PHB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4496), putative

Species:

Leishmania major

UniProt:

Q4Q0Q1_LEIMA

TriTrypDb:

LmjF.36.5110 , LMJLV39_360063100 , LMJSD75_360062800

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	2
GO:0005930	axoneme	2	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q0Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Q1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.480
CLV_C14_Caspase3-7	249	253	PF00656	0.593
CLV_NRD_NRD_1	260	262	PF00675	0.655
CLV_PCSK_KEX2_1	260	262	PF00082	0.687
CLV_PCSK_KEX2_1	35	37	PF00082	0.388
CLV_PCSK_KEX2_1	61	63	PF00082	0.333
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.388
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.333
CLV_PCSK_SKI1_1	107	111	PF00082	0.528
CLV_PCSK_SKI1_1	186	190	PF00082	0.330
CLV_PCSK_SKI1_1	78	82	PF00082	0.362
DEG_APCC_DBOX_1	185	193	PF00400	0.330
DEG_Nend_UBRbox_2	1	3	PF02207	0.685
DOC_CKS1_1	201	206	PF01111	0.557
DOC_MAPK_gen_1	60	69	PF00069	0.410
DOC_MAPK_MEF2A_6	60	69	PF00069	0.419
DOC_MAPK_NFAT4_5	62	70	PF00069	0.419
DOC_SPAK_OSR1_1	138	142	PF12202	0.333
DOC_USP7_UBL2_3	103	107	PF12436	0.419
DOC_WW_Pin1_4	200	205	PF00397	0.492
LIG_14-3-3_CanoR_1	158	168	PF00244	0.419
LIG_14-3-3_CanoR_1	191	197	PF00244	0.406
LIG_14-3-3_CanoR_1	236	240	PF00244	0.584
LIG_14-3-3_CanoR_1	244	250	PF00244	0.573
LIG_BRCT_BRCA1_1	184	188	PF00533	0.368
LIG_FHA_1	161	167	PF00498	0.359
LIG_FHA_2	201	207	PF00498	0.539
LIG_LIR_Apic_2	203	208	PF02991	0.456
LIG_LIR_Gen_1	124	134	PF02991	0.336
LIG_LIR_Nem_3	124	130	PF02991	0.312
LIG_Pex14_1	184	188	PF04695	0.307
LIG_Pex14_2	100	104	PF04695	0.333
LIG_PTAP_UEV_1	214	219	PF05743	0.526
LIG_SH2_CRK	205	209	PF00017	0.483
LIG_SH2_NCK_1	205	209	PF00017	0.483
LIG_SH2_PTP2	127	130	PF00017	0.362
LIG_SH2_SRC	205	208	PF00017	0.460
LIG_SH2_STAT3	30	33	PF00017	0.307
LIG_SH2_STAT5	127	130	PF00017	0.441
LIG_SH2_STAT5	155	158	PF00017	0.326
LIG_SH3_2	215	220	PF14604	0.637
LIG_SH3_3	198	204	PF00018	0.463
LIG_SH3_3	212	218	PF00018	0.516
LIG_SH3_3	92	98	PF00018	0.285
LIG_SUMO_SIM_par_1	162	167	PF11976	0.368
LIG_SUMO_SIM_par_1	93	99	PF11976	0.309
LIG_TYR_ITIM	125	130	PF00017	0.333
MOD_CK1_1	126	132	PF00069	0.363
MOD_CK1_1	162	168	PF00069	0.438
MOD_CK1_1	243	249	PF00069	0.642
MOD_CK2_1	145	151	PF00069	0.307
MOD_CK2_1	243	249	PF00069	0.602
MOD_GlcNHglycan	245	248	PF01048	0.640
MOD_GlcNHglycan	62	65	PF01048	0.419
MOD_GlcNHglycan	7	10	PF01048	0.635
MOD_GSK3_1	1	8	PF00069	0.679
MOD_GSK3_1	117	124	PF00069	0.542
MOD_GSK3_1	129	136	PF00069	0.359
MOD_GSK3_1	255	262	PF00069	0.563
MOD_NEK2_1	1	6	PF00069	0.682
MOD_NEK2_1	192	197	PF00069	0.425
MOD_NEK2_1	230	235	PF00069	0.525
MOD_NEK2_1	240	245	PF00069	0.540
MOD_NEK2_1	254	259	PF00069	0.515
MOD_NEK2_1	31	36	PF00069	0.362
MOD_NEK2_1	70	75	PF00069	0.314
MOD_NEK2_1	82	87	PF00069	0.352
MOD_PIKK_1	230	236	PF00454	0.610
MOD_PKA_1	60	66	PF00069	0.368
MOD_PKA_2	192	198	PF00069	0.408
MOD_PKA_2	235	241	PF00069	0.551
MOD_PKA_2	243	249	PF00069	0.547
MOD_Plk_1	1	7	PF00069	0.484
MOD_Plk_1	176	182	PF00069	0.425
MOD_Plk_1	82	88	PF00069	0.419
MOD_Plk_4	123	129	PF00069	0.486
MOD_Plk_4	235	241	PF00069	0.586
MOD_ProDKin_1	200	206	PF00069	0.499
MOD_SUMO_rev_2	83	92	PF00179	0.401
TRG_ENDOCYTIC_2	127	130	PF00928	0.333
TRG_ENDOCYTIC_2	16	19	PF00928	0.393
TRG_ER_diArg_1	259	261	PF00400	0.701
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P360	Leptomonas seymouri	78%	100%
A0A1X0NFH5	Trypanosomatidae	54%	100%
A0A3Q8IJR1	Leishmania donovani	95%	100%
A0A422N6F8	Trypanosoma rangeli	55%	83%
A4HQ27	Leishmania braziliensis	86%	100%
A4IDT3	Leishmania infantum	95%	100%
D0A8U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9ATU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%