Kinesin motor domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin-D

Species:

Leishmania major

UniProt:

Q4Q0P7_LEIMA

TriTrypDb:

LmjF.36.5150 , LMJLV39_360063500 , LMJSD75_360063400

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	yes	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	2
GO:0005875	microtubule associated complex	2	2
GO:0015630	microtubule cytoskeleton	6	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0P7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0P7

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0000902	cell morphogenesis	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	13
GO:0007018	microtubule-based movement	3	13
GO:0009653	anatomical structure morphogenesis	2	2
GO:0009987	cellular process	1	13
GO:0016043	cellular component organization	3	2
GO:0030865	cortical cytoskeleton organization	6	2
GO:0031122	cytoplasmic microtubule organization	4	2
GO:0032502	developmental process	1	2
GO:0043622	cortical microtubule organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0097435	supramolecular fiber organization	4	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003774	cytoskeletal motor activity	1	13
GO:0003777	microtubule motor activity	2	13
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	13
GO:0005515	protein binding	2	13
GO:0005524	ATP binding	5	13
GO:0008017	microtubule binding	5	13
GO:0008092	cytoskeletal protein binding	3	13
GO:0015631	tubulin binding	4	13
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017076	purine nucleotide binding	4	13
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140657	ATP-dependent activity	1	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.433
CLV_NRD_NRD_1	265	267	PF00675	0.466
CLV_NRD_NRD_1	367	369	PF00675	0.618
CLV_NRD_NRD_1	380	382	PF00675	0.597
CLV_NRD_NRD_1	439	441	PF00675	0.683
CLV_NRD_NRD_1	528	530	PF00675	0.791
CLV_NRD_NRD_1	58	60	PF00675	0.553
CLV_NRD_NRD_1	607	609	PF00675	0.620
CLV_PCSK_KEX2_1	234	236	PF00082	0.554
CLV_PCSK_KEX2_1	265	267	PF00082	0.466
CLV_PCSK_KEX2_1	367	369	PF00082	0.650
CLV_PCSK_KEX2_1	450	452	PF00082	0.628
CLV_PCSK_KEX2_1	469	471	PF00082	0.598
CLV_PCSK_KEX2_1	528	530	PF00082	0.759
CLV_PCSK_KEX2_1	539	541	PF00082	0.748
CLV_PCSK_KEX2_1	58	60	PF00082	0.641
CLV_PCSK_KEX2_1	607	609	PF00082	0.656
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.569
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.674
CLV_PCSK_PC1ET2_1	469	471	PF00082	0.567
CLV_PCSK_PC1ET2_1	539	541	PF00082	0.800
CLV_PCSK_PC7_1	230	236	PF00082	0.531
CLV_PCSK_SKI1_1	138	142	PF00082	0.420
CLV_PCSK_SKI1_1	17	21	PF00082	0.551
CLV_PCSK_SKI1_1	349	353	PF00082	0.556
CLV_PCSK_SKI1_1	35	39	PF00082	0.421
CLV_PCSK_SKI1_1	423	427	PF00082	0.624
CLV_PCSK_SKI1_1	528	532	PF00082	0.755
CLV_PCSK_SKI1_1	87	91	PF00082	0.466
DOC_CKS1_1	18	23	PF01111	0.622
DOC_CKS1_1	199	204	PF01111	0.517
DOC_MAPK_gen_1	263	272	PF00069	0.483
DOC_MAPK_gen_1	381	389	PF00069	0.681
DOC_MAPK_MEF2A_6	263	271	PF00069	0.498
DOC_MAPK_RevD_3	219	235	PF00069	0.479
DOC_PP4_FxxP_1	251	254	PF00568	0.568
DOC_PP4_FxxP_1	72	75	PF00568	0.677
DOC_PP4_FxxP_1	98	101	PF00568	0.316
DOC_USP7_MATH_1	117	121	PF00917	0.466
DOC_USP7_MATH_1	214	218	PF00917	0.453
DOC_USP7_MATH_1	28	32	PF00917	0.700
DOC_USP7_MATH_1	579	583	PF00917	0.771
DOC_USP7_UBL2_3	81	85	PF12436	0.834
DOC_WW_Pin1_4	17	22	PF00397	0.547
DOC_WW_Pin1_4	198	203	PF00397	0.502
DOC_WW_Pin1_4	215	220	PF00397	0.462
DOC_WW_Pin1_4	326	331	PF00397	0.444
DOC_WW_Pin1_4	520	525	PF00397	0.723
LIG_14-3-3_CanoR_1	124	129	PF00244	0.411
LIG_14-3-3_CanoR_1	235	243	PF00244	0.533
LIG_14-3-3_CanoR_1	244	251	PF00244	0.561
LIG_14-3-3_CanoR_1	381	389	PF00244	0.653
LIG_14-3-3_CanoR_1	552	558	PF00244	0.828
LIG_14-3-3_CanoR_1	87	95	PF00244	0.512
LIG_APCC_ABBA_1	328	333	PF00400	0.485
LIG_BRCT_BRCA1_1	241	245	PF00533	0.557
LIG_CaM_IQ_9	222	237	PF13499	0.573
LIG_CaM_IQ_9	339	354	PF13499	0.623
LIG_deltaCOP1_diTrp_1	67	72	PF00928	0.624
LIG_FHA_1	216	222	PF00498	0.526
LIG_FHA_1	236	242	PF00498	0.401
LIG_FHA_1	511	517	PF00498	0.819
LIG_FHA_2	173	179	PF00498	0.448
LIG_FHA_2	18	24	PF00498	0.543
LIG_FHA_2	189	195	PF00498	0.469
LIG_FHA_2	409	415	PF00498	0.646
LIG_FHA_2	552	558	PF00498	0.733
LIG_FHA_2	600	606	PF00498	0.634
LIG_FHA_2	88	94	PF00498	0.432
LIG_KLC1_Yacidic_2	174	178	PF13176	0.469
LIG_LIR_Apic_2	248	254	PF02991	0.547
LIG_LIR_Apic_2	71	75	PF02991	0.664
LIG_LIR_Gen_1	12	21	PF02991	0.550
LIG_LIR_Gen_1	174	181	PF02991	0.405
LIG_LIR_Gen_1	305	316	PF02991	0.483
LIG_LIR_Gen_1	329	339	PF02991	0.564
LIG_LIR_Gen_1	360	370	PF02991	0.696
LIG_LIR_Gen_1	456	464	PF02991	0.655
LIG_LIR_Gen_1	93	103	PF02991	0.426
LIG_LIR_Nem_3	12	16	PF02991	0.534
LIG_LIR_Nem_3	174	179	PF02991	0.405
LIG_LIR_Nem_3	305	311	PF02991	0.483
LIG_LIR_Nem_3	93	98	PF02991	0.436
LIG_NRBOX	269	275	PF00104	0.465
LIG_Pex14_2	245	249	PF04695	0.516
LIG_Pex14_2	308	312	PF04695	0.544
LIG_SH2_NCK_1	110	114	PF00017	0.429
LIG_SH2_NCK_1	572	576	PF00017	0.672
LIG_SH2_PTP2	176	179	PF00017	0.448
LIG_SH2_SRC	572	575	PF00017	0.653
LIG_SH2_STAP1	499	503	PF00017	0.757
LIG_SH2_STAP1	572	576	PF00017	0.693
LIG_SH2_STAP1	595	599	PF00017	0.719
LIG_SH2_STAT5	126	129	PF00017	0.478
LIG_SH2_STAT5	176	179	PF00017	0.442
LIG_SH2_STAT5	54	57	PF00017	0.597
LIG_SH3_1	15	21	PF00018	0.599
LIG_SH3_3	15	21	PF00018	0.599
LIG_SH3_3	199	205	PF00018	0.471
LIG_SH3_3	45	51	PF00018	0.590
LIG_SH3_3	518	524	PF00018	0.752
LIG_SH3_3	98	104	PF00018	0.432
LIG_SUMO_SIM_anti_2	174	182	PF11976	0.438
LIG_SUMO_SIM_anti_2	385	391	PF11976	0.689
LIG_SUMO_SIM_anti_2	398	403	PF11976	0.429
LIG_SUMO_SIM_par_1	44	50	PF11976	0.495
LIG_TRAF2_1	71	74	PF00917	0.641
LIG_TRAF2_1	75	78	PF00917	0.734
LIG_WRC_WIRS_1	149	154	PF05994	0.472
LIG_WRC_WIRS_1	69	74	PF05994	0.519
MOD_CK1_1	151	157	PF00069	0.517
MOD_CK1_1	160	166	PF00069	0.447
MOD_CK1_1	172	178	PF00069	0.462
MOD_CK1_1	188	194	PF00069	0.471
MOD_CK1_1	200	206	PF00069	0.504
MOD_CK1_1	237	243	PF00069	0.516
MOD_CK1_1	306	312	PF00069	0.528
MOD_CK1_1	326	332	PF00069	0.492
MOD_CK1_1	4	10	PF00069	0.688
MOD_CK2_1	128	134	PF00069	0.529
MOD_CK2_1	17	23	PF00069	0.524
MOD_CK2_1	214	220	PF00069	0.499
MOD_CK2_1	359	365	PF00069	0.649
MOD_CK2_1	408	414	PF00069	0.625
MOD_CK2_1	520	526	PF00069	0.691
MOD_CK2_1	551	557	PF00069	0.730
MOD_CK2_1	599	605	PF00069	0.705
MOD_CK2_1	68	74	PF00069	0.587
MOD_DYRK1A_RPxSP_1	17	21	PF00069	0.614
MOD_GlcNHglycan	121	124	PF01048	0.431
MOD_GlcNHglycan	170	174	PF01048	0.550
MOD_GlcNHglycan	191	194	PF01048	0.559
MOD_GlcNHglycan	202	205	PF01048	0.518
MOD_GlcNHglycan	278	281	PF01048	0.578
MOD_GlcNHglycan	29	33	PF01048	0.704
MOD_GlcNHglycan	292	295	PF01048	0.413
MOD_GlcNHglycan	305	308	PF01048	0.487
MOD_GlcNHglycan	532	535	PF01048	0.834
MOD_GSK3_1	1	8	PF00069	0.760
MOD_GSK3_1	124	131	PF00069	0.443
MOD_GSK3_1	147	154	PF00069	0.469
MOD_GSK3_1	185	192	PF00069	0.495
MOD_GSK3_1	235	242	PF00069	0.512
MOD_GSK3_1	257	264	PF00069	0.640
MOD_GSK3_1	338	345	PF00069	0.588
MOD_GSK3_1	76	83	PF00069	0.775
MOD_N-GLC_1	158	163	PF02516	0.444
MOD_N-GLC_1	235	240	PF02516	0.614
MOD_N-GLC_1	257	262	PF02516	0.687
MOD_N-GLC_1	408	413	PF02516	0.650
MOD_NEK2_1	1	6	PF00069	0.754
MOD_NEK2_1	179	184	PF00069	0.529
MOD_NEK2_1	342	347	PF00069	0.582
MOD_NEK2_1	530	535	PF00069	0.827
MOD_NEK2_2	76	81	PF00069	0.685
MOD_PIKK_1	558	564	PF00454	0.577
MOD_PIKK_1	599	605	PF00454	0.713
MOD_PIKK_1	615	621	PF00454	0.691
MOD_PIKK_1	87	93	PF00454	0.446
MOD_PKA_1	234	240	PF00069	0.531
MOD_PKA_1	615	621	PF00069	0.720
MOD_PKA_2	234	240	PF00069	0.539
MOD_PKA_2	243	249	PF00069	0.529
MOD_PKA_2	303	309	PF00069	0.470
MOD_PKA_2	380	386	PF00069	0.665
MOD_PKA_2	551	557	PF00069	0.823
MOD_Plk_1	158	164	PF00069	0.423
MOD_Plk_1	257	263	PF00069	0.677
MOD_Plk_1	28	34	PF00069	0.685
MOD_Plk_1	359	365	PF00069	0.666
MOD_Plk_1	408	414	PF00069	0.641
MOD_Plk_1	76	82	PF00069	0.773
MOD_Plk_4	124	130	PF00069	0.405
MOD_Plk_4	172	178	PF00069	0.422
MOD_Plk_4	311	317	PF00069	0.547
MOD_Plk_4	359	365	PF00069	0.666
MOD_Plk_4	385	391	PF00069	0.623
MOD_ProDKin_1	17	23	PF00069	0.543
MOD_ProDKin_1	198	204	PF00069	0.502
MOD_ProDKin_1	215	221	PF00069	0.462
MOD_ProDKin_1	326	332	PF00069	0.453
MOD_ProDKin_1	520	526	PF00069	0.722
MOD_SUMO_for_1	402	405	PF00179	0.605
MOD_SUMO_for_1	511	514	PF00179	0.637
MOD_SUMO_for_1	593	596	PF00179	0.655
MOD_SUMO_rev_2	371	376	PF00179	0.576
MOD_SUMO_rev_2	379	383	PF00179	0.566
MOD_SUMO_rev_2	474	480	PF00179	0.657
MOD_SUMO_rev_2	508	513	PF00179	0.763
MOD_SUMO_rev_2	533	541	PF00179	0.830
MOD_SUMO_rev_2	611	618	PF00179	0.662
TRG_DiLeu_BaEn_1	526	531	PF01217	0.736
TRG_DiLeu_LyEn_5	526	531	PF01217	0.736
TRG_ENDOCYTIC_2	176	179	PF00928	0.411
TRG_ENDOCYTIC_2	332	335	PF00928	0.622
TRG_ENDOCYTIC_2	54	57	PF00928	0.597
TRG_ENDOCYTIC_2	95	98	PF00928	0.411
TRG_ER_diArg_1	14	17	PF00400	0.458
TRG_ER_diArg_1	265	267	PF00400	0.466
TRG_ER_diArg_1	366	368	PF00400	0.651
TRG_ER_diArg_1	528	530	PF00400	0.736
TRG_ER_diArg_1	57	59	PF00400	0.648
TRG_ER_diArg_1	606	608	PF00400	0.662
TRG_NLS_MonoExtC_3	83	88	PF00514	0.550
TRG_NLS_MonoExtN_4	347	353	PF00514	0.629
TRG_NLS_MonoExtN_4	81	88	PF00514	0.565
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	607	611	PF00026	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K9	Leptomonas seymouri	69%	100%
A0A0S4J0Q2	Bodo saltans	21%	75%
A0A0S4JFN9	Bodo saltans	25%	73%
A0A0S4JPE8	Bodo saltans	34%	69%
A0A1X0NP27	Trypanosomatidae	21%	84%
A0A1X0NPH9	Trypanosomatidae	21%	68%
A0A1X0P435	Trypanosomatidae	43%	100%
A0A3R7KHX7	Trypanosoma rangeli	22%	85%
A0A3S7WU64	Leishmania donovani	22%	72%
A0A3S7XBW9	Leishmania donovani	94%	100%
A0A422NMD1	Trypanosoma rangeli	45%	100%
A4HQ31	Leishmania braziliensis	74%	100%
A4HX45	Leishmania infantum	22%	79%
A4IDT7	Leishmania infantum	94%	100%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	83%
D0A8T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ATU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P46873	Caenorhabditis elegans	22%	89%
Q1MTQ1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q4QEL8	Leishmania major	22%	77%
V5B325	Trypanosoma cruzi	22%	75%
V5B6Q5	Trypanosoma cruzi	45%	100%
V5D733	Trypanosoma cruzi	23%	83%