Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0L3_LEIMA

TriTrypDb:

LmjF.36.5480 , LMJLV39_360067000 , LMJSD75_360067000

Length:

666

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0L3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.637
CLV_NRD_NRD_1	286	288	PF00675	0.544
CLV_NRD_NRD_1	293	295	PF00675	0.439
CLV_PCSK_FUR_1	284	288	PF00082	0.484
CLV_PCSK_KEX2_1	286	288	PF00082	0.544
CLV_PCSK_KEX2_1	293	295	PF00082	0.439
CLV_PCSK_KEX2_1	301	303	PF00082	0.607
CLV_PCSK_KEX2_1	411	413	PF00082	0.523
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.507
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.523
CLV_PCSK_SKI1_1	119	123	PF00082	0.557
CLV_PCSK_SKI1_1	391	395	PF00082	0.532
CLV_PCSK_SKI1_1	521	525	PF00082	0.580
DEG_Nend_UBRbox_2	1	3	PF02207	0.690
DEG_SCF_FBW7_1	564	570	PF00400	0.559
DOC_CKS1_1	564	569	PF01111	0.670
DOC_MAPK_gen_1	298	305	PF00069	0.509
DOC_MAPK_MEF2A_6	166	173	PF00069	0.452
DOC_PP2B_LxvP_1	627	630	PF13499	0.695
DOC_PP4_FxxP_1	21	24	PF00568	0.686
DOC_PP4_FxxP_1	237	240	PF00568	0.656
DOC_PP4_FxxP_1	656	659	PF00568	0.608
DOC_USP7_MATH_1	120	124	PF00917	0.689
DOC_USP7_MATH_1	143	147	PF00917	0.639
DOC_USP7_MATH_1	17	21	PF00917	0.575
DOC_USP7_MATH_1	211	215	PF00917	0.518
DOC_USP7_MATH_1	251	255	PF00917	0.640
DOC_USP7_MATH_1	32	36	PF00917	0.643
DOC_USP7_MATH_1	368	372	PF00917	0.498
DOC_USP7_MATH_1	536	540	PF00917	0.654
DOC_USP7_MATH_1	562	566	PF00917	0.646
DOC_WW_Pin1_4	235	240	PF00397	0.665
DOC_WW_Pin1_4	247	252	PF00397	0.568
DOC_WW_Pin1_4	475	480	PF00397	0.670
DOC_WW_Pin1_4	481	486	PF00397	0.653
DOC_WW_Pin1_4	563	568	PF00397	0.670
DOC_WW_Pin1_4	66	71	PF00397	0.689
DOC_WW_Pin1_4	660	665	PF00397	0.580
DOC_WW_Pin1_4	79	84	PF00397	0.599
LIG_14-3-3_CanoR_1	119	128	PF00244	0.600
LIG_14-3-3_CanoR_1	187	191	PF00244	0.484
LIG_14-3-3_CanoR_1	225	231	PF00244	0.533
LIG_14-3-3_CanoR_1	243	252	PF00244	0.667
LIG_14-3-3_CanoR_1	319	325	PF00244	0.539
LIG_14-3-3_CanoR_1	521	526	PF00244	0.575
LIG_Actin_WH2_2	172	189	PF00022	0.451
LIG_BRCT_BRCA1_1	17	21	PF00533	0.590
LIG_BRCT_BRCA1_1	260	264	PF00533	0.668
LIG_BRCT_BRCA1_1	652	656	PF00533	0.616
LIG_Clathr_ClatBox_1	170	174	PF01394	0.435
LIG_Clathr_ClatBox_1	5	9	PF01394	0.631
LIG_FHA_1	187	193	PF00498	0.521
LIG_FHA_1	225	231	PF00498	0.543
LIG_FHA_1	339	345	PF00498	0.443
LIG_FHA_1	35	41	PF00498	0.670
LIG_FHA_1	388	394	PF00498	0.533
LIG_FHA_1	520	526	PF00498	0.659
LIG_FHA_1	634	640	PF00498	0.553
LIG_FHA_2	111	117	PF00498	0.657
LIG_FHA_2	120	126	PF00498	0.571
LIG_FHA_2	199	205	PF00498	0.497
LIG_FHA_2	294	300	PF00498	0.540
LIG_FHA_2	362	368	PF00498	0.512
LIG_FHA_2	635	641	PF00498	0.664
LIG_LIR_Apic_2	18	24	PF02991	0.673
LIG_LIR_Apic_2	653	659	PF02991	0.613
LIG_LIR_Gen_1	400	407	PF02991	0.508
LIG_LIR_Gen_1	636	644	PF02991	0.680
LIG_LIR_Gen_1	646	657	PF02991	0.568
LIG_LIR_Nem_3	373	379	PF02991	0.597
LIG_LIR_Nem_3	400	406	PF02991	0.506
LIG_LIR_Nem_3	590	596	PF02991	0.672
LIG_LIR_Nem_3	636	641	PF02991	0.684
LIG_LIR_Nem_3	646	652	PF02991	0.564
LIG_LIR_Nem_3	653	657	PF02991	0.504
LIG_LYPXL_yS_3	547	550	PF13949	0.668
LIG_LYPXL_yS_3	654	657	PF13949	0.667
LIG_MAD2	243	251	PF02301	0.621
LIG_PCNA_yPIPBox_3	307	318	PF02747	0.425
LIG_Pex14_2	173	177	PF04695	0.446
LIG_PTAP_UEV_1	611	616	PF05743	0.571
LIG_RPA_C_Fungi	302	314	PF08784	0.487
LIG_SH2_CRK	403	407	PF00017	0.506
LIG_SH2_CRK	649	653	PF00017	0.663
LIG_SH2_GRB2like	343	346	PF00017	0.326
LIG_SH2_NCK_1	403	407	PF00017	0.506
LIG_SH2_NCK_1	500	504	PF00017	0.675
LIG_SH2_SRC	343	346	PF00017	0.351
LIG_SH2_STAP1	403	407	PF00017	0.506
LIG_SH2_STAT3	507	510	PF00017	0.680
LIG_SH2_STAT3	58	61	PF00017	0.719
LIG_SH2_STAT5	200	203	PF00017	0.457
LIG_SH2_STAT5	304	307	PF00017	0.506
LIG_SH2_STAT5	343	346	PF00017	0.463
LIG_SH2_STAT5	464	467	PF00017	0.688
LIG_SH2_STAT5	500	503	PF00017	0.610
LIG_SH2_STAT5	507	510	PF00017	0.610
LIG_SH2_STAT5	595	598	PF00017	0.675
LIG_SH3_2	612	617	PF14604	0.580
LIG_SH3_3	101	107	PF00018	0.709
LIG_SH3_3	130	136	PF00018	0.632
LIG_SH3_3	144	150	PF00018	0.537
LIG_SH3_3	428	434	PF00018	0.660
LIG_SH3_3	482	488	PF00018	0.600
LIG_SH3_3	503	509	PF00018	0.660
LIG_SH3_3	53	59	PF00018	0.638
LIG_SH3_3	542	548	PF00018	0.677
LIG_SH3_3	561	567	PF00018	0.506
LIG_SH3_3	585	591	PF00018	0.624
LIG_SH3_3	606	612	PF00018	0.579
LIG_SH3_3	636	642	PF00018	0.649
LIG_SH3_3	649	655	PF00018	0.494
LIG_SH3_3	69	75	PF00018	0.533
LIG_SUMO_SIM_anti_2	539	544	PF11976	0.635
LIG_SUMO_SIM_par_1	168	174	PF11976	0.438
LIG_SUMO_SIM_par_1	2	9	PF11976	0.631
LIG_SUMO_SIM_par_1	521	527	PF11976	0.662
LIG_TRAF2_1	113	116	PF00917	0.654
LIG_TRFH_1	500	504	PF08558	0.675
LIG_TYR_ITIM	401	406	PF00017	0.499
LIG_TYR_ITIM	545	550	PF00017	0.671
LIG_TYR_ITIM	652	657	PF00017	0.664
MOD_CDC14_SPxK_1	82	85	PF00782	0.705
MOD_CDK_SPxK_1	79	85	PF00069	0.715
MOD_CK1_1	226	232	PF00069	0.664
MOD_CK1_1	250	256	PF00069	0.545
MOD_CK1_1	396	402	PF00069	0.374
MOD_CK1_1	459	465	PF00069	0.632
MOD_CK1_1	481	487	PF00069	0.674
MOD_CK1_1	648	654	PF00069	0.576
MOD_CK1_1	97	103	PF00069	0.701
MOD_CK2_1	110	116	PF00069	0.661
MOD_CK2_1	198	204	PF00069	0.541
MOD_CK2_1	251	257	PF00069	0.679
MOD_CK2_1	634	640	PF00069	0.665
MOD_GlcNHglycan	108	111	PF01048	0.612
MOD_GlcNHglycan	122	125	PF01048	0.585
MOD_GlcNHglycan	183	186	PF01048	0.468
MOD_GlcNHglycan	260	263	PF01048	0.681
MOD_GlcNHglycan	276	279	PF01048	0.459
MOD_GlcNHglycan	329	332	PF01048	0.456
MOD_GlcNHglycan	353	356	PF01048	0.531
MOD_GlcNHglycan	395	398	PF01048	0.398
MOD_GlcNHglycan	413	416	PF01048	0.531
MOD_GlcNHglycan	42	45	PF01048	0.675
MOD_GlcNHglycan	472	475	PF01048	0.726
MOD_GlcNHglycan	585	588	PF01048	0.638
MOD_GlcNHglycan	598	601	PF01048	0.571
MOD_GlcNHglycan	612	615	PF01048	0.602
MOD_GlcNHglycan	96	99	PF01048	0.694
MOD_GSK3_1	106	113	PF00069	0.632
MOD_GSK3_1	115	122	PF00069	0.608
MOD_GSK3_1	15	22	PF00069	0.573
MOD_GSK3_1	247	254	PF00069	0.788
MOD_GSK3_1	265	272	PF00069	0.684
MOD_GSK3_1	32	39	PF00069	0.636
MOD_GSK3_1	387	394	PF00069	0.559
MOD_GSK3_1	455	462	PF00069	0.635
MOD_GSK3_1	515	522	PF00069	0.682
MOD_GSK3_1	524	531	PF00069	0.632
MOD_GSK3_1	563	570	PF00069	0.580
MOD_GSK3_1	579	586	PF00069	0.600
MOD_GSK3_1	92	99	PF00069	0.654
MOD_LATS_1	409	415	PF00433	0.568
MOD_N-GLC_1	40	45	PF02516	0.704
MOD_N-GLC_1	562	567	PF02516	0.645
MOD_N-GLC_1	660	665	PF02516	0.542
MOD_NEK2_1	1	6	PF00069	0.684
MOD_NEK2_1	186	191	PF00069	0.480
MOD_NEK2_1	19	24	PF00069	0.503
MOD_NEK2_1	264	269	PF00069	0.699
MOD_NEK2_1	36	41	PF00069	0.543
MOD_NEK2_1	361	366	PF00069	0.607
MOD_NEK2_1	387	392	PF00069	0.567
MOD_NEK2_1	573	578	PF00069	0.569
MOD_NEK2_2	338	343	PF00069	0.387
MOD_PIKK_1	346	352	PF00454	0.519
MOD_PIKK_1	438	444	PF00454	0.709
MOD_PIKK_1	548	554	PF00454	0.551
MOD_PIKK_1	567	573	PF00454	0.512
MOD_PKA_1	293	299	PF00069	0.497
MOD_PKA_1	411	417	PF00069	0.568
MOD_PKA_2	186	192	PF00069	0.483
MOD_PKA_2	224	230	PF00069	0.512
MOD_PKA_2	293	299	PF00069	0.622
MOD_PKA_2	411	417	PF00069	0.568
MOD_Plk_1	1	7	PF00069	0.685
MOD_Plk_1	211	217	PF00069	0.526
MOD_Plk_1	32	38	PF00069	0.647
MOD_Plk_4	1	7	PF00069	0.645
MOD_Plk_4	143	149	PF00069	0.551
MOD_Plk_4	205	211	PF00069	0.448
MOD_Plk_4	212	218	PF00069	0.446
MOD_Plk_4	251	257	PF00069	0.623
MOD_Plk_4	338	344	PF00069	0.369
MOD_Plk_4	361	367	PF00069	0.503
MOD_Plk_4	456	462	PF00069	0.675
MOD_Plk_4	465	471	PF00069	0.718
MOD_Plk_4	538	544	PF00069	0.685
MOD_Plk_4	617	623	PF00069	0.695
MOD_Plk_4	634	640	PF00069	0.541
MOD_ProDKin_1	235	241	PF00069	0.666
MOD_ProDKin_1	247	253	PF00069	0.567
MOD_ProDKin_1	475	481	PF00069	0.671
MOD_ProDKin_1	484	490	PF00069	0.637
MOD_ProDKin_1	563	569	PF00069	0.672
MOD_ProDKin_1	66	72	PF00069	0.683
MOD_ProDKin_1	660	666	PF00069	0.583
MOD_ProDKin_1	79	85	PF00069	0.598
TRG_ENDOCYTIC_2	403	406	PF00928	0.502
TRG_ENDOCYTIC_2	547	550	PF00928	0.668
TRG_ENDOCYTIC_2	593	596	PF00928	0.682
TRG_ENDOCYTIC_2	649	652	PF00928	0.661
TRG_ENDOCYTIC_2	654	657	PF00928	0.617
TRG_ER_diArg_1	284	287	PF00400	0.544
TRG_ER_diArg_1	292	294	PF00400	0.449
TRG_Pf-PMV_PEXEL_1	319	324	PF00026	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJZ7	Leishmania donovani	91%	100%
A4HQ65	Leishmania braziliensis	69%	100%
A4IDW2	Leishmania infantum	91%	100%
E9ATY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%