Hemolysin-III channel protein-like protein Izh2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Haemolysin-III related, putative

Species:

Leishmania major

UniProt:

Q4Q0L1_LEIMA

TriTrypDb:

LmjF.36.5500 , LMJLV39_360067200 , LMJSD75_360067200

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 28
NetGPI	no	yes: 0, no: 28

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	29
GO:0110165	cellular anatomical entity	1	29

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Expansion

Sequence features

Q4Q0L1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0L1

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0038023	signaling receptor activity	2	4
GO:0060089	molecular transducer activity	1	4

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.541
CLV_NRD_NRD_1	3	5	PF00675	0.549
CLV_NRD_NRD_1	50	52	PF00675	0.465
CLV_PCSK_FUR_1	17	21	PF00082	0.379
CLV_PCSK_KEX2_1	19	21	PF00082	0.542
CLV_PCSK_SKI1_1	264	268	PF00082	0.330
CLV_PCSK_SKI1_1	296	300	PF00082	0.531
DEG_Nend_Nbox_1	1	3	PF02207	0.681
DOC_CYCLIN_RxL_1	293	300	PF00134	0.331
DOC_MAPK_MEF2A_6	161	169	PF00069	0.209

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I280	Leptomonas seymouri	63%	100%
A0A0N1I909	Leptomonas seymouri	37%	100%
A0A0N1PEB9	Leptomonas seymouri	36%	67%
A0A0S4J7T5	Bodo saltans	33%	98%
A0A0S4J8V2	Bodo saltans	42%	100%
A0A0S4JQM0	Bodo saltans	42%	100%
A0A0S4KIQ2	Bodo saltans	37%	100%
A0A1X0P1D6	Trypanosomatidae	35%	100%
A0A1X0P1Q2	Trypanosomatidae	48%	100%
A0A3R7L1Y6	Trypanosoma rangeli	51%	100%

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