Magnesium chelatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Magnesium chelatase

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0Q2_LEIMA

TriTrypDb:

LmjF.36.5100 , LMJLV39_360063000 , LMJSD75_360062700

Length:

981

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0Q2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Q2

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0005488	binding	1	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	449	453	PF00656	0.844
CLV_C14_Caspase3-7	641	645	PF00656	0.812
CLV_C14_Caspase3-7	798	802	PF00656	0.595
CLV_NRD_NRD_1	273	275	PF00675	0.607
CLV_NRD_NRD_1	509	511	PF00675	0.529
CLV_NRD_NRD_1	629	631	PF00675	0.844
CLV_NRD_NRD_1	711	713	PF00675	0.734
CLV_NRD_NRD_1	773	775	PF00675	0.608
CLV_NRD_NRD_1	831	833	PF00675	0.537
CLV_PCSK_FUR_1	711	715	PF00082	0.660

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II64	Leptomonas seymouri	61%	100%
A0A1X0NFU9	Trypanosomatidae	28%	100%
A0A3Q8IRM7	Leishmania donovani	89%	100%
A0A422N6K0	Trypanosoma rangeli	28%	100%
A4HQ26	Leishmania braziliensis	76%	100%
A4IDT2	Leishmania infantum	89%	100%
D0A8U2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
E9ATU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%

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