Cyclin N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cyclin 12, L-type

Species:

Leishmania major

UniProt:

Q4Q0J7_LEIMA

TriTrypDb:

LmjF.36.5640 , LMJLV39_360068800 , LMJSD75_360068800

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0J7

Function

Biological processes
Term	Name	Level	Count
GO:0000365	mRNA trans splicing, via spliceosome	9	2
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006355	regulation of DNA-templated transcription	6	12
GO:0006357	regulation of transcription by RNA polymerase II	7	12
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009889	regulation of biosynthetic process	4	12
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0045291	mRNA trans splicing, SL addition	10	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051252	regulation of RNA metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	12
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1903506	regulation of nucleic acid-templated transcription	7	12
GO:2001141	regulation of RNA biosynthetic process	6	12

Molecular functions
Term	Name	Level	Count
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	5	12
GO:0019207	kinase regulator activity	3	12
GO:0019887	protein kinase regulator activity	4	12
GO:0030234	enzyme regulator activity	2	12
GO:0098772	molecular function regulator activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.453
CLV_NRD_NRD_1	297	299	PF00675	0.539
CLV_NRD_NRD_1	455	457	PF00675	0.677
CLV_NRD_NRD_1	467	469	PF00675	0.663
CLV_NRD_NRD_1	479	481	PF00675	0.675
CLV_NRD_NRD_1	489	491	PF00675	0.743
CLV_NRD_NRD_1	492	494	PF00675	0.718
CLV_PCSK_FUR_1	295	299	PF00082	0.531
CLV_PCSK_FUR_1	487	491	PF00082	0.756
CLV_PCSK_KEX2_1	180	182	PF00082	0.450
CLV_PCSK_KEX2_1	297	299	PF00082	0.512
CLV_PCSK_KEX2_1	454	456	PF00082	0.682
CLV_PCSK_KEX2_1	474	476	PF00082	0.764
CLV_PCSK_KEX2_1	478	480	PF00082	0.710
CLV_PCSK_KEX2_1	487	489	PF00082	0.801
CLV_PCSK_KEX2_1	72	74	PF00082	0.648
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.719
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.648
CLV_PCSK_PC7_1	176	182	PF00082	0.414
CLV_PCSK_PC7_1	475	481	PF00082	0.696
CLV_PCSK_SKI1_1	226	230	PF00082	0.470
CLV_PCSK_SKI1_1	297	301	PF00082	0.521
CLV_PCSK_SKI1_1	335	339	PF00082	0.520
CLV_PCSK_SKI1_1	355	359	PF00082	0.291
DEG_APCC_DBOX_1	119	127	PF00400	0.612
DEG_APCC_DBOX_1	72	80	PF00400	0.660
DEG_SCF_FBW7_1	84	91	PF00400	0.513
DEG_SPOP_SBC_1	413	417	PF00917	0.755
DOC_CYCLIN_yCln2_LP_2	129	135	PF00134	0.523
DOC_CYCLIN_yCln2_LP_2	300	306	PF00134	0.525
DOC_MAPK_DCC_7	120	129	PF00069	0.602
DOC_MAPK_gen_1	118	126	PF00069	0.647
DOC_MAPK_gen_1	166	173	PF00069	0.436
DOC_MAPK_gen_1	180	186	PF00069	0.398
DOC_MAPK_gen_1	295	302	PF00069	0.508
DOC_MAPK_gen_1	72	78	PF00069	0.654
DOC_MAPK_HePTP_8	117	129	PF00069	0.640
DOC_MAPK_MEF2A_6	120	129	PF00069	0.591
DOC_MAPK_MEF2A_6	166	175	PF00069	0.436
DOC_MAPK_MEF2A_6	226	234	PF00069	0.385
DOC_PP2B_LxvP_1	129	132	PF13499	0.534
DOC_PP2B_LxvP_1	300	303	PF13499	0.543
DOC_PP2B_LxvP_1	320	323	PF13499	0.264
DOC_PP2B_LxvP_1	58	61	PF13499	0.656
DOC_PP4_FxxP_1	427	430	PF00568	0.746
DOC_USP7_MATH_1	243	247	PF00917	0.566
DOC_USP7_MATH_1	397	401	PF00917	0.596
DOC_USP7_MATH_1	414	418	PF00917	0.672
DOC_WW_Pin1_4	220	225	PF00397	0.447
DOC_WW_Pin1_4	25	30	PF00397	0.420
DOC_WW_Pin1_4	405	410	PF00397	0.635
DOC_WW_Pin1_4	80	85	PF00397	0.624
LIG_14-3-3_CanoR_1	176	180	PF00244	0.496
LIG_14-3-3_CanoR_1	365	371	PF00244	0.630
LIG_Actin_WH2_2	11	28	PF00022	0.446
LIG_Actin_WH2_2	164	182	PF00022	0.550
LIG_BRCT_BRCA1_1	326	330	PF00533	0.532
LIG_BRCT_BRCA1_1	35	39	PF00533	0.439
LIG_CtBP_PxDLS_1	317	321	PF00389	0.517
LIG_deltaCOP1_diTrp_1	324	330	PF00928	0.455
LIG_eIF4E_1	33	39	PF01652	0.374
LIG_FHA_1	119	125	PF00498	0.602
LIG_FHA_1	18	24	PF00498	0.437
LIG_FHA_1	356	362	PF00498	0.606
LIG_FHA_1	367	373	PF00498	0.441
LIG_FHA_2	156	162	PF00498	0.467
LIG_FHA_2	217	223	PF00498	0.402
LIG_FHA_2	319	325	PF00498	0.569
LIG_FHA_2	373	379	PF00498	0.552
LIG_FHA_2	393	399	PF00498	0.580
LIG_Integrin_RGD_1	251	253	PF01839	0.655
LIG_LIR_Apic_2	108	112	PF02991	0.491
LIG_LIR_Apic_2	426	430	PF02991	0.744
LIG_LIR_Gen_1	36	46	PF02991	0.456
LIG_LIR_Nem_3	222	228	PF02991	0.448
LIG_LIR_Nem_3	341	347	PF02991	0.525
LIG_LIR_Nem_3	36	42	PF02991	0.446
LIG_LIR_Nem_3	8	13	PF02991	0.409
LIG_LYPXL_SIV_4	224	232	PF13949	0.488
LIG_Pex14_1	326	330	PF04695	0.412
LIG_SH2_CRK	225	229	PF00017	0.407
LIG_SH2_CRK	373	377	PF00017	0.584
LIG_SH2_GRB2like	231	234	PF00017	0.506
LIG_SH2_PTP2	227	230	PF00017	0.499
LIG_SH2_SRC	231	234	PF00017	0.494
LIG_SH2_STAT3	310	313	PF00017	0.488
LIG_SH2_STAT5	10	13	PF00017	0.437
LIG_SH2_STAT5	109	112	PF00017	0.501
LIG_SH2_STAT5	135	138	PF00017	0.434
LIG_SH2_STAT5	148	151	PF00017	0.326
LIG_SH2_STAT5	227	230	PF00017	0.499
LIG_SH2_STAT5	231	234	PF00017	0.506
LIG_SH2_STAT5	54	57	PF00017	0.638
LIG_SH3_3	189	195	PF00018	0.556
LIG_SH3_3	218	224	PF00018	0.362
LIG_SH3_3	406	412	PF00018	0.587
LIG_SH3_3	78	84	PF00018	0.703
LIG_SUMO_SIM_par_1	77	83	PF11976	0.450
LIG_TRAF2_1	432	435	PF00917	0.672
LIG_TYR_ITIM	229	234	PF00017	0.513
LIG_WRC_WIRS_1	217	222	PF05994	0.408
MOD_CDC14_SPxK_1	223	226	PF00782	0.444
MOD_CDK_SPxK_1	220	226	PF00069	0.453
MOD_CK1_1	190	196	PF00069	0.536
MOD_CK1_1	245	251	PF00069	0.605
MOD_CK1_1	348	354	PF00069	0.591
MOD_CK1_1	400	406	PF00069	0.609
MOD_CK1_1	443	449	PF00069	0.704
MOD_CK1_1	82	88	PF00069	0.686
MOD_CK2_1	138	144	PF00069	0.598
MOD_CK2_1	155	161	PF00069	0.379
MOD_CK2_1	216	222	PF00069	0.413
MOD_CK2_1	372	378	PF00069	0.545
MOD_CK2_1	392	398	PF00069	0.573
MOD_CK2_1	429	435	PF00069	0.655
MOD_CK2_1	467	473	PF00069	0.757
MOD_CK2_1	86	92	PF00069	0.756
MOD_GlcNHglycan	181	184	PF01048	0.597
MOD_GlcNHglycan	247	250	PF01048	0.654
MOD_GlcNHglycan	253	257	PF01048	0.637
MOD_GlcNHglycan	264	267	PF01048	0.552
MOD_GlcNHglycan	350	353	PF01048	0.577
MOD_GlcNHglycan	398	402	PF01048	0.618
MOD_GlcNHglycan	416	419	PF01048	0.676
MOD_GlcNHglycan	55	58	PF01048	0.626
MOD_GSK3_1	175	182	PF00069	0.543
MOD_GSK3_1	216	223	PF00069	0.461
MOD_GSK3_1	233	240	PF00069	0.533
MOD_GSK3_1	24	31	PF00069	0.461
MOD_GSK3_1	258	265	PF00069	0.661
MOD_GSK3_1	397	404	PF00069	0.583
MOD_GSK3_1	450	457	PF00069	0.731
MOD_GSK3_1	49	56	PF00069	0.547
MOD_GSK3_1	80	87	PF00069	0.635
MOD_N-GLC_1	258	263	PF02516	0.716
MOD_N-GLC_2	172	174	PF02516	0.493
MOD_NEK2_1	155	160	PF00069	0.456
MOD_NEK2_1	17	22	PF00069	0.377
MOD_NEK2_1	175	180	PF00069	0.209
MOD_NEK2_1	24	29	PF00069	0.413
MOD_NEK2_1	372	377	PF00069	0.581
MOD_NEK2_1	79	84	PF00069	0.668
MOD_PIKK_1	277	283	PF00454	0.532
MOD_PIKK_1	49	55	PF00454	0.600
MOD_PKA_1	454	460	PF00069	0.725
MOD_PKA_2	175	181	PF00069	0.520
MOD_PKA_2	18	24	PF00069	0.456
MOD_PKA_2	262	268	PF00069	0.630
MOD_PKA_2	33	39	PF00069	0.405
MOD_PKA_2	392	398	PF00069	0.595
MOD_PKA_2	454	460	PF00069	0.767
MOD_PKA_2	467	473	PF00069	0.631
MOD_Plk_1	318	324	PF00069	0.539
MOD_Plk_1	42	48	PF00069	0.512
MOD_Plk_2-3	86	92	PF00069	0.506
MOD_Plk_4	216	222	PF00069	0.405
MOD_Plk_4	28	34	PF00069	0.449
MOD_ProDKin_1	220	226	PF00069	0.453
MOD_ProDKin_1	25	31	PF00069	0.412
MOD_ProDKin_1	405	411	PF00069	0.634
MOD_ProDKin_1	80	86	PF00069	0.628
MOD_SUMO_rev_2	193	202	PF00179	0.497
MOD_SUMO_rev_2	69	74	PF00179	0.642
TRG_DiLeu_BaEn_1	435	440	PF01217	0.717
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.531
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.529
TRG_ENDOCYTIC_2	197	200	PF00928	0.426
TRG_ENDOCYTIC_2	225	228	PF00928	0.399
TRG_ENDOCYTIC_2	231	234	PF00928	0.332
TRG_ENDOCYTIC_2	373	376	PF00928	0.533
TRG_ER_diArg_1	179	181	PF00400	0.458
TRG_ER_diArg_1	294	297	PF00400	0.495
TRG_ER_diArg_1	454	456	PF00400	0.700
TRG_ER_diArg_1	478	480	PF00400	0.653
TRG_ER_diArg_1	487	490	PF00400	0.726
TRG_ER_FFAT_2	52	59	PF00635	0.564
TRG_NLS_Bipartite_1	454	472	PF00514	0.654
TRG_NLS_MonoExtC_3	467	473	PF00514	0.740
TRG_NLS_MonoExtN_4	466	472	PF00514	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDY9	Leptomonas seymouri	58%	100%
A0A0S4IZS7	Bodo saltans	25%	86%
A0A1X0P050	Trypanosomatidae	40%	72%
A0A3S7XBU2	Leishmania donovani	93%	100%
A0A422NSB3	Trypanosoma rangeli	42%	100%
A4HQ80	Leishmania braziliensis	82%	100%
A4IDX8	Leishmania infantum	93%	100%
D0A432	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	77%
E9ATZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BNQ3	Trypanosoma cruzi	42%	82%