Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0L2_LEIMA

TriTrypDb:

LmjF.36.5490 , LMJLV39_360067100 , LMJSD75_360067100

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0L2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0L2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.586
CLV_NRD_NRD_1	161	163	PF00675	0.544
CLV_PCSK_FUR_1	159	163	PF00082	0.553
CLV_PCSK_KEX2_1	161	163	PF00082	0.554
CLV_PCSK_SKI1_1	166	170	PF00082	0.563
CLV_PCSK_SKI1_1	248	252	PF00082	0.591
DEG_APCC_DBOX_1	272	280	PF00400	0.580
DEG_Nend_UBRbox_3	1	3	PF02207	0.711
DEG_SPOP_SBC_1	57	61	PF00917	0.502
DOC_CYCLIN_RxL_1	270	282	PF00134	0.551
DOC_MAPK_gen_1	270	279	PF00069	0.437
DOC_PP2B_LxvP_1	136	139	PF13499	0.537
DOC_PP2B_LxvP_1	204	207	PF13499	0.497
DOC_USP7_MATH_1	113	117	PF00917	0.503
DOC_USP7_MATH_1	137	141	PF00917	0.531
DOC_USP7_MATH_1	210	214	PF00917	0.550
DOC_USP7_MATH_1	6	10	PF00917	0.633
DOC_USP7_MATH_1	67	71	PF00917	0.566
DOC_WW_Pin1_4	2	7	PF00397	0.718
LIG_14-3-3_CanoR_1	102	110	PF00244	0.613
LIG_14-3-3_CanoR_1	128	136	PF00244	0.523
LIG_14-3-3_CanoR_1	144	152	PF00244	0.458
LIG_14-3-3_CanoR_1	173	181	PF00244	0.503
LIG_14-3-3_CanoR_1	22	28	PF00244	0.513
LIG_14-3-3_CanoR_1	248	258	PF00244	0.664
LIG_14-3-3_CanoR_1	56	66	PF00244	0.582
LIG_BRCT_BRCA1_1	110	114	PF00533	0.538
LIG_BRCT_BRCA1_1	119	123	PF00533	0.479
LIG_deltaCOP1_diTrp_1	99	104	PF00928	0.538
LIG_DLG_GKlike_1	39	47	PF00625	0.522
LIG_FAT_LD_1	40	48	PF03623	0.545
LIG_FHA_1	144	150	PF00498	0.572
LIG_FHA_1	282	288	PF00498	0.585
LIG_FHA_1	57	63	PF00498	0.621
LIG_FHA_1	78	84	PF00498	0.738
LIG_FHA_2	153	159	PF00498	0.463
LIG_FHA_2	58	64	PF00498	0.668
LIG_GBD_Chelix_1	19	27	PF00786	0.563
LIG_LIR_Gen_1	120	130	PF02991	0.584
LIG_LIR_Nem_3	120	126	PF02991	0.506
LIG_LIR_Nem_3	232	238	PF02991	0.519
LIG_LIR_Nem_3	81	87	PF02991	0.650
LIG_LYPXL_S_1	83	87	PF13949	0.627
LIG_LYPXL_yS_3	84	87	PF13949	0.629
LIG_NRBOX	275	281	PF00104	0.572
LIG_NRBOX	39	45	PF00104	0.544
LIG_SH2_NCK_1	196	200	PF00017	0.591
LIG_SH2_SRC	196	199	PF00017	0.591
LIG_SH2_STAP1	196	200	PF00017	0.591
LIG_SH3_3	188	194	PF00018	0.577
LIG_SH3_3	204	210	PF00018	0.618
LIG_SUMO_SIM_par_1	134	140	PF11976	0.534
LIG_SUMO_SIM_par_1	275	282	PF11976	0.572
MOD_CK1_1	108	114	PF00069	0.519
MOD_CK1_1	117	123	PF00069	0.496
MOD_CK1_1	252	258	PF00069	0.646
MOD_CK1_1	42	48	PF00069	0.539
MOD_CK1_1	58	64	PF00069	0.562
MOD_CK1_1	70	76	PF00069	0.594
MOD_CK2_1	103	109	PF00069	0.594
MOD_CK2_1	121	127	PF00069	0.405
MOD_CK2_1	152	158	PF00069	0.460
MOD_CK2_1	35	41	PF00069	0.597
MOD_CK2_1	6	12	PF00069	0.535
MOD_CMANNOS	101	104	PF00535	0.535
MOD_GlcNHglycan	105	108	PF01048	0.566
MOD_GlcNHglycan	116	119	PF01048	0.483
MOD_GlcNHglycan	123	126	PF01048	0.462
MOD_GlcNHglycan	23	26	PF01048	0.534
MOD_GlcNHglycan	252	255	PF01048	0.649
MOD_GlcNHglycan	289	294	PF01048	0.528
MOD_GlcNHglycan	48	51	PF01048	0.564
MOD_GSK3_1	113	120	PF00069	0.480
MOD_GSK3_1	2	9	PF00069	0.751
MOD_GSK3_1	23	30	PF00069	0.668
MOD_GSK3_1	246	253	PF00069	0.640
MOD_GSK3_1	35	42	PF00069	0.509
MOD_GSK3_1	57	64	PF00069	0.686
MOD_GSK3_1	83	90	PF00069	0.668
MOD_N-GLC_1	95	100	PF02516	0.491
MOD_NEK2_1	114	119	PF00069	0.508
MOD_NEK2_1	126	131	PF00069	0.517
MOD_NEK2_1	152	157	PF00069	0.512
MOD_NEK2_1	221	226	PF00069	0.600
MOD_NEK2_1	23	28	PF00069	0.604
MOD_NEK2_1	246	251	PF00069	0.656
MOD_NEK2_1	43	48	PF00069	0.388
MOD_NEK2_2	6	11	PF00069	0.537
MOD_PIKK_1	67	73	PF00454	0.668
MOD_PKA_2	143	149	PF00069	0.575
MOD_PKA_2	174	180	PF00069	0.535
MOD_PKA_2	21	27	PF00069	0.533
MOD_PKA_2	55	61	PF00069	0.641
MOD_Plk_1	126	132	PF00069	0.532
MOD_Plk_1	281	287	PF00069	0.583
MOD_Plk_1	35	41	PF00069	0.621
MOD_Plk_4	281	287	PF00069	0.662
MOD_Plk_4	39	45	PF00069	0.520
MOD_ProDKin_1	2	8	PF00069	0.716
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.586
TRG_ENDOCYTIC_2	84	87	PF00928	0.660
TRG_ER_diArg_1	159	162	PF00400	0.551
TRG_ER_diArg_1	172	175	PF00400	0.448
TRG_ER_diArg_1	273	276	PF00400	0.517
TRG_NES_CRM1_1	274	289	PF08389	0.557
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK9	Leptomonas seymouri	28%	100%
A0A3Q8IWF6	Leishmania donovani	87%	100%
A4HQ66	Leishmania braziliensis	63%	100%
A4IDW3	Leishmania infantum	87%	100%
E9ATY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%