DUF2040 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0N3_LEIMA

TriTrypDb:

LmjF.36.5290 , LMJLV39_360065100 , LMJSD75_360064800

Length:

195

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0N3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0N3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	64	66	PF00675	0.479
CLV_PCSK_KEX2_1	112	114	PF00082	0.567
CLV_PCSK_KEX2_1	64	66	PF00082	0.455
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.567
CLV_PCSK_SKI1_1	12	16	PF00082	0.543
CLV_PCSK_SKI1_1	131	135	PF00082	0.467
CLV_PCSK_SKI1_1	175	179	PF00082	0.480
CLV_PCSK_SKI1_1	47	51	PF00082	0.445
CLV_PCSK_SKI1_1	82	86	PF00082	0.676
DOC_MAPK_gen_1	152	160	PF00069	0.472
DOC_MAPK_gen_1	28	36	PF00069	0.569
DOC_MAPK_gen_1	81	88	PF00069	0.639
DOC_MAPK_MEF2A_6	28	36	PF00069	0.605
DOC_MAPK_RevD_3	98	112	PF00069	0.556
DOC_USP7_UBL2_3	132	136	PF12436	0.576
LIG_FHA_1	128	134	PF00498	0.540
LIG_FHA_1	31	37	PF00498	0.571
LIG_FHA_1	83	89	PF00498	0.599
LIG_FHA_2	13	19	PF00498	0.445
LIG_FHA_2	174	180	PF00498	0.490
LIG_FHA_2	186	192	PF00498	0.497
LIG_FHA_2	90	96	PF00498	0.529
LIG_Rb_pABgroove_1	52	60	PF01858	0.537
LIG_Rb_pABgroove_1	98	106	PF01858	0.495
LIG_SH2_SRC	58	61	PF00017	0.470
LIG_SH2_STAP1	104	108	PF00017	0.444
LIG_SH2_STAP1	161	165	PF00017	0.515
LIG_SH2_STAP1	58	62	PF00017	0.472
LIG_SH2_STAT5	164	167	PF00017	0.481
LIG_SH2_STAT5	8	11	PF00017	0.522
LIG_SH3_2	7	12	PF14604	0.429
LIG_SH3_3	35	41	PF00018	0.555
LIG_SH3_3	4	10	PF00018	0.606
LIG_SUMO_SIM_par_1	83	89	PF11976	0.551
LIG_TRAF2_1	15	18	PF00917	0.547
LIG_TRAF2_1	93	96	PF00917	0.505
MOD_CK1_1	43	49	PF00069	0.599
MOD_CK2_1	12	18	PF00069	0.523
MOD_CK2_1	121	127	PF00069	0.660
MOD_CK2_1	173	179	PF00069	0.468
MOD_CK2_1	185	191	PF00069	0.500
MOD_CK2_1	89	95	PF00069	0.541
MOD_GlcNHglycan	182	185	PF01048	0.477
MOD_GSK3_1	127	134	PF00069	0.550
MOD_GSK3_1	26	33	PF00069	0.613
MOD_GSK3_1	82	89	PF00069	0.591
MOD_NEK2_1	173	178	PF00069	0.547
MOD_NEK2_1	26	31	PF00069	0.586
MOD_PKA_1	131	137	PF00069	0.552
MOD_PKA_2	127	133	PF00069	0.535
MOD_PKA_2	24	30	PF00069	0.507
MOD_Plk_1	104	110	PF00069	0.406
MOD_Plk_1	58	64	PF00069	0.488
MOD_Plk_1	82	88	PF00069	0.605
MOD_SUMO_rev_2	29	39	PF00179	0.539
TRG_DiLeu_BaEn_1	95	100	PF01217	0.491
TRG_ER_diArg_1	64	67	PF00400	0.560
TRG_NLS_MonoExtC_3	110	116	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAU2	Leptomonas seymouri	66%	100%
A0A0S4ITG8	Bodo saltans	29%	94%
A0A0S4ITU7	Bodo saltans	28%	100%
A0A0S4IZ88	Bodo saltans	27%	100%
A0A0S4KH12	Bodo saltans	34%	98%
A0A1X0P384	Trypanosomatidae	41%	100%
A0A1X0P828	Trypanosomatidae	28%	100%
A0A3Q8IJ52	Leishmania donovani	93%	100%
A0A422NMA5	Trypanosoma rangeli	41%	100%
A4HQ43	Leishmania braziliensis	76%	100%
A4IDV0	Leishmania infantum	93%	100%
D0A8S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AIX6	Leishmania braziliensis	29%	100%
E9ATW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%