VHS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

VHS domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q0P8_LEIMA

TriTrypDb:

LmjF.36.5140 , LMJLV39_360063400 , LMJSD75_360063300

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0P8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0P8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	8
GO:0006886	intracellular protein transport	4	8
GO:0007034	vacuolar transport	4	8
GO:0008104	protein localization	4	8
GO:0009987	cellular process	1	8
GO:0015031	protein transport	4	8
GO:0016192	vesicle-mediated transport	4	8
GO:0016197	endosomal transport	4	8
GO:0032509	endosome transport via multivesicular body sorting pathway	5	8
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	8
GO:0033036	macromolecule localization	2	8
GO:0033365	protein localization to organelle	5	8
GO:0043328	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	5	8
GO:0045184	establishment of protein localization	3	8
GO:0045324	late endosome to vacuole transport	5	8
GO:0046907	intracellular transport	3	8
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0051641	cellular localization	2	8
GO:0051649	establishment of localization in cell	3	8
GO:0070727	cellular macromolecule localization	3	8
GO:0071702	organic substance transport	4	8
GO:0071705	nitrogen compound transport	4	8
GO:0071985	multivesicular body sorting pathway	5	8
GO:0072594	establishment of protein localization to organelle	4	8
GO:0072665	protein localization to vacuole	6	8
GO:0072666	establishment of protein localization to vacuole	5	8

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0005543	phospholipid binding	3	8
GO:0008289	lipid binding	2	8
GO:0032182	ubiquitin-like protein binding	3	8
GO:0035091	phosphatidylinositol binding	4	8
GO:0043130	ubiquitin binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.390
CLV_NRD_NRD_1	209	211	PF00675	0.664
CLV_NRD_NRD_1	213	215	PF00675	0.670
CLV_NRD_NRD_1	65	67	PF00675	0.292
CLV_PCSK_FUR_1	210	214	PF00082	0.579
CLV_PCSK_KEX2_1	209	211	PF00082	0.700
CLV_PCSK_KEX2_1	212	214	PF00082	0.704
CLV_PCSK_KEX2_1	64	66	PF00082	0.292
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.591
CLV_PCSK_PC7_1	209	215	PF00082	0.496
CLV_PCSK_PC7_1	61	67	PF00082	0.292
CLV_PCSK_SKI1_1	101	105	PF00082	0.340
CLV_PCSK_SKI1_1	286	290	PF00082	0.467
CLV_PCSK_SKI1_1	75	79	PF00082	0.294
DEG_APCC_DBOX_1	285	293	PF00400	0.460
DEG_SPOP_SBC_1	448	452	PF00917	0.593
DOC_CKS1_1	378	383	PF01111	0.619
DOC_CYCLIN_RxL_1	98	106	PF00134	0.455
DOC_MAPK_gen_1	172	180	PF00069	0.500
DOC_MAPK_gen_1	212	221	PF00069	0.516
DOC_MAPK_gen_1	51	59	PF00069	0.357
DOC_MAPK_MEF2A_6	124	132	PF00069	0.351
DOC_MAPK_MEF2A_6	16	25	PF00069	0.308
DOC_MAPK_MEF2A_6	172	180	PF00069	0.498
DOC_MAPK_MEF2A_6	214	223	PF00069	0.576
DOC_MAPK_MEF2A_6	268	276	PF00069	0.486
DOC_PP2B_LxvP_1	34	37	PF13499	0.353
DOC_USP7_MATH_1	123	127	PF00917	0.472
DOC_USP7_MATH_1	316	320	PF00917	0.632
DOC_USP7_MATH_1	402	406	PF00917	0.685
DOC_USP7_MATH_1	448	452	PF00917	0.668
DOC_USP7_MATH_1	462	466	PF00917	0.658
DOC_USP7_MATH_1	481	485	PF00917	0.614
DOC_WW_Pin1_4	354	359	PF00397	0.612
DOC_WW_Pin1_4	371	376	PF00397	0.688
DOC_WW_Pin1_4	377	382	PF00397	0.488
DOC_WW_Pin1_4	408	413	PF00397	0.639
DOC_WW_Pin1_4	421	426	PF00397	0.636
DOC_WW_Pin1_4	492	497	PF00397	0.565
LIG_14-3-3_CanoR_1	290	299	PF00244	0.543
LIG_14-3-3_CanoR_1	309	316	PF00244	0.502
LIG_Actin_WH2_2	275	292	PF00022	0.431
LIG_BH_BH3_1	141	157	PF00452	0.421
LIG_BIR_III_2	195	199	PF00653	0.537
LIG_BIR_III_2	313	317	PF00653	0.612
LIG_BRCT_BRCA1_1	134	138	PF00533	0.333
LIG_BRCT_BRCA1_1	89	93	PF00533	0.357
LIG_EH_1	19	23	PF12763	0.297
LIG_FHA_1	129	135	PF00498	0.388
LIG_FHA_1	273	279	PF00498	0.443
LIG_FHA_1	378	384	PF00498	0.808
LIG_FHA_1	444	450	PF00498	0.550
LIG_FHA_1	54	60	PF00498	0.458
LIG_FHA_1	76	82	PF00498	0.292
LIG_FHA_2	149	155	PF00498	0.355
LIG_FHA_2	236	242	PF00498	0.395
LIG_FHA_2	289	295	PF00498	0.397
LIG_FHA_2	508	514	PF00498	0.496
LIG_GBD_Chelix_1	215	223	PF00786	0.648
LIG_HCF-1_HBM_1	270	273	PF13415	0.422
LIG_LIR_Gen_1	270	278	PF02991	0.454
LIG_LIR_Gen_1	38	45	PF02991	0.311
LIG_LIR_Gen_1	506	512	PF02991	0.566
LIG_LIR_Nem_3	238	242	PF02991	0.453
LIG_LIR_Nem_3	270	276	PF02991	0.460
LIG_LIR_Nem_3	38	42	PF02991	0.352
LIG_LIR_Nem_3	506	511	PF02991	0.566
LIG_LIR_Nem_3	90	95	PF02991	0.291
LIG_SH2_CRK	200	204	PF00017	0.538
LIG_SH2_GRB2like	242	245	PF00017	0.398
LIG_SH2_PTP2	273	276	PF00017	0.446
LIG_SH2_SRC	39	42	PF00017	0.282
LIG_SH2_STAT3	263	266	PF00017	0.444
LIG_SH2_STAT5	147	150	PF00017	0.371
LIG_SH2_STAT5	242	245	PF00017	0.411
LIG_SH2_STAT5	263	266	PF00017	0.530
LIG_SH2_STAT5	273	276	PF00017	0.417
LIG_SH3_3	177	183	PF00018	0.554
LIG_SH3_3	353	359	PF00018	0.672
LIG_SH3_3	424	430	PF00018	0.614
LIG_SH3_3	470	476	PF00018	0.621
LIG_SH3_3	491	497	PF00018	0.679
LIG_SUMO_SIM_anti_2	53	61	PF11976	0.347
LIG_SUMO_SIM_par_1	274	280	PF11976	0.389
LIG_TRAF2_1	142	145	PF00917	0.448
LIG_TRAF2_1	346	349	PF00917	0.676
LIG_TRAF2_1	429	432	PF00917	0.601
LIG_TRAF2_2	190	195	PF00917	0.629
LIG_UBA3_1	81	87	PF00899	0.351
LIG_WRC_WIRS_1	508	513	PF05994	0.494
LIG_WW_3	357	361	PF00397	0.681
MOD_CDC14_SPxK_1	357	360	PF00782	0.534
MOD_CDK_SPxK_1	354	360	PF00069	0.637
MOD_CK1_1	262	268	PF00069	0.444
MOD_CK1_1	482	488	PF00069	0.650
MOD_CK1_1	53	59	PF00069	0.289
MOD_CK1_1	88	94	PF00069	0.335
MOD_CK2_1	2	8	PF00069	0.453
MOD_CK2_1	426	432	PF00069	0.614
MOD_CK2_1	507	513	PF00069	0.676
MOD_GlcNHglycan	125	128	PF01048	0.368
MOD_GlcNHglycan	229	232	PF01048	0.432
MOD_GlcNHglycan	296	299	PF01048	0.451
MOD_GlcNHglycan	319	322	PF01048	0.681
MOD_GlcNHglycan	332	335	PF01048	0.654
MOD_GlcNHglycan	338	342	PF01048	0.695
MOD_GlcNHglycan	343	347	PF01048	0.659
MOD_GlcNHglycan	397	400	PF01048	0.605
MOD_GlcNHglycan	418	421	PF01048	0.662
MOD_GlcNHglycan	485	488	PF01048	0.724
MOD_GSK3_1	128	135	PF00069	0.332
MOD_GSK3_1	223	230	PF00069	0.462
MOD_GSK3_1	272	279	PF00069	0.446
MOD_GSK3_1	288	295	PF00069	0.442
MOD_GSK3_1	330	337	PF00069	0.779
MOD_GSK3_1	402	409	PF00069	0.608
MOD_GSK3_1	416	423	PF00069	0.759
MOD_GSK3_1	426	433	PF00069	0.786
MOD_GSK3_1	443	450	PF00069	0.612
MOD_GSK3_1	479	486	PF00069	0.670
MOD_GSK3_1	81	88	PF00069	0.377
MOD_N-GLC_1	132	137	PF02516	0.338
MOD_N-GLC_2	251	253	PF02516	0.455
MOD_NEK2_1	128	133	PF00069	0.331
MOD_NEK2_1	232	237	PF00069	0.465
MOD_NEK2_1	277	282	PF00069	0.483
MOD_NEK2_1	288	293	PF00069	0.496
MOD_NEK2_1	330	335	PF00069	0.657
MOD_NEK2_1	347	352	PF00069	0.623
MOD_NEK2_1	370	375	PF00069	0.616
MOD_NEK2_1	444	449	PF00069	0.662
MOD_NEK2_1	81	86	PF00069	0.371
MOD_PIKK_1	262	268	PF00454	0.438
MOD_PIKK_1	292	298	PF00454	0.435
MOD_PIKK_1	96	102	PF00454	0.314
MOD_PKA_2	171	177	PF00069	0.656
MOD_PKA_2	227	233	PF00069	0.483
MOD_Plk_1	132	138	PF00069	0.335
MOD_Plk_1	303	309	PF00069	0.469
MOD_Plk_1	342	348	PF00069	0.615
MOD_Plk_1	53	59	PF00069	0.335
MOD_Plk_2-3	507	513	PF00069	0.495
MOD_Plk_4	132	138	PF00069	0.348
MOD_Plk_4	2	8	PF00069	0.394
MOD_Plk_4	259	265	PF00069	0.538
MOD_Plk_4	272	278	PF00069	0.354
MOD_Plk_4	507	513	PF00069	0.495
MOD_Plk_4	81	87	PF00069	0.305
MOD_Plk_4	88	94	PF00069	0.314
MOD_ProDKin_1	354	360	PF00069	0.614
MOD_ProDKin_1	371	377	PF00069	0.685
MOD_ProDKin_1	408	414	PF00069	0.639
MOD_ProDKin_1	421	427	PF00069	0.639
MOD_ProDKin_1	492	498	PF00069	0.567
MOD_SUMO_for_1	176	179	PF00179	0.514
MOD_SUMO_for_1	301	304	PF00179	0.486
TRG_DiLeu_BaEn_1	125	130	PF01217	0.400
TRG_DiLeu_BaEn_2	39	45	PF01217	0.351
TRG_DiLeu_BaEn_4	144	150	PF01217	0.437
TRG_ENDOCYTIC_2	273	276	PF00928	0.460
TRG_ENDOCYTIC_2	39	42	PF00928	0.430
TRG_ER_diArg_1	213	215	PF00400	0.658
TRG_ER_diArg_1	63	66	PF00400	0.292
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.272

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB53	Leptomonas seymouri	53%	96%
A0A3Q8IJX3	Leishmania donovani	87%	100%
A4HQ30	Leishmania braziliensis	62%	100%
A4IDT6	Leishmania infantum	87%	100%
E9ATU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
V5BM99	Trypanosoma cruzi	36%	100%