PRKCSH_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0P0_LEIMA

TriTrypDb:

LmjF.36.5220 , LMJLV39_360064200 , LMJSD75_360064100

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 1
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005788	endoplasmic reticulum lumen	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	4
GO:0005783	endoplasmic reticulum	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

Q4Q0P0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0P0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	8
GO:0006511	ubiquitin-dependent protein catabolic process	7	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006950	response to stress	2	8
GO:0007165	signal transduction	2	8
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	8
GO:0009056	catabolic process	2	8
GO:0009057	macromolecule catabolic process	4	8
GO:0009987	cellular process	1	8
GO:0010033	response to organic substance	3	8
GO:0010243	response to organonitrogen compound	4	8
GO:0010498	proteasomal protein catabolic process	5	8
GO:0015031	protein transport	4	2
GO:0019538	protein metabolic process	3	8
GO:0019941	modification-dependent protein catabolic process	6	8
GO:0030163	protein catabolic process	4	8
GO:0030433	ubiquitin-dependent ERAD pathway	6	8
GO:0030968	endoplasmic reticulum unfolded protein response	3	8
GO:0030970	retrograde protein transport, ER to cytosol	5	2
GO:0032527	protein exit from endoplasmic reticulum	5	2
GO:0033036	macromolecule localization	2	2
GO:0033554	cellular response to stress	3	8
GO:0034976	response to endoplasmic reticulum stress	4	8
GO:0036503	ERAD pathway	5	8
GO:0042221	response to chemical	2	8
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043632	modification-dependent macromolecule catabolic process	5	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044248	cellular catabolic process	3	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0044265	obsolete cellular macromolecule catabolic process	4	8
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0050789	regulation of biological process	2	8
GO:0050794	regulation of cellular process	3	8
GO:0050896	response to stimulus	1	8
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051603	proteolysis involved in protein catabolic process	5	8
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051716	cellular response to stimulus	2	8
GO:0065007	biological regulation	1	8
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	8
GO:0071705	nitrogen compound transport	4	2
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901565	organonitrogen compound catabolic process	4	8
GO:1901575	organic substance catabolic process	3	8
GO:1901698	response to nitrogen compound	3	8
GO:1903513	endoplasmic reticulum to cytosol transport	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	147	149	PF00675	0.620
CLV_NRD_NRD_1	182	184	PF00675	0.543
CLV_NRD_NRD_1	3	5	PF00675	0.466
CLV_NRD_NRD_1	84	86	PF00675	0.681
CLV_PCSK_KEX2_1	146	148	PF00082	0.609
CLV_PCSK_KEX2_1	182	184	PF00082	0.543
CLV_PCSK_KEX2_1	3	5	PF00082	0.583
CLV_PCSK_KEX2_1	83	85	PF00082	0.686
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.647
CLV_PCSK_SKI1_1	213	217	PF00082	0.463
DEG_APCC_DBOX_1	212	220	PF00400	0.451
DOC_CYCLIN_yCln2_LP_2	44	50	PF00134	0.574
DOC_MAPK_gen_1	180	190	PF00069	0.538
DOC_MAPK_gen_1	3	11	PF00069	0.450
DOC_PP2B_LxvP_1	44	47	PF13499	0.730
DOC_PP4_FxxP_1	197	200	PF00568	0.625
DOC_USP7_MATH_1	117	121	PF00917	0.369
DOC_USP7_MATH_1	202	206	PF00917	0.493
LIG_14-3-3_CanoR_1	146	155	PF00244	0.628
LIG_14-3-3_CanoR_1	164	170	PF00244	0.417
LIG_14-3-3_CanoR_1	193	201	PF00244	0.582
LIG_14-3-3_CanoR_1	217	226	PF00244	0.428
LIG_BIR_III_4	160	164	PF00653	0.543
LIG_BRCT_BRCA1_1	219	223	PF00533	0.497
LIG_CtBP_PxDLS_1	30	34	PF00389	0.678
LIG_EH1_1	96	104	PF00400	0.501
LIG_FHA_1	18	24	PF00498	0.668
LIG_LIR_Apic_2	195	200	PF02991	0.623
LIG_LIR_Gen_1	118	125	PF02991	0.512
LIG_LIR_Gen_1	220	229	PF02991	0.469
LIG_LIR_Nem_3	118	124	PF02991	0.438
LIG_LIR_Nem_3	160	165	PF02991	0.470
LIG_LIR_Nem_3	220	226	PF02991	0.460
LIG_LIR_Nem_3	63	69	PF02991	0.538
LIG_SH2_CRK	203	207	PF00017	0.583
LIG_SH2_PTP2	121	124	PF00017	0.541
LIG_SH2_PTP2	66	69	PF00017	0.590
LIG_SH2_STAP1	165	169	PF00017	0.343
LIG_SH2_STAT5	121	124	PF00017	0.493
LIG_SH2_STAT5	125	128	PF00017	0.367
LIG_SH2_STAT5	191	194	PF00017	0.405
LIG_SH2_STAT5	66	69	PF00017	0.538
LIG_SH3_3	24	30	PF00018	0.499
LIG_TRAF2_1	232	235	PF00917	0.664
LIG_TYR_ITIM	201	206	PF00017	0.585
LIG_UBA3_1	215	222	PF00899	0.459
LIG_WRC_WIRS_1	102	107	PF05994	0.345
MOD_CK1_1	101	107	PF00069	0.506
MOD_CK1_1	120	126	PF00069	0.443
MOD_CK1_1	70	76	PF00069	0.497
MOD_CK2_1	192	198	PF00069	0.560
MOD_CK2_1	202	208	PF00069	0.504
MOD_CK2_1	230	236	PF00069	0.576
MOD_Cter_Amidation	1	4	PF01082	0.474
MOD_Cter_Amidation	144	147	PF01082	0.590
MOD_Cter_Amidation	180	183	PF01082	0.517
MOD_GlcNHglycan	24	27	PF01048	0.643
MOD_GlcNHglycan	4	7	PF01048	0.489
MOD_GlcNHglycan	53	56	PF01048	0.705
MOD_GSK3_1	202	209	PF00069	0.527
MOD_GSK3_1	218	225	PF00069	0.398
MOD_GSK3_1	230	237	PF00069	0.577
MOD_N-GLC_1	70	75	PF02516	0.504
MOD_NEK2_1	218	223	PF00069	0.514
MOD_NEK2_1	31	36	PF00069	0.741
MOD_NEK2_2	165	170	PF00069	0.412
MOD_NEK2_2	202	207	PF00069	0.558
MOD_PIKK_1	207	213	PF00454	0.505
MOD_PK_1	222	228	PF00069	0.576
MOD_PKA_1	146	152	PF00069	0.515
MOD_PKA_2	106	112	PF00069	0.601
MOD_PKA_2	146	152	PF00069	0.613
MOD_PKA_2	192	198	PF00069	0.542
MOD_PKA_2	2	8	PF00069	0.641
MOD_Plk_1	117	123	PF00069	0.440
MOD_Plk_1	234	240	PF00069	0.661
MOD_Plk_2-3	230	236	PF00069	0.576
MOD_Plk_4	117	123	PF00069	0.494
MOD_Plk_4	165	171	PF00069	0.437
MOD_Plk_4	98	104	PF00069	0.585
MOD_SUMO_rev_2	133	142	PF00179	0.507
TRG_DiLeu_BaEn_2	37	43	PF01217	0.737
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.522
TRG_ENDOCYTIC_2	121	124	PF00928	0.496
TRG_ENDOCYTIC_2	194	197	PF00928	0.613
TRG_ENDOCYTIC_2	203	206	PF00928	0.478
TRG_ENDOCYTIC_2	66	69	PF00928	0.514
TRG_ER_diArg_1	146	148	PF00400	0.542
TRG_ER_diArg_1	182	184	PF00400	0.543
TRG_ER_diArg_1	50	53	PF00400	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N4	Leptomonas seymouri	46%	100%
A0A3R7KHI0	Trypanosoma rangeli	26%	98%
A0A3S7XBS9	Leishmania donovani	87%	100%
A4HQ37	Leishmania braziliensis	70%	100%
A4IDU3	Leishmania infantum	87%	100%
D0A8S9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	82%
E9ATV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%