Magnesium chelatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Magnesium chelatase

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0Q2_LEIMA

TriTrypDb:

LmjF.36.5100 , LMJLV39_360063000 , LMJSD75_360062700

Length:

981

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0Q2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Q2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0005488	binding	1	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	449	453	PF00656	0.844
CLV_C14_Caspase3-7	641	645	PF00656	0.812
CLV_C14_Caspase3-7	798	802	PF00656	0.595
CLV_NRD_NRD_1	273	275	PF00675	0.607
CLV_NRD_NRD_1	509	511	PF00675	0.529
CLV_NRD_NRD_1	629	631	PF00675	0.844
CLV_NRD_NRD_1	711	713	PF00675	0.734
CLV_NRD_NRD_1	773	775	PF00675	0.608
CLV_NRD_NRD_1	831	833	PF00675	0.537
CLV_PCSK_FUR_1	711	715	PF00082	0.660
CLV_PCSK_KEX2_1	489	491	PF00082	0.724
CLV_PCSK_KEX2_1	511	513	PF00082	0.492
CLV_PCSK_KEX2_1	635	637	PF00082	0.761
CLV_PCSK_KEX2_1	711	713	PF00082	0.733
CLV_PCSK_PC1ET2_1	489	491	PF00082	0.724
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.520
CLV_PCSK_PC1ET2_1	635	637	PF00082	0.761
CLV_PCSK_PC1ET2_1	713	715	PF00082	0.788
CLV_PCSK_SKI1_1	275	279	PF00082	0.689
CLV_PCSK_SKI1_1	486	490	PF00082	0.769
CLV_PCSK_SKI1_1	503	507	PF00082	0.369
CLV_PCSK_SKI1_1	512	516	PF00082	0.482
CLV_PCSK_SKI1_1	571	575	PF00082	0.760
CLV_PCSK_SKI1_1	732	736	PF00082	0.565
CLV_PCSK_SKI1_1	754	758	PF00082	0.510
CLV_PCSK_SKI1_1	811	815	PF00082	0.568
CLV_PCSK_SKI1_1	832	836	PF00082	0.609
DEG_APCC_DBOX_1	810	818	PF00400	0.562
DEG_APCC_DBOX_1	831	839	PF00400	0.599
DEG_Nend_UBRbox_3	1	3	PF02207	0.871
DOC_CDC14_PxL_1	546	554	PF14671	0.609
DOC_CKS1_1	110	115	PF01111	0.784
DOC_CKS1_1	378	383	PF01111	0.775
DOC_CKS1_1	755	760	PF01111	0.375
DOC_CKS1_1	823	828	PF01111	0.582
DOC_CYCLIN_RxL_1	808	816	PF00134	0.529
DOC_CYCLIN_RxL_1	829	836	PF00134	0.413
DOC_CYCLIN_yClb5_NLxxxL_5	811	817	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	542	548	PF00134	0.622
DOC_MAPK_gen_1	293	301	PF00069	0.685
DOC_MAPK_gen_1	500	508	PF00069	0.554
DOC_MAPK_gen_1	510	516	PF00069	0.544
DOC_MAPK_MEF2A_6	295	303	PF00069	0.671
DOC_PP1_RVXF_1	510	517	PF00149	0.533
DOC_PP1_RVXF_1	531	537	PF00149	0.710
DOC_PP2B_LxvP_1	314	317	PF13499	0.668
DOC_PP4_FxxP_1	374	377	PF00568	0.747
DOC_USP7_MATH_1	289	293	PF00917	0.717
DOC_USP7_MATH_1	294	298	PF00917	0.679
DOC_USP7_MATH_1	417	421	PF00917	0.614
DOC_USP7_MATH_1	53	57	PF00917	0.653
DOC_USP7_MATH_1	58	62	PF00917	0.618
DOC_USP7_MATH_1	63	67	PF00917	0.596
DOC_USP7_MATH_1	883	887	PF00917	0.575
DOC_USP7_MATH_1	916	920	PF00917	0.655
DOC_USP7_UBL2_3	485	489	PF12436	0.803
DOC_USP7_UBL2_3	631	635	PF12436	0.757
DOC_WW_Pin1_4	109	114	PF00397	0.810
DOC_WW_Pin1_4	184	189	PF00397	0.809
DOC_WW_Pin1_4	377	382	PF00397	0.757
DOC_WW_Pin1_4	492	497	PF00397	0.639
DOC_WW_Pin1_4	656	661	PF00397	0.709
DOC_WW_Pin1_4	667	672	PF00397	0.804
DOC_WW_Pin1_4	754	759	PF00397	0.378
DOC_WW_Pin1_4	767	772	PF00397	0.654
DOC_WW_Pin1_4	822	827	PF00397	0.482
DOC_WW_Pin1_4	890	895	PF00397	0.534
DOC_WW_Pin1_4	974	979	PF00397	0.837
LIG_14-3-3_CanoR_1	274	284	PF00244	0.643
LIG_14-3-3_CanoR_1	425	433	PF00244	0.589
LIG_14-3-3_CanoR_1	490	496	PF00244	0.644
LIG_14-3-3_CanoR_1	503	509	PF00244	0.601
LIG_14-3-3_CanoR_1	714	723	PF00244	0.703
LIG_14-3-3_CanoR_1	870	874	PF00244	0.586
LIG_Actin_WH2_2	527	543	PF00022	0.719
LIG_APCC_ABBAyCdc20_2	511	517	PF00400	0.596
LIG_eIF4E_1	742	748	PF01652	0.627
LIG_FHA_1	276	282	PF00498	0.637
LIG_FHA_1	296	302	PF00498	0.376
LIG_FHA_1	401	407	PF00498	0.604
LIG_FHA_1	870	876	PF00498	0.578
LIG_FHA_1	910	916	PF00498	0.618
LIG_FHA_1	935	941	PF00498	0.616
LIG_FHA_2	370	376	PF00498	0.737
LIG_FHA_2	378	384	PF00498	0.795
LIG_FHA_2	392	398	PF00498	0.484
LIG_FHA_2	652	658	PF00498	0.822
LIG_FHA_2	823	829	PF00498	0.556
LIG_FHA_2	839	845	PF00498	0.435
LIG_GBD_Chelix_1	899	907	PF00786	0.486
LIG_IBAR_NPY_1	10	12	PF08397	0.841
LIG_IRF3_LxIS_1	887	893	PF10401	0.606
LIG_LIR_Apic_2	372	377	PF02991	0.743
LIG_LIR_Gen_1	256	266	PF02991	0.628
LIG_LIR_Gen_1	408	417	PF02991	0.624
LIG_LIR_Gen_1	424	433	PF02991	0.548
LIG_LIR_Gen_1	554	565	PF02991	0.576
LIG_LIR_Gen_1	757	768	PF02991	0.353
LIG_LIR_Gen_1	884	894	PF02991	0.550
LIG_LIR_Nem_3	256	261	PF02991	0.597
LIG_LIR_Nem_3	264	269	PF02991	0.551
LIG_LIR_Nem_3	331	336	PF02991	0.654
LIG_LIR_Nem_3	362	367	PF02991	0.741
LIG_LIR_Nem_3	408	412	PF02991	0.593
LIG_LIR_Nem_3	424	430	PF02991	0.541
LIG_LIR_Nem_3	554	560	PF02991	0.545
LIG_LIR_Nem_3	691	695	PF02991	0.416
LIG_LIR_Nem_3	757	763	PF02991	0.404
LIG_LIR_Nem_3	884	890	PF02991	0.600
LIG_LIR_Nem_3	929	935	PF02991	0.545
LIG_LYPXL_yS_3	549	552	PF13949	0.630
LIG_MAD2	518	526	PF02301	0.656
LIG_NRBOX	366	372	PF00104	0.746
LIG_NRBOX	830	836	PF00104	0.603
LIG_PAM2_1	788	800	PF00658	0.617
LIG_Pex14_1	692	696	PF04695	0.519
LIG_PTB_Apo_2	174	181	PF02174	0.827
LIG_PTB_Apo_2	837	844	PF02174	0.551
LIG_PTB_Phospho_1	174	180	PF10480	0.828
LIG_REV1ctd_RIR_1	513	520	PF16727	0.618
LIG_SH2_CRK	258	262	PF00017	0.727
LIG_SH2_CRK	755	759	PF00017	0.529
LIG_SH2_CRK	810	814	PF00017	0.600
LIG_SH2_GRB2like	175	178	PF00017	0.787
LIG_SH2_NCK_1	186	190	PF00017	0.867
LIG_SH2_NCK_1	696	700	PF00017	0.556
LIG_SH2_NCK_1	95	99	PF00017	0.853
LIG_SH2_STAP1	409	413	PF00017	0.581
LIG_SH2_STAP1	95	99	PF00017	0.837
LIG_SH2_STAT3	167	170	PF00017	0.761
LIG_SH2_STAT3	175	178	PF00017	0.725
LIG_SH2_STAT3	19	22	PF00017	0.869
LIG_SH2_STAT3	199	202	PF00017	0.815
LIG_SH2_STAT3	28	31	PF00017	0.734
LIG_SH2_STAT3	41	44	PF00017	0.674
LIG_SH2_STAT3	590	593	PF00017	0.605
LIG_SH2_STAT5	186	189	PF00017	0.698
LIG_SH2_STAT5	742	745	PF00017	0.617
LIG_SH2_STAT5	830	833	PF00017	0.532
LIG_SH2_STAT5	850	853	PF00017	0.471
LIG_SH2_STAT5	898	901	PF00017	0.473
LIG_SH2_STAT5	933	936	PF00017	0.458
LIG_SH3_1	518	524	PF00018	0.702
LIG_SH3_1	820	826	PF00018	0.566
LIG_SH3_3	108	114	PF00018	0.787
LIG_SH3_3	202	208	PF00018	0.762
LIG_SH3_3	209	215	PF00018	0.693
LIG_SH3_3	314	320	PF00018	0.701
LIG_SH3_3	331	337	PF00018	0.691
LIG_SH3_3	42	48	PF00018	0.856
LIG_SH3_3	435	441	PF00018	0.672
LIG_SH3_3	517	523	PF00018	0.683
LIG_SH3_3	820	826	PF00018	0.580
LIG_SH3_3	972	978	PF00018	0.805
LIG_SH3_4	631	638	PF00018	0.836
LIG_SUMO_SIM_anti_2	603	609	PF11976	0.635
LIG_TRAF2_1	446	449	PF00917	0.894
LIG_TRAF2_1	624	627	PF00917	0.731
LIG_TRAF2_1	659	662	PF00917	0.782
LIG_TYR_ITIM	547	552	PF00017	0.661
LIG_UBA3_1	367	376	PF00899	0.727
LIG_UBA3_1	398	404	PF00899	0.619
LIG_WRC_WIRS_1	361	366	PF05994	0.746
LIG_WRC_WIRS_1	371	376	PF05994	0.618
LIG_WRC_WIRS_1	748	753	PF05994	0.560
LIG_WRC_WIRS_1	932	937	PF05994	0.491
MOD_CDK_SPxxK_3	184	191	PF00069	0.615
MOD_CDK_SPxxK_3	667	674	PF00069	0.816
MOD_CDK_SPxxK_3	767	774	PF00069	0.464
MOD_CK1_1	326	332	PF00069	0.667
MOD_CK1_1	420	426	PF00069	0.603
MOD_CK1_1	596	602	PF00069	0.605
MOD_CK1_1	701	707	PF00069	0.584
MOD_CK1_1	770	776	PF00069	0.488
MOD_CK1_1	816	822	PF00069	0.545
MOD_CK2_1	377	383	PF00069	0.805
MOD_CK2_1	391	397	PF00069	0.496
MOD_CK2_1	431	437	PF00069	0.725
MOD_CK2_1	616	622	PF00069	0.731
MOD_CK2_1	651	657	PF00069	0.821
MOD_CK2_1	676	682	PF00069	0.579
MOD_CK2_1	822	828	PF00069	0.485
MOD_CK2_1	838	844	PF00069	0.391
MOD_Cter_Amidation	272	275	PF01082	0.649
MOD_GlcNHglycan	287	290	PF01048	0.702
MOD_GlcNHglycan	596	599	PF01048	0.595
MOD_GlcNHglycan	685	688	PF01048	0.540
MOD_GlcNHglycan	765	768	PF01048	0.497
MOD_GlcNHglycan	894	897	PF01048	0.564
MOD_GlcNHglycan	966	969	PF01048	0.684
MOD_GlcNHglycan	972	975	PF01048	0.656
MOD_GSK3_1	285	292	PF00069	0.693
MOD_GSK3_1	359	366	PF00069	0.736
MOD_GSK3_1	417	424	PF00069	0.586
MOD_GSK3_1	488	495	PF00069	0.583
MOD_GSK3_1	592	599	PF00069	0.503
MOD_GSK3_1	712	719	PF00069	0.719
MOD_GSK3_1	73	80	PF00069	0.635
MOD_GSK3_1	763	770	PF00069	0.541
MOD_GSK3_1	785	792	PF00069	0.545
MOD_GSK3_1	796	803	PF00069	0.593
MOD_GSK3_1	812	819	PF00069	0.543
MOD_GSK3_1	838	845	PF00069	0.598
MOD_GSK3_1	905	912	PF00069	0.511
MOD_GSK3_1	970	977	PF00069	0.804
MOD_N-GLC_1	184	189	PF02516	0.761
MOD_N-GLC_1	99	104	PF02516	0.624
MOD_NEK2_1	254	259	PF00069	0.704
MOD_NEK2_1	369	374	PF00069	0.726
MOD_NEK2_1	506	511	PF00069	0.597
MOD_NEK2_1	594	599	PF00069	0.533
MOD_NEK2_1	747	752	PF00069	0.605
MOD_NEK2_1	813	818	PF00069	0.546
MOD_NEK2_2	536	541	PF00069	0.626
MOD_PIKK_1	222	228	PF00454	0.790
MOD_PIKK_1	53	59	PF00454	0.686
MOD_PIKK_1	63	69	PF00454	0.648
MOD_PIKK_1	716	722	PF00454	0.736
MOD_PIKK_1	73	79	PF00454	0.694
MOD_PIKK_1	93	99	PF00454	0.601
MOD_PKA_1	712	718	PF00069	0.725
MOD_PKA_2	294	300	PF00069	0.732
MOD_PKA_2	431	437	PF00069	0.585
MOD_PKA_2	715	721	PF00069	0.685
MOD_PKA_2	862	868	PF00069	0.613
MOD_PKA_2	869	875	PF00069	0.577
MOD_PKB_1	293	301	PF00069	0.727
MOD_PKB_1	714	722	PF00069	0.745
MOD_Plk_1	320	326	PF00069	0.725
MOD_Plk_1	421	427	PF00069	0.602
MOD_Plk_1	800	806	PF00069	0.562
MOD_Plk_1	883	889	PF00069	0.645
MOD_Plk_1	99	105	PF00069	0.625
MOD_Plk_2-3	405	411	PF00069	0.670
MOD_Plk_4	277	283	PF00069	0.616
MOD_Plk_4	320	326	PF00069	0.734
MOD_Plk_4	329	335	PF00069	0.671
MOD_Plk_4	600	606	PF00069	0.533
MOD_Plk_4	747	753	PF00069	0.480
MOD_Plk_4	785	791	PF00069	0.557
MOD_Plk_4	838	844	PF00069	0.504
MOD_Plk_4	883	889	PF00069	0.587
MOD_Plk_4	931	937	PF00069	0.563
MOD_ProDKin_1	109	115	PF00069	0.814
MOD_ProDKin_1	184	190	PF00069	0.810
MOD_ProDKin_1	377	383	PF00069	0.764
MOD_ProDKin_1	492	498	PF00069	0.632
MOD_ProDKin_1	656	662	PF00069	0.708
MOD_ProDKin_1	667	673	PF00069	0.793
MOD_ProDKin_1	754	760	PF00069	0.377
MOD_ProDKin_1	767	773	PF00069	0.654
MOD_ProDKin_1	822	828	PF00069	0.481
MOD_ProDKin_1	890	896	PF00069	0.530
MOD_ProDKin_1	974	980	PF00069	0.838
MOD_SUMO_rev_2	462	472	PF00179	0.853
MOD_SUMO_rev_2	678	686	PF00179	0.625
MOD_SUMO_rev_2	918	928	PF00179	0.533
TRG_DiLeu_BaEn_2	777	783	PF01217	0.590
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.657
TRG_DiLeu_BaLyEn_6	538	543	PF01217	0.589
TRG_DiLeu_BaLyEn_6	547	552	PF01217	0.619
TRG_ENDOCYTIC_2	166	169	PF00928	0.771
TRG_ENDOCYTIC_2	258	261	PF00928	0.618
TRG_ENDOCYTIC_2	266	269	PF00928	0.565
TRG_ENDOCYTIC_2	409	412	PF00928	0.589
TRG_ENDOCYTIC_2	549	552	PF00928	0.597
TRG_ENDOCYTIC_2	695	698	PF00928	0.503
TRG_ENDOCYTIC_2	810	813	PF00928	0.561
TRG_ENDOCYTIC_2	932	935	PF00928	0.523
TRG_ER_diArg_1	290	293	PF00400	0.702
TRG_ER_diArg_1	710	712	PF00400	0.742
TRG_ER_diArg_1	714	717	PF00400	0.740
TRG_ER_diArg_1	739	742	PF00400	0.520
TRG_NES_CRM1_1	554	568	PF08389	0.602
TRG_NLS_MonoExtC_3	711	716	PF00514	0.739
TRG_NLS_MonoExtN_4	711	717	PF00514	0.737
TRG_Pf-PMV_PEXEL_1	832	836	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	901	906	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II64	Leptomonas seymouri	61%	100%
A0A1X0NFU9	Trypanosomatidae	28%	100%
A0A3Q8IRM7	Leishmania donovani	89%	100%
A0A422N6K0	Trypanosoma rangeli	28%	100%
A4HQ26	Leishmania braziliensis	76%	100%
A4IDT2	Leishmania infantum	89%	100%
D0A8U2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
E9ATU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%