Hemolysin-III channel protein-like protein Izh2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Haemolysin-III related, putative

Species:

Leishmania major

UniProt:

Q4Q0L1_LEIMA

TriTrypDb:

LmjF.36.5500 , LMJLV39_360067200 , LMJSD75_360067200

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 28
NetGPI	no	yes: 0, no: 28

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	29
GO:0110165	cellular anatomical entity	1	29

Expansion

Sequence features

Q4Q0L1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0L1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0038023	signaling receptor activity	2	4
GO:0060089	molecular transducer activity	1	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.541
CLV_NRD_NRD_1	3	5	PF00675	0.549
CLV_NRD_NRD_1	50	52	PF00675	0.465
CLV_PCSK_FUR_1	17	21	PF00082	0.379
CLV_PCSK_KEX2_1	19	21	PF00082	0.542
CLV_PCSK_SKI1_1	264	268	PF00082	0.330
CLV_PCSK_SKI1_1	296	300	PF00082	0.531
DEG_Nend_Nbox_1	1	3	PF02207	0.681
DOC_CYCLIN_RxL_1	293	300	PF00134	0.331
DOC_MAPK_MEF2A_6	161	169	PF00069	0.209
DOC_PP1_RVXF_1	261	268	PF00149	0.481
DOC_PP4_FxxP_1	247	250	PF00568	0.457
DOC_PP4_FxxP_1	314	317	PF00568	0.333
DOC_WW_Pin1_4	10	15	PF00397	0.751
DOC_WW_Pin1_4	318	323	PF00397	0.409
LIG_14-3-3_CanoR_1	150	156	PF00244	0.247
LIG_14-3-3_CanoR_1	253	260	PF00244	0.468
LIG_14-3-3_CanoR_1	4	14	PF00244	0.733
LIG_14-3-3_CanoR_1	91	97	PF00244	0.494
LIG_APCC_ABBA_1	104	109	PF00400	0.432
LIG_BRCT_BRCA1_1	182	186	PF00533	0.260
LIG_BRCT_BRCA1_1	193	197	PF00533	0.422
LIG_BRCT_BRCA1_1	256	260	PF00533	0.494
LIG_BRCT_BRCA1_2	256	262	PF00533	0.353
LIG_eIF4E_1	207	213	PF01652	0.345
LIG_FHA_1	108	114	PF00498	0.445
LIG_FHA_1	130	136	PF00498	0.385
LIG_FHA_1	169	175	PF00498	0.332
LIG_FHA_1	208	214	PF00498	0.331
LIG_FHA_1	277	283	PF00498	0.282
LIG_FHA_1	65	71	PF00498	0.554
LIG_FHA_1	99	105	PF00498	0.515
LIG_IRF3_LxIS_1	286	291	PF10401	0.209
LIG_LIR_Gen_1	183	193	PF02991	0.245
LIG_LIR_Gen_1	195	206	PF02991	0.437
LIG_LIR_Gen_1	210	219	PF02991	0.188
LIG_LIR_Gen_1	345	355	PF02991	0.326
LIG_LIR_LC3C_4	210	214	PF02991	0.302
LIG_LIR_Nem_3	162	167	PF02991	0.246
LIG_LIR_Nem_3	183	189	PF02991	0.320
LIG_LIR_Nem_3	205	209	PF02991	0.308
LIG_LIR_Nem_3	210	214	PF02991	0.311
LIG_LIR_Nem_3	216	220	PF02991	0.328
LIG_LIR_Nem_3	241	245	PF02991	0.256
LIG_LIR_Nem_3	324	328	PF02991	0.498
LIG_LIR_Nem_3	345	351	PF02991	0.326
LIG_PDZ_Class_2	358	363	PF00595	0.329
LIG_Pex14_1	231	235	PF04695	0.257
LIG_Pex14_2	247	251	PF04695	0.320
LIG_Pex14_2	310	314	PF04695	0.271
LIG_Pex14_2	325	329	PF04695	0.370
LIG_REV1ctd_RIR_1	249	257	PF16727	0.308
LIG_SH2_CRK	348	352	PF00017	0.241
LIG_SH2_NCK_1	348	352	PF00017	0.241
LIG_SH2_STAP1	312	316	PF00017	0.273
LIG_SH2_STAT5	139	142	PF00017	0.301
LIG_SH2_STAT5	235	238	PF00017	0.309
LIG_SH2_STAT5	268	271	PF00017	0.221
LIG_SH2_STAT5	328	331	PF00017	0.456
LIG_SH2_STAT5	354	357	PF00017	0.294
LIG_SH2_STAT5	85	88	PF00017	0.516
LIG_SH2_STAT5	94	97	PF00017	0.506
LIG_TYR_ITIM	204	209	PF00017	0.295
LIG_WRC_WIRS_1	169	174	PF05994	0.320
LIG_WRC_WIRS_1	186	191	PF05994	0.489
LIG_WRC_WIRS_1	214	219	PF05994	0.306
LIG_WRC_WIRS_1	239	244	PF05994	0.382
MOD_CDK_SPK_2	12	17	PF00069	0.576
MOD_CDK_SPxxK_3	10	17	PF00069	0.590
MOD_CK1_1	24	30	PF00069	0.616
MOD_CK1_1	3	9	PF00069	0.714
MOD_CK1_1	321	327	PF00069	0.409
MOD_CK1_1	356	362	PF00069	0.263
MOD_GlcNHglycan	182	185	PF01048	0.326
MOD_GlcNHglycan	273	276	PF01048	0.305
MOD_GlcNHglycan	290	293	PF01048	0.455
MOD_GlcNHglycan	8	11	PF01048	0.524
MOD_GSK3_1	234	241	PF00069	0.359
MOD_GSK3_1	276	283	PF00069	0.340
MOD_GSK3_1	4	11	PF00069	0.748
MOD_LATS_1	79	85	PF00433	0.398
MOD_N-GLC_1	107	112	PF02516	0.254
MOD_N-GLC_1	39	44	PF02516	0.426
MOD_N-GLC_1	63	68	PF02516	0.395
MOD_NEK2_1	180	185	PF00069	0.247
MOD_NEK2_1	238	243	PF00069	0.305
MOD_NEK2_1	271	276	PF00069	0.300
MOD_NEK2_1	288	293	PF00069	0.290
MOD_NEK2_1	327	332	PF00069	0.447
MOD_NEK2_2	148	153	PF00069	0.352
MOD_OFUCOSY	221	227	PF10250	0.390
MOD_PIKK_1	129	135	PF00454	0.432
MOD_PIKK_1	280	286	PF00454	0.241
MOD_PKA_1	4	10	PF00069	0.609
MOD_PKA_2	3	9	PF00069	0.712
MOD_PKA_2	356	362	PF00069	0.383
MOD_Plk_1	107	113	PF00069	0.461
MOD_Plk_1	21	27	PF00069	0.745
MOD_Plk_1	63	69	PF00069	0.631
MOD_Plk_1	81	87	PF00069	0.534
MOD_Plk_4	185	191	PF00069	0.289
MOD_Plk_4	213	219	PF00069	0.305
MOD_Plk_4	234	240	PF00069	0.283
MOD_Plk_4	297	303	PF00069	0.342
MOD_Plk_4	356	362	PF00069	0.346
MOD_Plk_4	81	87	PF00069	0.547
MOD_Plk_4	99	105	PF00069	0.562
MOD_ProDKin_1	10	16	PF00069	0.751
MOD_ProDKin_1	318	324	PF00069	0.409
TRG_ENDOCYTIC_2	198	201	PF00928	0.458
TRG_ENDOCYTIC_2	206	209	PF00928	0.228
TRG_ENDOCYTIC_2	235	238	PF00928	0.327
TRG_ENDOCYTIC_2	268	271	PF00928	0.296
TRG_ENDOCYTIC_2	348	351	PF00928	0.303
TRG_ER_diArg_1	16	19	PF00400	0.729

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I280	Leptomonas seymouri	63%	100%
A0A0N1I909	Leptomonas seymouri	37%	100%
A0A0N1PEB9	Leptomonas seymouri	36%	67%
A0A0S4J7T5	Bodo saltans	33%	98%
A0A0S4J8V2	Bodo saltans	42%	100%
A0A0S4JQM0	Bodo saltans	42%	100%
A0A0S4KIQ2	Bodo saltans	37%	100%
A0A1X0P1D6	Trypanosomatidae	35%	100%
A0A1X0P1Q2	Trypanosomatidae	48%	100%
A0A3R7L1Y6	Trypanosoma rangeli	51%	100%
A0A3S7XBT4	Leishmania donovani	94%	100%
A0A3S7XBU6	Leishmania donovani	37%	71%
A0A3S7XC05	Leishmania donovani	37%	100%
A4HQ64	Leishmania braziliensis	37%	71%
A4HQ67	Leishmania braziliensis	77%	100%
A4HQ68	Leishmania braziliensis	34%	100%
A4IDW4	Leishmania infantum	94%	100%
A4IDW5	Leishmania infantum	36%	71%
A4IDW6	Leishmania infantum	37%	100%
B7F9G7	Oryza sativa subsp. japonica	29%	97%
C9ZTI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	20%	100%
D0A450	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A451	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ATY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9ATY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	73%
E9ATY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q03419	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q07959	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	67%
Q09749	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q09910	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	82%
Q12442	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q4Q0K9	Leishmania major	35%	100%
Q4Q0L0	Leishmania major	38%	72%
Q6DC77	Danio rerio	26%	100%
Q6TCG5	Mus musculus	27%	100%
Q6TCG8	Mus musculus	32%	100%
Q6TCH4	Homo sapiens	27%	100%
Q6TCH7	Homo sapiens	33%	100%
Q753H5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	100%
Q75F81	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	87%
Q801D8	Cynoscion nebulosus	26%	100%
Q84N34	Arabidopsis thaliana	29%	100%
Q86V24	Homo sapiens	33%	94%
Q8BQS5	Mus musculus	33%	94%
Q91VH1	Mus musculus	33%	97%
Q93ZH9	Arabidopsis thaliana	31%	100%
Q94177	Caenorhabditis elegans	28%	84%
Q96A54	Homo sapiens	33%	97%
Q9DCU0	Mus musculus	28%	100%
Q9JJE4	Mus musculus	27%	100%
Q9NXK6	Homo sapiens	27%	100%
Q9SVF3	Arabidopsis thaliana	29%	97%
Q9SZG0	Arabidopsis thaliana	29%	94%
Q9VCY8	Drosophila melanogaster	32%	82%
Q9ZUH8	Arabidopsis thaliana	32%	100%
V5BJ57	Trypanosoma cruzi	35%	100%
V5DK49	Trypanosoma cruzi	50%	100%