DUF3456 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0J6_LEIMA

TriTrypDb:

LmjF.36.5650 , LMJLV39_360068900 , LMJSD75_360068900

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 0
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q0J6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0J6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.505
CLV_C14_Caspase3-7	184	188	PF00656	0.413
CLV_NRD_NRD_1	268	270	PF00675	0.525
CLV_NRD_NRD_1	308	310	PF00675	0.539
CLV_NRD_NRD_1	318	320	PF00675	0.756
CLV_NRD_NRD_1	37	39	PF00675	0.631
CLV_NRD_NRD_1	79	81	PF00675	0.491
CLV_PCSK_FUR_1	316	320	PF00082	0.593
CLV_PCSK_KEX2_1	268	270	PF00082	0.525
CLV_PCSK_KEX2_1	318	320	PF00082	0.712
CLV_PCSK_KEX2_1	74	76	PF00082	0.394
CLV_PCSK_KEX2_1	81	83	PF00082	0.439
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.454
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.553
CLV_PCSK_PC7_1	264	270	PF00082	0.602
CLV_PCSK_SKI1_1	174	178	PF00082	0.453
CLV_PCSK_SKI1_1	268	272	PF00082	0.550
DOC_CKS1_1	43	48	PF01111	0.417
DOC_CYCLIN_RxL_1	207	221	PF00134	0.458
DOC_CYCLIN_RxL_1	36	45	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	43	49	PF00134	0.461
DOC_MAPK_gen_1	147	157	PF00069	0.397
DOC_MAPK_gen_1	206	212	PF00069	0.516
DOC_MAPK_MEF2A_6	134	141	PF00069	0.622
DOC_PP4_FxxP_1	198	201	PF00568	0.485
DOC_USP7_MATH_1	181	185	PF00917	0.346
DOC_WW_Pin1_4	129	134	PF00397	0.732
DOC_WW_Pin1_4	199	204	PF00397	0.411
DOC_WW_Pin1_4	2	7	PF00397	0.537
DOC_WW_Pin1_4	42	47	PF00397	0.542
LIG_14-3-3_CanoR_1	134	140	PF00244	0.567
LIG_14-3-3_CanoR_1	14	24	PF00244	0.546
LIG_Actin_WH2_2	212	228	PF00022	0.567
LIG_APCC_ABBAyCdc20_2	301	307	PF00400	0.391
LIG_FHA_1	11	17	PF00498	0.659
LIG_FHA_1	152	158	PF00498	0.466
LIG_FHA_1	18	24	PF00498	0.587
LIG_FHA_2	219	225	PF00498	0.518
LIG_FHA_2	286	292	PF00498	0.593
LIG_FHA_2	297	303	PF00498	0.533
LIG_GBD_Chelix_1	24	32	PF00786	0.437
LIG_LIR_Apic_2	196	201	PF02991	0.422
LIG_LIR_Gen_1	192	203	PF02991	0.357
LIG_LIR_Gen_1	294	304	PF02991	0.483
LIG_LIR_Gen_1	61	69	PF02991	0.441
LIG_LIR_Nem_3	192	198	PF02991	0.438
LIG_LIR_Nem_3	294	300	PF02991	0.478
LIG_LIR_Nem_3	45	50	PF02991	0.476
LIG_LIR_Nem_3	61	65	PF02991	0.426
LIG_LYPXL_yS_3	47	50	PF13949	0.421
LIG_PDZ_Class_3	324	329	PF00595	0.697
LIG_PTAP_UEV_1	319	324	PF05743	0.599
LIG_PTB_Apo_2	63	70	PF02174	0.343
LIG_PTB_Phospho_1	63	69	PF10480	0.341
LIG_SH3_3	317	323	PF00018	0.595
LIG_SH3_3	43	49	PF00018	0.495
LIG_SH3_3	9	15	PF00018	0.630
LIG_SUMO_SIM_anti_2	153	161	PF11976	0.549
LIG_SUMO_SIM_anti_2	18	26	PF11976	0.459
LIG_TYR_ITSM	43	50	PF00017	0.409
LIG_WRC_WIRS_1	195	200	PF05994	0.380
LIG_WRC_WIRS_1	59	64	PF05994	0.395
MOD_CDK_SPK_2	129	134	PF00069	0.550
MOD_CDK_SPxxK_3	199	206	PF00069	0.299
MOD_CK1_1	321	327	PF00069	0.646
MOD_CK1_1	5	11	PF00069	0.685
MOD_CK2_1	218	224	PF00069	0.549
MOD_CK2_1	260	266	PF00069	0.494
MOD_CK2_1	290	296	PF00069	0.501
MOD_GlcNHglycan	164	167	PF01048	0.407
MOD_GlcNHglycan	257	260	PF01048	0.634
MOD_GlcNHglycan	320	323	PF01048	0.684
MOD_GlcNHglycan	35	38	PF01048	0.579
MOD_GSK3_1	118	125	PF00069	0.677
MOD_N-GLC_2	96	98	PF02516	0.493
MOD_NEK2_1	16	21	PF00069	0.605
MOD_PKA_1	318	324	PF00069	0.598
MOD_PKA_2	122	128	PF00069	0.642
MOD_PKA_2	225	231	PF00069	0.622
MOD_PKA_2	249	255	PF00069	0.572
MOD_PKA_2	318	324	PF00069	0.710
MOD_PKB_1	316	324	PF00069	0.594
MOD_Plk_1	295	301	PF00069	0.584
MOD_Plk_2-3	236	242	PF00069	0.598
MOD_Plk_2-3	296	302	PF00069	0.591
MOD_Plk_4	17	23	PF00069	0.479
MOD_Plk_4	243	249	PF00069	0.575
MOD_Plk_4	58	64	PF00069	0.362
MOD_ProDKin_1	129	135	PF00069	0.718
MOD_ProDKin_1	199	205	PF00069	0.409
MOD_ProDKin_1	2	8	PF00069	0.539
MOD_ProDKin_1	42	48	PF00069	0.536
MOD_SUMO_for_1	73	76	PF00179	0.379
TRG_ENDOCYTIC_2	47	50	PF00928	0.421
TRG_ER_diArg_1	267	269	PF00400	0.483
TRG_ER_diArg_1	316	319	PF00400	0.746
TRG_ER_diArg_1	80	83	PF00400	0.470
TRG_NES_CRM1_1	89	103	PF08389	0.448
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P915	Leptomonas seymouri	50%	100%
A0A0S4IVP5	Bodo saltans	25%	100%
A0A1X0P0S9	Trypanosomatidae	30%	100%
A0A3R7NVI0	Trypanosoma rangeli	30%	100%
A0A3S7XC03	Leishmania donovani	92%	100%
A4HQ81	Leishmania braziliensis	63%	100%
A4IDX9	Leishmania infantum	92%	100%
D0A431	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ATZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DK35	Trypanosoma cruzi	32%	100%