LeishMANIAdb
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NERD domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
NERD domain-containing protein
Gene product:
Nuclease-related domain containing protein, putative
Species:
Leishmania major
UniProt:
Q4Q0K0_LEIMA
TriTrypDb:
LmjF.36.5610 * , LMJLV39_360068500 * , LMJSD75_360068500 *
Length:
545

Annotations

LeishMANIAdb annotations

A conserved signal-anchored protein family of obscure function also found in plants and bacteria.. Some of the Leishmaniid proteins might have 3 TM segments instead of 1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4Q0K0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0K0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 272 276 PF00656 0.562
CLV_NRD_NRD_1 154 156 PF00675 0.475
CLV_NRD_NRD_1 180 182 PF00675 0.305
CLV_NRD_NRD_1 192 194 PF00675 0.234
CLV_NRD_NRD_1 238 240 PF00675 0.368
CLV_NRD_NRD_1 262 264 PF00675 0.280
CLV_NRD_NRD_1 269 271 PF00675 0.262
CLV_NRD_NRD_1 439 441 PF00675 0.337
CLV_NRD_NRD_1 482 484 PF00675 0.489
CLV_PCSK_KEX2_1 154 156 PF00082 0.475
CLV_PCSK_KEX2_1 191 193 PF00082 0.276
CLV_PCSK_KEX2_1 240 242 PF00082 0.322
CLV_PCSK_KEX2_1 262 264 PF00082 0.300
CLV_PCSK_KEX2_1 269 271 PF00082 0.266
CLV_PCSK_KEX2_1 295 297 PF00082 0.325
CLV_PCSK_KEX2_1 477 479 PF00082 0.430
CLV_PCSK_KEX2_1 482 484 PF00082 0.480
CLV_PCSK_PC1ET2_1 240 242 PF00082 0.341
CLV_PCSK_PC1ET2_1 295 297 PF00082 0.369
CLV_PCSK_PC1ET2_1 477 479 PF00082 0.447
CLV_PCSK_PC1ET2_1 482 484 PF00082 0.505
CLV_PCSK_PC7_1 150 156 PF00082 0.488
CLV_PCSK_PC7_1 478 484 PF00082 0.476
CLV_PCSK_SKI1_1 295 299 PF00082 0.379
CLV_PCSK_SKI1_1 335 339 PF00082 0.384
CLV_PCSK_SKI1_1 420 424 PF00082 0.414
CLV_PCSK_SKI1_1 441 445 PF00082 0.337
CLV_PCSK_SKI1_1 459 463 PF00082 0.456
CLV_PCSK_SKI1_1 478 482 PF00082 0.349
DEG_APCC_DBOX_1 439 447 PF00400 0.574
DEG_APCC_KENBOX_2 504 508 PF00400 0.684
DEG_COP1_1 425 434 PF00400 0.559
DEG_Nend_UBRbox_3 1 3 PF02207 0.538
DOC_CKS1_1 374 379 PF01111 0.728
DOC_CKS1_1 60 65 PF01111 0.328
DOC_CYCLIN_RxL_1 456 465 PF00134 0.650
DOC_CYCLIN_yCln2_LP_2 86 89 PF00134 0.366
DOC_MAPK_DCC_7 311 319 PF00069 0.562
DOC_MAPK_gen_1 237 247 PF00069 0.562
DOC_MAPK_gen_1 440 448 PF00069 0.528
DOC_MAPK_gen_1 449 457 PF00069 0.580
DOC_MAPK_MEF2A_6 311 319 PF00069 0.509
DOC_MAPK_MEF2A_6 440 448 PF00069 0.522
DOC_MAPK_RevD_3 322 335 PF00069 0.627
DOC_MAPK_RevD_3 469 483 PF00069 0.618
DOC_PP1_RVXF_1 24 30 PF00149 0.360
DOC_PP2B_LxvP_1 85 88 PF13499 0.387
DOC_PP2B_PxIxI_1 211 217 PF00149 0.562
DOC_PP4_FxxP_1 319 322 PF00568 0.533
DOC_USP7_MATH_1 364 368 PF00917 0.696
DOC_USP7_MATH_1 94 98 PF00917 0.379
DOC_USP7_UBL2_3 303 307 PF12436 0.568
DOC_USP7_UBL2_3 477 481 PF12436 0.655
DOC_USP7_UBL2_3 482 486 PF12436 0.705
DOC_WW_Pin1_4 373 378 PF00397 0.706
DOC_WW_Pin1_4 59 64 PF00397 0.378
LIG_14-3-3_CanoR_1 296 300 PF00244 0.579
LIG_14-3-3_CanoR_1 49 58 PF00244 0.333
LIG_BRCT_BRCA1_1 27 31 PF00533 0.189
LIG_CaM_IQ_9 167 183 PF13499 0.562
LIG_eIF4E_1 438 444 PF01652 0.573
LIG_FHA_1 123 129 PF00498 0.334
LIG_FHA_1 340 346 PF00498 0.619
LIG_FHA_1 408 414 PF00498 0.571
LIG_FHA_1 421 427 PF00498 0.561
LIG_FHA_1 45 51 PF00498 0.427
LIG_FHA_1 461 467 PF00498 0.593
LIG_FHA_1 515 521 PF00498 0.571
LIG_GBD_Chelix_1 413 421 PF00786 0.407
LIG_LIR_Apic_2 64 69 PF02991 0.351
LIG_LIR_Gen_1 116 127 PF02991 0.357
LIG_LIR_Gen_1 244 255 PF02991 0.481
LIG_LIR_Gen_1 28 37 PF02991 0.182
LIG_LIR_Gen_1 341 351 PF02991 0.466
LIG_LIR_Gen_1 410 417 PF02991 0.505
LIG_LIR_Gen_1 506 515 PF02991 0.646
LIG_LIR_Nem_3 116 122 PF02991 0.357
LIG_LIR_Nem_3 244 250 PF02991 0.487
LIG_LIR_Nem_3 28 32 PF02991 0.189
LIG_LIR_Nem_3 341 346 PF02991 0.537
LIG_LIR_Nem_3 370 375 PF02991 0.681
LIG_LIR_Nem_3 410 414 PF02991 0.502
LIG_LIR_Nem_3 433 438 PF02991 0.610
LIG_LIR_Nem_3 72 78 PF02991 0.330
LIG_LYPXL_yS_3 82 85 PF13949 0.327
LIG_NRBOX 412 418 PF00104 0.598
LIG_Pex14_1 185 189 PF04695 0.487
LIG_Pex14_1 411 415 PF04695 0.514
LIG_Pex14_1 74 78 PF04695 0.330
LIG_Pex14_2 29 33 PF04695 0.167
LIG_RPA_C_Fungi 187 199 PF08784 0.448
LIG_SH2_CRK 66 70 PF00017 0.434
LIG_SH2_PTP2 119 122 PF00017 0.429
LIG_SH2_STAP1 300 304 PF00017 0.385
LIG_SH2_STAT5 119 122 PF00017 0.413
LIG_SH2_STAT5 264 267 PF00017 0.418
LIG_SH2_STAT5 336 339 PF00017 0.453
LIG_SH2_STAT5 415 418 PF00017 0.411
LIG_SH2_STAT5 509 512 PF00017 0.546
LIG_SH3_2 498 503 PF14604 0.580
LIG_SH3_3 268 274 PF00018 0.413
LIG_SH3_3 371 377 PF00018 0.648
LIG_SH3_3 378 384 PF00018 0.664
LIG_SH3_3 495 501 PF00018 0.471
LIG_SH3_3 9 15 PF00018 0.401
LIG_SUMO_SIM_anti_2 204 209 PF11976 0.328
LIG_SUMO_SIM_anti_2 34 39 PF11976 0.167
LIG_SUMO_SIM_anti_2 468 475 PF11976 0.510
LIG_SUMO_SIM_par_1 212 218 PF11976 0.332
LIG_SUMO_SIM_par_1 314 320 PF11976 0.343
LIG_SUMO_SIM_par_1 521 527 PF11976 0.410
LIG_WRC_WIRS_1 340 345 PF05994 0.429
MOD_CDK_SPxK_1 59 65 PF00069 0.488
MOD_CDK_SPxxK_3 373 380 PF00069 0.483
MOD_CK1_1 367 373 PF00069 0.640
MOD_CK1_1 465 471 PF00069 0.530
MOD_CK1_1 97 103 PF00069 0.456
MOD_CMANNOS 369 372 PF00535 0.658
MOD_Cter_Amidation 293 296 PF01082 0.473
MOD_GlcNHglycan 385 388 PF01048 0.606
MOD_GlcNHglycan 432 435 PF01048 0.498
MOD_GlcNHglycan 51 54 PF01048 0.482
MOD_GlcNHglycan 99 102 PF01048 0.605
MOD_GSK3_1 21 28 PF00069 0.384
MOD_GSK3_1 364 371 PF00069 0.608
MOD_GSK3_1 93 100 PF00069 0.473
MOD_NEK2_1 122 127 PF00069 0.413
MOD_NEK2_1 134 139 PF00069 0.441
MOD_NEK2_1 166 171 PF00069 0.496
MOD_NEK2_1 225 230 PF00069 0.473
MOD_NEK2_1 27 32 PF00069 0.203
MOD_NEK2_1 457 462 PF00069 0.453
MOD_NEK2_1 471 476 PF00069 0.422
MOD_NEK2_1 514 519 PF00069 0.521
MOD_NEK2_2 141 146 PF00069 0.594
MOD_PIKK_1 148 154 PF00454 0.624
MOD_PKA_1 295 301 PF00069 0.473
MOD_PKA_2 141 147 PF00069 0.473
MOD_PKA_2 295 301 PF00069 0.445
MOD_PKA_2 351 357 PF00069 0.548
MOD_PKB_1 239 247 PF00069 0.473
MOD_Plk_1 94 100 PF00069 0.471
MOD_Plk_4 109 115 PF00069 0.536
MOD_Plk_4 123 129 PF00069 0.221
MOD_Plk_4 295 301 PF00069 0.357
MOD_Plk_4 364 370 PF00069 0.592
MOD_Plk_4 457 463 PF00069 0.535
MOD_Plk_4 519 525 PF00069 0.544
MOD_ProDKin_1 373 379 PF00069 0.652
MOD_ProDKin_1 59 65 PF00069 0.470
MOD_SUMO_rev_2 169 176 PF00179 0.435
TRG_DiLeu_BaEn_1 506 511 PF01217 0.572
TRG_DiLeu_BaEn_2 161 167 PF01217 0.515
TRG_DiLeu_BaLyEn_6 417 422 PF01217 0.521
TRG_ENDOCYTIC_2 119 122 PF00928 0.413
TRG_ENDOCYTIC_2 509 512 PF00928 0.546
TRG_ENDOCYTIC_2 75 78 PF00928 0.436
TRG_ENDOCYTIC_2 82 85 PF00928 0.480
TRG_ER_diArg_1 153 155 PF00400 0.596
TRG_ER_diArg_1 190 193 PF00400 0.328
TRG_ER_diArg_1 239 242 PF00400 0.473
TRG_ER_diArg_1 261 263 PF00400 0.319
TRG_ER_diArg_1 269 271 PF00400 0.306
TRG_Pf-PMV_PEXEL_1 535 539 PF00026 0.608

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDN0 Leptomonas seymouri 72% 100%
A0A0S4J7E4 Bodo saltans 36% 100%
A0A1X0P0I4 Trypanosomatidae 41% 100%
A0A3R7R7J3 Trypanosoma rangeli 43% 100%
A0A3S7XC13 Leishmania donovani 92% 100%
A4HQ77 Leishmania braziliensis 85% 100%
A4IDX5 Leishmania infantum 90% 100%
D0A437 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9ATZ5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
V5B3M2 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS