SEP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SEP domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q0L7_LEIMA

TriTrypDb:

LmjF.36.5440 , LMJLV39_360066600 , LMJSD75_360066500

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q0L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0L7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030163	protein catabolic process	4	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0032182	ubiquitin-like protein binding	3	2
GO:0043130	ubiquitin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.684
CLV_C14_Caspase3-7	465	469	PF00656	0.574
CLV_NRD_NRD_1	281	283	PF00675	0.564
CLV_NRD_NRD_1	413	415	PF00675	0.746
CLV_NRD_NRD_1	45	47	PF00675	0.560
CLV_NRD_NRD_1	504	506	PF00675	0.542
CLV_NRD_NRD_1	56	58	PF00675	0.655
CLV_NRD_NRD_1	561	563	PF00675	0.418
CLV_NRD_NRD_1	6	8	PF00675	0.764
CLV_PCSK_FUR_1	54	58	PF00082	0.726
CLV_PCSK_KEX2_1	264	266	PF00082	0.797
CLV_PCSK_KEX2_1	281	283	PF00082	0.524
CLV_PCSK_KEX2_1	413	415	PF00082	0.746
CLV_PCSK_KEX2_1	45	47	PF00082	0.560
CLV_PCSK_KEX2_1	5	7	PF00082	0.768
CLV_PCSK_KEX2_1	504	506	PF00082	0.530
CLV_PCSK_KEX2_1	56	58	PF00082	0.657
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.552
CLV_PCSK_SKI1_1	159	163	PF00082	0.558
CLV_PCSK_SKI1_1	211	215	PF00082	0.751
CLV_PCSK_SKI1_1	307	311	PF00082	0.546
CLV_PCSK_SKI1_1	46	50	PF00082	0.582
CLV_PCSK_SKI1_1	610	614	PF00082	0.623
DEG_APCC_DBOX_1	45	53	PF00400	0.624
DEG_Nend_UBRbox_3	1	3	PF02207	0.782
DOC_AGCK_PIF_2	359	364	PF00069	0.517
DOC_CKS1_1	206	211	PF01111	0.729
DOC_CYCLIN_RxL_1	43	51	PF00134	0.647
DOC_CYCLIN_yClb5_NLxxxL_5	530	539	PF00134	0.564
DOC_MAPK_gen_1	319	328	PF00069	0.460
DOC_MAPK_MEF2A_6	319	328	PF00069	0.423
DOC_MAPK_MEF2A_6	603	611	PF00069	0.534
DOC_USP7_MATH_1	174	178	PF00917	0.678
DOC_USP7_MATH_1	200	204	PF00917	0.801
DOC_USP7_MATH_1	207	211	PF00917	0.641
DOC_USP7_MATH_1	239	243	PF00917	0.662
DOC_USP7_MATH_1	392	396	PF00917	0.713
DOC_USP7_MATH_1	568	572	PF00917	0.485
DOC_USP7_UBL2_3	232	236	PF12436	0.808
DOC_USP7_UBL2_3	307	311	PF12436	0.559
DOC_WW_Pin1_4	11	16	PF00397	0.729
DOC_WW_Pin1_4	183	188	PF00397	0.704
DOC_WW_Pin1_4	198	203	PF00397	0.652
DOC_WW_Pin1_4	205	210	PF00397	0.641
DOC_WW_Pin1_4	251	256	PF00397	0.727
DOC_WW_Pin1_4	272	277	PF00397	0.672
DOC_WW_Pin1_4	33	38	PF00397	0.698
DOC_WW_Pin1_4	438	443	PF00397	0.610
DOC_WW_Pin1_4	515	520	PF00397	0.724
DOC_WW_Pin1_4	56	61	PF00397	0.727
LIG_14-3-3_CanoR_1	281	286	PF00244	0.609
LIG_14-3-3_CanoR_1	298	306	PF00244	0.396
LIG_14-3-3_CanoR_1	428	433	PF00244	0.747
LIG_14-3-3_CanoR_1	54	60	PF00244	0.602
LIG_14-3-3_CanoR_1	594	600	PF00244	0.494
LIG_APCC_ABBA_1	153	158	PF00400	0.479
LIG_BRCT_BRCA1_1	218	222	PF00533	0.656
LIG_BRCT_BRCA1_1	527	531	PF00533	0.679
LIG_deltaCOP1_diTrp_1	588	596	PF00928	0.573
LIG_eIF4E_1	156	162	PF01652	0.610
LIG_FHA_1	148	154	PF00498	0.523
LIG_FHA_1	238	244	PF00498	0.768
LIG_FHA_1	604	610	PF00498	0.432
LIG_FHA_2	152	158	PF00498	0.547
LIG_FHA_2	232	238	PF00498	0.612
LIG_FHA_2	42	48	PF00498	0.631
LIG_FHA_2	429	435	PF00498	0.707
LIG_FHA_2	76	82	PF00498	0.746
LIG_Integrin_isoDGR_2	3	5	PF01839	0.810
LIG_LIR_Gen_1	595	601	PF02991	0.514
LIG_LIR_Nem_3	357	362	PF02991	0.494
LIG_LIR_Nem_3	595	599	PF02991	0.522
LIG_NRBOX	28	34	PF00104	0.534
LIG_Pex14_1	306	310	PF04695	0.526
LIG_Pex14_2	218	222	PF04695	0.727
LIG_Rb_pABgroove_1	150	158	PF01858	0.584
LIG_SH2_CRK	131	135	PF00017	0.600
LIG_SH2_CRK	440	444	PF00017	0.575
LIG_SH2_NCK_1	440	444	PF00017	0.633
LIG_SH2_STAT5	303	306	PF00017	0.556
LIG_SH2_STAT5	440	443	PF00017	0.639
LIG_SH3_2	206	211	PF14604	0.789
LIG_SH3_2	276	281	PF14604	0.501
LIG_SH3_2	419	424	PF14604	0.718
LIG_SH3_3	203	209	PF00018	0.771
LIG_SH3_3	273	279	PF00018	0.712
LIG_SH3_3	336	342	PF00018	0.487
LIG_SH3_3	416	422	PF00018	0.787
LIG_SH3_3	60	66	PF00018	0.766
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.522
LIG_SUMO_SIM_par_1	149	158	PF11976	0.503
LIG_SUMO_SIM_par_1	30	36	PF11976	0.711
LIG_SUMO_SIM_par_1	372	378	PF11976	0.476
LIG_SUMO_SIM_par_1	441	446	PF11976	0.528
LIG_SUMO_SIM_par_1	462	468	PF11976	0.552
LIG_TYR_ITIM	438	443	PF00017	0.659
LIG_UBA3_1	539	547	PF00899	0.560
LIG_UBA3_1	607	613	PF00899	0.514
LIG_WRPW_2	340	343	PF00400	0.476
MOD_CDC14_SPxK_1	254	257	PF00782	0.726
MOD_CDK_SPxK_1	205	211	PF00069	0.674
MOD_CDK_SPxK_1	251	257	PF00069	0.737
MOD_CDK_SPxxK_3	183	190	PF00069	0.717
MOD_CK1_1	205	211	PF00069	0.680
MOD_CK1_1	242	248	PF00069	0.593
MOD_CK1_1	284	290	PF00069	0.573
MOD_CK1_1	482	488	PF00069	0.719
MOD_CK1_1	518	524	PF00069	0.691
MOD_CK1_1	59	65	PF00069	0.776
MOD_CK1_1	9	15	PF00069	0.715
MOD_CK2_1	231	237	PF00069	0.614
MOD_CK2_1	41	47	PF00069	0.639
MOD_CK2_1	428	434	PF00069	0.685
MOD_CK2_1	494	500	PF00069	0.472
MOD_CK2_1	568	574	PF00069	0.439
MOD_CK2_1	75	81	PF00069	0.733
MOD_Cter_Amidation	262	265	PF01082	0.533
MOD_Cter_Amidation	3	6	PF01082	0.732
MOD_Cter_Amidation	411	414	PF01082	0.754
MOD_GlcNHglycan	11	14	PF01048	0.805
MOD_GlcNHglycan	176	179	PF01048	0.672
MOD_GlcNHglycan	218	221	PF01048	0.697
MOD_GlcNHglycan	268	271	PF01048	0.756
MOD_GlcNHglycan	459	462	PF01048	0.655
MOD_GlcNHglycan	482	485	PF01048	0.666
MOD_GlcNHglycan	496	499	PF01048	0.367
MOD_GlcNHglycan	515	518	PF01048	0.432
MOD_GlcNHglycan	523	526	PF01048	0.655
MOD_GlcNHglycan	92	95	PF01048	0.637
MOD_GSK3_1	147	154	PF00069	0.588
MOD_GSK3_1	174	181	PF00069	0.579
MOD_GSK3_1	198	205	PF00069	0.783
MOD_GSK3_1	216	223	PF00069	0.670
MOD_GSK3_1	247	254	PF00069	0.652
MOD_GSK3_1	392	399	PF00069	0.696
MOD_GSK3_1	476	483	PF00069	0.657
MOD_GSK3_1	5	12	PF00069	0.787
MOD_GSK3_1	521	528	PF00069	0.669
MOD_GSK3_1	55	62	PF00069	0.668
MOD_GSK3_1	86	93	PF00069	0.691
MOD_NEK2_2	151	156	PF00069	0.584
MOD_NEK2_2	489	494	PF00069	0.580
MOD_PIKK_1	112	118	PF00454	0.607
MOD_PIKK_1	396	402	PF00454	0.693
MOD_PK_1	281	287	PF00069	0.591
MOD_PKA_1	281	287	PF00069	0.589
MOD_PKA_1	5	11	PF00069	0.717
MOD_PKA_2	281	287	PF00069	0.637
MOD_PKA_2	5	11	PF00069	0.790
MOD_PKA_2	55	61	PF00069	0.656
MOD_PKA_2	64	70	PF00069	0.682
MOD_PKB_1	88	96	PF00069	0.660
MOD_Plk_1	554	560	PF00069	0.430
MOD_Plk_2-3	224	230	PF00069	0.627
MOD_Plk_2-3	75	81	PF00069	0.729
MOD_Plk_4	151	157	PF00069	0.550
MOD_Plk_4	247	253	PF00069	0.668
MOD_Plk_4	402	408	PF00069	0.530
MOD_Plk_4	526	532	PF00069	0.644
MOD_Plk_4	603	609	PF00069	0.421
MOD_ProDKin_1	11	17	PF00069	0.729
MOD_ProDKin_1	183	189	PF00069	0.705
MOD_ProDKin_1	198	204	PF00069	0.653
MOD_ProDKin_1	205	211	PF00069	0.641
MOD_ProDKin_1	251	257	PF00069	0.729
MOD_ProDKin_1	272	278	PF00069	0.669
MOD_ProDKin_1	33	39	PF00069	0.693
MOD_ProDKin_1	438	444	PF00069	0.600
MOD_ProDKin_1	515	521	PF00069	0.722
MOD_ProDKin_1	56	62	PF00069	0.730
MOD_SUMO_for_1	585	588	PF00179	0.626
MOD_SUMO_rev_2	433	438	PF00179	0.696
TRG_ENDOCYTIC_2	131	134	PF00928	0.605
TRG_ENDOCYTIC_2	440	443	PF00928	0.587
TRG_ER_diArg_1	281	283	PF00400	0.626
TRG_ER_diArg_1	413	415	PF00400	0.766
TRG_ER_diArg_1	5	7	PF00400	0.804
TRG_ER_diArg_1	503	505	PF00400	0.556
TRG_ER_diArg_1	53	56	PF00400	0.637
TRG_ER_diArg_1	87	90	PF00400	0.674
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMT0	Leptomonas seymouri	56%	98%
A0A0S4JTW8	Bodo saltans	35%	100%
A0A1X0P060	Trypanosomatidae	33%	100%
A0A3R7LYT2	Trypanosoma rangeli	32%	100%
A0A3S7XBW1	Leishmania donovani	93%	100%
A4HQ59	Leishmania braziliensis	77%	100%
A4IDV8	Leishmania infantum	93%	100%
D0A458	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ATX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BQB1	Trypanosoma cruzi	34%	100%