SWIM-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0J8_LEIMA

TriTrypDb:

LmjF.36.5630 , LMJLV39_360068700 , LMJSD75_360068700

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	2
GO:0097196	Shu complex	2	2

Expansion

Sequence features

Q4Q0J8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0J8

Function

Biological processes
Term	Name	Level	Count
GO:0000724	double-strand break repair via homologous recombination	7	2
GO:0000725	recombinational repair	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006302	double-strand break repair	6	2
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0008270	zinc ion binding	6	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0046914	transition metal ion binding	5	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.756
CLV_PCSK_SKI1_1	195	199	PF00082	0.369
CLV_PCSK_SKI1_1	21	25	PF00082	0.533
CLV_PCSK_SKI1_1	71	75	PF00082	0.428
DEG_SPOP_SBC_1	128	132	PF00917	0.751
DOC_MAPK_MEF2A_6	195	204	PF00069	0.354
DOC_MAPK_NFAT4_5	195	203	PF00069	0.351
DOC_USP7_MATH_1	121	125	PF00917	0.723
DOC_USP7_MATH_1	128	132	PF00917	0.662
DOC_USP7_MATH_1	148	152	PF00917	0.693
DOC_USP7_MATH_1	182	186	PF00917	0.575
DOC_WW_Pin1_4	129	134	PF00397	0.737
DOC_WW_Pin1_4	169	174	PF00397	0.423
DOC_WW_Pin1_4	219	224	PF00397	0.514
LIG_14-3-3_CanoR_1	120	129	PF00244	0.656
LIG_BIR_II_1	1	5	PF00653	0.599
LIG_FHA_1	18	24	PF00498	0.451
LIG_FHA_1	207	213	PF00498	0.468
LIG_FHA_1	82	88	PF00498	0.436
LIG_FHA_2	104	110	PF00498	0.693
LIG_LIR_Apic_2	172	177	PF02991	0.435
LIG_LIR_Gen_1	225	234	PF02991	0.474
LIG_LIR_Nem_3	13	18	PF02991	0.507
LIG_LIR_Nem_3	169	174	PF02991	0.550
LIG_LIR_Nem_3	225	229	PF02991	0.481
LIG_LIR_Nem_3	25	30	PF02991	0.409
LIG_LYPXL_yS_3	15	18	PF13949	0.547
LIG_SH2_CRK	183	187	PF00017	0.495
LIG_SH2_STAP1	226	230	PF00017	0.515
LIG_SH2_STAP1	27	31	PF00017	0.392
LIG_SH2_STAT3	181	184	PF00017	0.466
LIG_SH2_STAT5	175	178	PF00017	0.423
LIG_SH2_STAT5	30	33	PF00017	0.454
LIG_SH2_STAT5	90	93	PF00017	0.471
LIG_TRAF2_1	57	60	PF00917	0.508
MOD_CDK_SPK_2	129	134	PF00069	0.517
MOD_CK1_1	103	109	PF00069	0.571
MOD_CK1_1	151	157	PF00069	0.584
MOD_CK1_1	35	41	PF00069	0.631
MOD_CK2_1	219	225	PF00069	0.484
MOD_CK2_1	54	60	PF00069	0.494
MOD_CK2_1	96	102	PF00069	0.556
MOD_GlcNHglycan	123	126	PF01048	0.643
MOD_GlcNHglycan	145	148	PF01048	0.717
MOD_GlcNHglycan	153	156	PF01048	0.611
MOD_GlcNHglycan	178	181	PF01048	0.531
MOD_GlcNHglycan	74	77	PF01048	0.408
MOD_GSK3_1	128	135	PF00069	0.749
MOD_GSK3_1	96	103	PF00069	0.655
MOD_N-GLC_1	214	219	PF02516	0.455
MOD_NEK2_1	3	8	PF00069	0.471
MOD_NEK2_2	166	171	PF00069	0.528
MOD_PIKK_1	136	142	PF00454	0.770
MOD_PIKK_1	149	155	PF00454	0.498
MOD_PKA_2	121	127	PF00069	0.568
MOD_Plk_1	100	106	PF00069	0.676
MOD_Plk_1	166	172	PF00069	0.534
MOD_Plk_1	214	220	PF00069	0.456
MOD_Plk_4	166	172	PF00069	0.519
MOD_ProDKin_1	129	135	PF00069	0.740
MOD_ProDKin_1	169	175	PF00069	0.428
MOD_ProDKin_1	219	225	PF00069	0.512
TRG_DiLeu_BaEn_1	225	230	PF01217	0.452
TRG_ENDOCYTIC_2	15	18	PF00928	0.547
TRG_ENDOCYTIC_2	183	186	PF00928	0.474
TRG_ENDOCYTIC_2	226	229	PF00928	0.516
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I274	Leptomonas seymouri	53%	95%
A0A0S4J7F5	Bodo saltans	26%	95%
A0A1X0P068	Trypanosomatidae	33%	100%
A0A3R7L646	Trypanosoma rangeli	39%	100%
A0A3S7XBY1	Leishmania donovani	90%	100%
A4HQ79	Leishmania braziliensis	69%	100%
A4IDX7	Leishmania infantum	90%	100%
D0A433	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ATZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BTC7	Trypanosoma cruzi	38%	100%