Anaphase-promoting complex subunit 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0M9_LEIMA

TriTrypDb:

LmjF.36.5330 , LMJLV39_360065500 , LMJSD75_360065200

Length:

1073

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0M9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0M9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1058	1062	PF00656	0.621
CLV_C14_Caspase3-7	228	232	PF00656	0.705
CLV_C14_Caspase3-7	330	334	PF00656	0.600
CLV_C14_Caspase3-7	861	865	PF00656	0.669
CLV_MEL_PAP_1	114	120	PF00089	0.583
CLV_NRD_NRD_1	388	390	PF00675	0.622
CLV_NRD_NRD_1	493	495	PF00675	0.636
CLV_NRD_NRD_1	515	517	PF00675	0.590
CLV_NRD_NRD_1	590	592	PF00675	0.668
CLV_NRD_NRD_1	636	638	PF00675	0.632
CLV_NRD_NRD_1	725	727	PF00675	0.639
CLV_NRD_NRD_1	748	750	PF00675	0.690
CLV_NRD_NRD_1	886	888	PF00675	0.609
CLV_NRD_NRD_1	923	925	PF00675	0.756
CLV_NRD_NRD_1	961	963	PF00675	0.712
CLV_PCSK_FUR_1	386	390	PF00082	0.637
CLV_PCSK_KEX2_1	1016	1018	PF00082	0.755
CLV_PCSK_KEX2_1	175	177	PF00082	0.724
CLV_PCSK_KEX2_1	388	390	PF00082	0.622
CLV_PCSK_KEX2_1	493	495	PF00082	0.593
CLV_PCSK_KEX2_1	515	517	PF00082	0.590
CLV_PCSK_KEX2_1	590	592	PF00082	0.735
CLV_PCSK_KEX2_1	636	638	PF00082	0.684
CLV_PCSK_KEX2_1	725	727	PF00082	0.695
CLV_PCSK_KEX2_1	747	749	PF00082	0.646
CLV_PCSK_KEX2_1	831	833	PF00082	0.500
CLV_PCSK_KEX2_1	961	963	PF00082	0.712
CLV_PCSK_PC1ET2_1	1016	1018	PF00082	0.755
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.809
CLV_PCSK_PC1ET2_1	831	833	PF00082	0.563
CLV_PCSK_SKI1_1	194	198	PF00082	0.734
CLV_PCSK_SKI1_1	474	478	PF00082	0.635
CLV_PCSK_SKI1_1	494	498	PF00082	0.601
CLV_PCSK_SKI1_1	674	678	PF00082	0.566
CLV_PCSK_SKI1_1	814	818	PF00082	0.569
DEG_APCC_DBOX_1	473	481	PF00400	0.647
DEG_APCC_DBOX_1	813	821	PF00400	0.619
DEG_SCF_FBW7_1	364	371	PF00400	0.541
DEG_SPOP_SBC_1	107	111	PF00917	0.604
DEG_SPOP_SBC_1	232	236	PF00917	0.685
DEG_SPOP_SBC_1	479	483	PF00917	0.628
DEG_SPOP_SBC_1	895	899	PF00917	0.644
DOC_CKS1_1	58	63	PF01111	0.752
DOC_CYCLIN_yCln2_LP_2	576	582	PF00134	0.737
DOC_CYCLIN_yCln2_LP_2	763	769	PF00134	0.576
DOC_MAPK_gen_1	386	393	PF00069	0.616
DOC_MAPK_gen_1	515	522	PF00069	0.586
DOC_MAPK_gen_1	747	753	PF00069	0.691
DOC_MAPK_HePTP_8	751	763	PF00069	0.512
DOC_MAPK_JIP1_4	862	868	PF00069	0.632
DOC_MAPK_MEF2A_6	515	522	PF00069	0.586
DOC_MAPK_MEF2A_6	754	763	PF00069	0.513
DOC_MAPK_MEF2A_6	990	998	PF00069	0.638
DOC_PP1_RVXF_1	491	498	PF00149	0.614
DOC_PP2B_LxvP_1	340	343	PF13499	0.548
DOC_PP4_FxxP_1	358	361	PF00568	0.634
DOC_PP4_FxxP_1	784	787	PF00568	0.612
DOC_USP7_MATH_1	155	159	PF00917	0.732
DOC_USP7_MATH_1	180	184	PF00917	0.818
DOC_USP7_MATH_1	216	220	PF00917	0.822
DOC_USP7_MATH_1	225	229	PF00917	0.689
DOC_USP7_MATH_1	232	236	PF00917	0.548
DOC_USP7_MATH_1	240	244	PF00917	0.649
DOC_USP7_MATH_1	246	250	PF00917	0.686
DOC_USP7_MATH_1	28	32	PF00917	0.748
DOC_USP7_MATH_1	479	483	PF00917	0.643
DOC_USP7_MATH_1	582	586	PF00917	0.674
DOC_USP7_MATH_1	665	669	PF00917	0.742
DOC_USP7_MATH_1	681	685	PF00917	0.659
DOC_USP7_MATH_1	697	701	PF00917	0.523
DOC_USP7_MATH_1	73	77	PF00917	0.548
DOC_USP7_MATH_1	857	861	PF00917	0.678
DOC_USP7_MATH_1	889	893	PF00917	0.660
DOC_USP7_MATH_1	895	899	PF00917	0.700
DOC_USP7_MATH_1	964	968	PF00917	0.709
DOC_USP7_MATH_2	285	291	PF00917	0.742
DOC_USP7_UBL2_3	182	186	PF12436	0.750
DOC_USP7_UBL2_3	190	194	PF12436	0.713
DOC_WW_Pin1_4	1034	1039	PF00397	0.707
DOC_WW_Pin1_4	153	158	PF00397	0.713
DOC_WW_Pin1_4	289	294	PF00397	0.583
DOC_WW_Pin1_4	364	369	PF00397	0.562
DOC_WW_Pin1_4	392	397	PF00397	0.467
DOC_WW_Pin1_4	405	410	PF00397	0.667
DOC_WW_Pin1_4	487	492	PF00397	0.616
DOC_WW_Pin1_4	57	62	PF00397	0.678
DOC_WW_Pin1_4	783	788	PF00397	0.638
DOC_WW_Pin1_4	939	944	PF00397	0.619
LIG_14-3-3_CanoR_1	125	134	PF00244	0.555
LIG_14-3-3_CanoR_1	143	151	PF00244	0.528
LIG_14-3-3_CanoR_1	48	54	PF00244	0.607
LIG_14-3-3_CanoR_1	539	547	PF00244	0.688
LIG_14-3-3_CanoR_1	725	729	PF00244	0.724
LIG_14-3-3_CanoR_1	814	822	PF00244	0.616
LIG_14-3-3_CanoR_1	858	866	PF00244	0.736
LIG_Actin_WH2_2	384	402	PF00022	0.545
LIG_BRCT_BRCA1_1	681	685	PF00533	0.713
LIG_eIF4E_1	503	509	PF01652	0.595
LIG_FHA_1	100	106	PF00498	0.549
LIG_FHA_1	1047	1053	PF00498	0.639
LIG_FHA_1	108	114	PF00498	0.512
LIG_FHA_1	281	287	PF00498	0.856
LIG_FHA_1	335	341	PF00498	0.697
LIG_FHA_1	369	375	PF00498	0.718
LIG_FHA_1	419	425	PF00498	0.620
LIG_FHA_1	603	609	PF00498	0.557
LIG_FHA_1	716	722	PF00498	0.634
LIG_FHA_1	89	95	PF00498	0.700
LIG_FHA_1	975	981	PF00498	0.508
LIG_FHA_2	303	309	PF00498	0.555
LIG_FHA_2	543	549	PF00498	0.697
LIG_FHA_2	850	856	PF00498	0.707
LIG_FHA_2	859	865	PF00498	0.662
LIG_FHA_2	903	909	PF00498	0.727
LIG_FHA_2	945	951	PF00498	0.441
LIG_LIR_Apic_2	782	787	PF02991	0.607
LIG_LIR_Gen_1	303	312	PF02991	0.578
LIG_LIR_Gen_1	561	570	PF02991	0.639
LIG_LIR_LC3C_4	110	115	PF02991	0.567
LIG_LIR_Nem_3	303	307	PF02991	0.578
LIG_LIR_Nem_3	561	566	PF02991	0.630
LIG_LIR_Nem_3	682	688	PF02991	0.643
LIG_LIR_Nem_3	796	802	PF02991	0.575
LIG_NRBOX	54	60	PF00104	0.669
LIG_SH2_CRK	705	709	PF00017	0.524
LIG_SH2_GRB2like	835	838	PF00017	0.591
LIG_SH2_STAP1	420	424	PF00017	0.673
LIG_SH2_STAP1	563	567	PF00017	0.625
LIG_SH2_STAP1	688	692	PF00017	0.643
LIG_SH2_STAT5	1046	1049	PF00017	0.611
LIG_SH2_STAT5	304	307	PF00017	0.555
LIG_SH2_STAT5	420	423	PF00017	0.681
LIG_SH2_STAT5	54	57	PF00017	0.650
LIG_SH2_STAT5	750	753	PF00017	0.536
LIG_SH2_STAT5	833	836	PF00017	0.635
LIG_SH3_3	1018	1024	PF00018	0.805
LIG_SH3_3	419	425	PF00018	0.550
LIG_SH3_3	450	456	PF00018	0.727
LIG_SH3_3	461	467	PF00018	0.481
LIG_SH3_3	909	915	PF00018	0.780
LIG_SH3_3	94	100	PF00018	0.628
LIG_SH3_4	190	197	PF00018	0.740
LIG_SUMO_SIM_anti_2	310	316	PF11976	0.478
LIG_SUMO_SIM_anti_2	457	462	PF11976	0.626
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.657
LIG_SUMO_SIM_par_1	310	316	PF11976	0.478
LIG_SUMO_SIM_par_1	389	395	PF11976	0.518
LIG_SUMO_SIM_par_1	420	426	PF11976	0.633
LIG_SUMO_SIM_par_1	624	630	PF11976	0.717
LIG_SxIP_EBH_1	725	735	PF03271	0.509
LIG_TYR_ITIM	302	307	PF00017	0.614
LIG_WW_1	342	345	PF00397	0.552
LIG_WW_3	587	591	PF00397	0.675
MOD_CDC14_SPxK_1	490	493	PF00782	0.596
MOD_CDK_SPxK_1	487	493	PF00069	0.612
MOD_CDK_SPxxK_3	153	160	PF00069	0.706
MOD_CDK_SPxxK_3	487	494	PF00069	0.611
MOD_CK1_1	1001	1007	PF00069	0.657
MOD_CK1_1	1026	1032	PF00069	0.627
MOD_CK1_1	1034	1040	PF00069	0.629
MOD_CK1_1	145	151	PF00069	0.714
MOD_CK1_1	212	218	PF00069	0.754
MOD_CK1_1	224	230	PF00069	0.761
MOD_CK1_1	233	239	PF00069	0.793
MOD_CK1_1	249	255	PF00069	0.759
MOD_CK1_1	262	268	PF00069	0.766
MOD_CK1_1	377	383	PF00069	0.708
MOD_CK1_1	426	432	PF00069	0.613
MOD_CK1_1	481	487	PF00069	0.669
MOD_CK1_1	542	548	PF00069	0.710
MOD_CK1_1	627	633	PF00069	0.716
MOD_CK1_1	668	674	PF00069	0.722
MOD_CK1_1	786	792	PF00069	0.614
MOD_CK1_1	897	903	PF00069	0.691
MOD_CK1_1	944	950	PF00069	0.608
MOD_CK1_1	975	981	PF00069	0.706
MOD_CK2_1	153	159	PF00069	0.709
MOD_CK2_1	258	264	PF00069	0.720
MOD_CK2_1	479	485	PF00069	0.634
MOD_CK2_1	540	546	PF00069	0.730
MOD_CK2_1	558	564	PF00069	0.688
MOD_CK2_1	73	79	PF00069	0.695
MOD_CK2_1	849	855	PF00069	0.678
MOD_CK2_1	9	15	PF00069	0.744
MOD_CK2_1	944	950	PF00069	0.574
MOD_CMANNOS	797	800	PF00535	0.559
MOD_Cter_Amidation	173	176	PF01082	0.744
MOD_GlcNHglycan	1031	1034	PF01048	0.596
MOD_GlcNHglycan	11	14	PF01048	0.653
MOD_GlcNHglycan	144	147	PF01048	0.671
MOD_GlcNHglycan	218	221	PF01048	0.798
MOD_GlcNHglycan	222	226	PF01048	0.779
MOD_GlcNHglycan	235	238	PF01048	0.800
MOD_GlcNHglycan	251	254	PF01048	0.767
MOD_GlcNHglycan	264	267	PF01048	0.797
MOD_GlcNHglycan	271	274	PF01048	0.610
MOD_GlcNHglycan	289	292	PF01048	0.777
MOD_GlcNHglycan	30	33	PF01048	0.436
MOD_GlcNHglycan	464	467	PF01048	0.578
MOD_GlcNHglycan	485	488	PF01048	0.635
MOD_GlcNHglycan	571	574	PF01048	0.569
MOD_GlcNHglycan	602	605	PF01048	0.656
MOD_GlcNHglycan	655	659	PF01048	0.789
MOD_GlcNHglycan	667	671	PF01048	0.634
MOD_GlcNHglycan	777	780	PF01048	0.727
MOD_GlcNHglycan	855	858	PF01048	0.709
MOD_GlcNHglycan	962	965	PF01048	0.665
MOD_GlcNHglycan	967	970	PF01048	0.718
MOD_GSK3_1	1019	1026	PF00069	0.694
MOD_GSK3_1	181	188	PF00069	0.794
MOD_GSK3_1	190	197	PF00069	0.690
MOD_GSK3_1	211	218	PF00069	0.839
MOD_GSK3_1	221	228	PF00069	0.771
MOD_GSK3_1	231	238	PF00069	0.767
MOD_GSK3_1	240	247	PF00069	0.752
MOD_GSK3_1	258	265	PF00069	0.814
MOD_GSK3_1	364	371	PF00069	0.618
MOD_GSK3_1	425	432	PF00069	0.666
MOD_GSK3_1	479	486	PF00069	0.642
MOD_GSK3_1	668	675	PF00069	0.641
MOD_GSK3_1	692	699	PF00069	0.656
MOD_GSK3_1	73	80	PF00069	0.691
MOD_GSK3_1	733	740	PF00069	0.670
MOD_GSK3_1	775	782	PF00069	0.711
MOD_GSK3_1	836	843	PF00069	0.691
MOD_GSK3_1	849	856	PF00069	0.760
MOD_GSK3_1	890	897	PF00069	0.696
MOD_GSK3_1	941	948	PF00069	0.647
MOD_GSK3_1	956	963	PF00069	0.563
MOD_GSK3_1	972	979	PF00069	0.708
MOD_GSK3_1	998	1005	PF00069	0.738
MOD_N-GLC_1	216	221	PF02516	0.767
MOD_N-GLC_1	327	332	PF02516	0.660
MOD_N-GLC_1	410	415	PF02516	0.570
MOD_N-GLC_1	540	545	PF02516	0.732
MOD_N-GLC_1	836	841	PF02516	0.643
MOD_N-GLC_1	889	894	PF02516	0.683
MOD_N-GLC_1	972	977	PF02516	0.705
MOD_NEK2_1	1031	1036	PF00069	0.637
MOD_NEK2_1	313	318	PF00069	0.611
MOD_NEK2_1	374	379	PF00069	0.716
MOD_NEK2_1	767	772	PF00069	0.639
MOD_NEK2_1	793	798	PF00069	0.570
MOD_NEK2_1	820	825	PF00069	0.543
MOD_NEK2_1	953	958	PF00069	0.559
MOD_NEK2_1	998	1003	PF00069	0.632
MOD_NEK2_2	181	186	PF00069	0.640
MOD_NEK2_2	49	54	PF00069	0.647
MOD_NEK2_2	558	563	PF00069	0.616
MOD_NEK2_2	63	68	PF00069	0.702
MOD_NEK2_2	681	686	PF00069	0.655
MOD_NEK2_2	842	847	PF00069	0.722
MOD_OFUCOSY	988	993	PF10250	0.591
MOD_PIKK_1	890	896	PF00454	0.754
MOD_PK_1	1017	1023	PF00069	0.696
MOD_PKA_2	116	122	PF00069	0.515
MOD_PKA_2	142	148	PF00069	0.660
MOD_PKA_2	249	255	PF00069	0.825
MOD_PKA_2	439	445	PF00069	0.589
MOD_PKA_2	724	730	PF00069	0.729
MOD_PKA_2	767	773	PF00069	0.520
MOD_PKA_2	857	863	PF00069	0.732
MOD_PKA_2	960	966	PF00069	0.622
MOD_PKA_2	989	995	PF00069	0.627
MOD_Plk_1	1017	1023	PF00069	0.730
MOD_Plk_1	302	308	PF00069	0.607
MOD_Plk_1	410	416	PF00069	0.585
MOD_Plk_1	558	564	PF00069	0.584
MOD_Plk_1	654	660	PF00069	0.810
MOD_Plk_1	836	842	PF00069	0.647
MOD_Plk_1	953	959	PF00069	0.632
MOD_Plk_1	975	981	PF00069	0.549
MOD_Plk_2-3	297	303	PF00069	0.620
MOD_Plk_2-3	77	83	PF00069	0.669
MOD_Plk_4	1026	1032	PF00069	0.619
MOD_Plk_4	1037	1043	PF00069	0.591
MOD_Plk_4	266	272	PF00069	0.840
MOD_Plk_4	297	303	PF00069	0.672
MOD_Plk_4	49	55	PF00069	0.719
MOD_Plk_4	558	564	PF00069	0.674
MOD_Plk_4	668	674	PF00069	0.616
MOD_Plk_4	681	687	PF00069	0.562
MOD_Plk_4	779	785	PF00069	0.752
MOD_Plk_4	89	95	PF00069	0.480
MOD_Plk_4	941	947	PF00069	0.649
MOD_ProDKin_1	1034	1040	PF00069	0.706
MOD_ProDKin_1	153	159	PF00069	0.713
MOD_ProDKin_1	289	295	PF00069	0.579
MOD_ProDKin_1	364	370	PF00069	0.567
MOD_ProDKin_1	392	398	PF00069	0.469
MOD_ProDKin_1	405	411	PF00069	0.668
MOD_ProDKin_1	487	493	PF00069	0.612
MOD_ProDKin_1	57	63	PF00069	0.679
MOD_ProDKin_1	783	789	PF00069	0.631
MOD_ProDKin_1	939	945	PF00069	0.612
TRG_DiLeu_BaEn_1	640	645	PF01217	0.729
TRG_DiLeu_BaLyEn_6	576	581	PF01217	0.630
TRG_DiLeu_BaLyEn_6	798	803	PF01217	0.637
TRG_DiLeu_BaLyEn_6	992	997	PF01217	0.650
TRG_ENDOCYTIC_2	304	307	PF00928	0.539
TRG_ENDOCYTIC_2	563	566	PF00928	0.645
TRG_ENDOCYTIC_2	688	691	PF00928	0.640
TRG_ENDOCYTIC_2	705	708	PF00928	0.587
TRG_ENDOCYTIC_2	750	753	PF00928	0.531
TRG_ENDOCYTIC_2	835	838	PF00928	0.547
TRG_ER_diArg_1	1063	1066	PF00400	0.642
TRG_ER_diArg_1	386	389	PF00400	0.645
TRG_ER_diArg_1	471	474	PF00400	0.521
TRG_ER_diArg_1	493	495	PF00400	0.631
TRG_ER_diArg_1	514	516	PF00400	0.667
TRG_ER_diArg_1	589	591	PF00400	0.742
TRG_ER_diArg_1	635	637	PF00400	0.675
TRG_ER_diArg_1	724	726	PF00400	0.645
TRG_ER_diArg_1	747	749	PF00400	0.717
TRG_NLS_MonoExtN_4	172	179	PF00514	0.706
TRG_Pf-PMV_PEXEL_1	636	640	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P433	Leptomonas seymouri	43%	95%
A0A3Q8IJY6	Leishmania donovani	93%	100%
A4HQ47	Leishmania braziliensis	75%	100%
A4IC75	Leishmania infantum	92%	100%
D0A8R3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9ATW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%