Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0P2_LEIMA

TriTrypDb:

LmjF.36.5200 , LMJLV39_360064000 , LMJSD75_360063900

Length:

1021

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0P2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	933	937	PF00656	0.578
CLV_NRD_NRD_1	405	407	PF00675	0.565
CLV_NRD_NRD_1	516	518	PF00675	0.681
CLV_NRD_NRD_1	786	788	PF00675	0.623
CLV_NRD_NRD_1	989	991	PF00675	0.588
CLV_PCSK_KEX2_1	121	123	PF00082	0.469
CLV_PCSK_KEX2_1	219	221	PF00082	0.560
CLV_PCSK_KEX2_1	240	242	PF00082	0.542
CLV_PCSK_KEX2_1	343	345	PF00082	0.610
CLV_PCSK_KEX2_1	405	407	PF00082	0.565
CLV_PCSK_KEX2_1	515	517	PF00082	0.647
CLV_PCSK_KEX2_1	544	546	PF00082	0.511
CLV_PCSK_KEX2_1	786	788	PF00082	0.623
CLV_PCSK_KEX2_1	988	990	PF00082	0.604
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.469
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.560
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.542
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.702
CLV_PCSK_PC1ET2_1	544	546	PF00082	0.511
CLV_PCSK_PC7_1	117	123	PF00082	0.568
CLV_PCSK_PC7_1	236	242	PF00082	0.416
CLV_PCSK_SKI1_1	117	121	PF00082	0.491
CLV_PCSK_SKI1_1	153	157	PF00082	0.468
CLV_PCSK_SKI1_1	989	993	PF00082	0.498
CLV_Separin_Metazoa	792	796	PF03568	0.504
DEG_APCC_DBOX_1	745	753	PF00400	0.511
DEG_Nend_UBRbox_4	1	3	PF02207	0.563
DEG_SCF_FBW7_1	138	143	PF00400	0.707
DEG_SPOP_SBC_1	731	735	PF00917	0.629
DOC_CDC14_PxL_1	490	498	PF14671	0.454
DOC_CDC14_PxL_1	653	661	PF14671	0.595
DOC_CKS1_1	137	142	PF01111	0.712
DOC_CKS1_1	675	680	PF01111	0.537
DOC_CYCLIN_yCln2_LP_2	639	645	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	835	841	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	864	870	PF00134	0.505
DOC_MAPK_gen_1	405	412	PF00069	0.519
DOC_MAPK_gen_1	68	76	PF00069	0.617
DOC_MAPK_gen_1	799	807	PF00069	0.591
DOC_MAPK_gen_1	988	996	PF00069	0.498
DOC_MAPK_MEF2A_6	405	412	PF00069	0.519
DOC_MAPK_MEF2A_6	673	682	PF00069	0.714
DOC_MAPK_MEF2A_6	68	76	PF00069	0.551
DOC_MAPK_MEF2A_6	801	809	PF00069	0.563
DOC_MAPK_MEF2A_6	988	996	PF00069	0.392
DOC_MAPK_NFAT4_5	989	997	PF00069	0.392
DOC_PP1_RVXF_1	225	232	PF00149	0.568
DOC_PP1_RVXF_1	793	799	PF00149	0.582
DOC_PP2B_LxvP_1	255	258	PF13499	0.542
DOC_PP2B_LxvP_1	639	642	PF13499	0.503
DOC_PP4_MxPP_1	584	587	PF00568	0.584
DOC_SPAK_OSR1_1	445	449	PF12202	0.547
DOC_USP7_MATH_1	132	136	PF00917	0.686
DOC_USP7_MATH_1	140	144	PF00917	0.715
DOC_USP7_MATH_1	264	268	PF00917	0.732
DOC_USP7_MATH_1	368	372	PF00917	0.641
DOC_USP7_MATH_1	37	41	PF00917	0.570
DOC_USP7_MATH_1	387	391	PF00917	0.692
DOC_USP7_MATH_1	51	55	PF00917	0.423
DOC_USP7_MATH_1	569	573	PF00917	0.737
DOC_USP7_MATH_1	7	11	PF00917	0.537
DOC_USP7_MATH_1	731	735	PF00917	0.639
DOC_USP7_MATH_1	907	911	PF00917	0.599
DOC_USP7_MATH_1	947	951	PF00917	0.764
DOC_WW_Pin1_4	136	141	PF00397	0.652
DOC_WW_Pin1_4	24	29	PF00397	0.568
DOC_WW_Pin1_4	30	35	PF00397	0.521
DOC_WW_Pin1_4	439	444	PF00397	0.547
DOC_WW_Pin1_4	474	479	PF00397	0.745
DOC_WW_Pin1_4	496	501	PF00397	0.594
DOC_WW_Pin1_4	608	613	PF00397	0.670
DOC_WW_Pin1_4	674	679	PF00397	0.718
DOC_WW_Pin1_4	699	704	PF00397	0.486
DOC_WW_Pin1_4	863	868	PF00397	0.516
LIG_14-3-3_CanoR_1	103	108	PF00244	0.580
LIG_14-3-3_CanoR_1	176	182	PF00244	0.514
LIG_14-3-3_CanoR_1	210	218	PF00244	0.518
LIG_14-3-3_CanoR_1	220	226	PF00244	0.516
LIG_14-3-3_CanoR_1	236	240	PF00244	0.485
LIG_14-3-3_CanoR_1	370	375	PF00244	0.662
LIG_14-3-3_CanoR_1	425	435	PF00244	0.547
LIG_14-3-3_CanoR_1	50	60	PF00244	0.586
LIG_14-3-3_CanoR_1	509	515	PF00244	0.544
LIG_14-3-3_CanoR_1	545	555	PF00244	0.456
LIG_14-3-3_CanoR_1	571	580	PF00244	0.721
LIG_14-3-3_CanoR_1	62	69	PF00244	0.404
LIG_14-3-3_CanoR_1	881	885	PF00244	0.444
LIG_Actin_WH2_2	225	242	PF00022	0.526
LIG_Actin_WH2_2	411	429	PF00022	0.521
LIG_Actin_WH2_2	54	70	PF00022	0.585
LIG_Actin_WH2_2	924	942	PF00022	0.524
LIG_APCC_ABBA_1	994	999	PF00400	0.511
LIG_BRCT_BRCA1_1	227	231	PF00533	0.484
LIG_BRCT_BRCA1_1	370	374	PF00533	0.678
LIG_BRCT_BRCA1_1	528	532	PF00533	0.573
LIG_BRCT_BRCA1_1	701	705	PF00533	0.621
LIG_CSL_BTD_1	835	838	PF09270	0.559
LIG_DLG_GKlike_1	370	377	PF00625	0.710
LIG_EH1_1	445	453	PF00400	0.458
LIG_EH1_1	693	701	PF00400	0.643
LIG_eIF4E_1	555	561	PF01652	0.477
LIG_EVH1_2	757	761	PF00568	0.620
LIG_FHA_1	139	145	PF00498	0.642
LIG_FHA_1	169	175	PF00498	0.572
LIG_FHA_1	204	210	PF00498	0.557
LIG_FHA_1	213	219	PF00498	0.497
LIG_FHA_1	318	324	PF00498	0.513
LIG_FHA_1	575	581	PF00498	0.814
LIG_FHA_1	650	656	PF00498	0.716
LIG_FHA_1	675	681	PF00498	0.707
LIG_FHA_1	87	93	PF00498	0.451
LIG_FHA_1	889	895	PF00498	0.519
LIG_FHA_1	896	902	PF00498	0.504
LIG_FHA_1	904	910	PF00498	0.415
LIG_FHA_2	178	184	PF00498	0.519
LIG_FHA_2	757	763	PF00498	0.671
LIG_FHA_2	881	887	PF00498	0.566
LIG_FHA_2	940	946	PF00498	0.607
LIG_GBD_Chelix_1	246	254	PF00786	0.443
LIG_GBD_Chelix_1	600	608	PF00786	0.592
LIG_LIR_Apic_2	135	140	PF02991	0.580
LIG_LIR_Gen_1	10	20	PF02991	0.507
LIG_LIR_Gen_1	371	380	PF02991	0.703
LIG_LIR_Gen_1	883	892	PF02991	0.536
LIG_LIR_Nem_3	10	16	PF02991	0.513
LIG_LIR_Nem_3	281	286	PF02991	0.604
LIG_LIR_Nem_3	371	377	PF02991	0.685
LIG_LIR_Nem_3	402	407	PF02991	0.441
LIG_LIR_Nem_3	477	482	PF02991	0.636
LIG_LIR_Nem_3	883	888	PF02991	0.523
LIG_MAD2	673	681	PF02301	0.524
LIG_NRBOX	177	183	PF00104	0.483
LIG_NRBOX	249	255	PF00104	0.435
LIG_NRBOX	627	633	PF00104	0.604
LIG_PCNA_PIPBox_1	663	672	PF02747	0.612
LIG_PCNA_yPIPBox_3	663	673	PF02747	0.616
LIG_PDZ_Class_3	1016	1021	PF00595	0.529
LIG_Pex14_2	283	287	PF04695	0.582
LIG_Pex14_2	304	308	PF04695	0.457
LIG_RPA_C_Fungi	687	699	PF08784	0.513
LIG_SH2_CRK	557	561	PF00017	0.486
LIG_SH2_GRB2like	199	202	PF00017	0.529
LIG_SH2_GRB2like	776	779	PF00017	0.601
LIG_SH2_PTP2	195	198	PF00017	0.428
LIG_SH2_PTP2	537	540	PF00017	0.384
LIG_SH2_SRC	199	202	PF00017	0.529
LIG_SH2_SRC	555	558	PF00017	0.561
LIG_SH2_STAP1	205	209	PF00017	0.544
LIG_SH2_STAP1	557	561	PF00017	0.508
LIG_SH2_STAT3	205	208	PF00017	0.517
LIG_SH2_STAT3	52	55	PF00017	0.486
LIG_SH2_STAT5	195	198	PF00017	0.428
LIG_SH2_STAT5	199	202	PF00017	0.436
LIG_SH2_STAT5	205	208	PF00017	0.517
LIG_SH2_STAT5	286	289	PF00017	0.594
LIG_SH2_STAT5	301	304	PF00017	0.307
LIG_SH2_STAT5	455	458	PF00017	0.424
LIG_SH2_STAT5	537	540	PF00017	0.575
LIG_SH2_STAT5	670	673	PF00017	0.647
LIG_SH2_STAT5	767	770	PF00017	0.521
LIG_SH2_STAT5	776	779	PF00017	0.430
LIG_SH2_STAT5	997	1000	PF00017	0.405
LIG_SH3_2	678	683	PF14604	0.552
LIG_SH3_3	142	148	PF00018	0.701
LIG_SH3_3	253	259	PF00018	0.449
LIG_SH3_3	437	443	PF00018	0.616
LIG_SH3_3	535	541	PF00018	0.426
LIG_SH3_3	672	678	PF00018	0.506
LIG_SH3_3	909	915	PF00018	0.580
LIG_SUMO_SIM_anti_2	1006	1012	PF11976	0.487
LIG_SUMO_SIM_anti_2	56	62	PF11976	0.473
LIG_SUMO_SIM_par_1	459	465	PF11976	0.425
LIG_TRAF2_1	942	945	PF00917	0.553
LIG_TYR_ITIM	193	198	PF00017	0.522
LIG_UBA3_1	323	332	PF00899	0.650
LIG_UBA3_1	627	636	PF00899	0.607
LIG_Vh1_VBS_1	920	938	PF01044	0.554
LIG_WRC_WIRS_1	305	310	PF05994	0.459
MOD_CDC14_SPxK_1	442	445	PF00782	0.592
MOD_CDK_SPxK_1	439	445	PF00069	0.633
MOD_CDK_SPxxK_3	24	31	PF00069	0.544
MOD_CK1_1	204	210	PF00069	0.597
MOD_CK1_1	221	227	PF00069	0.427
MOD_CK1_1	267	273	PF00069	0.611
MOD_CK1_1	27	33	PF00069	0.555
MOD_CK1_1	307	313	PF00069	0.545
MOD_CK1_1	390	396	PF00069	0.650
MOD_CK1_1	510	516	PF00069	0.615
MOD_CK1_1	567	573	PF00069	0.672
MOD_CK1_1	574	580	PF00069	0.737
MOD_CK1_1	649	655	PF00069	0.655
MOD_CK1_1	707	713	PF00069	0.649
MOD_CK1_1	84	90	PF00069	0.491
MOD_CK1_1	903	909	PF00069	0.586
MOD_CK2_1	177	183	PF00069	0.511
MOD_CK2_1	546	552	PF00069	0.477
MOD_CK2_1	67	73	PF00069	0.627
MOD_CK2_1	820	826	PF00069	0.598
MOD_CK2_1	85	91	PF00069	0.469
MOD_CK2_1	880	886	PF00069	0.561
MOD_CK2_1	939	945	PF00069	0.527
MOD_CK2_1	977	983	PF00069	0.596
MOD_CK2_1	998	1004	PF00069	0.546
MOD_Cter_Amidation	784	787	PF01082	0.643
MOD_GlcNHglycan	108	111	PF01048	0.498
MOD_GlcNHglycan	242	245	PF01048	0.497
MOD_GlcNHglycan	270	273	PF01048	0.592
MOD_GlcNHglycan	288	291	PF01048	0.356
MOD_GlcNHglycan	296	299	PF01048	0.444
MOD_GlcNHglycan	335	338	PF01048	0.738
MOD_GlcNHglycan	35	38	PF01048	0.558
MOD_GlcNHglycan	354	357	PF01048	0.533
MOD_GlcNHglycan	370	373	PF01048	0.435
MOD_GlcNHglycan	385	388	PF01048	0.660
MOD_GlcNHglycan	464	467	PF01048	0.628
MOD_GlcNHglycan	482	485	PF01048	0.593
MOD_GlcNHglycan	486	489	PF01048	0.496
MOD_GlcNHglycan	527	531	PF01048	0.453
MOD_GlcNHglycan	594	597	PF01048	0.566
MOD_GlcNHglycan	639	642	PF01048	0.590
MOD_GlcNHglycan	64	67	PF01048	0.446
MOD_GlcNHglycan	709	712	PF01048	0.614
MOD_GlcNHglycan	936	939	PF01048	0.618
MOD_GlcNHglycan	980	983	PF01048	0.609
MOD_GlcNHglycan	999	1003	PF01048	0.621
MOD_GSK3_1	132	139	PF00069	0.682
MOD_GSK3_1	199	206	PF00069	0.477
MOD_GSK3_1	221	228	PF00069	0.444
MOD_GSK3_1	263	270	PF00069	0.636
MOD_GSK3_1	282	289	PF00069	0.483
MOD_GSK3_1	33	40	PF00069	0.546
MOD_GSK3_1	348	355	PF00069	0.557
MOD_GSK3_1	359	366	PF00069	0.372
MOD_GSK3_1	383	390	PF00069	0.631
MOD_GSK3_1	480	487	PF00069	0.601
MOD_GSK3_1	546	553	PF00069	0.472
MOD_GSK3_1	567	574	PF00069	0.776
MOD_GSK3_1	699	706	PF00069	0.657
MOD_GSK3_1	752	759	PF00069	0.668
MOD_GSK3_1	81	88	PF00069	0.379
MOD_GSK3_1	859	866	PF00069	0.538
MOD_GSK3_1	903	910	PF00069	0.490
MOD_GSK3_1	930	937	PF00069	0.558
MOD_N-GLC_1	567	572	PF02516	0.580
MOD_N-GLC_1	828	833	PF02516	0.684
MOD_N-GLC_1	903	908	PF02516	0.588
MOD_NEK2_1	161	166	PF00069	0.523
MOD_NEK2_1	177	182	PF00069	0.505
MOD_NEK2_1	203	208	PF00069	0.444
MOD_NEK2_1	218	223	PF00069	0.546
MOD_NEK2_1	225	230	PF00069	0.441
MOD_NEK2_1	263	268	PF00069	0.525
MOD_NEK2_1	304	309	PF00069	0.454
MOD_NEK2_1	317	322	PF00069	0.472
MOD_NEK2_1	410	415	PF00069	0.427
MOD_NEK2_1	426	431	PF00069	0.569
MOD_NEK2_1	436	441	PF00069	0.500
MOD_NEK2_1	451	456	PF00069	0.456
MOD_NEK2_1	472	477	PF00069	0.725
MOD_NEK2_1	482	487	PF00069	0.418
MOD_NEK2_1	507	512	PF00069	0.448
MOD_NEK2_1	526	531	PF00069	0.484
MOD_NEK2_1	662	667	PF00069	0.590
MOD_NEK2_1	67	72	PF00069	0.618
MOD_NEK2_1	765	770	PF00069	0.530
MOD_NEK2_1	819	824	PF00069	0.708
MOD_NEK2_1	85	90	PF00069	0.435
MOD_NEK2_1	880	885	PF00069	0.450
MOD_NEK2_1	900	905	PF00069	0.238
MOD_NEK2_1	934	939	PF00069	0.598
MOD_NEK2_1	966	971	PF00069	0.545
MOD_NEK2_1	998	1003	PF00069	0.609
MOD_NEK2_2	132	137	PF00069	0.574
MOD_OFUCOSY	842	849	PF10250	0.581
MOD_PIKK_1	204	210	PF00454	0.607
MOD_PIKK_1	258	264	PF00454	0.635
MOD_PIKK_1	338	344	PF00454	0.745
MOD_PIKK_1	387	393	PF00454	0.657
MOD_PIKK_1	51	57	PF00454	0.581
MOD_PIKK_1	828	834	PF00454	0.565
MOD_PIKK_1	859	865	PF00454	0.540
MOD_PIKK_1	907	913	PF00454	0.498
MOD_PIKK_1	966	972	PF00454	0.380
MOD_PKA_1	240	246	PF00069	0.538
MOD_PKA_2	235	241	PF00069	0.477
MOD_PKA_2	426	432	PF00069	0.654
MOD_PKA_2	472	478	PF00069	0.675
MOD_PKA_2	67	73	PF00069	0.627
MOD_PKA_2	880	886	PF00069	0.459
MOD_Plk_1	684	690	PF00069	0.479
MOD_Plk_1	819	825	PF00069	0.576
MOD_Plk_1	828	834	PF00069	0.459
MOD_Plk_2-3	820	826	PF00069	0.510
MOD_Plk_4	177	183	PF00069	0.574
MOD_Plk_4	282	288	PF00069	0.526
MOD_Plk_4	37	43	PF00069	0.498
MOD_Plk_4	436	442	PF00069	0.718
MOD_Plk_4	499	505	PF00069	0.472
MOD_Plk_4	550	556	PF00069	0.418
MOD_Plk_4	579	585	PF00069	0.600
MOD_Plk_4	723	729	PF00069	0.608
MOD_Plk_4	733	739	PF00069	0.440
MOD_Plk_4	820	826	PF00069	0.573
MOD_Plk_4	873	879	PF00069	0.538
MOD_Plk_4	880	886	PF00069	0.528
MOD_Plk_4	930	936	PF00069	0.463
MOD_ProDKin_1	136	142	PF00069	0.652
MOD_ProDKin_1	24	30	PF00069	0.567
MOD_ProDKin_1	439	445	PF00069	0.541
MOD_ProDKin_1	474	480	PF00069	0.737
MOD_ProDKin_1	496	502	PF00069	0.598
MOD_ProDKin_1	608	614	PF00069	0.679
MOD_ProDKin_1	674	680	PF00069	0.722
MOD_ProDKin_1	699	705	PF00069	0.480
MOD_ProDKin_1	863	869	PF00069	0.512
MOD_SUMO_for_1	330	333	PF00179	0.690
TRG_DiLeu_BaEn_1	916	921	PF01217	0.419
TRG_DiLeu_BaEn_1	968	973	PF01217	0.370
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.478
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.589
TRG_DiLeu_BaLyEn_6	896	901	PF01217	0.461
TRG_DiLeu_LyEn_5	654	659	PF01217	0.663
TRG_ENDOCYTIC_2	195	198	PF00928	0.376
TRG_ENDOCYTIC_2	301	304	PF00928	0.411
TRG_ENDOCYTIC_2	537	540	PF00928	0.585
TRG_ENDOCYTIC_2	557	560	PF00928	0.340
TRG_ER_diArg_1	404	406	PF00400	0.570
TRG_ER_diArg_1	514	517	PF00400	0.572
TRG_ER_diArg_1	798	801	PF00400	0.435
TRG_ER_diArg_1	987	990	PF00400	0.595
TRG_NLS_MonoExtN_4	541	547	PF00514	0.612
TRG_Pf-PMV_PEXEL_1	545	550	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P493	Leptomonas seymouri	36%	100%
A0A3S7XBS3	Leishmania donovani	88%	100%
E9AHY3	Leishmania infantum	88%	100%
E9ATV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%