Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0N9_LEIMA

TriTrypDb:

LmjF.36.5230 , LMJLV39_360064300 , LMJSD75_360064200

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q0N9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0N9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	389	393	PF00656	0.398
CLV_NRD_NRD_1	102	104	PF00675	0.711
CLV_NRD_NRD_1	186	188	PF00675	0.597
CLV_NRD_NRD_1	294	296	PF00675	0.590
CLV_NRD_NRD_1	320	322	PF00675	0.509
CLV_NRD_NRD_1	64	66	PF00675	0.456
CLV_PCSK_FUR_1	61	65	PF00082	0.415
CLV_PCSK_FUR_1	99	103	PF00082	0.611
CLV_PCSK_KEX2_1	101	103	PF00082	0.679
CLV_PCSK_KEX2_1	186	188	PF00082	0.571
CLV_PCSK_KEX2_1	294	296	PF00082	0.622
CLV_PCSK_KEX2_1	320	322	PF00082	0.482
CLV_PCSK_KEX2_1	63	65	PF00082	0.437
CLV_PCSK_PC7_1	59	65	PF00082	0.382
CLV_PCSK_SKI1_1	197	201	PF00082	0.531
DEG_APCC_DBOX_1	294	302	PF00400	0.407
DEG_Nend_Nbox_1	1	3	PF02207	0.628
DOC_CDC14_PxL_1	128	136	PF14671	0.410
DOC_CKS1_1	405	410	PF01111	0.315
DOC_MAPK_MEF2A_6	113	120	PF00069	0.369
DOC_MAPK_NFAT4_5	113	121	PF00069	0.366
DOC_PP4_FxxP_1	405	408	PF00568	0.345
DOC_USP7_MATH_1	189	193	PF00917	0.298
DOC_USP7_MATH_1	44	48	PF00917	0.685
DOC_USP7_MATH_1	51	55	PF00917	0.640
DOC_WW_Pin1_4	258	263	PF00397	0.404
DOC_WW_Pin1_4	404	409	PF00397	0.303
LIG_14-3-3_CanoR_1	18	25	PF00244	0.686
LIG_14-3-3_CanoR_1	217	221	PF00244	0.307
LIG_14-3-3_CanoR_1	263	268	PF00244	0.423
LIG_14-3-3_CanoR_1	321	327	PF00244	0.452
LIG_14-3-3_CanoR_1	35	40	PF00244	0.631
LIG_Actin_WH2_2	370	387	PF00022	0.319
LIG_Actin_WH2_2	399	414	PF00022	0.325
LIG_BRCT_BRCA1_1	345	349	PF00533	0.345
LIG_BRCT_BRCA1_1	88	92	PF00533	0.418
LIG_FHA_1	120	126	PF00498	0.377
LIG_FHA_1	20	26	PF00498	0.637
LIG_FHA_1	211	217	PF00498	0.405
LIG_FHA_1	253	259	PF00498	0.259
LIG_FHA_1	279	285	PF00498	0.428
LIG_FHA_1	361	367	PF00498	0.428
LIG_FHA_1	480	486	PF00498	0.404
LIG_FHA_2	323	329	PF00498	0.449
LIG_FHA_2	352	358	PF00498	0.437
LIG_FHA_2	387	393	PF00498	0.295
LIG_LIR_Apic_2	403	408	PF02991	0.295
LIG_LIR_Apic_2	451	455	PF02991	0.321
LIG_LIR_Gen_1	190	201	PF02991	0.325
LIG_LIR_Gen_1	313	323	PF02991	0.374
LIG_LIR_Gen_1	325	334	PF02991	0.291
LIG_LIR_Gen_1	346	356	PF02991	0.395
LIG_LIR_Nem_3	190	196	PF02991	0.321
LIG_LIR_Nem_3	236	240	PF02991	0.461
LIG_LIR_Nem_3	281	285	PF02991	0.376
LIG_LIR_Nem_3	313	318	PF02991	0.391
LIG_LIR_Nem_3	325	329	PF02991	0.264
LIG_LIR_Nem_3	335	339	PF02991	0.265
LIG_LIR_Nem_3	346	350	PF02991	0.280
LIG_LYPXL_yS_3	107	110	PF13949	0.433
LIG_NRBOX	461	467	PF00104	0.316
LIG_PDZ_Class_2	482	487	PF00595	0.381
LIG_SH2_CRK	193	197	PF00017	0.357
LIG_SH2_CRK	230	234	PF00017	0.285
LIG_SH2_CRK	336	340	PF00017	0.280
LIG_SH2_CRK	452	456	PF00017	0.316
LIG_SH2_NCK_1	388	392	PF00017	0.288
LIG_SH2_PTP2	83	86	PF00017	0.325
LIG_SH2_SRC	228	231	PF00017	0.331
LIG_SH2_SRC	343	346	PF00017	0.290
LIG_SH2_STAP1	230	234	PF00017	0.322
LIG_SH2_STAP1	326	330	PF00017	0.298
LIG_SH2_STAP1	343	347	PF00017	0.292
LIG_SH2_STAT5	228	231	PF00017	0.327
LIG_SH2_STAT5	238	241	PF00017	0.282
LIG_SH2_STAT5	388	391	PF00017	0.291
LIG_SH2_STAT5	83	86	PF00017	0.389
LIG_SH3_3	328	334	PF00018	0.309
LIG_SH3_3	34	40	PF00018	0.618
LIG_SUMO_SIM_anti_2	327	333	PF11976	0.309
LIG_SUMO_SIM_par_1	248	255	PF11976	0.280
LIG_SUMO_SIM_par_1	397	403	PF11976	0.287
LIG_SUMO_SIM_par_1	407	413	PF11976	0.328
LIG_TRAF2_1	157	160	PF00917	0.355
LIG_TRAF2_1	325	328	PF00917	0.348
LIG_TYR_ITIM	191	196	PF00017	0.321
LIG_TYR_ITIM	81	86	PF00017	0.304
MOD_CDK_SPK_2	258	263	PF00069	0.367
MOD_CK1_1	176	182	PF00069	0.290
MOD_CK1_1	19	25	PF00069	0.705
MOD_CK1_1	310	316	PF00069	0.340
MOD_CK1_1	379	385	PF00069	0.379
MOD_CK2_1	137	143	PF00069	0.342
MOD_CK2_1	322	328	PF00069	0.351
MOD_CK2_1	426	432	PF00069	0.359
MOD_GlcNHglycan	139	142	PF01048	0.555
MOD_GlcNHglycan	179	182	PF01048	0.630
MOD_GlcNHglycan	230	233	PF01048	0.624
MOD_GlcNHglycan	25	28	PF01048	0.490
MOD_GlcNHglycan	268	271	PF01048	0.601
MOD_GlcNHglycan	287	290	PF01048	0.633
MOD_GlcNHglycan	315	318	PF01048	0.505
MOD_GlcNHglycan	37	40	PF01048	0.433
MOD_GlcNHglycan	41	44	PF01048	0.477
MOD_GlcNHglycan	46	49	PF01048	0.446
MOD_GlcNHglycan	53	56	PF01048	0.394
MOD_GlcNHglycan	94	97	PF01048	0.639
MOD_GSK3_1	17	24	PF00069	0.655
MOD_GSK3_1	173	180	PF00069	0.480
MOD_GSK3_1	211	218	PF00069	0.377
MOD_GSK3_1	252	259	PF00069	0.284
MOD_GSK3_1	307	314	PF00069	0.327
MOD_GSK3_1	35	42	PF00069	0.807
MOD_GSK3_1	356	363	PF00069	0.365
MOD_GSK3_1	51	58	PF00069	0.734
MOD_N-GLC_1	285	290	PF02516	0.582
MOD_NEK2_1	1	6	PF00069	0.712
MOD_NEK2_1	137	142	PF00069	0.328
MOD_NEK2_1	16	21	PF00069	0.632
MOD_NEK2_1	171	176	PF00069	0.360
MOD_NEK2_1	215	220	PF00069	0.356
MOD_NEK2_1	251	256	PF00069	0.296
MOD_NEK2_1	285	290	PF00069	0.428
MOD_NEK2_1	307	312	PF00069	0.318
MOD_NEK2_1	384	389	PF00069	0.400
MOD_NEK2_1	438	443	PF00069	0.352
MOD_NEK2_1	86	91	PF00069	0.559
MOD_NEK2_1	92	97	PF00069	0.426
MOD_NEK2_2	181	186	PF00069	0.321
MOD_NEK2_2	479	484	PF00069	0.330
MOD_PIKK_1	120	126	PF00454	0.357
MOD_PIKK_1	171	177	PF00454	0.359
MOD_PIKK_1	360	366	PF00454	0.471
MOD_PKA_2	17	23	PF00069	0.691
MOD_PKA_2	216	222	PF00069	0.306
MOD_PKA_2	252	258	PF00069	0.309
MOD_PKA_2	51	57	PF00069	0.667
MOD_PKB_1	33	41	PF00069	0.678
MOD_Plk_1	189	195	PF00069	0.325
MOD_Plk_1	308	314	PF00069	0.331
MOD_Plk_1	438	444	PF00069	0.348
MOD_Plk_4	1	7	PF00069	0.715
MOD_Plk_4	211	217	PF00069	0.405
MOD_Plk_4	86	92	PF00069	0.560
MOD_ProDKin_1	258	264	PF00069	0.407
MOD_ProDKin_1	404	410	PF00069	0.311
TRG_DiLeu_BaEn_4	327	333	PF01217	0.309
TRG_DiLeu_BaLyEn_6	452	457	PF01217	0.314
TRG_ENDOCYTIC_2	107	110	PF00928	0.433
TRG_ENDOCYTIC_2	193	196	PF00928	0.358
TRG_ENDOCYTIC_2	220	223	PF00928	0.307
TRG_ENDOCYTIC_2	230	233	PF00928	0.329
TRG_ENDOCYTIC_2	237	240	PF00928	0.422
TRG_ENDOCYTIC_2	282	285	PF00928	0.365
TRG_ENDOCYTIC_2	326	329	PF00928	0.300
TRG_ENDOCYTIC_2	336	339	PF00928	0.277
TRG_ENDOCYTIC_2	83	86	PF00928	0.304
TRG_ER_diArg_1	185	187	PF00400	0.437
TRG_ER_diArg_1	32	35	PF00400	0.667
TRG_ER_diArg_1	320	322	PF00400	0.338
TRG_ER_diArg_1	59	62	PF00400	0.652
TRG_ER_diArg_1	63	65	PF00400	0.655
TRG_ER_diArg_1	99	102	PF00400	0.451
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P492	Leptomonas seymouri	54%	100%
A0A3S7XBP8	Leishmania donovani	89%	100%
A4HQ38	Leishmania braziliensis	76%	100%
A4IDU4	Leishmania infantum	90%	100%
E9ATV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%