Mitochondrial chaperone BCS1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial chaperone BCS1, putative

Species:

Leishmania major

UniProt:

Q4Q0M1_LEIMA

TriTrypDb:

LmjF.36.5400 , LMJLV39_360066200 , LMJSD75_360066000

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	9
GO:0016020	membrane	2	9
GO:0019866	organelle inner membrane	4	9
GO:0031090	organelle membrane	3	9
GO:0031966	mitochondrial membrane	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q0M1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0M1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0016887	ATP hydrolysis activity	7	10
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.359
CLV_NRD_NRD_1	123	125	PF00675	0.391
CLV_NRD_NRD_1	166	168	PF00675	0.324
CLV_NRD_NRD_1	203	205	PF00675	0.394
CLV_NRD_NRD_1	255	257	PF00675	0.423
CLV_NRD_NRD_1	359	361	PF00675	0.309
CLV_PCSK_FUR_1	164	168	PF00082	0.328
CLV_PCSK_KEX2_1	122	124	PF00082	0.402
CLV_PCSK_KEX2_1	166	168	PF00082	0.320
CLV_PCSK_KEX2_1	203	205	PF00082	0.394
CLV_PCSK_KEX2_1	255	257	PF00082	0.423
CLV_PCSK_KEX2_1	359	361	PF00082	0.309
CLV_PCSK_SKI1_1	186	190	PF00082	0.382
CLV_PCSK_SKI1_1	256	260	PF00082	0.293
CLV_PCSK_SKI1_1	276	280	PF00082	0.123
CLV_PCSK_SKI1_1	333	337	PF00082	0.373
CLV_PCSK_SKI1_1	44	48	PF00082	0.421
CLV_PCSK_SKI1_1	70	74	PF00082	0.337
DEG_APCC_DBOX_1	165	173	PF00400	0.328
DEG_MDM2_SWIB_1	84	91	PF02201	0.421
DEG_Nend_Nbox_1	1	3	PF02207	0.240
DOC_CKS1_1	268	273	PF01111	0.376
DOC_CYCLIN_RxL_1	34	47	PF00134	0.421
DOC_CYCLIN_yCln2_LP_2	227	233	PF00134	0.352
DOC_MAPK_DCC_7	39	48	PF00069	0.328
DOC_MAPK_gen_1	107	117	PF00069	0.352
DOC_MAPK_gen_1	164	174	PF00069	0.312
DOC_MAPK_gen_1	255	261	PF00069	0.454
DOC_MAPK_gen_1	34	43	PF00069	0.385
DOC_MAPK_gen_1	353	363	PF00069	0.314
DOC_MAPK_MEF2A_6	110	119	PF00069	0.309
DOC_MAPK_MEF2A_6	143	150	PF00069	0.311
DOC_PP1_RVXF_1	357	364	PF00149	0.328
DOC_PP2B_LxvP_1	172	175	PF13499	0.383
DOC_PP2B_LxvP_1	198	201	PF13499	0.414
DOC_PP2B_LxvP_1	227	230	PF13499	0.352
DOC_USP7_MATH_1	254	258	PF00917	0.450
DOC_USP7_MATH_1	274	278	PF00917	0.123
DOC_USP7_MATH_1	292	296	PF00917	0.394
DOC_USP7_MATH_1	398	402	PF00917	0.718
DOC_WW_Pin1_4	267	272	PF00397	0.384
DOC_WW_Pin1_4	295	300	PF00397	0.405
DOC_WW_Pin1_4	382	387	PF00397	0.575
DOC_WW_Pin1_4	409	414	PF00397	0.453
DOC_WW_Pin1_4	56	61	PF00397	0.372
LIG_14-3-3_CanoR_1	143	147	PF00244	0.342
LIG_14-3-3_CanoR_1	16	24	PF00244	0.418
LIG_14-3-3_CanoR_1	166	175	PF00244	0.317
LIG_14-3-3_CanoR_1	312	318	PF00244	0.403
LIG_14-3-3_CanoR_1	83	89	PF00244	0.379
LIG_Actin_WH2_2	67	85	PF00022	0.415
LIG_FHA_1	10	16	PF00498	0.323
LIG_FHA_1	143	149	PF00498	0.328
LIG_FHA_1	169	175	PF00498	0.410
LIG_FHA_1	176	182	PF00498	0.396
LIG_FHA_1	215	221	PF00498	0.352
LIG_FHA_1	248	254	PF00498	0.454
LIG_FHA_1	284	290	PF00498	0.376
LIG_FHA_1	340	346	PF00498	0.382
LIG_FHA_2	336	342	PF00498	0.309
LIG_FHA_2	45	51	PF00498	0.391
LIG_FHA_2	9	15	PF00498	0.418
LIG_FHA_2	90	96	PF00498	0.421
LIG_LIR_Gen_1	193	201	PF02991	0.404
LIG_LIR_Gen_1	21	29	PF02991	0.379
LIG_LIR_Gen_1	422	432	PF02991	0.496
LIG_LIR_Gen_1	86	94	PF02991	0.353
LIG_LIR_Nem_3	193	198	PF02991	0.389
LIG_LIR_Nem_3	21	25	PF02991	0.379
LIG_LIR_Nem_3	422	428	PF02991	0.583
LIG_LIR_Nem_3	86	91	PF02991	0.337
LIG_NRBOX	316	322	PF00104	0.309
LIG_PCNA_yPIPBox_3	418	431	PF02747	0.473
LIG_Pex14_1	202	206	PF04695	0.351
LIG_Pex14_2	84	88	PF04695	0.363
LIG_REV1ctd_RIR_1	117	128	PF16727	0.328
LIG_SH2_CRK	195	199	PF00017	0.422
LIG_SH2_CRK	425	429	PF00017	0.530
LIG_SH2_SRC	173	176	PF00017	0.514
LIG_SH2_STAP1	303	307	PF00017	0.421
LIG_SH2_STAT5	149	152	PF00017	0.309
LIG_SH2_STAT5	173	176	PF00017	0.458
LIG_SH2_STAT5	206	209	PF00017	0.319
LIG_SH2_STAT5	90	93	PF00017	0.398
LIG_SH3_3	296	302	PF00018	0.421
LIG_SH3_3	387	393	PF00018	0.682
LIG_SUMO_SIM_anti_2	257	263	PF11976	0.309
LIG_SUMO_SIM_par_1	11	18	PF11976	0.323
LIG_SUMO_SIM_par_1	232	239	PF11976	0.342
LIG_SUMO_SIM_par_1	242	252	PF11976	0.309
LIG_SUMO_SIM_par_1	257	263	PF11976	0.211
LIG_SUMO_SIM_par_1	333	339	PF11976	0.309
LIG_SUMO_SIM_par_1	44	51	PF11976	0.309
LIG_TRAF2_1	18	21	PF00917	0.323
LIG_UBA3_1	187	192	PF00899	0.495
LIG_UBA3_1	260	269	PF00899	0.454
MOD_CK1_1	235	241	PF00069	0.339
MOD_CK1_1	248	254	PF00069	0.309
MOD_CK1_1	277	283	PF00069	0.360
MOD_CK1_1	295	301	PF00069	0.268
MOD_CK1_1	313	319	PF00069	0.182
MOD_CK1_1	385	391	PF00069	0.588
MOD_CK1_1	427	433	PF00069	0.661
MOD_CK1_1	61	67	PF00069	0.454
MOD_CK2_1	15	21	PF00069	0.297
MOD_CK2_1	325	331	PF00069	0.400
MOD_CK2_1	385	391	PF00069	0.623
MOD_CK2_1	398	404	PF00069	0.653
MOD_CK2_1	8	14	PF00069	0.357
MOD_CK2_1	89	95	PF00069	0.392
MOD_GlcNHglycan	17	20	PF01048	0.205
MOD_GlcNHglycan	276	279	PF01048	0.419
MOD_GlcNHglycan	280	283	PF01048	0.415
MOD_GlcNHglycan	293	297	PF01048	0.240
MOD_GlcNHglycan	312	315	PF01048	0.219
MOD_GlcNHglycan	317	320	PF01048	0.265
MOD_GlcNHglycan	387	390	PF01048	0.657
MOD_GlcNHglycan	396	399	PF01048	0.555
MOD_GlcNHglycan	400	403	PF01048	0.410
MOD_GSK3_1	211	218	PF00069	0.309
MOD_GSK3_1	245	252	PF00069	0.467
MOD_GSK3_1	274	281	PF00069	0.410
MOD_GSK3_1	291	298	PF00069	0.356
MOD_GSK3_1	335	342	PF00069	0.319
MOD_GSK3_1	394	401	PF00069	0.642
MOD_GSK3_1	405	412	PF00069	0.489
MOD_GSK3_1	5	12	PF00069	0.438
MOD_N-GLC_1	339	344	PF02516	0.370
MOD_NEK2_1	115	120	PF00069	0.421
MOD_NEK2_1	191	196	PF00069	0.393
MOD_NEK2_1	247	252	PF00069	0.342
MOD_NEK2_1	315	320	PF00069	0.421
MOD_NEK2_1	335	340	PF00069	0.123
MOD_NEK2_1	374	379	PF00069	0.430
MOD_NEK2_1	84	89	PF00069	0.287
MOD_NEK2_2	168	173	PF00069	0.352
MOD_PKA_2	142	148	PF00069	0.352
MOD_PKA_2	15	21	PF00069	0.323
MOD_PKA_2	254	260	PF00069	0.454
MOD_PKA_2	398	404	PF00069	0.680
MOD_Plk_1	340	346	PF00069	0.323
MOD_Plk_1	374	380	PF00069	0.549
MOD_Plk_1	405	411	PF00069	0.698
MOD_Plk_4	115	121	PF00069	0.421
MOD_Plk_4	168	174	PF00069	0.338
MOD_Plk_4	215	221	PF00069	0.321
MOD_Plk_4	5	11	PF00069	0.420
MOD_Plk_4	51	57	PF00069	0.366
MOD_Plk_4	84	90	PF00069	0.453
MOD_ProDKin_1	267	273	PF00069	0.384
MOD_ProDKin_1	295	301	PF00069	0.405
MOD_ProDKin_1	382	388	PF00069	0.582
MOD_ProDKin_1	409	415	PF00069	0.470
MOD_ProDKin_1	56	62	PF00069	0.372
MOD_SUMO_rev_2	50	55	PF00179	0.407
TRG_DiLeu_BaEn_1	331	336	PF01217	0.309
TRG_DiLeu_BaEn_3	183	189	PF01217	0.413
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.352
TRG_DiLeu_BaLyEn_6	416	421	PF01217	0.459
TRG_ENDOCYTIC_2	195	198	PF00928	0.398
TRG_ENDOCYTIC_2	425	428	PF00928	0.600
TRG_ER_diArg_1	122	124	PF00400	0.402
TRG_ER_diArg_1	164	167	PF00400	0.329
TRG_ER_diArg_1	202	204	PF00400	0.400
TRG_ER_diArg_1	254	256	PF00400	0.425
TRG_ER_diArg_1	359	362	PF00400	0.328
TRG_NES_CRM1_1	163	177	PF08389	0.421
TRG_NES_CRM1_1	226	239	PF08389	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFP5	Leptomonas seymouri	69%	95%
A0A0S4IXD9	Bodo saltans	30%	100%
A0A0S4IXV8	Bodo saltans	29%	95%
A0A1X0NQP6	Trypanosomatidae	29%	92%
A0A1X0P1R2	Trypanosomatidae	45%	79%
A0A3Q8IUI9	Leishmania donovani	29%	100%
A0A3R7RKG3	Trypanosoma rangeli	47%	100%
A0A3S7XBS4	Leishmania donovani	94%	99%
A0A422MTV6	Trypanosoma rangeli	30%	93%
A4HAQ0	Leishmania braziliensis	29%	100%
A4HQ55	Leishmania braziliensis	86%	80%
A4IDV4	Leishmania infantum	94%	75%
C9ZVE3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	91%
D0A462	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	82%
E9ATX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	73%
E9B4V7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
P32839	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	96%
Q4Q369	Leishmania major	29%	100%
Q54DY9	Dictyostelium discoideum	31%	95%
Q54HY8	Dictyostelium discoideum	31%	100%
Q5E9H5	Bos taurus	29%	100%
Q7ZTL7	Xenopus laevis	29%	100%
Q7ZV60	Danio rerio	28%	100%
Q8GW96	Arabidopsis thaliana	30%	88%
Q9CZP5	Mus musculus	28%	100%
Q9FN77	Arabidopsis thaliana	27%	82%
Q9LH83	Arabidopsis thaliana	26%	89%
Q9LP11	Arabidopsis thaliana	27%	92%
Q9P6Q3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	97%
Q9Y276	Homo sapiens	28%	100%
V5BA71	Trypanosoma cruzi	30%	93%
V5BUW7	Trypanosoma cruzi	48%	79%
V5DQN5	Trypanosoma cruzi	24%	84%