	PF00675	0.390
CLV_NRD_NRD_1	373	375	PF00675	0.370
CLV_NRD_NRD_1	57	59	PF00675	0.546
CLV_PCSK_FUR_1	55	59	PF00082	0.557
CLV_PCSK_KEX2_1	160	162	PF00082	0.402
CLV_PCSK_KEX2_1	329	331	PF00082	0.457
CLV_PCSK_KEX2_1	373	375	PF00082	0.446
CLV_PCSK_KEX2_1	57	59	PF00082	0.535
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.402
CLV_PCSK_SKI1_1	10	14	PF00082	0.664
CLV_PCSK_SKI1_1	160	164	PF00082	0.407
CLV_PCSK_SKI1_1	373	377	PF00082	0.370
CLV_PCSK_SKI1_1	379	383	PF00082	0.393
CLV_PCSK_SKI1_1	392	396	PF00082	0.507
CLV_PCSK_SKI1_1	46	50	PF00082	0.526
CLV_Separin_Metazoa	256	260	PF03568	0.477
DOC_CDC14_PxL_1	305	313	PF14671	0.493
DOC_CKS1_1	318	323	PF01111	0.361
DOC_MAPK_FxFP_2	346	349	PF00069	0.388
DOC_MAPK_gen_1	248	257	PF00069	0.436
DOC_MAPK_gen_1	329	340	PF00069	0.399
DOC_MAPK_gen_1	34	42	PF00069	0.550
DOC_MAPK_gen_1	373	382	PF00069	0.368
DOC_MAPK_gen_1	97	105	PF00069	0.492
DOC_MAPK_MEF2A_6	376	384	PF00069	0.399
DOC_PP1_RVXF_1	208	215	PF00149	0.369
DOC_PP4_FxxP_1	346	349	PF00568	0.319
DOC_USP7_MATH_1	133	137	PF00917	0.615
DOC_USP7_MATH_1	144	148	PF00917	0.663
DOC_WW_Pin1_4	198	203	PF00397	0.471
DOC_WW_Pin1_4	250	255	PF00397	0.510
DOC_WW_Pin1_4	317	322	PF00397	0.328
LIG_14-3-3_CanoR_1	14	19	PF00244	0.559
LIG_14-3-3_CanoR_1	165	170	PF00244	0.444
LIG_14-3-3_CanoR_1	379	385	PF00244	0.420
LIG_BIR_II_1	1	5	PF00653	0.677
LIG_Clathr_ClatBox_1	368	372	PF01394	0.452
LIG_CSL_BTD_1	154	157	PF09270	0.397
LIG_FHA_1	318	324	PF00498	0.404
LIG_FHA_1	393	399	PF00498	0.596
LIG_FHA_1	49	55	PF00498	0.650
LIG_FHA_1	87	93	PF00498	0.380
LIG_FHA_2	251	257	PF00498	0.543
LIG_LIR_Gen_1	116	125	PF02991	0.433
LIG_LIR_Gen_1	166	176	PF02991	0.458
LIG_LIR_Gen_1	73	79	PF02991	0.349
LIG_LIR_Nem_3	116	120	PF02991	0.443
LIG_LIR_Nem_3	166	172	PF02991	0.440
LIG_LIR_Nem_3	73	78	PF02991	0.349
LIG_PTB_Apo_2	340	347	PF02174	0.398
LIG_SH2_CRK	167	171	PF00017	0.378
LIG_SH2_GRB2like	233	236	PF00017	0.364
LIG_SH2_SRC	171	174	PF00017	0.371
LIG_SH2_STAP1	167	171	PF00017	0.396
LIG_SH2_STAP1	245	249	PF00017	0.308
LIG_SH2_STAT5	167	170	PF00017	0.315
LIG_SH2_STAT5	171	174	PF00017	0.353
LIG_SH2_STAT5	28	31	PF00017	0.587
LIG_SH3_2	292	297	PF14604	0.546
LIG_SH3_2	321	326	PF14604	0.361
LIG_SH3_3	205	211	PF00018	0.484
LIG_SH3_3	244	250	PF00018	0.410
LIG_SH3_3	285	291	PF00018	0.403
LIG_SH3_3	315	321	PF00018	0.369
LIG_SUMO_SIM_anti_2	253	259	PF11976	0.441
LIG_SUMO_SIM_anti_2	363	370	PF11976	0.375
LIG_SUMO_SIM_par_1	380	386	PF11976	0.433
LIG_TRAF2_1	179	182	PF00917	0.556
LIG_WRC_WIRS_1	368	373	PF05994	0.362
MOD_CK1_1	106	112	PF00069	0.580
MOD_CK1_1	113	119	PF00069	0.516
MOD_CK1_1	136	142	PF00069	0.596
MOD_CK1_1	174	180	PF00069	0.399
MOD_CK1_1	296	302	PF00069	0.489
MOD_CK2_1	106	112	PF00069	0.490
MOD_CK2_1	176	182	PF00069	0.541
MOD_CK2_1	250	256	PF00069	0.536
MOD_CK2_1	380	386	PF00069	0.418
MOD_Cter_Amidation	389	392	PF01082	0.469
MOD_GlcNHglycan	136	139	PF01048	0.549
MOD_GlcNHglycan	173	176	PF01048	0.406
MOD_GlcNHglycan	305	308	PF01048	0.591
MOD_GlcNHglycan	333	336	PF01048	0.396
MOD_GlcNHglycan	94	97	PF01048	0.412
MOD_GSK3_1	10	17	PF00069	0.560
MOD_GSK3_1	106	113	PF00069	0.551
MOD_GSK3_1	133	140	PF00069	0.532
MOD_GSK3_1	176	183	PF00069	0.389
MOD_GSK3_1	222	229	PF00069	0.363
MOD_LATS_1	44	50	PF00433	0.526
MOD_N-GLC_1	106	111	PF02516	0.340
MOD_N-GLC_1	235	240	PF02516	0.492
MOD_N-GLC_1	360	365	PF02516	0.359
MOD_N-GLC_1	392	397	PF02516	0.413
MOD_NEK2_1	134	139	PF00069	0.580
MOD_NEK2_1	163	168	PF00069	0.447
MOD_NEK2_1	331	336	PF00069	0.406
MOD_NEK2_1	380	385	PF00069	0.506
MOD_NEK2_1	48	53	PF00069	0.507
MOD_NEK2_1	86	91	PF00069	0.389
MOD_NEK2_1	92	97	PF00069	0.355
MOD_PIKK_1	110	116	PF00454	0.472
MOD_PIKK_1	86	92	PF00454	0.427
MOD_PK_1	14	20	PF00069	0.546
MOD_PKA_2	144	150	PF00069	0.617
MOD_PKA_2	296	302	PF00069	0.518
MOD_Plk_1	145	151	PF00069	0.458
MOD_Plk_1	226	232	PF00069	0.355
MOD_Plk_1	235	241	PF00069	0.486
MOD_Plk_1	265	271	PF00069	0.559
MOD_Plk_1	392	398	PF00069	0.578
MOD_Plk_4	151	157	PF00069	0.445
MOD_Plk_4	165	171	PF00069	0.454
MOD_Plk_4	226	232	PF00069	0.384
MOD_Plk_4	348	354	PF00069	0.452
MOD_Plk_4	70	76	PF00069	0.374
MOD_ProDKin_1	198	204	PF00069	0.468
MOD_ProDKin_1	250	256	PF00069	0.516
MOD_ProDKin_1	317	323	PF00069	0.328
TRG_DiLeu_BaEn_1	313	318	PF01217	0.463
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.547
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.515
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.351
TRG_DiLeu_BaLyEn_6	318	323	PF01217	0.319
TRG_ENDOCYTIC_2	167	170	PF00928	0.301
TRG_ENDOCYTIC_2	75	78	PF00928	0.339
TRG_ER_diArg_1	329	331	PF00400	0.451
TRG_ER_diArg_1	373	375	PF00400	0.446
TRG_ER_diArg_1	54	57	PF00400	0.563
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSQ0	Leptomonas seymouri	73%	100%
A0A0S4JP54	Bodo saltans	36%	83%
A0A1X0NDW4	Trypanosomatidae	51%	96%
A0A3Q8IHT7	Leishmania donovani	95%	100%
A0A3R7K3H2	Trypanosoma rangeli	55%	97%
A4HQ23	Leishmania braziliensis	86%	100%
A4IDT0	Leishmania infantum	95%	100%
D0A8U6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	96%
E9ATU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5AZJ2	Trypanosoma cruzi	55%	88%