Glutathione S-transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glutathione S-transferase, C-terminal domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q0N0_LEIMA

TriTrypDb:

LmjF.36.5320 , LMJLV39_360065400 , LMJSD75_360065100

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0N0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0N0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	477	481	PF00656	0.770
CLV_NRD_NRD_1	126	128	PF00675	0.449
CLV_NRD_NRD_1	371	373	PF00675	0.530
CLV_NRD_NRD_1	433	435	PF00675	0.596
CLV_NRD_NRD_1	606	608	PF00675	0.448
CLV_NRD_NRD_1	621	623	PF00675	0.439
CLV_NRD_NRD_1	629	631	PF00675	0.427
CLV_PCSK_KEX2_1	371	373	PF00082	0.467
CLV_PCSK_KEX2_1	433	435	PF00082	0.596
CLV_PCSK_KEX2_1	606	608	PF00082	0.463
CLV_PCSK_PC7_1	429	435	PF00082	0.416
CLV_PCSK_SKI1_1	172	176	PF00082	0.344
CLV_PCSK_SKI1_1	284	288	PF00082	0.524
CLV_PCSK_SKI1_1	40	44	PF00082	0.499
CLV_PCSK_SKI1_1	421	425	PF00082	0.456
CLV_PCSK_SKI1_1	55	59	PF00082	0.505
CLV_PCSK_SKI1_1	562	566	PF00082	0.457
CLV_PCSK_SKI1_1	640	644	PF00082	0.382
CLV_PCSK_SKI1_1	89	93	PF00082	0.552
DEG_SCF_FBW7_1	235	242	PF00400	0.490
DOC_CKS1_1	236	241	PF01111	0.490
DOC_MAPK_DCC_7	172	182	PF00069	0.444
DOC_MAPK_gen_1	157	166	PF00069	0.425
DOC_MAPK_gen_1	606	612	PF00069	0.589
DOC_MAPK_HePTP_8	124	136	PF00069	0.660
DOC_MAPK_MEF2A_6	127	136	PF00069	0.553
DOC_MAPK_MEF2A_6	409	417	PF00069	0.576
DOC_PP4_FxxP_1	13	16	PF00568	0.662
DOC_PP4_FxxP_1	175	178	PF00568	0.444
DOC_PP4_FxxP_1	519	522	PF00568	0.760
DOC_USP7_MATH_1	109	113	PF00917	0.733
DOC_USP7_MATH_1	251	255	PF00917	0.473
DOC_USP7_MATH_1	318	322	PF00917	0.719
DOC_USP7_MATH_1	456	460	PF00917	0.764
DOC_USP7_MATH_1	461	465	PF00917	0.746
DOC_USP7_MATH_1	478	482	PF00917	0.636
DOC_USP7_MATH_1	590	594	PF00917	0.661
DOC_USP7_MATH_1	629	633	PF00917	0.674
DOC_WW_Pin1_4	105	110	PF00397	0.627
DOC_WW_Pin1_4	12	17	PF00397	0.589
DOC_WW_Pin1_4	235	240	PF00397	0.496
DOC_WW_Pin1_4	439	444	PF00397	0.775
DOC_WW_Pin1_4	5	10	PF00397	0.690
DOC_WW_Pin1_4	59	64	PF00397	0.637
LIG_14-3-3_CanoR_1	284	289	PF00244	0.725
LIG_14-3-3_CanoR_1	325	333	PF00244	0.717
LIG_14-3-3_CanoR_1	40	50	PF00244	0.660
LIG_14-3-3_CanoR_1	53	58	PF00244	0.631
LIG_14-3-3_CanoR_1	562	572	PF00244	0.730
LIG_14-3-3_CanoR_1	575	585	PF00244	0.611
LIG_14-3-3_CanoR_1	630	639	PF00244	0.693
LIG_BIR_II_1	1	5	PF00653	0.711
LIG_BRCT_BRCA1_1	252	256	PF00533	0.487
LIG_BRCT_BRCA1_1	48	52	PF00533	0.664
LIG_Clathr_ClatBox_1	255	259	PF01394	0.536
LIG_Clathr_ClatBox_1	396	400	PF01394	0.631
LIG_CtBP_PxDLS_1	334	338	PF00389	0.585
LIG_FHA_1	119	125	PF00498	0.694
LIG_FHA_1	16	22	PF00498	0.642
LIG_FHA_1	272	278	PF00498	0.591
LIG_FHA_1	381	387	PF00498	0.722
LIG_FHA_1	41	47	PF00498	0.660
LIG_FHA_1	568	574	PF00498	0.769
LIG_FHA_1	577	583	PF00498	0.649
LIG_FHA_2	240	246	PF00498	0.490
LIG_FHA_2	289	295	PF00498	0.753
LIG_FHA_2	296	302	PF00498	0.746
LIG_FHA_2	330	336	PF00498	0.650
LIG_FHA_2	425	431	PF00498	0.680
LIG_FHA_2	497	503	PF00498	0.787
LIG_FHA_2	582	588	PF00498	0.597
LIG_FHA_2	76	82	PF00498	0.656
LIG_Integrin_RGD_1	160	162	PF01839	0.665
LIG_LIR_Apic_2	383	388	PF02991	0.665
LIG_LIR_Gen_1	138	144	PF02991	0.369
LIG_LIR_Gen_1	212	222	PF02991	0.494
LIG_LIR_Gen_1	26	35	PF02991	0.665
LIG_LIR_Gen_1	357	363	PF02991	0.655
LIG_LIR_Gen_1	56	66	PF02991	0.666
LIG_LIR_Gen_1	584	592	PF02991	0.606
LIG_LIR_Nem_3	138	142	PF02991	0.369
LIG_LIR_Nem_3	168	173	PF02991	0.290
LIG_LIR_Nem_3	212	218	PF02991	0.480
LIG_LIR_Nem_3	26	30	PF02991	0.566
LIG_LIR_Nem_3	268	273	PF02991	0.536
LIG_LIR_Nem_3	357	361	PF02991	0.626
LIG_LIR_Nem_3	45	51	PF02991	0.620
LIG_LIR_Nem_3	534	539	PF02991	0.674
LIG_LIR_Nem_3	56	61	PF02991	0.616
LIG_LIR_Nem_3	584	589	PF02991	0.601
LIG_LIR_Nem_3	8	13	PF02991	0.671
LIG_MLH1_MIPbox_1	48	52	PF16413	0.646
LIG_Pex14_2	252	256	PF04695	0.494
LIG_SH2_NCK_1	539	543	PF00017	0.715
LIG_SH2_PTP2	609	612	PF00017	0.645
LIG_SH2_STAP1	144	148	PF00017	0.369
LIG_SH2_STAP1	17	21	PF00017	0.609
LIG_SH2_STAP1	48	52	PF00017	0.646
LIG_SH2_STAP1	586	590	PF00017	0.659
LIG_SH2_STAT5	144	147	PF00017	0.480
LIG_SH2_STAT5	158	161	PF00017	0.329
LIG_SH2_STAT5	17	20	PF00017	0.606
LIG_SH2_STAT5	170	173	PF00017	0.284
LIG_SH2_STAT5	27	30	PF00017	0.564
LIG_SH2_STAT5	276	279	PF00017	0.494
LIG_SH2_STAT5	38	41	PF00017	0.636
LIG_SH2_STAT5	385	388	PF00017	0.647
LIG_SH2_STAT5	51	54	PF00017	0.639
LIG_SH2_STAT5	539	542	PF00017	0.750
LIG_SH2_STAT5	597	600	PF00017	0.591
LIG_SH2_STAT5	609	612	PF00017	0.566
LIG_SH3_3	203	209	PF00018	0.607
LIG_SH3_3	519	525	PF00018	0.669
LIG_SUMO_SIM_anti_2	162	169	PF11976	0.405
LIG_SUMO_SIM_anti_2	395	401	PF11976	0.620
LIG_TRAF2_1	487	490	PF00917	0.750
LIG_TRAF2_1	624	627	PF00917	0.712
LIG_TYR_ITIM	25	30	PF00017	0.489
MOD_CDK_SPxK_1	5	11	PF00069	0.710
MOD_CK1_1	15	21	PF00069	0.538
MOD_CK1_1	204	210	PF00069	0.431
MOD_CK1_1	303	309	PF00069	0.731
MOD_CK1_1	317	323	PF00069	0.716
MOD_CK1_1	41	47	PF00069	0.646
MOD_CK1_1	566	572	PF00069	0.687
MOD_CK1_1	64	70	PF00069	0.618
MOD_CK2_1	329	335	PF00069	0.610
MOD_CK2_1	496	502	PF00069	0.763
MOD_CK2_1	574	580	PF00069	0.606
MOD_CK2_1	581	587	PF00069	0.528
MOD_Cter_Amidation	431	434	PF01082	0.754
MOD_Cter_Amidation	604	607	PF01082	0.588
MOD_GlcNHglycan	1	4	PF01048	0.705
MOD_GlcNHglycan	111	114	PF01048	0.746
MOD_GlcNHglycan	198	201	PF01048	0.592
MOD_GlcNHglycan	305	308	PF01048	0.706
MOD_GlcNHglycan	316	319	PF01048	0.744
MOD_GlcNHglycan	320	323	PF01048	0.655
MOD_GlcNHglycan	453	456	PF01048	0.740
MOD_GlcNHglycan	458	461	PF01048	0.753
MOD_GlcNHglycan	463	466	PF01048	0.677
MOD_GlcNHglycan	472	475	PF01048	0.635
MOD_GlcNHglycan	512	517	PF01048	0.766
MOD_GlcNHglycan	565	568	PF01048	0.628
MOD_GlcNHglycan	627	630	PF01048	0.450
MOD_GlcNHglycan	63	66	PF01048	0.641
MOD_GSK3_1	105	112	PF00069	0.734
MOD_GSK3_1	235	242	PF00069	0.355
MOD_GSK3_1	284	291	PF00069	0.671
MOD_GSK3_1	303	310	PF00069	0.769
MOD_GSK3_1	314	321	PF00069	0.639
MOD_GSK3_1	329	336	PF00069	0.561
MOD_GSK3_1	350	357	PF00069	0.522
MOD_GSK3_1	38	45	PF00069	0.538
MOD_GSK3_1	435	442	PF00069	0.678
MOD_GSK3_1	451	458	PF00069	0.518
MOD_GSK3_1	466	473	PF00069	0.616
MOD_GSK3_1	53	60	PF00069	0.480
MOD_GSK3_1	562	569	PF00069	0.644
MOD_GSK3_1	625	632	PF00069	0.578
MOD_N-GLC_1	401	406	PF02516	0.674
MOD_N-GLC_1	451	456	PF02516	0.766
MOD_NEK2_1	149	154	PF00069	0.385
MOD_NEK2_1	350	355	PF00069	0.452
MOD_NEK2_1	42	47	PF00069	0.524
MOD_NEK2_1	424	429	PF00069	0.633
MOD_NEK2_2	17	22	PF00069	0.623
MOD_NEK2_2	251	256	PF00069	0.389
MOD_NEK2_2	366	371	PF00069	0.654
MOD_OFUCOSY	140	146	PF10250	0.429
MOD_PIKK_1	118	124	PF00454	0.653
MOD_PIKK_1	350	356	PF00454	0.448
MOD_PIKK_1	407	413	PF00454	0.568
MOD_PK_1	53	59	PF00069	0.637
MOD_PKA_1	127	133	PF00069	0.550
MOD_PKA_1	630	636	PF00069	0.659
MOD_PKA_2	278	284	PF00069	0.538
MOD_PKA_2	3	9	PF00069	0.759
MOD_PKA_2	324	330	PF00069	0.703
MOD_PKA_2	574	580	PF00069	0.513
MOD_PKA_2	629	635	PF00069	0.555
MOD_PKB_1	560	568	PF00069	0.517
MOD_Plk_1	244	250	PF00069	0.401
MOD_Plk_1	300	306	PF00069	0.713
MOD_Plk_1	401	407	PF00069	0.627
MOD_Plk_1	424	430	PF00069	0.688
MOD_Plk_1	93	99	PF00069	0.698
MOD_Plk_4	23	29	PF00069	0.605
MOD_Plk_4	251	257	PF00069	0.380
MOD_Plk_4	261	267	PF00069	0.352
MOD_Plk_4	284	290	PF00069	0.636
MOD_Plk_4	42	48	PF00069	0.529
MOD_Plk_4	581	587	PF00069	0.466
MOD_ProDKin_1	105	111	PF00069	0.534
MOD_ProDKin_1	12	18	PF00069	0.475
MOD_ProDKin_1	235	241	PF00069	0.352
MOD_ProDKin_1	439	445	PF00069	0.746
MOD_ProDKin_1	5	11	PF00069	0.620
MOD_ProDKin_1	59	65	PF00069	0.553
MOD_SUMO_for_1	91	94	PF00179	0.652
MOD_SUMO_rev_2	632	642	PF00179	0.459
TRG_DiLeu_BaEn_2	345	351	PF01217	0.500
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.613
TRG_ENDOCYTIC_2	27	30	PF00928	0.580
TRG_ENDOCYTIC_2	586	589	PF00928	0.533
TRG_ENDOCYTIC_2	609	612	PF00928	0.561
TRG_ER_diArg_1	370	372	PF00400	0.658
TRG_ER_diArg_1	52	55	PF00400	0.553
TRG_ER_diArg_1	559	562	PF00400	0.633
TRG_ER_diArg_1	606	608	PF00400	0.600
TRG_NES_CRM1_1	389	401	PF08389	0.601
TRG_NLS_Bipartite_1	606	626	PF00514	0.533
TRG_NLS_MonoExtC_3	621	627	PF00514	0.601
TRG_NLS_MonoExtN_4	620	626	PF00514	0.604
TRG_Pf-PMV_PEXEL_1	368	373	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3U3	Leptomonas seymouri	60%	100%
A0A0S4ITV1	Bodo saltans	32%	100%
A0A3Q8IPN5	Leishmania donovani	94%	100%
A4HQ46	Leishmania braziliensis	80%	100%
A4IC82	Leishmania infantum	94%	100%
D0A8R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ATW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B6S7	Trypanosoma cruzi	43%	100%