RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0M8_LEIMA

TriTrypDb:

LmjF.36.5340 , LMJLV39_360065600 , LMJSD75_360065300

Length:

869

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0M8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	489	493	PF00656	0.530
CLV_C14_Caspase3-7	783	787	PF00656	0.598
CLV_NRD_NRD_1	124	126	PF00675	0.424
CLV_NRD_NRD_1	158	160	PF00675	0.619
CLV_NRD_NRD_1	257	259	PF00675	0.481
CLV_NRD_NRD_1	303	305	PF00675	0.524
CLV_NRD_NRD_1	435	437	PF00675	0.513
CLV_NRD_NRD_1	53	55	PF00675	0.482
CLV_NRD_NRD_1	531	533	PF00675	0.536
CLV_NRD_NRD_1	613	615	PF00675	0.534
CLV_NRD_NRD_1	726	728	PF00675	0.489
CLV_NRD_NRD_1	733	735	PF00675	0.489
CLV_NRD_NRD_1	75	77	PF00675	0.466
CLV_PCSK_KEX2_1	124	126	PF00082	0.424
CLV_PCSK_KEX2_1	283	285	PF00082	0.467
CLV_PCSK_KEX2_1	291	293	PF00082	0.463
CLV_PCSK_KEX2_1	303	305	PF00082	0.330
CLV_PCSK_KEX2_1	500	502	PF00082	0.586
CLV_PCSK_KEX2_1	613	615	PF00082	0.445
CLV_PCSK_KEX2_1	655	657	PF00082	0.421
CLV_PCSK_KEX2_1	715	717	PF00082	0.501
CLV_PCSK_KEX2_1	726	728	PF00082	0.489
CLV_PCSK_KEX2_1	733	735	PF00082	0.489
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.467
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.463
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.538
CLV_PCSK_PC1ET2_1	655	657	PF00082	0.397
CLV_PCSK_PC1ET2_1	715	717	PF00082	0.417
CLV_PCSK_PC7_1	279	285	PF00082	0.463
CLV_PCSK_SKI1_1	413	417	PF00082	0.492
CLV_PCSK_SKI1_1	439	443	PF00082	0.490
CLV_PCSK_SKI1_1	484	488	PF00082	0.511
CLV_PCSK_SKI1_1	54	58	PF00082	0.441
CLV_PCSK_SKI1_1	672	676	PF00082	0.575
CLV_Separin_Metazoa	27	31	PF03568	0.596
DEG_APCC_DBOX_1	487	495	PF00400	0.618
DEG_APCC_DBOX_1	67	75	PF00400	0.508
DOC_CYCLIN_RxL_1	326	336	PF00134	0.548
DOC_CYCLIN_RxL_1	721	732	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	737	743	PF00134	0.540
DOC_MAPK_gen_1	392	399	PF00069	0.554
DOC_MAPK_gen_1	4	15	PF00069	0.576
DOC_MAPK_gen_1	645	653	PF00069	0.522
DOC_MAPK_gen_1	696	704	PF00069	0.538
DOC_MAPK_gen_1	733	741	PF00069	0.482
DOC_MAPK_MEF2A_6	263	270	PF00069	0.450
DOC_MAPK_MEF2A_6	329	337	PF00069	0.436
DOC_MAPK_MEF2A_6	392	399	PF00069	0.550
DOC_MAPK_MEF2A_6	696	704	PF00069	0.538
DOC_MAPK_MEF2A_6	733	741	PF00069	0.482
DOC_MIT_MIM_1	421	430	PF04212	0.432
DOC_PP2B_LxvP_1	737	740	PF13499	0.528
DOC_USP7_MATH_1	215	219	PF00917	0.651
DOC_USP7_MATH_1	309	313	PF00917	0.615
DOC_USP7_MATH_1	776	780	PF00917	0.617
DOC_USP7_MATH_1	828	832	PF00917	0.617
DOC_USP7_MATH_1	9	13	PF00917	0.572
DOC_USP7_UBL2_3	259	263	PF12436	0.546
DOC_USP7_UBL2_3	409	413	PF12436	0.570
DOC_WW_Pin1_4	816	821	PF00397	0.663
LIG_14-3-3_CanoR_1	139	147	PF00244	0.556
LIG_14-3-3_CanoR_1	214	223	PF00244	0.636
LIG_14-3-3_CanoR_1	242	250	PF00244	0.671
LIG_14-3-3_CanoR_1	310	318	PF00244	0.638
LIG_14-3-3_CanoR_1	515	523	PF00244	0.561
LIG_14-3-3_CanoR_1	672	681	PF00244	0.583
LIG_14-3-3_CanoR_1	68	72	PF00244	0.452
LIG_14-3-3_CanoR_1	690	696	PF00244	0.306
LIG_14-3-3_CanoR_1	727	737	PF00244	0.538
LIG_14-3-3_CanoR_1	770	775	PF00244	0.666
LIG_14-3-3_CanoR_1	8	14	PF00244	0.621
LIG_Actin_WH2_2	126	141	PF00022	0.631
LIG_CaM_IQ_9	682	698	PF13499	0.505
LIG_FHA_1	102	108	PF00498	0.589
LIG_FHA_1	128	134	PF00498	0.487
LIG_FHA_1	227	233	PF00498	0.571
LIG_FHA_1	442	448	PF00498	0.427
LIG_FHA_1	468	474	PF00498	0.526
LIG_FHA_1	539	545	PF00498	0.536
LIG_FHA_1	568	574	PF00498	0.530
LIG_FHA_1	586	592	PF00498	0.380
LIG_FHA_1	680	686	PF00498	0.547
LIG_FHA_1	697	703	PF00498	0.574
LIG_FHA_1	770	776	PF00498	0.646
LIG_FHA_1	797	803	PF00498	0.701
LIG_FHA_1	806	812	PF00498	0.667
LIG_FHA_1	817	823	PF00498	0.660
LIG_FHA_2	244	250	PF00498	0.669
LIG_FHA_2	271	277	PF00498	0.500
LIG_FHA_2	338	344	PF00498	0.632
LIG_FHA_2	402	408	PF00498	0.503
LIG_FHA_2	414	420	PF00498	0.523
LIG_FHA_2	476	482	PF00498	0.594
LIG_FHA_2	516	522	PF00498	0.623
LIG_FHA_2	68	74	PF00498	0.457
LIG_FHA_2	692	698	PF00498	0.554
LIG_FHA_2	849	855	PF00498	0.628
LIG_GBD_Chelix_1	267	275	PF00786	0.478
LIG_LIR_Apic_2	755	759	PF02991	0.564
LIG_LIR_Gen_1	162	171	PF02991	0.490
LIG_LIR_Gen_1	440	450	PF02991	0.426
LIG_LIR_Gen_1	504	514	PF02991	0.561
LIG_LIR_Gen_1	760	768	PF02991	0.505
LIG_LIR_Nem_3	162	168	PF02991	0.495
LIG_LIR_Nem_3	440	445	PF02991	0.428
LIG_LIR_Nem_3	50	56	PF02991	0.447
LIG_LIR_Nem_3	504	509	PF02991	0.555
LIG_LIR_Nem_3	732	738	PF02991	0.625
LIG_LIR_Nem_3	760	765	PF02991	0.580
LIG_PCNA_yPIPBox_3	304	318	PF02747	0.456
LIG_PDZ_Class_1	864	869	PF00595	0.592
LIG_Pex14_1	161	165	PF04695	0.504
LIG_PTB_Apo_2	537	544	PF02174	0.434
LIG_PTB_Phospho_1	537	543	PF10480	0.464
LIG_SH2_CRK	165	169	PF00017	0.541
LIG_SH2_CRK	671	675	PF00017	0.469
LIG_SH2_CRK	735	739	PF00017	0.533
LIG_SH2_CRK	762	766	PF00017	0.502
LIG_SH2_GRB2like	543	546	PF00017	0.453
LIG_SH2_PTP2	756	759	PF00017	0.491
LIG_SH2_SRC	543	546	PF00017	0.453
LIG_SH2_SRC	756	759	PF00017	0.624
LIG_SH2_STAT3	768	771	PF00017	0.588
LIG_SH2_STAT5	537	540	PF00017	0.557
LIG_SH2_STAT5	543	546	PF00017	0.538
LIG_SH2_STAT5	752	755	PF00017	0.658
LIG_SH2_STAT5	756	759	PF00017	0.630
LIG_SH3_3	819	825	PF00018	0.621
LIG_SUMO_SIM_anti_2	224	234	PF11976	0.579
LIG_SUMO_SIM_anti_2	443	449	PF11976	0.426
LIG_TRAF2_1	153	156	PF00917	0.532
LIG_TRAF2_1	171	174	PF00917	0.454
LIG_TRAF2_1	207	210	PF00917	0.774
LIG_TRAF2_1	453	456	PF00917	0.502
LIG_TRAF2_1	493	496	PF00917	0.514
LIG_TRAF2_1	519	522	PF00917	0.625
LIG_TRAF2_1	717	720	PF00917	0.588
LIG_TRAF2_1	810	813	PF00917	0.630
MOD_CK1_1	312	318	PF00069	0.570
MOD_CK1_1	422	428	PF00069	0.543
MOD_CK1_1	556	562	PF00069	0.457
MOD_CK1_1	585	591	PF00069	0.478
MOD_CK1_1	593	599	PF00069	0.414
MOD_CK1_1	830	836	PF00069	0.677
MOD_CK1_1	843	849	PF00069	0.673
MOD_CK2_1	221	227	PF00069	0.541
MOD_CK2_1	243	249	PF00069	0.614
MOD_CK2_1	270	276	PF00069	0.442
MOD_CK2_1	337	343	PF00069	0.534
MOD_CK2_1	413	419	PF00069	0.512
MOD_CK2_1	475	481	PF00069	0.538
MOD_CK2_1	490	496	PF00069	0.466
MOD_CK2_1	515	521	PF00069	0.614
MOD_CK2_1	67	73	PF00069	0.452
MOD_GlcNHglycan	120	123	PF01048	0.434
MOD_GlcNHglycan	217	220	PF01048	0.720
MOD_GlcNHglycan	311	314	PF01048	0.490
MOD_GlcNHglycan	321	324	PF01048	0.407
MOD_GlcNHglycan	458	461	PF01048	0.535
MOD_GlcNHglycan	595	598	PF01048	0.483
MOD_GSK3_1	270	277	PF00069	0.509
MOD_GSK3_1	343	350	PF00069	0.355
MOD_GSK3_1	373	380	PF00069	0.580
MOD_GSK3_1	472	479	PF00069	0.609
MOD_GSK3_1	486	493	PF00069	0.404
MOD_GSK3_1	510	517	PF00069	0.716
MOD_GSK3_1	556	563	PF00069	0.511
MOD_GSK3_1	776	783	PF00069	0.675
MOD_GSK3_1	826	833	PF00069	0.648
MOD_GSK3_1	840	847	PF00069	0.692
MOD_N-GLC_1	690	695	PF02516	0.485
MOD_N-GLC_1	777	782	PF02516	0.730
MOD_N-GLC_1	840	845	PF02516	0.743
MOD_NEK2_1	133	138	PF00069	0.515
MOD_NEK2_1	494	499	PF00069	0.619
MOD_NEK2_1	558	563	PF00069	0.603
MOD_NEK2_1	67	72	PF00069	0.358
MOD_NEK2_1	87	92	PF00069	0.428
MOD_PIKK_1	133	139	PF00454	0.518
MOD_PIKK_1	140	146	PF00454	0.460
MOD_PIKK_1	270	276	PF00454	0.442
MOD_PIKK_1	582	588	PF00454	0.645
MOD_PIKK_1	590	596	PF00454	0.429
MOD_PK_1	454	460	PF00069	0.408
MOD_PK_1	840	846	PF00069	0.622
MOD_PKA_1	532	538	PF00069	0.526
MOD_PKA_2	138	144	PF00069	0.590
MOD_PKA_2	309	315	PF00069	0.530
MOD_PKA_2	514	520	PF00069	0.556
MOD_PKA_2	626	632	PF00069	0.625
MOD_PKA_2	67	73	PF00069	0.558
MOD_PKA_2	769	775	PF00069	0.558
MOD_PKA_2	826	832	PF00069	0.688
MOD_PKA_2	844	850	PF00069	0.704
MOD_PKB_1	525	533	PF00069	0.500
MOD_Plk_1	133	139	PF00069	0.518
MOD_Plk_1	226	232	PF00069	0.657
MOD_Plk_1	361	367	PF00069	0.534
MOD_Plk_1	690	696	PF00069	0.487
MOD_Plk_1	840	846	PF00069	0.622
MOD_Plk_2-3	343	349	PF00069	0.516
MOD_Plk_2-3	490	496	PF00069	0.481
MOD_Plk_4	226	232	PF00069	0.685
MOD_Plk_4	538	544	PF00069	0.528
MOD_Plk_4	752	758	PF00069	0.562
MOD_Plk_4	770	776	PF00069	0.426
MOD_Plk_4	844	850	PF00069	0.690
MOD_ProDKin_1	816	822	PF00069	0.664
MOD_SUMO_for_1	359	362	PF00179	0.520
MOD_SUMO_for_1	453	456	PF00179	0.506
MOD_SUMO_for_1	631	634	PF00179	0.405
MOD_SUMO_rev_2	174	180	PF00179	0.635
MOD_SUMO_rev_2	255	264	PF00179	0.472
MOD_SUMO_rev_2	276	285	PF00179	0.456
MOD_SUMO_rev_2	403	410	PF00179	0.461
MOD_SUMO_rev_2	73	78	PF00179	0.505
TRG_DiLeu_BaEn_1	228	233	PF01217	0.551
TRG_DiLeu_BaEn_1	262	267	PF01217	0.545
TRG_DiLeu_BaEn_1	44	49	PF01217	0.479
TRG_DiLeu_BaEn_1	52	57	PF01217	0.434
TRG_DiLeu_BaEn_1	719	724	PF01217	0.554
TRG_DiLeu_BaEn_4	521	527	PF01217	0.559
TRG_DiLeu_BaLyEn_6	733	738	PF01217	0.535
TRG_ENDOCYTIC_2	165	168	PF00928	0.508
TRG_ENDOCYTIC_2	506	509	PF00928	0.601
TRG_ENDOCYTIC_2	671	674	PF00928	0.480
TRG_ENDOCYTIC_2	735	738	PF00928	0.569
TRG_ENDOCYTIC_2	762	765	PF00928	0.501
TRG_ER_diArg_1	123	125	PF00400	0.426
TRG_ER_diArg_1	302	304	PF00400	0.551
TRG_ER_diArg_1	612	614	PF00400	0.511
TRG_ER_diArg_1	726	728	PF00400	0.489
TRG_ER_diArg_1	733	735	PF00400	0.489
TRG_NES_CRM1_1	96	111	PF08389	0.452
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	329	334	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	613	617	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	645	650	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	672	676	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	746	750	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ64	Leptomonas seymouri	52%	100%
A0A1X0P393	Trypanosomatidae	34%	100%
A0A3S7XBY8	Leishmania donovani	93%	100%
A0A422NT20	Trypanosoma rangeli	34%	100%
A4HQ48	Leishmania braziliensis	77%	100%
A4IC76	Leishmania infantum	93%	100%
D0A8R1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ATW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%