Putative G-actin binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adenylyl cyclase-associated protein, putative

Species:

Leishmania major

UniProt:

Q4Q0K2_LEIMA

TriTrypDb:

LmjF.36.5590 , LMJLV39_360068100 , LMJSD75_360068100

Length:

272

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0K2

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	7
GO:0007010	cytoskeleton organization	5	7
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0071840	cellular component organization or biogenesis	2	9
GO:0007015	actin filament organization	5	2
GO:0097435	supramolecular fiber organization	4	2

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	9
GO:0005488	binding	1	9
GO:0005515	protein binding	2	9
GO:0008092	cytoskeletal protein binding	3	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	87	89	PF00675	0.571
CLV_PCSK_KEX2_1	113	115	PF00082	0.274
CLV_PCSK_KEX2_1	86	88	PF00082	0.550
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.274
CLV_PCSK_SKI1_1	53	57	PF00082	0.503
DEG_SPOP_SBC_1	224	228	PF00917	0.391
DOC_ANK_TNKS_1	252	259	PF00023	0.366
DOC_MAPK_MEF2A_6	167	176	PF00069	0.405
DOC_MAPK_MEF2A_6	202	210	PF00069	0.380
DOC_PP2B_PxIxI_1	195	201	PF00149	0.344
DOC_USP7_MATH_1	20	24	PF00917	0.586
DOC_USP7_MATH_1	224	228	PF00917	0.327
DOC_USP7_MATH_1	26	30	PF00917	0.574
DOC_USP7_MATH_1	268	272	PF00917	0.391
DOC_USP7_UBL2_3	259	263	PF12436	0.311
DOC_WW_Pin1_4	120	125	PF00397	0.354
LIG_14-3-3_CanoR_1	202	207	PF00244	0.405
LIG_14-3-3_CanoR_1	53	62	PF00244	0.518
LIG_BRCT_BRCA1_1	268	272	PF00533	0.366
LIG_FHA_1	152	158	PF00498	0.345
LIG_FHA_1	195	201	PF00498	0.293
LIG_FHA_1	217	223	PF00498	0.317
LIG_FHA_1	226	232	PF00498	0.284
LIG_FHA_1	250	256	PF00498	0.415
LIG_FHA_1	47	53	PF00498	0.498
LIG_FHA_2	94	100	PF00498	0.692
LIG_PDZ_Class_3	267	272	PF00595	0.298
LIG_PROFILIN_1	11	17	PF00235	0.532
LIG_PROFILIN_1	4	10	PF00235	0.543
LIG_SH2_PTP2	150	153	PF00017	0.340
LIG_SH2_STAT5	150	153	PF00017	0.307
LIG_SH2_STAT5	209	212	PF00017	0.334
LIG_SH3_3	1	7	PF00018	0.597
LIG_SH3_3	228	234	PF00018	0.298
LIG_SH3_3	8	14	PF00018	0.600
LIG_SUMO_SIM_anti_2	159	164	PF11976	0.276
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.274
LIG_SUMO_SIM_par_1	105	110	PF11976	0.341
LIG_SUMO_SIM_par_1	196	201	PF11976	0.391
LIG_TRAF2_1	82	85	PF00917	0.547
LIG_TRAF2_1	97	100	PF00917	0.605
MOD_CK2_1	174	180	PF00069	0.334
MOD_CK2_1	232	238	PF00069	0.312
MOD_CK2_1	71	77	PF00069	0.558
MOD_CK2_1	93	99	PF00069	0.718
MOD_GlcNHglycan	22	25	PF01048	0.687
MOD_GlcNHglycan	26	29	PF01048	0.651
MOD_GSK3_1	20	27	PF00069	0.580
MOD_GSK3_1	216	223	PF00069	0.358
MOD_GSK3_1	90	97	PF00069	0.634
MOD_N-GLC_1	163	168	PF02516	0.366
MOD_N-GLC_1	46	51	PF02516	0.496
MOD_PK_1	156	162	PF00069	0.298
MOD_PK_1	202	208	PF00069	0.297
MOD_PKA_2	201	207	PF00069	0.391
MOD_PKA_2	216	222	PF00069	0.391
MOD_PKB_1	51	59	PF00069	0.509
MOD_Plk_4	158	164	PF00069	0.289
MOD_ProDKin_1	120	126	PF00069	0.354
MOD_SUMO_rev_2	57	61	PF00179	0.496
MOD_SUMO_rev_2	72	81	PF00179	0.452
TRG_ENDOCYTIC_2	150	153	PF00928	0.307
TRG_ER_diArg_1	86	88	PF00400	0.577
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.273

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P914	Leptomonas seymouri	72%	99%
A0A1X0P0T3	Trypanosomatidae	56%	95%
A0A3Q8IRQ9	Leishmania donovani	96%	100%
A0A3R7NFV7	Trypanosoma rangeli	59%	99%
A4HQ75	Leishmania braziliensis	84%	100%
A4IDX3	Leishmania infantum	96%	100%
D0A444	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%