START domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0P9_LEIMA

TriTrypDb:

LmjF.36.5130 , LMJLV39_360063300 , LMJSD75_360063100

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0P9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0P9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.337
CLV_C14_Caspase3-7	196	200	PF00656	0.439
CLV_C14_Caspase3-7	272	276	PF00656	0.452
CLV_NRD_NRD_1	206	208	PF00675	0.502
CLV_PCSK_KEX2_1	152	154	PF00082	0.574
CLV_PCSK_KEX2_1	206	208	PF00082	0.523
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.570
CLV_PCSK_SKI1_1	157	161	PF00082	0.486
CLV_PCSK_SKI1_1	222	226	PF00082	0.518
DEG_APCC_DBOX_1	77	85	PF00400	0.499
DOC_MAPK_MEF2A_6	183	192	PF00069	0.465
DOC_PP4_FxxP_1	45	48	PF00568	0.396
DOC_USP7_MATH_1	102	106	PF00917	0.421
DOC_USP7_MATH_1	143	147	PF00917	0.377
DOC_USP7_MATH_1	151	155	PF00917	0.363
DOC_USP7_MATH_1	255	259	PF00917	0.559
DOC_USP7_MATH_1	73	77	PF00917	0.497
DOC_USP7_UBL2_3	107	111	PF12436	0.520
DOC_WW_Pin1_4	119	124	PF00397	0.550
DOC_WW_Pin1_4	214	219	PF00397	0.391
DOC_WW_Pin1_4	44	49	PF00397	0.543
LIG_BIR_II_1	1	5	PF00653	0.449
LIG_BRCT_BRCA1_1	36	40	PF00533	0.380
LIG_BRCT_BRCA1_1	70	74	PF00533	0.542
LIG_FHA_1	132	138	PF00498	0.403
LIG_FHA_1	231	237	PF00498	0.428
LIG_FHA_2	194	200	PF00498	0.518
LIG_FHA_2	270	276	PF00498	0.444
LIG_FHA_2	91	97	PF00498	0.537
LIG_LIR_Apic_2	56	60	PF02991	0.388
LIG_LIR_Gen_1	135	145	PF02991	0.279
LIG_LIR_Gen_1	158	167	PF02991	0.390
LIG_LIR_Gen_1	37	48	PF02991	0.428
LIG_LIR_Nem_3	135	141	PF02991	0.426
LIG_LIR_Nem_3	158	162	PF02991	0.419
LIG_LIR_Nem_3	37	43	PF02991	0.448
LIG_LIR_Nem_3	6	10	PF02991	0.385
LIG_LIR_Nem_3	75	80	PF02991	0.421
LIG_PTB_Apo_2	228	235	PF02174	0.295
LIG_PTB_Phospho_1	228	234	PF10480	0.300
LIG_SH2_CRK	166	170	PF00017	0.468
LIG_SH2_CRK	7	11	PF00017	0.379
LIG_SH2_NCK_1	57	61	PF00017	0.453
LIG_SH2_STAT5	17	20	PF00017	0.440
LIG_SH2_STAT5	234	237	PF00017	0.488
LIG_SH2_STAT5	80	83	PF00017	0.487
LIG_SH3_3	187	193	PF00018	0.319
LIG_WW_1	4	7	PF00397	0.487
MOD_CDK_SPK_2	44	49	PF00069	0.341
MOD_CK1_1	110	116	PF00069	0.488
MOD_CK1_1	118	124	PF00069	0.396
MOD_CK1_1	230	236	PF00069	0.518
MOD_CK1_1	61	67	PF00069	0.540
MOD_CK1_1	68	74	PF00069	0.523
MOD_CK2_1	73	79	PF00069	0.526
MOD_CK2_1	90	96	PF00069	0.477
MOD_GlcNHglycan	1	4	PF01048	0.552
MOD_GlcNHglycan	153	156	PF01048	0.410
MOD_GlcNHglycan	257	260	PF01048	0.524
MOD_GlcNHglycan	70	73	PF01048	0.445
MOD_GSK3_1	102	109	PF00069	0.427
MOD_GSK3_1	115	122	PF00069	0.455
MOD_GSK3_1	230	237	PF00069	0.446
MOD_GSK3_1	58	65	PF00069	0.425
MOD_GSK3_1	68	75	PF00069	0.412
MOD_N-GLC_1	115	120	PF02516	0.519
MOD_N-GLC_1	131	136	PF02516	0.374
MOD_N-GLC_1	227	232	PF02516	0.506
MOD_N-GLC_1	90	95	PF02516	0.415
MOD_NEK2_1	115	120	PF00069	0.502
MOD_NEK2_1	224	229	PF00069	0.385
MOD_NEK2_1	248	253	PF00069	0.450
MOD_NEK2_1	269	274	PF00069	0.493
MOD_NEK2_2	102	107	PF00069	0.507
MOD_NEK2_2	178	183	PF00069	0.498
MOD_NEK2_2	62	67	PF00069	0.512
MOD_Plk_1	157	163	PF00069	0.372
MOD_Plk_4	110	116	PF00069	0.449
MOD_Plk_4	193	199	PF00069	0.515
MOD_Plk_4	80	86	PF00069	0.442
MOD_ProDKin_1	119	125	PF00069	0.556
MOD_ProDKin_1	214	220	PF00069	0.396
MOD_ProDKin_1	44	50	PF00069	0.538
MOD_SUMO_rev_2	146	154	PF00179	0.516
TRG_DiLeu_BaEn_2	204	210	PF01217	0.444
TRG_ENDOCYTIC_2	7	10	PF00928	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P495	Leptomonas seymouri	61%	100%
A0A0S4JKK5	Bodo saltans	26%	98%
A0A1X0P327	Trypanosomatidae	33%	96%
A0A3Q8IPM4	Leishmania donovani	91%	100%
A0A422NMF9	Trypanosoma rangeli	33%	100%
A4HQ29	Leishmania braziliensis	74%	100%
A4IDT5	Leishmania infantum	90%	100%
D0A8T8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ATU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BWK1	Trypanosoma cruzi	34%	100%