PCIF1_WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphorylated CTD interacting factor 1 WW domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q0K8_LEIMA

TriTrypDb:

LmjF.36.5530 , LMJLV39_360067500 , LMJSD75_360067500

Length:

656

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0K8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0K8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000993	RNA polymerase II complex binding	5	8
GO:0001098	basal transcription machinery binding	3	8
GO:0001099	basal RNA polymerase II transcription machinery binding	4	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0008168	methyltransferase activity	4	8
GO:0008173	RNA methyltransferase activity	4	8
GO:0008174	mRNA methyltransferase activity	5	8
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	8
GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	6	8
GO:0016740	transferase activity	2	8
GO:0016741	transferase activity, transferring one-carbon groups	3	8
GO:0019899	enzyme binding	3	8
GO:0043175	RNA polymerase core enzyme binding	5	8
GO:0070063	RNA polymerase binding	4	8
GO:0099122	RNA polymerase II C-terminal domain binding	6	8
GO:0140098	catalytic activity, acting on RNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.433
CLV_NRD_NRD_1	213	215	PF00675	0.331
CLV_NRD_NRD_1	586	588	PF00675	0.629
CLV_NRD_NRD_1	82	84	PF00675	0.518
CLV_PCSK_KEX2_1	195	197	PF00082	0.430
CLV_PCSK_KEX2_1	234	236	PF00082	0.417
CLV_PCSK_KEX2_1	588	590	PF00082	0.620
CLV_PCSK_KEX2_1	82	84	PF00082	0.518
CLV_PCSK_KEX2_1	99	101	PF00082	0.331
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.430
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.365
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.627
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.331
CLV_PCSK_SKI1_1	12	16	PF00082	0.428
CLV_PCSK_SKI1_1	145	149	PF00082	0.476
CLV_PCSK_SKI1_1	171	175	PF00082	0.556
CLV_PCSK_SKI1_1	360	364	PF00082	0.364
CLV_PCSK_SKI1_1	38	42	PF00082	0.476
CLV_PCSK_SKI1_1	419	423	PF00082	0.376
CLV_Separin_Metazoa	7	11	PF03568	0.336
DEG_APCC_DBOX_1	99	107	PF00400	0.464
DEG_Nend_UBRbox_3	1	3	PF02207	0.495
DEG_SPOP_SBC_1	519	523	PF00917	0.328
DOC_CKS1_1	146	151	PF01111	0.495
DOC_CKS1_1	295	300	PF01111	0.490
DOC_CYCLIN_RxL_1	167	175	PF00134	0.518
DOC_CYCLIN_RxL_1	487	495	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.535
DOC_CYCLIN_yCln2_LP_2	324	330	PF00134	0.417
DOC_MAPK_gen_1	10	17	PF00069	0.425
DOC_MAPK_gen_1	234	243	PF00069	0.526
DOC_MAPK_gen_1	82	90	PF00069	0.490
DOC_MAPK_HePTP_8	322	334	PF00069	0.419
DOC_MAPK_JIP1_4	235	241	PF00069	0.440
DOC_MAPK_MEF2A_6	171	178	PF00069	0.465
DOC_MAPK_MEF2A_6	234	243	PF00069	0.466
DOC_MAPK_MEF2A_6	325	334	PF00069	0.541
DOC_MAPK_MEF2A_6	612	620	PF00069	0.298
DOC_MAPK_MEF2A_6	72	81	PF00069	0.432
DOC_MAPK_NFAT4_5	171	179	PF00069	0.469
DOC_PP2B_LxvP_1	324	327	PF13499	0.413
DOC_PP2B_LxvP_1	558	561	PF13499	0.328
DOC_PP4_FxxP_1	411	414	PF00568	0.300
DOC_USP7_MATH_1	253	257	PF00917	0.455
DOC_USP7_MATH_1	303	307	PF00917	0.594
DOC_USP7_MATH_1	31	35	PF00917	0.522
DOC_USP7_MATH_1	350	354	PF00917	0.363
DOC_USP7_MATH_1	432	436	PF00917	0.486
DOC_USP7_MATH_1	469	473	PF00917	0.585
DOC_USP7_MATH_1	480	484	PF00917	0.554
DOC_USP7_MATH_1	650	654	PF00917	0.493
DOC_USP7_UBL2_3	234	238	PF12436	0.361
DOC_WW_Pin1_4	132	137	PF00397	0.462
DOC_WW_Pin1_4	145	150	PF00397	0.407
DOC_WW_Pin1_4	29	34	PF00397	0.683
DOC_WW_Pin1_4	294	299	PF00397	0.469
DOC_WW_Pin1_4	410	415	PF00397	0.255
DOC_WW_Pin1_4	52	57	PF00397	0.482
LIG_14-3-3_CanoR_1	553	559	PF00244	0.416
LIG_14-3-3_CanoR_1	612	616	PF00244	0.450
LIG_APCC_ABBA_1	423	428	PF00400	0.376
LIG_BIR_III_4	36	40	PF00653	0.496
LIG_BRCT_BRCA1_1	42	46	PF00533	0.415
LIG_CaM_NSCaTE_8	177	184	PF13499	0.455
LIG_Clathr_ClatBox_1	491	495	PF01394	0.409
LIG_deltaCOP1_diTrp_1	285	292	PF00928	0.462
LIG_FHA_1	268	274	PF00498	0.450
LIG_FHA_1	336	342	PF00498	0.414
LIG_FHA_1	403	409	PF00498	0.426
LIG_FHA_1	479	485	PF00498	0.557
LIG_FHA_1	520	526	PF00498	0.304
LIG_LIR_Apic_2	409	414	PF02991	0.300
LIG_LIR_Apic_2	71	77	PF02991	0.449
LIG_LIR_Gen_1	284	293	PF02991	0.459
LIG_LIR_Gen_1	313	322	PF02991	0.464
LIG_LIR_Gen_1	601	610	PF02991	0.496
LIG_LIR_Nem_3	205	211	PF02991	0.445
LIG_LIR_Nem_3	284	289	PF02991	0.492
LIG_LIR_Nem_3	291	295	PF02991	0.465
LIG_LIR_Nem_3	313	317	PF02991	0.477
LIG_LIR_Nem_3	430	436	PF02991	0.416
LIG_LIR_Nem_3	601	605	PF02991	0.547
LIG_MYND_3	158	162	PF01753	0.491
LIG_NRBOX	357	363	PF00104	0.360
LIG_Pex14_2	411	415	PF04695	0.376
LIG_Pex14_2	422	426	PF04695	0.376
LIG_PTB_Apo_2	494	501	PF02174	0.300
LIG_SH2_CRK	365	369	PF00017	0.300
LIG_SH2_SRC	565	568	PF00017	0.300
LIG_SH2_SRC	583	586	PF00017	0.567
LIG_SH2_STAT5	108	111	PF00017	0.527
LIG_SH2_STAT5	208	211	PF00017	0.444
LIG_SH2_STAT5	242	245	PF00017	0.320
LIG_SH2_STAT5	340	343	PF00017	0.376
LIG_SH2_STAT5	565	568	PF00017	0.300
LIG_SH2_STAT5	583	586	PF00017	0.567
LIG_SH3_3	113	119	PF00018	0.448
LIG_SH3_3	27	33	PF00018	0.541
LIG_SH3_3	324	330	PF00018	0.368
LIG_SH3_3	53	59	PF00018	0.515
LIG_SUMO_SIM_anti_2	520	529	PF11976	0.361
LIG_SUMO_SIM_anti_2	617	626	PF11976	0.382
LIG_SUMO_SIM_par_1	404	409	PF11976	0.376
LIG_SUMO_SIM_par_1	480	486	PF11976	0.568
LIG_SUMO_SIM_par_1	526	534	PF11976	0.376
LIG_SUMO_SIM_par_1	86	91	PF11976	0.435
LIG_TRAF2_1	4	7	PF00917	0.418
LIG_TRAF2_1	465	468	PF00917	0.602
LIG_TRAF2_1	545	548	PF00917	0.328
LIG_TRAF2_2	384	389	PF00917	0.231
LIG_TYR_ITIM	363	368	PF00017	0.300
LIG_UBA3_1	173	180	PF00899	0.463
MOD_CK1_1	264	270	PF00069	0.541
MOD_CK1_1	296	302	PF00069	0.653
MOD_CK1_1	472	478	PF00069	0.572
MOD_CK1_1	483	489	PF00069	0.542
MOD_CK1_1	51	57	PF00069	0.452
MOD_CK1_1	518	524	PF00069	0.369
MOD_CK1_1	577	583	PF00069	0.727
MOD_CK1_1	614	620	PF00069	0.316
MOD_CK1_1	645	651	PF00069	0.449
MOD_CK2_1	285	291	PF00069	0.518
MOD_CK2_1	296	302	PF00069	0.580
MOD_CK2_1	307	313	PF00069	0.587
MOD_Cter_Amidation	232	235	PF01082	0.403
MOD_Cter_Amidation	585	588	PF01082	0.626
MOD_GlcNHglycan	2	5	PF01048	0.443
MOD_GlcNHglycan	244	247	PF01048	0.482
MOD_GlcNHglycan	263	266	PF01048	0.612
MOD_GlcNHglycan	308	312	PF01048	0.664
MOD_GlcNHglycan	376	379	PF01048	0.368
MOD_GlcNHglycan	42	45	PF01048	0.464
MOD_GlcNHglycan	467	472	PF01048	0.630
MOD_GlcNHglycan	474	477	PF01048	0.583
MOD_GlcNHglycan	517	520	PF01048	0.453
MOD_GlcNHglycan	533	536	PF01048	0.297
MOD_GlcNHglycan	576	579	PF01048	0.569
MOD_GlcNHglycan	652	655	PF01048	0.574
MOD_GSK3_1	127	134	PF00069	0.581
MOD_GSK3_1	200	207	PF00069	0.501
MOD_GSK3_1	253	260	PF00069	0.591
MOD_GSK3_1	281	288	PF00069	0.471
MOD_GSK3_1	303	310	PF00069	0.602
MOD_GSK3_1	48	55	PF00069	0.586
MOD_GSK3_1	515	522	PF00069	0.282
MOD_GSK3_1	574	581	PF00069	0.722
MOD_GSK3_1	645	652	PF00069	0.478
MOD_GSK3_1	88	95	PF00069	0.474
MOD_N-GLC_1	415	420	PF02516	0.300
MOD_N-GLC_1	593	598	PF02516	0.523
MOD_NEK2_1	188	193	PF00069	0.419
MOD_NEK2_1	293	298	PF00069	0.550
MOD_NEK2_1	415	420	PF00069	0.336
MOD_NEK2_1	421	426	PF00069	0.336
MOD_NEK2_2	137	142	PF00069	0.366
MOD_NEK2_2	578	583	PF00069	0.748
MOD_PIKK_1	483	489	PF00454	0.588
MOD_PKA_2	342	348	PF00069	0.388
MOD_PKA_2	402	408	PF00069	0.376
MOD_PKA_2	590	596	PF00069	0.667
MOD_PKA_2	611	617	PF00069	0.409
MOD_PKA_2	645	651	PF00069	0.413
MOD_Plk_1	188	194	PF00069	0.488
MOD_Plk_1	204	210	PF00069	0.325
MOD_Plk_1	312	318	PF00069	0.543
MOD_Plk_1	546	552	PF00069	0.300
MOD_Plk_1	578	584	PF00069	0.565
MOD_Plk_2-3	285	291	PF00069	0.411
MOD_Plk_4	204	210	PF00069	0.434
MOD_Plk_4	402	408	PF00069	0.352
MOD_Plk_4	523	529	PF00069	0.300
MOD_Plk_4	578	584	PF00069	0.654
MOD_Plk_4	598	604	PF00069	0.533
MOD_Plk_4	606	612	PF00069	0.401
MOD_Plk_4	614	620	PF00069	0.392
MOD_ProDKin_1	132	138	PF00069	0.455
MOD_ProDKin_1	145	151	PF00069	0.416
MOD_ProDKin_1	29	35	PF00069	0.673
MOD_ProDKin_1	294	300	PF00069	0.481
MOD_ProDKin_1	410	416	PF00069	0.255
MOD_ProDKin_1	52	58	PF00069	0.492
TRG_DiLeu_BaLyEn_6	357	362	PF01217	0.376
TRG_DiLeu_BaLyEn_6	487	492	PF01217	0.442
TRG_ENDOCYTIC_2	365	368	PF00928	0.300
TRG_ER_diArg_1	100	103	PF00400	0.451
TRG_ER_diArg_1	322	325	PF00400	0.418
TRG_ER_diArg_1	587	590	PF00400	0.624
TRG_ER_diArg_1	81	83	PF00400	0.463
TRG_NES_CRM1_1	216	230	PF08389	0.352
TRG_NLS_Bipartite_1	82	103	PF00514	0.367
TRG_NLS_MonoExtC_3	586	591	PF00514	0.691
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	490	495	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P0J4	Trypanosomatidae	32%	100%
A0A3Q8IGM5	Leishmania donovani	92%	100%
A0A422NKA3	Trypanosoma rangeli	33%	100%
A4HQ69	Leishmania braziliensis	77%	100%
A4IDW7	Leishmania infantum	92%	100%
E9ATY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%