Putative aminopeptidase P1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aminopeptidase P1, putative

Species:

Leishmania major

UniProt:

Q4Q0K5_LEIMA

TriTrypDb:

LmjF.36.5560 , LMJLV39_360067800 , LMJSD75_360067800

Length:

840

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0K5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0K5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004177	aminopeptidase activity	5	7
GO:0005488	binding	1	7
GO:0008233	peptidase activity	3	7
GO:0008235	metalloexopeptidase activity	5	7
GO:0008237	metallopeptidase activity	4	7
GO:0008238	exopeptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0030145	manganese ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0070006	metalloaminopeptidase activity	6	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.537
CLV_C14_Caspase3-7	470	474	PF00656	0.447
CLV_NRD_NRD_1	186	188	PF00675	0.481
CLV_NRD_NRD_1	3	5	PF00675	0.569
CLV_NRD_NRD_1	381	383	PF00675	0.516
CLV_NRD_NRD_1	46	48	PF00675	0.310
CLV_NRD_NRD_1	523	525	PF00675	0.337
CLV_NRD_NRD_1	559	561	PF00675	0.315
CLV_PCSK_FUR_1	44	48	PF00082	0.347
CLV_PCSK_KEX2_1	186	188	PF00082	0.481
CLV_PCSK_KEX2_1	3	5	PF00082	0.570
CLV_PCSK_KEX2_1	342	344	PF00082	0.628
CLV_PCSK_KEX2_1	381	383	PF00082	0.516
CLV_PCSK_KEX2_1	44	46	PF00082	0.304
CLV_PCSK_KEX2_1	559	561	PF00082	0.315
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.616
CLV_PCSK_SKI1_1	116	120	PF00082	0.510
CLV_PCSK_SKI1_1	187	191	PF00082	0.501
CLV_PCSK_SKI1_1	391	395	PF00082	0.340
CLV_PCSK_SKI1_1	46	50	PF00082	0.455
CLV_PCSK_SKI1_1	524	528	PF00082	0.304
CLV_PCSK_SKI1_1	548	552	PF00082	0.292
CLV_PCSK_SKI1_1	658	662	PF00082	0.446
CLV_PCSK_SKI1_1	764	768	PF00082	0.378
DEG_APCC_DBOX_1	45	53	PF00400	0.325
DEG_APCC_DBOX_1	523	531	PF00400	0.304
DEG_APCC_DBOX_1	547	555	PF00400	0.284
DEG_APCC_DBOX_1	657	665	PF00400	0.304
DEG_Nend_Nbox_1	1	3	PF02207	0.633
DEG_ODPH_VHL_1	96	109	PF01847	0.598
DEG_SPOP_SBC_1	271	275	PF00917	0.595
DOC_ANK_TNKS_1	498	505	PF00023	0.304
DOC_CKS1_1	347	352	PF01111	0.547
DOC_CYCLIN_RxL_1	296	305	PF00134	0.568
DOC_CYCLIN_yClb1_LxF_4	760	766	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	297	303	PF00134	0.566
DOC_MAPK_MEF2A_6	13	20	PF00069	0.595
DOC_MAPK_MEF2A_6	666	673	PF00069	0.375
DOC_PP2B_LxvP_1	127	130	PF13499	0.439
DOC_PP2B_LxvP_1	376	379	PF13499	0.549
DOC_PP2B_LxvP_1	686	689	PF13499	0.403
DOC_PP2B_LxvP_1	96	99	PF13499	0.545
DOC_PP4_FxxP_1	277	280	PF00568	0.472
DOC_USP7_MATH_1	201	205	PF00917	0.551
DOC_USP7_MATH_1	258	262	PF00917	0.584
DOC_USP7_MATH_1	341	345	PF00917	0.553
DOC_USP7_MATH_1	360	364	PF00917	0.593
DOC_USP7_MATH_1	502	506	PF00917	0.325
DOC_USP7_MATH_1	53	57	PF00917	0.369
DOC_USP7_MATH_1	532	536	PF00917	0.369
DOC_USP7_MATH_1	561	565	PF00917	0.388
DOC_USP7_MATH_1	572	576	PF00917	0.368
DOC_USP7_MATH_1	63	67	PF00917	0.276
DOC_USP7_MATH_1	745	749	PF00917	0.466
DOC_USP7_MATH_1	779	783	PF00917	0.383
DOC_USP7_MATH_1	810	814	PF00917	0.483
DOC_USP7_MATH_1	817	821	PF00917	0.499
DOC_WW_Pin1_4	162	167	PF00397	0.784
DOC_WW_Pin1_4	326	331	PF00397	0.564
DOC_WW_Pin1_4	346	351	PF00397	0.497
DOC_WW_Pin1_4	352	357	PF00397	0.670
DOC_WW_Pin1_4	578	583	PF00397	0.351
DOC_WW_Pin1_4	632	637	PF00397	0.284
DOC_WW_Pin1_4	687	692	PF00397	0.527
LIG_14-3-3_CanoR_1	13	19	PF00244	0.582
LIG_14-3-3_CanoR_1	381	389	PF00244	0.464
LIG_14-3-3_CanoR_1	4	10	PF00244	0.578
LIG_14-3-3_CanoR_1	407	414	PF00244	0.338
LIG_14-3-3_CanoR_1	507	513	PF00244	0.325
LIG_14-3-3_CanoR_1	531	537	PF00244	0.259
LIG_14-3-3_CanoR_1	707	716	PF00244	0.398
LIG_APCC_ABBA_1	606	611	PF00400	0.304
LIG_BRCT_BRCA1_1	504	508	PF00533	0.325
LIG_CaM_IQ_9	756	772	PF13499	0.356
LIG_Clathr_ClatBox_1	553	557	PF01394	0.303
LIG_Clathr_ClatBox_1	661	665	PF01394	0.369
LIG_deltaCOP1_diTrp_1	79	86	PF00928	0.304
LIG_FHA_1	102	108	PF00498	0.560
LIG_FHA_1	121	127	PF00498	0.349
LIG_FHA_1	134	140	PF00498	0.534
LIG_FHA_1	173	179	PF00498	0.585
LIG_FHA_1	21	27	PF00498	0.569
LIG_FHA_1	265	271	PF00498	0.532
LIG_FHA_1	327	333	PF00498	0.548
LIG_FHA_1	371	377	PF00498	0.590
LIG_FHA_1	496	502	PF00498	0.310
LIG_FHA_1	545	551	PF00498	0.304
LIG_FHA_1	633	639	PF00498	0.325
LIG_FHA_1	757	763	PF00498	0.386
LIG_FHA_1	822	828	PF00498	0.317
LIG_FHA_2	172	178	PF00498	0.516
LIG_FHA_2	421	427	PF00498	0.369
LIG_FHA_2	468	474	PF00498	0.340
LIG_FHA_2	809	815	PF00498	0.418
LIG_LIR_Apic_2	274	280	PF02991	0.498
LIG_LIR_Gen_1	282	293	PF02991	0.440
LIG_LIR_Gen_1	383	393	PF02991	0.467
LIG_LIR_Gen_1	410	421	PF02991	0.304
LIG_LIR_Gen_1	80	91	PF02991	0.304
LIG_LIR_Nem_3	282	288	PF02991	0.435
LIG_LIR_Nem_3	383	389	PF02991	0.484
LIG_LIR_Nem_3	410	416	PF02991	0.304
LIG_LIR_Nem_3	510	515	PF02991	0.366
LIG_LIR_Nem_3	79	85	PF02991	0.304
LIG_LIR_Nem_3	813	818	PF02991	0.370
LIG_MYND_1	330	334	PF01753	0.648
LIG_NRBOX	549	555	PF00104	0.303
LIG_Pex14_1	82	86	PF04695	0.304
LIG_Pex14_2	600	604	PF04695	0.369
LIG_PTB_Apo_2	795	802	PF02174	0.492
LIG_PTB_Phospho_1	795	801	PF10480	0.482
LIG_SH2_CRK	322	326	PF00017	0.583
LIG_SH2_CRK	390	394	PF00017	0.308
LIG_SH2_CRK	818	822	PF00017	0.332
LIG_SH2_GRB2like	801	804	PF00017	0.458
LIG_SH2_NCK_1	322	326	PF00017	0.627
LIG_SH2_PTP2	454	457	PF00017	0.304
LIG_SH2_PTP2	512	515	PF00017	0.369
LIG_SH2_SRC	454	457	PF00017	0.304
LIG_SH2_SRC	652	655	PF00017	0.369
LIG_SH2_STAP1	386	390	PF00017	0.463
LIG_SH2_STAP1	68	72	PF00017	0.304
LIG_SH2_STAP1	818	822	PF00017	0.332
LIG_SH2_STAT3	242	245	PF00017	0.473
LIG_SH2_STAT5	454	457	PF00017	0.312
LIG_SH2_STAT5	512	515	PF00017	0.369
LIG_SH2_STAT5	652	655	PF00017	0.423
LIG_SH2_STAT5	715	718	PF00017	0.326
LIG_SH3_3	292	298	PF00018	0.491
LIG_SH3_3	344	350	PF00018	0.774
LIG_SH3_3	472	478	PF00018	0.314
LIG_SH3_3	55	61	PF00018	0.369
LIG_SH3_3	612	618	PF00018	0.325
LIG_SH3_3	648	654	PF00018	0.375
LIG_SH3_3	703	709	PF00018	0.458
LIG_SH3_3	793	799	PF00018	0.406
LIG_SH3_3	802	808	PF00018	0.418
LIG_SUMO_SIM_anti_2	56	61	PF11976	0.304
LIG_SUMO_SIM_anti_2	682	690	PF11976	0.304
LIG_SUMO_SIM_anti_2	830	835	PF11976	0.411
LIG_SUMO_SIM_par_1	682	690	PF11976	0.369
LIG_SUMO_SIM_par_1	737	744	PF11976	0.368
LIG_TRAF2_1	37	40	PF00917	0.503
LIG_TRAF2_1	624	627	PF00917	0.303
LIG_UBA3_1	519	525	PF00899	0.369
MOD_CDC14_SPxK_1	165	168	PF00782	0.525
MOD_CDK_SPK_2	346	351	PF00069	0.683
MOD_CDK_SPK_2	632	637	PF00069	0.325
MOD_CDK_SPxK_1	162	168	PF00069	0.520
MOD_CDK_SPxxK_3	346	353	PF00069	0.592
MOD_CK1_1	101	107	PF00069	0.542
MOD_CK1_1	286	292	PF00069	0.588
MOD_CK1_1	313	319	PF00069	0.500
MOD_CK1_1	365	371	PF00069	0.608
MOD_CK1_1	613	619	PF00069	0.347
MOD_CK1_1	66	72	PF00069	0.369
MOD_CK1_1	782	788	PF00069	0.385
MOD_CK2_1	171	177	PF00069	0.522
MOD_CK2_1	201	207	PF00069	0.562
MOD_CK2_1	34	40	PF00069	0.441
MOD_CK2_1	420	426	PF00069	0.369
MOD_CK2_1	577	583	PF00069	0.440
MOD_GlcNHglycan	100	103	PF01048	0.628
MOD_GlcNHglycan	288	291	PF01048	0.543
MOD_GlcNHglycan	312	315	PF01048	0.562
MOD_GlcNHglycan	322	325	PF01048	0.587
MOD_GlcNHglycan	34	39	PF01048	0.449
MOD_GlcNHglycan	362	365	PF01048	0.657
MOD_GlcNHglycan	404	407	PF01048	0.304
MOD_GlcNHglycan	439	443	PF01048	0.321
MOD_GlcNHglycan	459	462	PF01048	0.222
MOD_GlcNHglycan	564	567	PF01048	0.315
MOD_GlcNHglycan	574	577	PF01048	0.311
MOD_GlcNHglycan	654	657	PF01048	0.353
MOD_GlcNHglycan	728	731	PF01048	0.600
MOD_GSK3_1	12	19	PF00069	0.642
MOD_GSK3_1	131	138	PF00069	0.573
MOD_GSK3_1	146	153	PF00069	0.587
MOD_GSK3_1	365	372	PF00069	0.764
MOD_GSK3_1	402	409	PF00069	0.292
MOD_GSK3_1	503	510	PF00069	0.325
MOD_GSK3_1	572	579	PF00069	0.358
MOD_GSK3_1	734	741	PF00069	0.454
MOD_GSK3_1	817	824	PF00069	0.400
MOD_GSK3_1	97	104	PF00069	0.534
MOD_N-GLC_1	360	365	PF02516	0.555
MOD_NEK2_1	20	25	PF00069	0.524
MOD_NEK2_1	284	289	PF00069	0.463
MOD_NEK2_1	320	325	PF00069	0.630
MOD_NEK2_1	590	595	PF00069	0.399
MOD_NEK2_1	738	743	PF00069	0.453
MOD_NEK2_1	823	828	PF00069	0.325
MOD_NEK2_2	532	537	PF00069	0.325
MOD_NEK2_2	63	68	PF00069	0.369
MOD_PIKK_1	120	126	PF00454	0.456
MOD_PIKK_1	394	400	PF00454	0.365
MOD_PIKK_1	756	762	PF00454	0.380
MOD_PKA_2	107	113	PF00069	0.416
MOD_PKA_2	12	18	PF00069	0.591
MOD_PKA_2	320	326	PF00069	0.587
MOD_PKA_2	380	386	PF00069	0.532
MOD_PKA_2	406	412	PF00069	0.319
MOD_PKA_2	462	468	PF00069	0.304
MOD_Plk_1	206	212	PF00069	0.613
MOD_Plk_1	271	277	PF00069	0.637
MOD_Plk_1	394	400	PF00069	0.306
MOD_Plk_1	53	59	PF00069	0.350
MOD_Plk_1	610	616	PF00069	0.325
MOD_Plk_1	63	69	PF00069	0.259
MOD_Plk_4	122	128	PF00069	0.433
MOD_Plk_4	135	141	PF00069	0.534
MOD_Plk_4	258	264	PF00069	0.536
MOD_Plk_4	272	278	PF00069	0.508
MOD_Plk_4	313	319	PF00069	0.609
MOD_Plk_4	508	514	PF00069	0.369
MOD_Plk_4	53	59	PF00069	0.369
MOD_Plk_4	63	69	PF00069	0.347
MOD_Plk_4	734	740	PF00069	0.538
MOD_Plk_4	746	752	PF00069	0.365
MOD_Plk_4	77	83	PF00069	0.231
MOD_Plk_4	791	797	PF00069	0.406
MOD_Plk_4	817	823	PF00069	0.343
MOD_ProDKin_1	162	168	PF00069	0.785
MOD_ProDKin_1	326	332	PF00069	0.565
MOD_ProDKin_1	346	352	PF00069	0.494
MOD_ProDKin_1	578	584	PF00069	0.351
MOD_ProDKin_1	632	638	PF00069	0.284
MOD_ProDKin_1	687	693	PF00069	0.542
MOD_SUMO_for_1	624	627	PF00179	0.303
MOD_SUMO_rev_2	144	153	PF00179	0.493
TRG_DiLeu_BaEn_1	546	551	PF01217	0.304
TRG_DiLeu_BaEn_1	682	687	PF01217	0.304
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.453
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.593
TRG_ENDOCYTIC_2	322	325	PF00928	0.625
TRG_ENDOCYTIC_2	386	389	PF00928	0.422
TRG_ENDOCYTIC_2	390	393	PF00928	0.355
TRG_ENDOCYTIC_2	454	457	PF00928	0.304
TRG_ENDOCYTIC_2	512	515	PF00928	0.322
TRG_ENDOCYTIC_2	516	519	PF00928	0.287
TRG_ENDOCYTIC_2	818	821	PF00928	0.337
TRG_ENDOCYTIC_2	83	86	PF00928	0.304
TRG_ER_diArg_1	185	187	PF00400	0.483
TRG_ER_diArg_1	2	4	PF00400	0.572
TRG_ER_diArg_1	253	256	PF00400	0.549
TRG_ER_diArg_1	343	346	PF00400	0.662
TRG_ER_diArg_1	350	353	PF00400	0.633
TRG_ER_diArg_1	380	382	PF00400	0.541
TRG_ER_diArg_1	44	47	PF00400	0.304
TRG_ER_diArg_1	558	560	PF00400	0.309
TRG_ER_diArg_1	631	634	PF00400	0.324
TRG_NES_CRM1_1	480	491	PF08389	0.237
TRG_NLS_MonoExtN_4	341	346	PF00514	0.615
TRG_Pf-PMV_PEXEL_1	186	191	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	764	769	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P918	Leptomonas seymouri	48%	98%
A0A3Q8IHX0	Leishmania donovani	93%	100%
A4HQ72	Leishmania braziliensis	74%	100%
A4IDX0	Leishmania infantum	93%	100%
E9ATZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%