WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0M5_LEIMA

TriTrypDb:

LmjF.36.5365 , LMJSD75_360065600

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0M5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.587
CLV_C14_Caspase3-7	395	399	PF00656	0.528
CLV_NRD_NRD_1	298	300	PF00675	0.696
CLV_NRD_NRD_1	334	336	PF00675	0.442
CLV_NRD_NRD_1	400	402	PF00675	0.474
CLV_NRD_NRD_1	76	78	PF00675	0.593
CLV_PCSK_FUR_1	30	34	PF00082	0.527
CLV_PCSK_KEX2_1	14	16	PF00082	0.740
CLV_PCSK_KEX2_1	298	300	PF00082	0.675
CLV_PCSK_KEX2_1	32	34	PF00082	0.619
CLV_PCSK_KEX2_1	336	338	PF00082	0.495
CLV_PCSK_KEX2_1	400	402	PF00082	0.474
CLV_PCSK_KEX2_1	76	78	PF00082	0.593
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.703
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.588
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.495
CLV_PCSK_SKI1_1	15	19	PF00082	0.609
CLV_PCSK_SKI1_1	162	166	PF00082	0.499
CLV_PCSK_SKI1_1	168	172	PF00082	0.423
CLV_Separin_Metazoa	222	226	PF03568	0.391
DEG_Nend_UBRbox_3	1	3	PF02207	0.601
DOC_CYCLIN_yClb1_LxF_4	429	435	PF00134	0.401
DOC_MAPK_gen_1	14	20	PF00069	0.579
DOC_MAPK_gen_1	335	343	PF00069	0.440
DOC_MAPK_MEF2A_6	363	371	PF00069	0.404
DOC_MAPK_MEF2A_6	497	506	PF00069	0.504
DOC_PP1_RVXF_1	179	185	PF00149	0.445
DOC_PP1_RVXF_1	228	235	PF00149	0.480
DOC_PP2B_LxvP_1	408	411	PF13499	0.455
DOC_PP4_FxxP_1	506	509	PF00568	0.416
DOC_USP7_MATH_1	102	106	PF00917	0.594
DOC_USP7_MATH_1	137	141	PF00917	0.345
DOC_USP7_MATH_1	258	262	PF00917	0.281
DOC_USP7_MATH_1	312	316	PF00917	0.492
DOC_USP7_MATH_1	342	346	PF00917	0.462
DOC_USP7_MATH_1	358	362	PF00917	0.386
DOC_USP7_MATH_1	425	429	PF00917	0.406
DOC_USP7_MATH_1	44	48	PF00917	0.550
DOC_USP7_MATH_1	443	447	PF00917	0.598
DOC_USP7_MATH_1	450	454	PF00917	0.587
DOC_USP7_UBL2_3	28	32	PF12436	0.642
DOC_WW_Pin1_4	110	115	PF00397	0.551
DOC_WW_Pin1_4	273	278	PF00397	0.504
DOC_WW_Pin1_4	406	411	PF00397	0.639
DOC_WW_Pin1_4	498	503	PF00397	0.468
LIG_14-3-3_CanoR_1	103	111	PF00244	0.517
LIG_14-3-3_CanoR_1	181	185	PF00244	0.427
LIG_14-3-3_CanoR_1	400	408	PF00244	0.487
LIG_14-3-3_CanoR_1	473	478	PF00244	0.607
LIG_14-3-3_CanoR_1	48	54	PF00244	0.614
LIG_14-3-3_CanoR_1	76	80	PF00244	0.545
LIG_14-3-3_CanoR_1	93	101	PF00244	0.520
LIG_BRCT_BRCA1_1	430	434	PF00533	0.378
LIG_BRCT_BRCA1_1	502	506	PF00533	0.455
LIG_BRCT_BRCA1_1	65	69	PF00533	0.596
LIG_CSL_BTD_1	499	502	PF09270	0.454
LIG_FHA_1	187	193	PF00498	0.396
LIG_FHA_1	224	230	PF00498	0.471
LIG_FHA_1	245	251	PF00498	0.361
LIG_FHA_1	254	260	PF00498	0.366
LIG_FHA_1	265	271	PF00498	0.221
LIG_FHA_1	295	301	PF00498	0.661
LIG_FHA_1	366	372	PF00498	0.348
LIG_FHA_1	4	10	PF00498	0.494
LIG_FHA_1	447	453	PF00498	0.619
LIG_FHA_1	48	54	PF00498	0.475
LIG_FHA_2	123	129	PF00498	0.450
LIG_FHA_2	250	256	PF00498	0.403
LIG_FHA_2	305	311	PF00498	0.366
LIG_LIR_Apic_2	503	509	PF02991	0.426
LIG_LIR_Gen_1	140	147	PF02991	0.356
LIG_LIR_Gen_1	386	394	PF02991	0.480
LIG_LIR_Gen_1	78	89	PF02991	0.514
LIG_LIR_Nem_3	140	145	PF02991	0.378
LIG_LIR_Nem_3	183	187	PF02991	0.448
LIG_LIR_Nem_3	386	391	PF02991	0.480
LIG_LIR_Nem_3	431	437	PF02991	0.361
LIG_LIR_Nem_3	78	84	PF02991	0.545
LIG_LYPXL_S_1	423	427	PF13949	0.338
LIG_LYPXL_yS_3	424	427	PF13949	0.340
LIG_MLH1_MIPbox_1	65	69	PF16413	0.596
LIG_PCNA_yPIPBox_3	2	15	PF02747	0.563
LIG_Pex14_2	468	472	PF04695	0.622
LIG_Pex14_2	506	510	PF04695	0.501
LIG_PTB_Apo_2	239	246	PF02174	0.390
LIG_SH2_SRC	133	136	PF00017	0.479
LIG_SH2_SRC	39	42	PF00017	0.626
LIG_SH2_SRC	435	438	PF00017	0.453
LIG_SH2_STAP1	39	43	PF00017	0.597
LIG_SH2_STAT5	133	136	PF00017	0.515
LIG_SH3_3	13	19	PF00018	0.612
LIG_SH3_3	281	287	PF00018	0.503
LIG_SH3_3	352	358	PF00018	0.418
LIG_SH3_3	474	480	PF00018	0.698
LIG_SUMO_SIM_par_1	163	169	PF11976	0.471
LIG_SUMO_SIM_par_1	247	256	PF11976	0.373
LIG_SUMO_SIM_par_1	267	274	PF11976	0.237
LIG_SUMO_SIM_par_1	326	333	PF11976	0.365
LIG_SUMO_SIM_par_1	339	345	PF11976	0.401
LIG_TRAF2_1	387	390	PF00917	0.409
LIG_TYR_ITIM	422	427	PF00017	0.337
LIG_UBA3_1	328	336	PF00899	0.448
LIG_WRC_WIRS_1	115	120	PF05994	0.432
MOD_CDC14_SPxK_1	409	412	PF00782	0.485
MOD_CDK_SPxK_1	406	412	PF00069	0.510
MOD_CK1_1	121	127	PF00069	0.409
MOD_CK1_1	195	201	PF00069	0.377
MOD_CK1_1	399	405	PF00069	0.527
MOD_CK1_1	428	434	PF00069	0.366
MOD_CK1_1	446	452	PF00069	0.717
MOD_CK1_1	453	459	PF00069	0.663
MOD_CK1_1	47	53	PF00069	0.510
MOD_CK1_1	498	504	PF00069	0.478
MOD_CK1_1	511	517	PF00069	0.382
MOD_CK2_1	304	310	PF00069	0.445
MOD_CK2_1	383	389	PF00069	0.432
MOD_CK2_1	481	487	PF00069	0.562
MOD_Cter_Amidation	74	77	PF01082	0.586
MOD_GlcNHglycan	139	142	PF01048	0.445
MOD_GlcNHglycan	168	171	PF01048	0.476
MOD_GlcNHglycan	202	205	PF01048	0.366
MOD_GlcNHglycan	290	293	PF01048	0.553
MOD_GlcNHglycan	374	377	PF01048	0.440
MOD_GlcNHglycan	404	407	PF01048	0.490
MOD_GlcNHglycan	520	523	PF01048	0.352
MOD_GlcNHglycan	65	68	PF01048	0.683
MOD_GSK3_1	110	117	PF00069	0.367
MOD_GSK3_1	118	125	PF00069	0.395
MOD_GSK3_1	191	198	PF00069	0.428
MOD_GSK3_1	245	252	PF00069	0.408
MOD_GSK3_1	260	267	PF00069	0.387
MOD_GSK3_1	379	386	PF00069	0.444
MOD_GSK3_1	389	396	PF00069	0.388
MOD_GSK3_1	402	409	PF00069	0.570
MOD_GSK3_1	441	448	PF00069	0.614
MOD_GSK3_1	453	460	PF00069	0.715
MOD_GSK3_1	496	503	PF00069	0.482
MOD_GSK3_1	504	511	PF00069	0.370
MOD_GSK3_1	516	523	PF00069	0.227
MOD_GSK3_1	539	546	PF00069	0.462
MOD_GSK3_1	91	98	PF00069	0.527
MOD_N-GLC_1	406	411	PF02516	0.451
MOD_N-GLC_2	264	266	PF02516	0.359
MOD_NEK2_1	1	6	PF00069	0.606
MOD_NEK2_1	118	123	PF00069	0.444
MOD_NEK2_1	145	150	PF00069	0.425
MOD_NEK2_1	186	191	PF00069	0.395
MOD_NEK2_1	192	197	PF00069	0.431
MOD_NEK2_1	245	250	PF00069	0.404
MOD_NEK2_1	457	462	PF00069	0.569
MOD_NEK2_1	472	477	PF00069	0.634
MOD_NEK2_1	495	500	PF00069	0.594
MOD_NEK2_1	504	509	PF00069	0.348
MOD_NEK2_1	541	546	PF00069	0.482
MOD_NEK2_1	69	74	PF00069	0.670
MOD_NEK2_1	8	13	PF00069	0.577
MOD_NEK2_2	114	119	PF00069	0.513
MOD_NEK2_2	358	363	PF00069	0.534
MOD_PIKK_1	186	192	PF00454	0.392
MOD_PIKK_1	399	405	PF00454	0.530
MOD_PIKK_1	457	463	PF00454	0.625
MOD_PIKK_1	511	517	PF00454	0.333
MOD_PIKK_1	52	58	PF00454	0.529
MOD_PK_1	473	479	PF00069	0.537
MOD_PKA_1	496	502	PF00069	0.500
MOD_PKA_2	102	108	PF00069	0.561
MOD_PKA_2	118	124	PF00069	0.304
MOD_PKA_2	180	186	PF00069	0.424
MOD_PKA_2	235	241	PF00069	0.410
MOD_PKA_2	392	398	PF00069	0.461
MOD_PKA_2	399	405	PF00069	0.456
MOD_PKA_2	47	53	PF00069	0.510
MOD_PKA_2	472	478	PF00069	0.647
MOD_PKA_2	481	487	PF00069	0.613
MOD_PKA_2	75	81	PF00069	0.535
MOD_Plk_1	389	395	PF00069	0.418
MOD_Plk_2-3	481	487	PF00069	0.657
MOD_Plk_4	118	124	PF00069	0.481
MOD_Plk_4	146	152	PF00069	0.590
MOD_Plk_4	365	371	PF00069	0.424
MOD_Plk_4	411	417	PF00069	0.505
MOD_Plk_4	428	434	PF00069	0.260
MOD_Plk_4	473	479	PF00069	0.548
MOD_Plk_4	500	506	PF00069	0.403
MOD_ProDKin_1	110	116	PF00069	0.546
MOD_ProDKin_1	273	279	PF00069	0.499
MOD_ProDKin_1	406	412	PF00069	0.633
MOD_ProDKin_1	498	504	PF00069	0.466
MOD_SUMO_for_1	20	23	PF00179	0.544
MOD_SUMO_rev_2	161	170	PF00179	0.414
MOD_SUMO_rev_2	493	498	PF00179	0.581
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.505
TRG_ENDOCYTIC_2	424	427	PF00928	0.340
TRG_ENDOCYTIC_2	81	84	PF00928	0.493
TRG_ER_diArg_1	298	300	PF00400	0.594
TRG_ER_diArg_1	334	337	PF00400	0.483
TRG_Pf-PMV_PEXEL_1	230	235	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC59	Leptomonas seymouri	42%	84%
A0A3Q8IGL8	Leishmania donovani	90%	100%
A4HQ51	Leishmania braziliensis	75%	100%
A4IC79	Leishmania infantum	90%	100%
E9ATX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%