PRKCSH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0L6_LEIMA

TriTrypDb:

LmjF.36.5450 , LMJLV39_360066700 , LMJSD75_360066600

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 2
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0L6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.669
CLV_NRD_NRD_1	139	141	PF00675	0.715
CLV_NRD_NRD_1	177	179	PF00675	0.588
CLV_PCSK_FUR_1	137	141	PF00082	0.645
CLV_PCSK_KEX2_1	139	141	PF00082	0.684
CLV_PCSK_KEX2_1	177	179	PF00082	0.555
CLV_PCSK_KEX2_1	380	382	PF00082	0.663
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.663
CLV_PCSK_SKI1_1	213	217	PF00082	0.591
CLV_PCSK_SKI1_1	239	243	PF00082	0.620
CLV_PCSK_SKI1_1	341	345	PF00082	0.660
DEG_Nend_Nbox_1	1	3	PF02207	0.659
DOC_CYCLIN_RxL_1	235	246	PF00134	0.632
DOC_CYCLIN_yClb1_LxF_4	262	268	PF00134	0.476
DOC_MAPK_MEF2A_6	13	20	PF00069	0.570
DOC_PP2B_LxvP_1	163	166	PF13499	0.496
DOC_PP2B_LxvP_1	242	245	PF13499	0.515
DOC_PP2B_LxvP_1	79	82	PF13499	0.654
DOC_PP4_FxxP_1	367	370	PF00568	0.519
DOC_USP7_MATH_1	115	119	PF00917	0.522
DOC_USP7_MATH_1	138	142	PF00917	0.758
DOC_USP7_MATH_1	185	189	PF00917	0.570
DOC_USP7_MATH_1	339	343	PF00917	0.692
DOC_USP7_MATH_1	370	374	PF00917	0.508
DOC_USP7_MATH_1	6	10	PF00917	0.594
DOC_WW_Pin1_4	2	7	PF00397	0.637
DOC_WW_Pin1_4	243	248	PF00397	0.656
DOC_WW_Pin1_4	258	263	PF00397	0.615
DOC_WW_Pin1_4	347	352	PF00397	0.744
LIG_14-3-3_CanoR_1	103	110	PF00244	0.715
LIG_14-3-3_CanoR_1	184	194	PF00244	0.528
LIG_14-3-3_CanoR_1	381	387	PF00244	0.523
LIG_BIR_III_4	98	102	PF00653	0.520
LIG_BRCT_BRCA1_1	287	291	PF00533	0.519
LIG_deltaCOP1_diTrp_1	129	133	PF00928	0.574
LIG_deltaCOP1_diTrp_1	358	367	PF00928	0.448
LIG_FHA_1	114	120	PF00498	0.596
LIG_FHA_1	259	265	PF00498	0.640
LIG_FHA_1	37	43	PF00498	0.473
LIG_FHA_2	214	220	PF00498	0.576
LIG_FHA_2	254	260	PF00498	0.689
LIG_FHA_2	383	389	PF00498	0.498
LIG_GBD_Chelix_1	15	23	PF00786	0.504
LIG_LIR_Apic_2	54	60	PF02991	0.567
LIG_LIR_Gen_1	288	299	PF02991	0.469
LIG_LIR_Gen_1	325	334	PF02991	0.697
LIG_LIR_Gen_1	36	46	PF02991	0.499
LIG_LIR_Nem_3	219	224	PF02991	0.415
LIG_LIR_Nem_3	288	294	PF02991	0.478
LIG_LIR_Nem_3	325	330	PF02991	0.646
LIG_LIR_Nem_3	358	364	PF02991	0.427
LIG_LIR_Nem_3	36	41	PF02991	0.526
LIG_NRBOX	237	243	PF00104	0.575
LIG_Pex14_1	306	310	PF04695	0.469
LIG_Pex14_1	313	317	PF04695	0.341
LIG_PTB_Apo_2	281	288	PF02174	0.555
LIG_PTB_Apo_2	304	311	PF02174	0.460
LIG_PTB_Phospho_1	281	287	PF10480	0.553
LIG_PTB_Phospho_1	304	310	PF10480	0.457
LIG_RPA_C_Fungi	173	185	PF08784	0.578
LIG_SH2_CRK	287	291	PF00017	0.529
LIG_SH2_CRK	327	331	PF00017	0.690
LIG_SH2_CRK	38	42	PF00017	0.552
LIG_SH2_CRK	57	61	PF00017	0.572
LIG_SH2_NCK_1	57	61	PF00017	0.570
LIG_SH2_STAP1	38	42	PF00017	0.552
LIG_SH2_STAT3	231	234	PF00017	0.530
LIG_SH2_STAT5	179	182	PF00017	0.497
LIG_SH2_STAT5	310	313	PF00017	0.499
LIG_SH2_STAT5	327	330	PF00017	0.596
LIG_SH2_STAT5	38	41	PF00017	0.523
LIG_SH3_2	244	249	PF14604	0.619
LIG_SH3_3	241	247	PF00018	0.561
LIG_SH3_3	90	96	PF00018	0.710
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.507
LIG_SUMO_SIM_anti_2	39	44	PF11976	0.462
LIG_TRAF2_1	152	155	PF00917	0.638
LIG_TRFH_1	222	226	PF08558	0.418
LIG_Vh1_VBS_1	7	25	PF01044	0.424
LIG_WRC_WIRS_1	411	416	PF05994	0.562
MOD_CDC14_SPxK_1	246	249	PF00782	0.670
MOD_CDK_SPK_2	347	352	PF00069	0.511
MOD_CDK_SPxK_1	243	249	PF00069	0.645
MOD_CK1_1	200	206	PF00069	0.628
MOD_CK1_1	274	280	PF00069	0.476
MOD_CK1_1	371	377	PF00069	0.633
MOD_CK1_1	382	388	PF00069	0.538
MOD_CK1_1	84	90	PF00069	0.762
MOD_CK2_1	213	219	PF00069	0.587
MOD_CK2_1	253	259	PF00069	0.684
MOD_CK2_1	371	377	PF00069	0.544
MOD_CK2_1	382	388	PF00069	0.442
MOD_CMANNOS	130	133	PF00535	0.573
MOD_CMANNOS	313	316	PF00535	0.466
MOD_GlcNHglycan	126	129	PF01048	0.489
MOD_GlcNHglycan	140	143	PF01048	0.625
MOD_GlcNHglycan	187	190	PF01048	0.526
MOD_GlcNHglycan	287	290	PF01048	0.485
MOD_GlcNHglycan	318	321	PF01048	0.446
MOD_GlcNHglycan	32	35	PF01048	0.658
MOD_GlcNHglycan	373	376	PF01048	0.636
MOD_GlcNHglycan	69	72	PF01048	0.603
MOD_GlcNHglycan	8	11	PF01048	0.653
MOD_GlcNHglycan	83	86	PF01048	0.667
MOD_GSK3_1	197	204	PF00069	0.568
MOD_GSK3_1	2	9	PF00069	0.676
MOD_GSK3_1	267	274	PF00069	0.447
MOD_GSK3_1	312	319	PF00069	0.435
MOD_GSK3_1	371	378	PF00069	0.560
MOD_GSK3_1	63	70	PF00069	0.588
MOD_GSK3_1	80	87	PF00069	0.533
MOD_N-GLC_1	339	344	PF02516	0.669
MOD_N-GLC_1	375	380	PF02516	0.628
MOD_N-GLC_1	60	65	PF02516	0.570
MOD_NEK2_1	1	6	PF00069	0.701
MOD_NEK2_1	267	272	PF00069	0.543
MOD_NEK2_1	333	338	PF00069	0.602
MOD_NEK2_2	89	94	PF00069	0.756
MOD_PKA_2	102	108	PF00069	0.703
MOD_PKA_2	124	130	PF00069	0.464
MOD_PKA_2	138	144	PF00069	0.585
MOD_PKA_2	248	254	PF00069	0.749
MOD_PKA_2	285	291	PF00069	0.552
MOD_PKA_2	299	305	PF00069	0.442
MOD_PKB_1	366	374	PF00069	0.559
MOD_Plk_1	339	345	PF00069	0.690
MOD_Plk_4	115	121	PF00069	0.502
MOD_Plk_4	312	318	PF00069	0.447
MOD_Plk_4	325	331	PF00069	0.588
MOD_Plk_4	36	42	PF00069	0.568
MOD_Plk_4	360	366	PF00069	0.406
MOD_Plk_4	60	66	PF00069	0.601
MOD_Plk_4	89	95	PF00069	0.653
MOD_ProDKin_1	2	8	PF00069	0.630
MOD_ProDKin_1	243	249	PF00069	0.665
MOD_ProDKin_1	258	264	PF00069	0.594
MOD_ProDKin_1	347	353	PF00069	0.739
TRG_DiLeu_BaEn_1	154	159	PF01217	0.614
TRG_DiLeu_BaEn_4	154	160	PF01217	0.606
TRG_ENDOCYTIC_2	221	224	PF00928	0.449
TRG_ENDOCYTIC_2	287	290	PF00928	0.525
TRG_ENDOCYTIC_2	327	330	PF00928	0.689
TRG_ENDOCYTIC_2	38	41	PF00928	0.526
TRG_ENDOCYTIC_2	72	75	PF00928	0.585
TRG_ER_diArg_1	122	125	PF00400	0.582
TRG_ER_diArg_1	137	140	PF00400	0.489
TRG_ER_diArg_1	177	179	PF00400	0.572
TRG_Pf-PMV_PEXEL_1	205	210	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P921	Leptomonas seymouri	57%	100%
A0A0S4JQR0	Bodo saltans	23%	100%
A0A1X0P090	Trypanosomatidae	29%	100%
A0A3Q8IRP6	Leishmania donovani	92%	100%
A0A422NKF7	Trypanosoma rangeli	32%	100%
A4HQ60	Leishmania braziliensis	76%	98%
A4IDV9	Leishmania infantum	92%	100%
D0A457	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ATY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%