Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphoseryl-tRNA Kinase, putative

Species:

Leishmania major

UniProt:

Q4Q0K7_LEIMA

TriTrypDb:

LmjF.36.5540 , LMJLV39_360067600 , LMJSD75_360067600

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0K7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0K7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	2
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.472
CLV_NRD_NRD_1	332	334	PF00675	0.516
CLV_NRD_NRD_1	382	384	PF00675	0.460
CLV_NRD_NRD_1	98	100	PF00675	0.493
CLV_PCSK_FUR_1	330	334	PF00082	0.522
CLV_PCSK_KEX2_1	102	104	PF00082	0.455
CLV_PCSK_KEX2_1	332	334	PF00082	0.599
CLV_PCSK_KEX2_1	381	383	PF00082	0.455
CLV_PCSK_KEX2_1	98	100	PF00082	0.455
CLV_PCSK_PC7_1	98	104	PF00082	0.474
CLV_PCSK_SKI1_1	176	180	PF00082	0.412
CLV_PCSK_SKI1_1	186	190	PF00082	0.505
CLV_PCSK_SKI1_1	37	41	PF00082	0.541
CLV_PCSK_SKI1_1	376	380	PF00082	0.551
CLV_PCSK_SKI1_1	389	393	PF00082	0.299
CLV_PCSK_SKI1_1	98	102	PF00082	0.461
DEG_APCC_DBOX_1	175	183	PF00400	0.392
DEG_APCC_DBOX_1	312	320	PF00400	0.448
DOC_CKS1_1	187	192	PF01111	0.384
DOC_CYCLIN_RxL_1	98	110	PF00134	0.438
DOC_MAPK_gen_1	406	415	PF00069	0.425
DOC_MAPK_gen_1	98	107	PF00069	0.323
DOC_MAPK_MEF2A_6	176	183	PF00069	0.389
DOC_MAPK_MEF2A_6	186	195	PF00069	0.358
DOC_MAPK_MEF2A_6	409	417	PF00069	0.433
DOC_PP4_FxxP_1	187	190	PF00568	0.488
DOC_USP7_MATH_1	11	15	PF00917	0.404
DOC_USP7_MATH_1	172	176	PF00917	0.564
DOC_USP7_MATH_1	213	217	PF00917	0.609
DOC_USP7_MATH_1	26	30	PF00917	0.463
DOC_WW_Pin1_4	186	191	PF00397	0.368
DOC_WW_Pin1_4	370	375	PF00397	0.603
DOC_WW_Pin1_4	4	9	PF00397	0.636
DOC_WW_Pin1_4	90	95	PF00397	0.455
LIG_14-3-3_CanoR_1	214	222	PF00244	0.576
LIG_14-3-3_CanoR_1	400	410	PF00244	0.540
LIG_BIR_II_1	1	5	PF00653	0.740
LIG_BIR_III_2	369	373	PF00653	0.416
LIG_BIR_III_3	1	5	PF00653	0.629
LIG_CSL_BTD_1	217	220	PF09270	0.474
LIG_deltaCOP1_diTrp_1	253	263	PF00928	0.321
LIG_FHA_1	326	332	PF00498	0.529
LIG_FHA_1	340	346	PF00498	0.348
LIG_FHA_1	410	416	PF00498	0.621
LIG_FHA_1	99	105	PF00498	0.440
LIG_FHA_2	75	81	PF00498	0.527
LIG_HCF-1_HBM_1	232	235	PF13415	0.490
LIG_LIR_Apic_2	184	190	PF02991	0.473
LIG_LIR_Apic_2	216	221	PF02991	0.485
LIG_LIR_Nem_3	146	151	PF02991	0.308
LIG_LIR_Nem_3	260	266	PF02991	0.410
LIG_LIR_Nem_3	439	444	PF02991	0.379
LIG_Pex14_2	183	187	PF04695	0.373
LIG_Rb_pABgroove_1	225	233	PF01858	0.463
LIG_SH2_NCK_1	235	239	PF00017	0.520
LIG_SH2_STAP1	341	345	PF00017	0.314
LIG_SH2_STAT3	160	163	PF00017	0.514
LIG_SH2_STAT3	341	344	PF00017	0.326
LIG_SH2_STAT5	341	344	PF00017	0.469
LIG_SH3_3	2	8	PF00018	0.657
LIG_SH3_3	216	222	PF00018	0.529
LIG_SUMO_SIM_anti_2	414	420	PF11976	0.414
LIG_SUMO_SIM_par_1	103	108	PF11976	0.426
LIG_SUMO_SIM_par_1	178	184	PF11976	0.351
LIG_SUMO_SIM_par_1	411	416	PF11976	0.503
LIG_SUMO_SIM_par_1	62	67	PF11976	0.433
LIG_SxIP_EBH_1	16	28	PF03271	0.397
LIG_TRAF2_1	303	306	PF00917	0.387
MOD_CDK_SPK_2	90	95	PF00069	0.475
MOD_CDK_SPxK_1	370	376	PF00069	0.528
MOD_CK1_1	161	167	PF00069	0.616
MOD_CK1_1	7	13	PF00069	0.542
MOD_CK2_1	140	146	PF00069	0.489
MOD_CK2_1	205	211	PF00069	0.738
MOD_CK2_1	74	80	PF00069	0.506
MOD_CK2_1	83	89	PF00069	0.618
MOD_CMANNOS	251	254	PF00535	0.530
MOD_GlcNHglycan	109	112	PF01048	0.465
MOD_GlcNHglycan	13	16	PF01048	0.417
MOD_GlcNHglycan	206	210	PF01048	0.621
MOD_GlcNHglycan	215	218	PF01048	0.584
MOD_GlcNHglycan	419	422	PF01048	0.610
MOD_GlcNHglycan	45	48	PF01048	0.487
MOD_GlcNHglycan	85	88	PF01048	0.678
MOD_GSK3_1	107	114	PF00069	0.434
MOD_GSK3_1	158	165	PF00069	0.521
MOD_GSK3_1	3	10	PF00069	0.653
MOD_LATS_1	407	413	PF00433	0.506
MOD_NEK2_1	105	110	PF00069	0.496
MOD_NEK2_1	162	167	PF00069	0.424
MOD_NEK2_1	18	23	PF00069	0.399
MOD_NEK2_1	283	288	PF00069	0.493
MOD_NEK2_1	325	330	PF00069	0.586
MOD_NEK2_1	417	422	PF00069	0.484
MOD_PIKK_1	105	111	PF00454	0.487
MOD_PIKK_1	162	168	PF00454	0.536
MOD_PIKK_1	257	263	PF00454	0.511
MOD_PIKK_1	267	273	PF00454	0.561
MOD_PIKK_1	389	395	PF00454	0.303
MOD_PKA_1	98	104	PF00069	0.326
MOD_PKA_2	213	219	PF00069	0.561
MOD_PKA_2	41	47	PF00069	0.495
MOD_PKA_2	98	104	PF00069	0.326
MOD_Plk_1	158	164	PF00069	0.563
MOD_Plk_1	326	332	PF00069	0.498
MOD_Plk_2-3	411	417	PF00069	0.435
MOD_Plk_2-3	74	80	PF00069	0.480
MOD_Plk_4	27	33	PF00069	0.474
MOD_Plk_4	425	431	PF00069	0.423
MOD_ProDKin_1	186	192	PF00069	0.377
MOD_ProDKin_1	370	376	PF00069	0.597
MOD_ProDKin_1	4	10	PF00069	0.623
MOD_ProDKin_1	90	96	PF00069	0.443
MOD_SUMO_for_1	387	390	PF00179	0.517
MOD_SUMO_for_1	405	408	PF00179	0.484
MOD_SUMO_rev_2	86	93	PF00179	0.509
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.406
TRG_ENDOCYTIC_2	141	144	PF00928	0.393
TRG_ENDOCYTIC_2	148	151	PF00928	0.347
TRG_ER_diArg_1	102	104	PF00400	0.506
TRG_ER_diArg_1	313	316	PF00400	0.556
TRG_ER_diArg_1	330	333	PF00400	0.658
TRG_ER_diArg_1	380	383	PF00400	0.427
TRG_ER_diArg_1	97	99	PF00400	0.524
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFJ4	Leptomonas seymouri	36%	96%
A0A1X0P061	Trypanosomatidae	23%	100%
A0A3Q8ILN7	Leishmania donovani	91%	100%
A0A422NKD5	Trypanosoma rangeli	26%	100%
A4HQ70	Leishmania braziliensis	71%	98%
A4IDW8	Leishmania infantum	92%	100%
E9ATY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
V5BNR2	Trypanosoma cruzi	27%	100%