Endonuclease/exonuclease protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease/exonuclease protein-like protein

Species:

Leishmania major

UniProt:

Q4Q0N5_LEIMA

TriTrypDb:

LmjF.36.5270 , LMJLV39_360064900 , LMJSD75_360064600

Length:

735

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0N5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006281	DNA repair	5	10
GO:0006284	base-excision repair	6	2
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	10
GO:0006974	DNA damage response	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0033554	cellular response to stress	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0050896	response to stimulus	1	10
GO:0051716	cellular response to stimulus	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003824	catalytic activity	1	10
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	4	4
GO:0004518	nuclease activity	4	10
GO:0004519	endonuclease activity	5	10
GO:0004527	exonuclease activity	5	7
GO:0004529	DNA exonuclease activity	5	2
GO:0004536	DNA nuclease activity	4	2
GO:0005488	binding	1	10
GO:0008081	phosphoric diester hydrolase activity	5	2
GO:0008296	3'-5'-DNA exonuclease activity	7	2
GO:0008309	double-stranded DNA exodeoxyribonuclease activity	7	2
GO:0008311	double-stranded DNA 3'-5' DNA exonuclease activity	8	2
GO:0008408	3'-5' exonuclease activity	6	2
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	2
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0097159	organic cyclic compound binding	2	10
GO:0140097	catalytic activity, acting on DNA	3	4
GO:0140640	catalytic activity, acting on a nucleic acid	2	4
GO:1901363	heterocyclic compound binding	2	10
GO:0016829	lyase activity	2	2
GO:0016835	carbon-oxygen lyase activity	3	2
GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.317
CLV_C14_Caspase3-7	440	444	PF00656	0.390
CLV_C14_Caspase3-7	88	92	PF00656	0.217
CLV_MEL_PAP_1	18	24	PF00089	0.217
CLV_NRD_NRD_1	132	134	PF00675	0.306
CLV_NRD_NRD_1	197	199	PF00675	0.292
CLV_NRD_NRD_1	225	227	PF00675	0.322
CLV_NRD_NRD_1	485	487	PF00675	0.343
CLV_NRD_NRD_1	65	67	PF00675	0.422
CLV_NRD_NRD_1	82	84	PF00675	0.398
CLV_PCSK_FUR_1	483	487	PF00082	0.308
CLV_PCSK_KEX2_1	225	227	PF00082	0.301
CLV_PCSK_KEX2_1	260	262	PF00082	0.355
CLV_PCSK_KEX2_1	485	487	PF00082	0.283
CLV_PCSK_KEX2_1	65	67	PF00082	0.422
CLV_PCSK_KEX2_1	685	687	PF00082	0.753
CLV_PCSK_KEX2_1	73	75	PF00082	0.415
CLV_PCSK_KEX2_1	80	82	PF00082	0.398
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.355
CLV_PCSK_PC1ET2_1	685	687	PF00082	0.753
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.282
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.295
CLV_PCSK_SKI1_1	134	138	PF00082	0.292
CLV_PCSK_SKI1_1	179	183	PF00082	0.278
CLV_PCSK_SKI1_1	312	316	PF00082	0.411
DEG_APCC_DBOX_1	225	233	PF00400	0.306
DEG_APCC_DBOX_1	311	319	PF00400	0.355
DEG_Nend_Nbox_1	1	3	PF02207	0.304
DEG_SCF_TRCP1_1	282	287	PF00400	0.217
DEG_SCF_TRCP1_1	689	695	PF00400	0.518
DEG_SPOP_SBC_1	288	292	PF00917	0.317
DEG_SPOP_SBC_1	401	405	PF00917	0.317
DEG_SPOP_SBC_1	693	697	PF00917	0.510
DOC_CKS1_1	594	599	PF01111	0.347
DOC_CKS1_1	658	663	PF01111	0.608
DOC_CYCLIN_yCln2_LP_2	321	324	PF00134	0.355
DOC_MAPK_gen_1	65	71	PF00069	0.217
DOC_MAPK_gen_1	711	720	PF00069	0.615
DOC_MAPK_MEF2A_6	199	208	PF00069	0.277
DOC_MAPK_MEF2A_6	394	402	PF00069	0.402
DOC_MAPK_MEF2A_6	633	642	PF00069	0.516
DOC_PP1_RVXF_1	132	139	PF00149	0.306
DOC_PP1_RVXF_1	181	187	PF00149	0.399
DOC_PP1_RVXF_1	579	586	PF00149	0.416
DOC_PP2B_LxvP_1	321	324	PF13499	0.355
DOC_PP2B_LxvP_1	398	401	PF13499	0.391
DOC_PP2B_PxIxI_1	203	209	PF00149	0.398
DOC_PP2B_PxIxI_1	452	458	PF00149	0.292
DOC_PP4_FxxP_1	594	597	PF00568	0.341
DOC_USP7_MATH_1	288	292	PF00917	0.353
DOC_USP7_MATH_1	324	328	PF00917	0.432
DOC_USP7_MATH_1	355	359	PF00917	0.317
DOC_USP7_MATH_1	367	371	PF00917	0.251
DOC_USP7_MATH_1	401	405	PF00917	0.345
DOC_USP7_MATH_1	522	526	PF00917	0.702
DOC_USP7_MATH_1	532	536	PF00917	0.631
DOC_USP7_MATH_1	654	658	PF00917	0.624
DOC_USP7_MATH_1	677	681	PF00917	0.715
DOC_USP7_MATH_1	693	697	PF00917	0.641
DOC_USP7_MATH_1	699	703	PF00917	0.611
DOC_USP7_MATH_1	93	97	PF00917	0.388
DOC_USP7_UBL2_3	199	203	PF12436	0.285
DOC_USP7_UBL2_3	256	260	PF12436	0.483
DOC_WW_Pin1_4	361	366	PF00397	0.487
DOC_WW_Pin1_4	449	454	PF00397	0.392
DOC_WW_Pin1_4	49	54	PF00397	0.403
DOC_WW_Pin1_4	593	598	PF00397	0.343
DOC_WW_Pin1_4	657	662	PF00397	0.641
LIG_14-3-3_CanoR_1	133	139	PF00244	0.306
LIG_14-3-3_CanoR_1	155	165	PF00244	0.306
LIG_14-3-3_CanoR_1	353	361	PF00244	0.361
LIG_14-3-3_CanoR_1	399	408	PF00244	0.410
LIG_14-3-3_CanoR_1	410	419	PF00244	0.373
LIG_14-3-3_CanoR_1	524	532	PF00244	0.650
LIG_14-3-3_CanoR_1	66	72	PF00244	0.340
LIG_APCC_ABBA_1	381	386	PF00400	0.306
LIG_BIR_III_2	724	728	PF00653	0.505
LIG_BRCT_BRCA1_1	141	145	PF00533	0.323
LIG_BRCT_BRCA1_1	387	391	PF00533	0.306
LIG_CtBP_PxDLS_1	341	345	PF00389	0.355
LIG_CtBP_PxDLS_1	53	57	PF00389	0.383
LIG_deltaCOP1_diTrp_1	109	115	PF00928	0.285
LIG_EVH1_1	563	567	PF00568	0.521
LIG_EVH1_2	564	568	PF00568	0.544
LIG_FHA_1	246	252	PF00498	0.327
LIG_FHA_1	292	298	PF00498	0.459
LIG_FHA_1	414	420	PF00498	0.253
LIG_FHA_1	432	438	PF00498	0.358
LIG_FHA_1	658	664	PF00498	0.598
LIG_FHA_2	235	241	PF00498	0.317
LIG_FHA_2	30	36	PF00498	0.291
LIG_FHA_2	475	481	PF00498	0.282
LIG_FHA_2	490	496	PF00498	0.282
LIG_FHA_2	615	621	PF00498	0.505
LIG_FHA_2	86	92	PF00498	0.375
LIG_GBD_Chelix_1	262	270	PF00786	0.317
LIG_LIR_Apic_2	591	597	PF02991	0.340
LIG_LIR_Gen_1	109	117	PF02991	0.306
LIG_LIR_Gen_1	162	172	PF02991	0.272
LIG_LIR_Gen_1	370	381	PF02991	0.359
LIG_LIR_Gen_1	495	504	PF02991	0.282
LIG_LIR_Gen_1	539	550	PF02991	0.477
LIG_LIR_Nem_3	109	114	PF02991	0.285
LIG_LIR_Nem_3	162	167	PF02991	0.307
LIG_LIR_Nem_3	20	25	PF02991	0.294
LIG_LIR_Nem_3	370	376	PF02991	0.334
LIG_LIR_Nem_3	495	499	PF02991	0.282
LIG_LIR_Nem_3	539	545	PF02991	0.496
LIG_LIR_Nem_3	582	588	PF02991	0.412
LIG_MYND_1	466	470	PF01753	0.398
LIG_NRBOX	228	234	PF00104	0.398
LIG_OCRL_FandH_1	21	33	PF00620	0.330
LIG_PCNA_yPIPBox_3	362	376	PF02747	0.342
LIG_PDZ_Class_3	730	735	PF00595	0.613
LIG_Pex14_2	182	186	PF04695	0.306
LIG_Pex14_2	2	6	PF04695	0.321
LIG_PTB_Apo_2	557	564	PF02174	0.500
LIG_PTB_Phospho_1	557	563	PF10480	0.498
LIG_Rb_pABgroove_1	342	350	PF01858	0.355
LIG_SH2_CRK	373	377	PF00017	0.299
LIG_SH2_CRK	636	640	PF00017	0.401
LIG_SH2_NCK_1	337	341	PF00017	0.398
LIG_SH2_PTP2	496	499	PF00017	0.282
LIG_SH2_STAP1	356	360	PF00017	0.398
LIG_SH2_STAT5	170	173	PF00017	0.282
LIG_SH2_STAT5	215	218	PF00017	0.317
LIG_SH2_STAT5	356	359	PF00017	0.267
LIG_SH2_STAT5	471	474	PF00017	0.317
LIG_SH2_STAT5	476	479	PF00017	0.246
LIG_SH2_STAT5	496	499	PF00017	0.282
LIG_SH3_1	467	473	PF00018	0.355
LIG_SH3_3	166	172	PF00018	0.429
LIG_SH3_3	460	466	PF00018	0.356
LIG_SH3_3	467	473	PF00018	0.275
LIG_SH3_3	561	567	PF00018	0.473
LIG_SH3_3	592	598	PF00018	0.345
LIG_SH3_3	655	661	PF00018	0.672
LIG_SUMO_SIM_anti_2	456	462	PF11976	0.383
LIG_SUMO_SIM_par_1	204	210	PF11976	0.342
LIG_SUMO_SIM_par_1	294	302	PF11976	0.358
LIG_SUMO_SIM_par_1	728	734	PF11976	0.630
LIG_TRAF2_1	76	79	PF00917	0.328
LIG_TRAF2_2	597	602	PF00917	0.351
LIG_TYR_ITIM	494	499	PF00017	0.282
LIG_UBA3_1	36	43	PF00899	0.398
LIG_UBA3_1	71	80	PF00899	0.217
LIG_WRC_WIRS_1	128	133	PF05994	0.334
LIG_WRC_WIRS_1	235	240	PF05994	0.397
LIG_WRC_WIRS_1	642	647	PF05994	0.516
LIG_WW_3	322	326	PF00397	0.355
MOD_CK1_1	113	119	PF00069	0.333
MOD_CK1_1	12	18	PF00069	0.342
MOD_CK1_1	291	297	PF00069	0.358
MOD_CK1_1	298	304	PF00069	0.439
MOD_CK1_1	327	333	PF00069	0.425
MOD_CK1_1	385	391	PF00069	0.437
MOD_CK1_1	526	532	PF00069	0.634
MOD_CK1_1	657	663	PF00069	0.620
MOD_CK1_1	697	703	PF00069	0.721
MOD_CK2_1	234	240	PF00069	0.414
MOD_CK2_1	614	620	PF00069	0.507
MOD_CK2_1	709	715	PF00069	0.646
MOD_GlcNHglycan	117	120	PF01048	0.306
MOD_GlcNHglycan	161	164	PF01048	0.272
MOD_GlcNHglycan	282	285	PF01048	0.388
MOD_GlcNHglycan	291	294	PF01048	0.398
MOD_GlcNHglycan	326	329	PF01048	0.418
MOD_GlcNHglycan	386	390	PF01048	0.423
MOD_GlcNHglycan	404	407	PF01048	0.403
MOD_GlcNHglycan	49	52	PF01048	0.430
MOD_GlcNHglycan	500	503	PF01048	0.411
MOD_GlcNHglycan	526	529	PF01048	0.650
MOD_GlcNHglycan	689	692	PF01048	0.751
MOD_GlcNHglycan	699	702	PF01048	0.676
MOD_GlcNHglycan	96	99	PF01048	0.434
MOD_GSK3_1	139	146	PF00069	0.390
MOD_GSK3_1	234	241	PF00069	0.227
MOD_GSK3_1	280	287	PF00069	0.415
MOD_GSK3_1	291	298	PF00069	0.415
MOD_GSK3_1	431	438	PF00069	0.405
MOD_GSK3_1	522	529	PF00069	0.623
MOD_GSK3_1	693	700	PF00069	0.729
MOD_N-GLC_1	211	216	PF02516	0.283
MOD_N-GLC_1	303	308	PF02516	0.317
MOD_N-GLC_1	697	702	PF02516	0.533
MOD_NEK2_1	2	7	PF00069	0.307
MOD_NEK2_1	211	216	PF00069	0.322
MOD_NEK2_1	238	243	PF00069	0.301
MOD_NEK2_1	280	285	PF00069	0.379
MOD_NEK2_1	360	365	PF00069	0.384
MOD_NEK2_1	431	436	PF00069	0.323
MOD_NEK2_1	498	503	PF00069	0.355
MOD_NEK2_1	568	573	PF00069	0.457
MOD_NEK2_1	694	699	PF00069	0.739
MOD_NEK2_2	220	225	PF00069	0.342
MOD_NEK2_2	641	646	PF00069	0.565
MOD_OFUCOSY	472	478	PF10250	0.353
MOD_PIKK_1	12	18	PF00454	0.378
MOD_PIKK_1	139	145	PF00454	0.454
MOD_PK_1	21	27	PF00069	0.217
MOD_PKA_1	198	204	PF00069	0.369
MOD_PKA_2	324	330	PF00069	0.447
MOD_PKA_2	523	529	PF00069	0.659
MOD_PKB_1	19	27	PF00069	0.217
MOD_Plk_1	211	217	PF00069	0.310
MOD_Plk_4	110	116	PF00069	0.282
MOD_Plk_4	228	234	PF00069	0.295
MOD_Plk_4	431	437	PF00069	0.342
MOD_Plk_4	641	647	PF00069	0.473
MOD_Plk_4	67	73	PF00069	0.324
MOD_ProDKin_1	361	367	PF00069	0.487
MOD_ProDKin_1	449	455	PF00069	0.392
MOD_ProDKin_1	49	55	PF00069	0.403
MOD_ProDKin_1	593	599	PF00069	0.346
MOD_ProDKin_1	657	663	PF00069	0.645
MOD_SUMO_rev_2	35	45	PF00179	0.282
MOD_SUMO_rev_2	630	635	PF00179	0.414
MOD_SUMO_rev_2	666	674	PF00179	0.639
TRG_AP2beta_CARGO_1	539	549	PF09066	0.532
TRG_DiLeu_BaEn_1	276	281	PF01217	0.286
TRG_DiLeu_BaLyEn_6	391	396	PF01217	0.398
TRG_DiLeu_BaLyEn_6	450	455	PF01217	0.355
TRG_ENDOCYTIC_2	373	376	PF00928	0.299
TRG_ENDOCYTIC_2	496	499	PF00928	0.282
TRG_ER_diArg_1	224	226	PF00400	0.302
TRG_ER_diArg_1	428	431	PF00400	0.330
TRG_ER_diArg_1	465	468	PF00400	0.326
TRG_ER_diArg_1	483	486	PF00400	0.343
TRG_ER_diArg_1	65	67	PF00400	0.420
TRG_ER_diArg_1	81	83	PF00400	0.398
TRG_NES_CRM1_1	599	611	PF08389	0.276
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB73	Leptomonas seymouri	57%	99%
A0A1X0P3V4	Trypanosomatidae	36%	100%
A0A3R7M024	Trypanosoma rangeli	41%	100%
A0A3S7XBT9	Leishmania donovani	92%	100%
A4IDU8	Leishmania infantum	93%	100%
D0A8S3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AIY2	Leishmania braziliensis	80%	99%
E9ATW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%