Adiponectin receptor protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adiponectin receptor protein 1, putative

Species:

Leishmania major

UniProt:

Q4Q0L0_LEIMA

TriTrypDb:

LmjF.36.5510 , LMJLV39_360067300 , LMJSD75_360067300

Length:

507

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

Q4Q0L0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0L0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0038023	signaling receptor activity	2	4
GO:0060089	molecular transducer activity	1	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.700
CLV_NRD_NRD_1	199	201	PF00675	0.525
CLV_PCSK_KEX2_1	198	200	PF00082	0.543
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.533
CLV_PCSK_SKI1_1	16	20	PF00082	0.436
CLV_PCSK_SKI1_1	262	266	PF00082	0.344
CLV_PCSK_SKI1_1	298	302	PF00082	0.467
CLV_PCSK_SKI1_1	339	343	PF00082	0.255
CLV_PCSK_SKI1_1	62	66	PF00082	0.485
DEG_COP1_1	159	169	PF00400	0.604
DEG_ODPH_VHL_1	417	429	PF01847	0.274
DEG_SPOP_SBC_1	124	128	PF00917	0.652
DEG_SPOP_SBC_1	77	81	PF00917	0.610
DOC_CKS1_1	145	150	PF01111	0.630
DOC_CKS1_1	174	179	PF01111	0.644
DOC_MAPK_gen_1	13	21	PF00069	0.628
DOC_MAPK_gen_1	400	410	PF00069	0.401
DOC_MAPK_HePTP_8	402	414	PF00069	0.430
DOC_MAPK_MEF2A_6	400	408	PF00069	0.438
DOC_PP1_RVXF_1	344	350	PF00149	0.451
DOC_PP4_FxxP_1	164	167	PF00568	0.629
DOC_PP4_FxxP_1	360	363	PF00568	0.362
DOC_USP7_MATH_1	124	128	PF00917	0.681
DOC_USP7_MATH_1	156	160	PF00917	0.657
DOC_USP7_MATH_1	190	194	PF00917	0.602
DOC_USP7_MATH_1	225	229	PF00917	0.501
DOC_USP7_MATH_1	40	44	PF00917	0.640
DOC_USP7_MATH_1	420	424	PF00917	0.344
DOC_USP7_MATH_1	432	436	PF00917	0.226
DOC_USP7_MATH_1	77	81	PF00917	0.670
DOC_WW_Pin1_4	144	149	PF00397	0.678
DOC_WW_Pin1_4	173	178	PF00397	0.702
DOC_WW_Pin1_4	84	89	PF00397	0.689
LIG_14-3-3_CanoR_1	13	19	PF00244	0.729
LIG_14-3-3_CanoR_1	138	148	PF00244	0.689
LIG_14-3-3_CanoR_1	199	204	PF00244	0.696
LIG_14-3-3_CanoR_1	218	224	PF00244	0.553
LIG_14-3-3_CanoR_1	252	258	PF00244	0.519
LIG_14-3-3_CanoR_1	339	347	PF00244	0.422
LIG_14-3-3_CanoR_1	403	409	PF00244	0.474
LIG_BIR_II_1	1	5	PF00653	0.631
LIG_BRCT_BRCA1_1	104	108	PF00533	0.783
LIG_BRCT_BRCA1_1	37	41	PF00533	0.627
LIG_deltaCOP1_diTrp_1	468	477	PF00928	0.493
LIG_eIF4E_1	378	384	PF01652	0.300
LIG_FHA_1	140	146	PF00498	0.640
LIG_FHA_1	153	159	PF00498	0.719
LIG_FHA_1	161	167	PF00498	0.776
LIG_FHA_1	269	275	PF00498	0.479
LIG_FHA_1	278	284	PF00498	0.310
LIG_FHA_1	286	292	PF00498	0.338
LIG_FHA_1	351	357	PF00498	0.338
LIG_FHA_1	374	380	PF00498	0.283
LIG_FHA_1	385	391	PF00498	0.373
LIG_FHA_1	4	10	PF00498	0.645
LIG_FHA_1	79	85	PF00498	0.638
LIG_FHA_2	160	166	PF00498	0.613
LIG_FHA_2	90	96	PF00498	0.639
LIG_IBAR_NPY_1	244	246	PF08397	0.496
LIG_LIR_Apic_2	162	167	PF02991	0.631
LIG_LIR_Apic_2	358	363	PF02991	0.364
LIG_LIR_Gen_1	128	139	PF02991	0.636
LIG_LIR_Gen_1	17	26	PF02991	0.634
LIG_LIR_Gen_1	280	289	PF02991	0.363
LIG_LIR_Gen_1	38	49	PF02991	0.625
LIG_LIR_Nem_3	128	134	PF02991	0.697
LIG_LIR_Nem_3	17	21	PF02991	0.630
LIG_LIR_Nem_3	249	254	PF02991	0.570
LIG_LIR_Nem_3	258	264	PF02991	0.509
LIG_LIR_Nem_3	280	284	PF02991	0.363
LIG_LIR_Nem_3	326	332	PF02991	0.491
LIG_LIR_Nem_3	348	352	PF02991	0.339
LIG_LIR_Nem_3	38	44	PF02991	0.627
LIG_LIR_Nem_3	407	412	PF02991	0.327
LIG_LIR_Nem_3	74	78	PF02991	0.623
LIG_NRBOX	286	292	PF00104	0.299
LIG_PCNA_yPIPBox_3	325	339	PF02747	0.300
LIG_Pex14_1	394	398	PF04695	0.300
LIG_REV1ctd_RIR_1	96	105	PF16727	0.633
LIG_SH2_CRK	292	296	PF00017	0.262
LIG_SH2_STAP1	255	259	PF00017	0.470
LIG_SH2_STAP1	292	296	PF00017	0.325
LIG_SH2_STAT3	454	457	PF00017	0.305
LIG_SH2_STAT5	194	197	PF00017	0.603
LIG_SH2_STAT5	246	249	PF00017	0.587
LIG_SH2_STAT5	255	258	PF00017	0.545
LIG_SH2_STAT5	292	295	PF00017	0.283
LIG_SH2_STAT5	365	368	PF00017	0.319
LIG_SH2_STAT5	378	381	PF00017	0.379
LIG_SH2_STAT5	447	450	PF00017	0.407
LIG_SH2_STAT5	454	457	PF00017	0.322
LIG_SH2_STAT5	489	492	PF00017	0.360
LIG_SH3_3	142	148	PF00018	0.627
LIG_SH3_3	297	303	PF00018	0.219
LIG_SH3_3	387	393	PF00018	0.198
LIG_SH3_3	39	45	PF00018	0.723
LIG_SH3_3	85	91	PF00018	0.674
LIG_Sin3_3	381	388	PF02671	0.254
LIG_SUMO_SIM_anti_2	380	387	PF11976	0.333
LIG_SUMO_SIM_anti_2	423	428	PF11976	0.416
LIG_SUMO_SIM_par_1	380	387	PF11976	0.358
LIG_TYR_ITIM	290	295	PF00017	0.300
LIG_Vh1_VBS_1	373	391	PF01044	0.215
LIG_WRC_WIRS_1	278	283	PF05994	0.300
LIG_WRC_WIRS_1	357	362	PF05994	0.338
LIG_WW_1	362	365	PF00397	0.300
MOD_CDK_SPK_2	173	178	PF00069	0.650
MOD_CK1_1	123	129	PF00069	0.808
MOD_CK1_1	149	155	PF00069	0.619
MOD_CK1_1	159	165	PF00069	0.597
MOD_CK1_1	334	340	PF00069	0.570
MOD_CK1_1	433	439	PF00069	0.314
MOD_CK1_1	67	73	PF00069	0.744
MOD_CK2_1	14	20	PF00069	0.667
MOD_CK2_1	89	95	PF00069	0.691
MOD_Cter_Amidation	196	199	PF01082	0.407
MOD_GlcNHglycan	122	125	PF01048	0.473
MOD_GlcNHglycan	148	151	PF01048	0.590
MOD_GlcNHglycan	167	170	PF01048	0.441
MOD_GlcNHglycan	305	308	PF01048	0.430
MOD_GlcNHglycan	325	328	PF01048	0.366
MOD_GlcNHglycan	414	417	PF01048	0.302
MOD_GlcNHglycan	448	451	PF01048	0.287
MOD_GlcNHglycan	66	69	PF01048	0.451
MOD_GSK3_1	120	127	PF00069	0.712
MOD_GSK3_1	152	159	PF00069	0.711
MOD_GSK3_1	180	187	PF00069	0.687
MOD_GSK3_1	273	280	PF00069	0.300
MOD_GSK3_1	290	297	PF00069	0.300
MOD_GSK3_1	301	308	PF00069	0.257
MOD_GSK3_1	373	380	PF00069	0.323
MOD_N-GLC_1	268	273	PF02516	0.290
MOD_N-GLC_2	273	275	PF02516	0.201
MOD_NEK2_1	139	144	PF00069	0.665
MOD_NEK2_1	180	185	PF00069	0.639
MOD_NEK2_1	285	290	PF00069	0.387
MOD_NEK2_1	291	296	PF00069	0.336
MOD_NEK2_1	305	310	PF00069	0.299
MOD_NEK2_1	323	328	PF00069	0.322
MOD_NEK2_1	331	336	PF00069	0.495
MOD_NEK2_1	355	360	PF00069	0.375
MOD_NEK2_1	383	388	PF00069	0.377
MOD_NEK2_1	412	417	PF00069	0.309
MOD_NEK2_1	446	451	PF00069	0.477
MOD_NEK2_1	453	458	PF00069	0.364
MOD_NEK2_1	479	484	PF00069	0.302
MOD_NEK2_1	83	88	PF00069	0.611
MOD_NEK2_2	113	118	PF00069	0.645
MOD_PIKK_1	102	108	PF00454	0.653
MOD_PIKK_1	149	155	PF00454	0.619
MOD_PIKK_1	192	198	PF00454	0.626
MOD_PIKK_1	453	459	PF00454	0.254
MOD_PKA_1	199	205	PF00069	0.621
MOD_PKA_2	199	205	PF00069	0.638
MOD_PKA_2	29	35	PF00069	0.627
MOD_PKA_2	404	410	PF00069	0.434
MOD_Plk_1	225	231	PF00069	0.627
MOD_Plk_1	268	274	PF00069	0.490
MOD_Plk_1	35	41	PF00069	0.656
MOD_Plk_2-3	104	110	PF00069	0.639
MOD_Plk_4	260	266	PF00069	0.551
MOD_Plk_4	277	283	PF00069	0.237
MOD_Plk_4	291	297	PF00069	0.370
MOD_Plk_4	316	322	PF00069	0.346
MOD_Plk_4	356	362	PF00069	0.330
MOD_Plk_4	404	410	PF00069	0.474
MOD_Plk_4	433	439	PF00069	0.299
MOD_Plk_4	491	497	PF00069	0.325
MOD_ProDKin_1	144	150	PF00069	0.678
MOD_ProDKin_1	173	179	PF00069	0.704
MOD_ProDKin_1	84	90	PF00069	0.687
MOD_SUMO_for_1	100	103	PF00179	0.631
TRG_DiLeu_BaEn_2	94	100	PF01217	0.655
TRG_DiLeu_BaEn_3	36	42	PF01217	0.600
TRG_ENDOCYTIC_2	251	254	PF00928	0.479
TRG_ENDOCYTIC_2	292	295	PF00928	0.325
TRG_ENDOCYTIC_2	312	315	PF00928	0.302
TRG_ENDOCYTIC_2	329	332	PF00928	0.543
TRG_ENDOCYTIC_2	365	368	PF00928	0.305
TRG_ER_diArg_1	199	201	PF00400	0.668
TRG_ER_diArg_1	247	250	PF00400	0.470
TRG_ER_diArg_1	402	405	PF00400	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEB9	Leptomonas seymouri	50%	94%
A0A3S7XBT4	Leishmania donovani	37%	100%
A0A3S7XBU6	Leishmania donovani	89%	100%
A0A3S7XC05	Leishmania donovani	38%	100%
A4HQ64	Leishmania braziliensis	68%	99%
A4HQ67	Leishmania braziliensis	35%	100%
A4HQ68	Leishmania braziliensis	39%	100%
A4IDW4	Leishmania infantum	37%	100%
A4IDW5	Leishmania infantum	88%	100%
A4IDW6	Leishmania infantum	38%	100%
E9ATY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ATY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9ATY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
Q07959	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	93%
Q4Q0K9	Leishmania major	38%	100%
Q4Q0L1	Leishmania major	38%	100%