Macrocin O-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Macrocin-O-methyltransferase (TylF), putative

Species:

Leishmania major

UniProt:

Q4Q0L8_LEIMA

TriTrypDb:

LmjF.36.5430 , LMJLV39_360066500 , LMJSD75_360066400

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0L8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0L8

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	3
GO:0032259	methylation	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.461
CLV_NRD_NRD_1	190	192	PF00675	0.250
CLV_NRD_NRD_1	313	315	PF00675	0.392
CLV_PCSK_KEX2_1	189	191	PF00082	0.344
CLV_PCSK_KEX2_1	312	314	PF00082	0.384
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.275
CLV_PCSK_SKI1_1	190	194	PF00082	0.341
CLV_PCSK_SKI1_1	301	305	PF00082	0.250
CLV_PCSK_SKI1_1	97	101	PF00082	0.438
DEG_APCC_DBOX_1	300	308	PF00400	0.313
DEG_Nend_Nbox_1	1	3	PF02207	0.590
DOC_CYCLIN_RxL_1	49	59	PF00134	0.345
DOC_CYCLIN_RxL_1	94	104	PF00134	0.419
DOC_MAPK_MEF2A_6	301	310	PF00069	0.391
DOC_MAPK_NFAT4_5	301	309	PF00069	0.391
DOC_PP1_RVXF_1	50	57	PF00149	0.301
DOC_PP2B_LxvP_1	306	309	PF13499	0.391
DOC_PP2B_LxvP_1	99	102	PF13499	0.332
DOC_PP4_MxPP_1	201	204	PF00568	0.319
DOC_USP7_MATH_1	146	150	PF00917	0.251
DOC_USP7_MATH_1	178	182	PF00917	0.327
DOC_USP7_MATH_1	194	198	PF00917	0.247
DOC_USP7_MATH_1	225	229	PF00917	0.414
DOC_USP7_MATH_1	232	236	PF00917	0.379
DOC_USP7_MATH_1	316	320	PF00917	0.413
DOC_USP7_MATH_1	380	384	PF00917	0.450
DOC_USP7_MATH_1	68	72	PF00917	0.457
DOC_WW_Pin1_4	184	189	PF00397	0.323
DOC_WW_Pin1_4	216	221	PF00397	0.382
DOC_WW_Pin1_4	240	245	PF00397	0.360
DOC_WW_Pin1_4	354	359	PF00397	0.299
LIG_14-3-3_CanoR_1	253	258	PF00244	0.297
LIG_14-3-3_CanoR_1	312	321	PF00244	0.299
LIG_14-3-3_CanoR_1	69	73	PF00244	0.492
LIG_Actin_WH2_2	25	41	PF00022	0.348
LIG_APCC_ABBA_1	356	361	PF00400	0.154
LIG_BIR_III_4	317	321	PF00653	0.178
LIG_Clathr_ClatBox_1	261	265	PF01394	0.323
LIG_Clathr_ClatBox_1	289	293	PF01394	0.391
LIG_eIF4E_1	83	89	PF01652	0.251
LIG_FHA_1	2	8	PF00498	0.639
LIG_FHA_1	267	273	PF00498	0.438
LIG_FHA_1	93	99	PF00498	0.461
LIG_FHA_2	203	209	PF00498	0.282
LIG_FHA_2	300	306	PF00498	0.380
LIG_LIR_LC3C_4	258	263	PF02991	0.341
LIG_LIR_Nem_3	127	131	PF02991	0.340
LIG_LIR_Nem_3	350	356	PF02991	0.154
LIG_PCNA_yPIPBox_3	107	116	PF02747	0.452
LIG_Pex14_2	113	117	PF04695	0.358
LIG_Rb_pABgroove_1	52	60	PF01858	0.346
LIG_SH2_STAP1	349	353	PF00017	0.178
LIG_SH2_STAP1	50	54	PF00017	0.387
LIG_SH2_STAP1	83	87	PF00017	0.417
LIG_SH2_STAT3	83	86	PF00017	0.260
LIG_SH2_STAT5	349	352	PF00017	0.227
LIG_SH3_3	208	214	PF00018	0.359
LIG_SH3_3	352	358	PF00018	0.203
LIG_SUMO_SIM_anti_2	258	265	PF11976	0.307
LIG_SUMO_SIM_anti_2	285	291	PF11976	0.391
LIG_SUMO_SIM_anti_2	302	308	PF11976	0.373
LIG_SUMO_SIM_par_1	258	265	PF11976	0.323
LIG_WRC_WIRS_1	195	200	PF05994	0.247
MOD_CDC14_SPxK_1	187	190	PF00782	0.323
MOD_CDC14_SPxK_1	224	227	PF00782	0.251
MOD_CDK_SPK_2	184	189	PF00069	0.275
MOD_CDK_SPxK_1	184	190	PF00069	0.323
MOD_CDK_SPxK_1	221	227	PF00069	0.251
MOD_CDK_SPxxK_3	184	191	PF00069	0.323
MOD_CK1_1	148	154	PF00069	0.263
MOD_CK1_1	218	224	PF00069	0.378
MOD_CK1_1	299	305	PF00069	0.354
MOD_CK2_1	225	231	PF00069	0.366
MOD_CK2_1	299	305	PF00069	0.373
MOD_CK2_1	68	74	PF00069	0.356
MOD_GlcNHglycan	148	151	PF01048	0.311
MOD_GlcNHglycan	166	169	PF01048	0.301
MOD_GlcNHglycan	181	184	PF01048	0.328
MOD_GlcNHglycan	211	214	PF01048	0.370
MOD_GlcNHglycan	317	321	PF01048	0.394
MOD_GlcNHglycan	382	385	PF01048	0.463
MOD_GSK3_1	120	127	PF00069	0.367
MOD_GSK3_1	179	186	PF00069	0.463
MOD_GSK3_1	221	228	PF00069	0.295
MOD_GSK3_1	312	319	PF00069	0.251
MOD_N-GLC_1	92	97	PF02516	0.502
MOD_NEK2_1	1	6	PF00069	0.546
MOD_NEK2_1	120	125	PF00069	0.303
MOD_NEK2_1	268	273	PF00069	0.260
MOD_NEK2_2	237	242	PF00069	0.323
MOD_PIKK_1	218	224	PF00454	0.323
MOD_PK_1	253	259	PF00069	0.275
MOD_PKA_1	312	318	PF00069	0.299
MOD_PKA_2	312	318	PF00069	0.299
MOD_PKA_2	68	74	PF00069	0.356
MOD_Plk_1	121	127	PF00069	0.300
MOD_Plk_4	121	127	PF00069	0.308
MOD_Plk_4	68	74	PF00069	0.457
MOD_ProDKin_1	184	190	PF00069	0.323
MOD_ProDKin_1	216	222	PF00069	0.382
MOD_ProDKin_1	240	246	PF00069	0.360
MOD_ProDKin_1	354	360	PF00069	0.299
MOD_SUMO_rev_2	139	149	PF00179	0.386
TRG_DiLeu_BaEn_1	61	66	PF01217	0.371
TRG_DiLeu_BaEn_1	84	89	PF01217	0.422
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.323
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.449
TRG_ER_diArg_1	190	192	PF00400	0.340
TRG_ER_diArg_1	311	314	PF00400	0.392
TRG_NLS_MonoExtN_4	188	193	PF00514	0.275
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC88	Leptomonas seymouri	58%	99%
A0A0S4JTC1	Bodo saltans	38%	100%
A0A1X0P072	Trypanosomatidae	41%	100%
A0A3S5IRD0	Trypanosoma rangeli	43%	100%
A0A3S7XBX8	Leishmania donovani	94%	100%
A4HQ58	Leishmania braziliensis	81%	100%
A4IDV7	Leishmania infantum	94%	100%
D0A459	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ATX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q9AJU0	Streptomyces olivaceus	27%	100%
V5DLQ3	Trypanosoma cruzi	41%	100%