Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0K1_LEIMA

TriTrypDb:

LmjF.36.5600 , LMJLV39_360068400 , LMJSD75_360068400

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0K1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0K1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.678
CLV_C14_Caspase3-7	238	242	PF00656	0.498
CLV_NRD_NRD_1	142	144	PF00675	0.658
CLV_NRD_NRD_1	28	30	PF00675	0.714
CLV_NRD_NRD_1	318	320	PF00675	0.581
CLV_NRD_NRD_1	375	377	PF00675	0.504
CLV_NRD_NRD_1	447	449	PF00675	0.545
CLV_NRD_NRD_1	477	479	PF00675	0.522
CLV_NRD_NRD_1	67	69	PF00675	0.762
CLV_PCSK_FUR_1	316	320	PF00082	0.529
CLV_PCSK_FUR_1	475	479	PF00082	0.508
CLV_PCSK_KEX2_1	142	144	PF00082	0.658
CLV_PCSK_KEX2_1	27	29	PF00082	0.737
CLV_PCSK_KEX2_1	318	320	PF00082	0.581
CLV_PCSK_KEX2_1	375	377	PF00082	0.474
CLV_PCSK_KEX2_1	381	383	PF00082	0.485
CLV_PCSK_KEX2_1	447	449	PF00082	0.545
CLV_PCSK_KEX2_1	477	479	PF00082	0.522
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.791
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.420
CLV_PCSK_PC7_1	23	29	PF00082	0.747
CLV_PCSK_SKI1_1	143	147	PF00082	0.598
CLV_PCSK_SKI1_1	150	154	PF00082	0.613
CLV_PCSK_SKI1_1	230	234	PF00082	0.459
CLV_PCSK_SKI1_1	269	273	PF00082	0.786
CLV_PCSK_SKI1_1	319	323	PF00082	0.476
CLV_PCSK_SKI1_1	353	357	PF00082	0.446
CLV_PCSK_SKI1_1	378	382	PF00082	0.492
CLV_PCSK_SKI1_1	503	507	PF00082	0.433
CLV_PCSK_SKI1_1	531	535	PF00082	0.566
DEG_APCC_DBOX_1	142	150	PF00400	0.658
DEG_Nend_Nbox_1	1	3	PF02207	0.616
DEG_SPOP_SBC_1	156	160	PF00917	0.644
DEG_SPOP_SBC_1	305	309	PF00917	0.347
DEG_SPOP_SBC_1	523	527	PF00917	0.557
DOC_CKS1_1	388	393	PF01111	0.559
DOC_CKS1_1	9	14	PF01111	0.735
DOC_CYCLIN_RxL_1	227	237	PF00134	0.571
DOC_CYCLIN_yCln2_LP_2	152	155	PF00134	0.705
DOC_CYCLIN_yCln2_LP_2	283	289	PF00134	0.499
DOC_CYCLIN_yCln2_LP_2	427	433	PF00134	0.523
DOC_MAPK_gen_1	170	178	PF00069	0.753
DOC_MAPK_gen_1	447	454	PF00069	0.425
DOC_MAPK_gen_1	503	513	PF00069	0.415
DOC_PP2B_LxvP_1	152	155	PF13499	0.701
DOC_PP2B_LxvP_1	283	286	PF13499	0.492
DOC_PP4_FxxP_1	198	201	PF00568	0.456
DOC_PP4_FxxP_1	9	12	PF00568	0.538
DOC_SPAK_OSR1_1	172	176	PF12202	0.713
DOC_USP7_MATH_1	157	161	PF00917	0.759
DOC_USP7_MATH_1	177	181	PF00917	0.748
DOC_USP7_MATH_1	276	280	PF00917	0.531
DOC_USP7_MATH_1	542	546	PF00917	0.707
DOC_WW_Pin1_4	126	131	PF00397	0.650
DOC_WW_Pin1_4	163	168	PF00397	0.682
DOC_WW_Pin1_4	179	184	PF00397	0.651
DOC_WW_Pin1_4	2	7	PF00397	0.720
DOC_WW_Pin1_4	248	253	PF00397	0.653
DOC_WW_Pin1_4	272	277	PF00397	0.683
DOC_WW_Pin1_4	278	283	PF00397	0.580
DOC_WW_Pin1_4	387	392	PF00397	0.737
DOC_WW_Pin1_4	476	481	PF00397	0.702
DOC_WW_Pin1_4	67	72	PF00397	0.772
DOC_WW_Pin1_4	75	80	PF00397	0.662
DOC_WW_Pin1_4	8	13	PF00397	0.658
DOC_WW_Pin1_4	92	97	PF00397	0.726
LIG_14-3-3_CanoR_1	110	115	PF00244	0.629
LIG_14-3-3_CanoR_1	191	198	PF00244	0.704
LIG_14-3-3_CanoR_1	246	252	PF00244	0.730
LIG_14-3-3_CanoR_1	327	332	PF00244	0.485
LIG_14-3-3_CanoR_1	360	364	PF00244	0.473
LIG_14-3-3_CanoR_1	365	373	PF00244	0.489
LIG_14-3-3_CanoR_1	375	381	PF00244	0.515
LIG_14-3-3_CanoR_1	447	455	PF00244	0.438
LIG_Actin_WH2_2	490	505	PF00022	0.513
LIG_BIR_III_2	34	38	PF00653	0.676
LIG_BRCT_BRCA1_1	421	425	PF00533	0.502
LIG_BRCT_BRCA1_1	518	522	PF00533	0.499
LIG_CSL_BTD_1	9	12	PF09270	0.733
LIG_DLG_GKlike_1	376	384	PF00625	0.404
LIG_EH1_1	328	336	PF00400	0.522
LIG_eIF4E_1	329	335	PF01652	0.432
LIG_FHA_1	350	356	PF00498	0.493
LIG_FHA_1	405	411	PF00498	0.613
LIG_FHA_1	447	453	PF00498	0.484
LIG_FHA_1	466	472	PF00498	0.605
LIG_FHA_1	48	54	PF00498	0.719
LIG_FHA_1	553	559	PF00498	0.554
LIG_FHA_2	236	242	PF00498	0.489
LIG_FHA_2	256	262	PF00498	0.571
LIG_LIR_Apic_2	197	201	PF02991	0.369
LIG_NRBOX	333	339	PF00104	0.391
LIG_Pex14_1	10	14	PF04695	0.617
LIG_RPA_C_Fungi	24	36	PF08784	0.749
LIG_SH2_CRK	323	327	PF00017	0.520
LIG_SH2_NCK_1	210	214	PF00017	0.512
LIG_SH2_NCK_1	329	333	PF00017	0.468
LIG_SH2_NCK_1	551	555	PF00017	0.582
LIG_SH2_SRC	551	554	PF00017	0.659
LIG_SH2_STAT5	14	17	PF00017	0.638
LIG_SH2_STAT5	24	27	PF00017	0.696
LIG_SH2_STAT5	290	293	PF00017	0.533
LIG_SH3_2	183	188	PF14604	0.698
LIG_SH3_2	63	68	PF14604	0.706
LIG_SH3_3	100	106	PF00018	0.519
LIG_SH3_3	142	148	PF00018	0.709
LIG_SH3_3	180	186	PF00018	0.703
LIG_SH3_3	385	391	PF00018	0.519
LIG_SH3_3	60	66	PF00018	0.715
LIG_SH3_3	73	79	PF00018	0.764
LIG_SUMO_SIM_par_1	299	309	PF11976	0.483
LIG_SUMO_SIM_par_1	456	462	PF11976	0.461
LIG_TRAF2_1	416	419	PF00917	0.541
LIG_TYR_ITIM	321	326	PF00017	0.503
LIG_WW_3	185	189	PF00397	0.767
MOD_CDK_SPK_2	8	13	PF00069	0.734
MOD_CDK_SPxK_1	2	8	PF00069	0.662
MOD_CDK_SPxxK_3	163	170	PF00069	0.678
MOD_CK1_1	126	132	PF00069	0.669
MOD_CK1_1	166	172	PF00069	0.628
MOD_CK1_1	250	256	PF00069	0.738
MOD_CK2_1	255	261	PF00069	0.747
MOD_CK2_1	389	395	PF00069	0.680
MOD_CK2_1	67	73	PF00069	0.826
MOD_Cter_Amidation	25	28	PF01082	0.784
MOD_Cter_Amidation	316	319	PF01082	0.589
MOD_Cter_Amidation	475	478	PF01082	0.503
MOD_DYRK1A_RPxSP_1	387	391	PF00069	0.654
MOD_GlcNHglycan	138	142	PF01048	0.694
MOD_GlcNHglycan	163	166	PF01048	0.763
MOD_GlcNHglycan	179	182	PF01048	0.711
MOD_GlcNHglycan	211	214	PF01048	0.611
MOD_GlcNHglycan	278	281	PF01048	0.699
MOD_GlcNHglycan	308	311	PF01048	0.530
MOD_GlcNHglycan	392	395	PF01048	0.728
MOD_GlcNHglycan	528	531	PF01048	0.511
MOD_GlcNHglycan	562	565	PF01048	0.705
MOD_GlcNHglycan	90	93	PF01048	0.722
MOD_GSK3_1	117	124	PF00069	0.701
MOD_GSK3_1	157	164	PF00069	0.741
MOD_GSK3_1	246	253	PF00069	0.671
MOD_GSK3_1	272	279	PF00069	0.724
MOD_GSK3_1	349	356	PF00069	0.554
MOD_GSK3_1	359	366	PF00069	0.527
MOD_GSK3_1	436	443	PF00069	0.507
MOD_GSK3_1	522	529	PF00069	0.476
MOD_GSK3_1	88	95	PF00069	0.719
MOD_LATS_1	374	380	PF00433	0.502
MOD_NEK2_1	209	214	PF00069	0.530
MOD_NEK2_1	235	240	PF00069	0.558
MOD_NEK2_1	254	259	PF00069	0.471
MOD_NEK2_1	288	293	PF00069	0.403
MOD_NEK2_1	321	326	PF00069	0.540
MOD_NEK2_1	359	364	PF00069	0.488
MOD_NEK2_1	438	443	PF00069	0.435
MOD_NEK2_1	495	500	PF00069	0.489
MOD_NEK2_1	522	527	PF00069	0.513
MOD_NEK2_2	47	52	PF00069	0.540
MOD_PIKK_1	121	127	PF00454	0.701
MOD_PIKK_1	321	327	PF00454	0.555
MOD_PK_1	327	333	PF00069	0.467
MOD_PKA_2	190	196	PF00069	0.642
MOD_PKA_2	359	365	PF00069	0.506
MOD_PKA_2	39	45	PF00069	0.739
MOD_PKA_2	446	452	PF00069	0.452
MOD_PKA_2	88	94	PF00069	0.692
MOD_Plk_1	418	424	PF00069	0.468
MOD_Plk_2-3	117	123	PF00069	0.639
MOD_Plk_4	110	116	PF00069	0.537
MOD_Plk_4	359	365	PF00069	0.532
MOD_ProDKin_1	126	132	PF00069	0.645
MOD_ProDKin_1	163	169	PF00069	0.679
MOD_ProDKin_1	179	185	PF00069	0.651
MOD_ProDKin_1	2	8	PF00069	0.716
MOD_ProDKin_1	248	254	PF00069	0.655
MOD_ProDKin_1	272	278	PF00069	0.679
MOD_ProDKin_1	387	393	PF00069	0.743
MOD_ProDKin_1	476	482	PF00069	0.698
MOD_ProDKin_1	67	73	PF00069	0.772
MOD_ProDKin_1	75	81	PF00069	0.660
MOD_ProDKin_1	92	98	PF00069	0.722
TRG_DiLeu_BaEn_1	216	221	PF01217	0.499
TRG_DiLeu_BaEn_2	488	494	PF01217	0.516
TRG_DiLeu_BaEn_4	418	424	PF01217	0.546
TRG_ENDOCYTIC_2	323	326	PF00928	0.508
TRG_ENDOCYTIC_2	551	554	PF00928	0.560
TRG_ER_diArg_1	170	173	PF00400	0.698
TRG_ER_diArg_1	28	31	PF00400	0.742
TRG_ER_diArg_1	316	319	PF00400	0.613
TRG_ER_diArg_1	375	378	PF00400	0.513
TRG_ER_diArg_1	475	478	PF00400	0.503
TRG_NLS_MonoExtC_3	26	31	PF00514	0.789

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMS8	Leptomonas seymouri	46%	95%
A0A1X0P1C1	Trypanosomatidae	28%	100%
A0A3Q8IJU5	Leishmania donovani	90%	100%
A0A3R7M711	Trypanosoma rangeli	29%	100%
A4HQ76	Leishmania braziliensis	72%	100%
A4IDX4	Leishmania infantum	90%	100%
D0A438	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ATZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%