MIF4G domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0Q4_LEIMA

TriTrypDb:

LmjF.36.5080 , LMJLV39_360062800 , LMJSD75_360062500

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0Q4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Q4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.418
CLV_C14_Caspase3-7	558	562	PF00656	0.427
CLV_NRD_NRD_1	218	220	PF00675	0.413
CLV_NRD_NRD_1	352	354	PF00675	0.399
CLV_NRD_NRD_1	385	387	PF00675	0.661
CLV_NRD_NRD_1	426	428	PF00675	0.592
CLV_NRD_NRD_1	587	589	PF00675	0.442
CLV_PCSK_KEX2_1	114	116	PF00082	0.628
CLV_PCSK_KEX2_1	352	354	PF00082	0.399
CLV_PCSK_KEX2_1	385	387	PF00082	0.637
CLV_PCSK_KEX2_1	426	428	PF00082	0.591
CLV_PCSK_KEX2_1	565	567	PF00082	0.427
CLV_PCSK_KEX2_1	587	589	PF00082	0.418
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.628
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.427
CLV_PCSK_SKI1_1	111	115	PF00082	0.674
CLV_PCSK_SKI1_1	26	30	PF00082	0.671
CLV_PCSK_SKI1_1	275	279	PF00082	0.474
CLV_PCSK_SKI1_1	478	482	PF00082	0.480
CLV_PCSK_SKI1_1	487	491	PF00082	0.434
CLV_PCSK_SKI1_1	50	54	PF00082	0.561
CLV_PCSK_SKI1_1	514	518	PF00082	0.458
CLV_PCSK_SKI1_1	587	591	PF00082	0.420
CLV_Separin_Metazoa	398	402	PF03568	0.529
DEG_APCC_DBOX_1	274	282	PF00400	0.414
DEG_APCC_DBOX_1	586	594	PF00400	0.399
DEG_Nend_UBRbox_2	1	3	PF02207	0.705
DOC_ANK_TNKS_1	363	370	PF00023	0.494
DOC_CYCLIN_RxL_1	475	485	PF00134	0.465
DOC_CYCLIN_RxL_1	585	596	PF00134	0.396
DOC_MAPK_gen_1	279	286	PF00069	0.510
DOC_PP1_RVXF_1	468	475	PF00149	0.425
DOC_PP1_RVXF_1	586	593	PF00149	0.398
DOC_PP4_FxxP_1	359	362	PF00568	0.537
DOC_PP4_MxPP_1	202	205	PF00568	0.407
DOC_USP7_MATH_1	328	332	PF00917	0.552
DOC_USP7_MATH_1	4	8	PF00917	0.711
DOC_USP7_MATH_1	534	538	PF00917	0.322
DOC_USP7_MATH_1	611	615	PF00917	0.587
DOC_USP7_UBL2_3	114	118	PF12436	0.641
DOC_USP7_UBL2_3	346	350	PF12436	0.362
DOC_WW_Pin1_4	102	107	PF00397	0.648
DOC_WW_Pin1_4	197	202	PF00397	0.528
DOC_WW_Pin1_4	250	255	PF00397	0.596
DOC_WW_Pin1_4	270	275	PF00397	0.468
DOC_WW_Pin1_4	538	543	PF00397	0.451
DOC_WW_Pin1_4	7	12	PF00397	0.669
LIG_14-3-3_CanoR_1	130	134	PF00244	0.517
LIG_14-3-3_CanoR_1	219	227	PF00244	0.482
LIG_14-3-3_CanoR_1	23	29	PF00244	0.618
LIG_14-3-3_CanoR_1	385	391	PF00244	0.604
LIG_14-3-3_CanoR_1	427	435	PF00244	0.538
LIG_14-3-3_CanoR_1	487	492	PF00244	0.505
LIG_14-3-3_CanoR_1	571	579	PF00244	0.407
LIG_14-3-3_CanoR_1	93	98	PF00244	0.692
LIG_Actin_WH2_2	509	527	PF00022	0.465
LIG_Actin_WH2_2	576	593	PF00022	0.480
LIG_BRCT_BRCA1_1	148	152	PF00533	0.489
LIG_BRCT_BRCA1_1	442	446	PF00533	0.429
LIG_BRCT_BRCA1_1	536	540	PF00533	0.305
LIG_CaM_IQ_9	338	354	PF13499	0.447
LIG_FHA_1	198	204	PF00498	0.425
LIG_FHA_1	227	233	PF00498	0.513
LIG_FHA_1	309	315	PF00498	0.537
LIG_FHA_1	519	525	PF00498	0.440
LIG_FHA_1	580	586	PF00498	0.495
LIG_FHA_2	103	109	PF00498	0.552
LIG_FHA_2	130	136	PF00498	0.464
LIG_FHA_2	184	190	PF00498	0.412
LIG_FHA_2	328	334	PF00498	0.525
LIG_FHA_2	400	406	PF00498	0.725
LIG_FHA_2	412	418	PF00498	0.660
LIG_FHA_2	429	435	PF00498	0.406
LIG_FHA_2	449	455	PF00498	0.287
LIG_FHA_2	488	494	PF00498	0.485
LIG_FHA_2	515	521	PF00498	0.431
LIG_FHA_2	616	622	PF00498	0.511
LIG_LIR_Apic_2	356	362	PF02991	0.506
LIG_LIR_Gen_1	124	133	PF02991	0.447
LIG_LIR_Gen_1	149	160	PF02991	0.351
LIG_LIR_Gen_1	182	193	PF02991	0.535
LIG_LIR_Gen_1	443	453	PF02991	0.454
LIG_LIR_Gen_1	466	472	PF02991	0.446
LIG_LIR_Gen_1	485	496	PF02991	0.282
LIG_LIR_Nem_3	124	129	PF02991	0.498
LIG_LIR_Nem_3	149	155	PF02991	0.531
LIG_LIR_Nem_3	182	188	PF02991	0.522
LIG_LIR_Nem_3	189	195	PF02991	0.473
LIG_LIR_Nem_3	443	449	PF02991	0.440
LIG_LIR_Nem_3	466	471	PF02991	0.460
LIG_LIR_Nem_3	485	491	PF02991	0.360
LIG_SH2_STAP1	173	177	PF00017	0.406
LIG_SH2_STAT5	142	145	PF00017	0.417
LIG_SH3_3	198	204	PF00018	0.490
LIG_SH3_3	251	257	PF00018	0.686
LIG_SH3_3	372	378	PF00018	0.623
LIG_SH3_3	580	586	PF00018	0.474
LIG_SUMO_SIM_anti_2	283	288	PF11976	0.395
LIG_SUMO_SIM_par_1	509	515	PF11976	0.412
LIG_TRAF2_1	378	381	PF00917	0.743
LIG_UBA3_1	191	199	PF00899	0.559
LIG_UBA3_1	343	350	PF00899	0.357
MOD_CDK_SPK_2	270	275	PF00069	0.429
MOD_CK1_1	18	24	PF00069	0.583
MOD_CK1_1	270	276	PF00069	0.633
MOD_CK1_1	409	415	PF00069	0.646
MOD_CK1_1	512	518	PF00069	0.430
MOD_CK1_1	541	547	PF00069	0.454
MOD_CK1_1	6	12	PF00069	0.684
MOD_CK2_1	135	141	PF00069	0.536
MOD_CK2_1	183	189	PF00069	0.407
MOD_CK2_1	270	276	PF00069	0.427
MOD_CK2_1	327	333	PF00069	0.678
MOD_CK2_1	399	405	PF00069	0.725
MOD_CK2_1	428	434	PF00069	0.544
MOD_CK2_1	448	454	PF00069	0.272
MOD_CK2_1	480	486	PF00069	0.427
MOD_CK2_1	487	493	PF00069	0.498
MOD_CK2_1	7	13	PF00069	0.571
MOD_GlcNHglycan	220	223	PF01048	0.561
MOD_GlcNHglycan	30	33	PF01048	0.576
MOD_GlcNHglycan	330	333	PF01048	0.614
MOD_GlcNHglycan	408	411	PF01048	0.672
MOD_GlcNHglycan	482	485	PF01048	0.393
MOD_GlcNHglycan	548	551	PF01048	0.354
MOD_GlcNHglycan	6	9	PF01048	0.706
MOD_GlcNHglycan	97	100	PF01048	0.674
MOD_GSK3_1	14	21	PF00069	0.660
MOD_GSK3_1	146	153	PF00069	0.447
MOD_GSK3_1	24	31	PF00069	0.532
MOD_GSK3_1	3	10	PF00069	0.651
MOD_GSK3_1	308	315	PF00069	0.548
MOD_GSK3_1	322	329	PF00069	0.507
MOD_GSK3_1	342	349	PF00069	0.389
MOD_GSK3_1	380	387	PF00069	0.620
MOD_GSK3_1	514	521	PF00069	0.538
MOD_GSK3_1	534	541	PF00069	0.530
MOD_GSK3_1	611	618	PF00069	0.589
MOD_NEK2_1	128	133	PF00069	0.433
MOD_NEK2_1	28	33	PF00069	0.577
MOD_NEK2_1	296	301	PF00069	0.403
MOD_NEK2_1	408	413	PF00069	0.553
MOD_NEK2_1	572	577	PF00069	0.441
MOD_NEK2_1	579	584	PF00069	0.324
MOD_NEK2_2	24	29	PF00069	0.621
MOD_PIKK_1	163	169	PF00454	0.460
MOD_PIKK_1	175	181	PF00454	0.452
MOD_PIKK_1	421	427	PF00454	0.571
MOD_PIKK_1	572	578	PF00454	0.392
MOD_PKA_1	150	156	PF00069	0.369
MOD_PKA_2	129	135	PF00069	0.443
MOD_PKA_2	18	24	PF00069	0.592
MOD_PKA_2	218	224	PF00069	0.499
MOD_PKA_2	32	38	PF00069	0.668
MOD_PKA_2	384	390	PF00069	0.599
MOD_PKB_1	41	49	PF00069	0.650
MOD_PKB_1	93	101	PF00069	0.667
MOD_Plk_1	380	386	PF00069	0.667
MOD_Plk_2-3	135	141	PF00069	0.462
MOD_Plk_4	267	273	PF00069	0.545
MOD_Plk_4	322	328	PF00069	0.575
MOD_Plk_4	448	454	PF00069	0.497
MOD_Plk_4	487	493	PF00069	0.458
MOD_Plk_4	506	512	PF00069	0.435
MOD_ProDKin_1	102	108	PF00069	0.647
MOD_ProDKin_1	197	203	PF00069	0.518
MOD_ProDKin_1	250	256	PF00069	0.595
MOD_ProDKin_1	270	276	PF00069	0.466
MOD_ProDKin_1	538	544	PF00069	0.449
MOD_ProDKin_1	7	13	PF00069	0.671
MOD_SUMO_for_1	113	116	PF00179	0.604
MOD_SUMO_rev_2	116	122	PF00179	0.584
MOD_SUMO_rev_2	148	158	PF00179	0.483
MOD_SUMO_rev_2	558	567	PF00179	0.465
TRG_DiLeu_BaEn_1	267	272	PF01217	0.574
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.415
TRG_ENDOCYTIC_2	173	176	PF00928	0.450
TRG_ER_diArg_1	352	354	PF00400	0.459
TRG_ER_diArg_1	384	386	PF00400	0.546
TRG_ER_diArg_1	426	428	PF00400	0.573
TRG_ER_diArg_1	586	588	PF00400	0.422
TRG_ER_diArg_1	92	95	PF00400	0.594
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	577	581	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHF8	Leptomonas seymouri	62%	100%
A0A3S7XBM9	Leishmania donovani	88%	100%
A4HQ24	Leishmania braziliensis	70%	100%
D0A8U5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AHY2	Leishmania infantum	88%	100%
E9ATU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%