Putative RNA helicase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA helicase, putative

Species:

Leishmania major

UniProt:

Q4Q0J4_LEIMA

TriTrypDb:

LmjF.36.5670 , LMJLV39_360069100 , LMJSD75_360069100

Length:

697

Annotations

LeishMANIAdb annotations

Unlikely to be a membrane protein.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0J4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016787	hydrolase activity	2	7
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	458	462	PF00656	0.397
CLV_C14_Caspase3-7	536	540	PF00656	0.427
CLV_NRD_NRD_1	21	23	PF00675	0.286
CLV_NRD_NRD_1	279	281	PF00675	0.207
CLV_NRD_NRD_1	367	369	PF00675	0.467
CLV_NRD_NRD_1	505	507	PF00675	0.372
CLV_NRD_NRD_1	601	603	PF00675	0.565
CLV_NRD_NRD_1	613	615	PF00675	0.181
CLV_NRD_NRD_1	65	67	PF00675	0.217
CLV_NRD_NRD_1	654	656	PF00675	0.207
CLV_PCSK_KEX2_1	237	239	PF00082	0.206
CLV_PCSK_KEX2_1	367	369	PF00082	0.467
CLV_PCSK_KEX2_1	52	54	PF00082	0.301
CLV_PCSK_KEX2_1	568	570	PF00082	0.638
CLV_PCSK_KEX2_1	613	615	PF00082	0.206
CLV_PCSK_KEX2_1	65	67	PF00082	0.129
CLV_PCSK_KEX2_1	671	673	PF00082	0.234
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.206
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.310
CLV_PCSK_PC1ET2_1	568	570	PF00082	0.578
CLV_PCSK_PC1ET2_1	671	673	PF00082	0.273
CLV_PCSK_SKI1_1	105	109	PF00082	0.217
CLV_PCSK_SKI1_1	237	241	PF00082	0.206
CLV_PCSK_SKI1_1	281	285	PF00082	0.230
CLV_PCSK_SKI1_1	468	472	PF00082	0.246
CLV_PCSK_SKI1_1	478	482	PF00082	0.217
CLV_PCSK_SKI1_1	518	522	PF00082	0.373
CLV_PCSK_SKI1_1	613	617	PF00082	0.203
CLV_PCSK_SKI1_1	657	661	PF00082	0.214
CLV_PCSK_SKI1_1	672	676	PF00082	0.185
CLV_Separin_Metazoa	610	614	PF03568	0.256
DEG_APCC_DBOX_1	237	245	PF00400	0.452
DEG_APCC_DBOX_1	367	375	PF00400	0.298
DEG_SPOP_SBC_1	456	460	PF00917	0.399
DOC_CYCLIN_RxL_1	235	242	PF00134	0.452
DOC_MAPK_gen_1	152	160	PF00069	0.418
DOC_MAPK_gen_1	19	29	PF00069	0.467
DOC_MAPK_gen_1	367	374	PF00069	0.404
DOC_MAPK_gen_1	65	72	PF00069	0.417
DOC_MAPK_gen_1	655	663	PF00069	0.406
DOC_MAPK_gen_1	671	679	PF00069	0.406
DOC_MAPK_MEF2A_6	154	162	PF00069	0.421
DOC_MAPK_MEF2A_6	367	376	PF00069	0.313
DOC_MAPK_MEF2A_6	449	457	PF00069	0.432
DOC_MAPK_MEF2A_6	655	662	PF00069	0.406
DOC_PP1_RVXF_1	101	107	PF00149	0.448
DOC_PP1_RVXF_1	612	619	PF00149	0.510
DOC_USP7_MATH_1	13	17	PF00917	0.548
DOC_USP7_MATH_1	289	293	PF00917	0.406
DOC_USP7_MATH_1	456	460	PF00917	0.473
DOC_USP7_MATH_1	68	72	PF00917	0.401
DOC_USP7_UBL2_3	671	675	PF12436	0.473
DOC_WW_Pin1_4	2	7	PF00397	0.551
DOC_WW_Pin1_4	498	503	PF00397	0.401
LIG_14-3-3_CanoR_1	348	355	PF00244	0.324
LIG_14-3-3_CanoR_1	367	372	PF00244	0.306
LIG_14-3-3_CanoR_1	425	433	PF00244	0.437
LIG_14-3-3_CanoR_1	506	510	PF00244	0.494
LIG_Actin_WH2_2	100	116	PF00022	0.430
LIG_Actin_WH2_2	135	150	PF00022	0.410
LIG_Actin_WH2_2	539	557	PF00022	0.527
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_BIR_III_2	687	691	PF00653	0.473
LIG_BRCT_BRCA1_1	466	470	PF00533	0.510
LIG_BRCT_BRCA1_1	648	652	PF00533	0.417
LIG_Clathr_ClatBox_1	269	273	PF01394	0.473
LIG_eIF4E_1	265	271	PF01652	0.519
LIG_FHA_1	106	112	PF00498	0.417
LIG_FHA_1	208	214	PF00498	0.291
LIG_FHA_1	36	42	PF00498	0.417
LIG_FHA_1	404	410	PF00498	0.422
LIG_FHA_1	458	464	PF00498	0.399
LIG_FHA_1	576	582	PF00498	0.625
LIG_FHA_2	226	232	PF00498	0.406
LIG_FHA_2	320	326	PF00498	0.434
LIG_FHA_2	360	366	PF00498	0.338
LIG_FHA_2	464	470	PF00498	0.430
LIG_FHA_2	506	512	PF00498	0.507
LIG_FXI_DFP_1	426	430	PF00024	0.217
LIG_LIR_Gen_1	11	21	PF02991	0.174
LIG_LIR_Gen_1	170	180	PF02991	0.460
LIG_LIR_Gen_1	253	262	PF02991	0.427
LIG_LIR_Gen_1	390	399	PF02991	0.328
LIG_LIR_Nem_3	11	17	PF02991	0.283
LIG_LIR_Nem_3	123	128	PF02991	0.416
LIG_LIR_Nem_3	141	147	PF02991	0.363
LIG_LIR_Nem_3	170	175	PF02991	0.484
LIG_LIR_Nem_3	253	257	PF02991	0.432
LIG_LIR_Nem_3	493	498	PF02991	0.325
LIG_LIR_Nem_3	583	588	PF02991	0.711
LIG_NRBOX	142	148	PF00104	0.406
LIG_Pex14_2	172	176	PF04695	0.283
LIG_PTB_Apo_2	620	627	PF02174	0.448
LIG_RPA_C_Fungi	444	456	PF08784	0.251
LIG_SH2_CRK	125	129	PF00017	0.289
LIG_SH2_CRK	634	638	PF00017	0.256
LIG_SH2_GRB2like	311	314	PF00017	0.386
LIG_SH2_PTP2	644	647	PF00017	0.240
LIG_SH2_SRC	203	206	PF00017	0.306
LIG_SH2_SRC	644	647	PF00017	0.240
LIG_SH2_STAP1	265	269	PF00017	0.241
LIG_SH2_STAP1	350	354	PF00017	0.311
LIG_SH2_STAP1	90	94	PF00017	0.256
LIG_SH2_STAT3	265	268	PF00017	0.265
LIG_SH2_STAT5	203	206	PF00017	0.306
LIG_SH2_STAT5	300	303	PF00017	0.241
LIG_SH2_STAT5	350	353	PF00017	0.309
LIG_SH2_STAT5	44	47	PF00017	0.275
LIG_SH2_STAT5	498	501	PF00017	0.495
LIG_SH2_STAT5	553	556	PF00017	0.561
LIG_SH2_STAT5	620	623	PF00017	0.309
LIG_SH2_STAT5	644	647	PF00017	0.453
LIG_SH3_3	268	274	PF00018	0.256
LIG_SH3_3	3	9	PF00018	0.568
LIG_SH3_3	427	433	PF00018	0.243
LIG_SH3_5	199	203	PF00018	0.359
LIG_SUMO_SIM_anti_2	209	215	PF11976	0.305
LIG_SUMO_SIM_anti_2	369	376	PF11976	0.301
LIG_SUMO_SIM_anti_2	404	411	PF11976	0.256
LIG_SUMO_SIM_anti_2	450	456	PF11976	0.386
LIG_SUMO_SIM_anti_2	676	683	PF11976	0.275
LIG_SUMO_SIM_par_1	26	33	PF11976	0.275
LIG_TRAF2_1	228	231	PF00917	0.256
LIG_UBA3_1	143	148	PF00899	0.241
LIG_UBA3_1	240	245	PF00899	0.310
LIG_UBA3_1	407	415	PF00899	0.389
MOD_CDK_SPK_2	498	503	PF00069	0.401
MOD_CK1_1	255	261	PF00069	0.386
MOD_CK1_1	35	41	PF00069	0.256
MOD_CK1_1	359	365	PF00069	0.386
MOD_CK1_1	370	376	PF00069	0.241
MOD_CK2_1	225	231	PF00069	0.241
MOD_CK2_1	313	319	PF00069	0.241
MOD_CK2_1	359	365	PF00069	0.363
MOD_CK2_1	463	469	PF00069	0.275
MOD_CK2_1	505	511	PF00069	0.537
MOD_CK2_1	535	541	PF00069	0.480
MOD_GlcNHglycan	163	166	PF01048	0.241
MOD_GlcNHglycan	303	306	PF01048	0.241
MOD_GlcNHglycan	315	318	PF01048	0.241
MOD_GlcNHglycan	34	37	PF01048	0.264
MOD_GlcNHglycan	483	486	PF01048	0.213
MOD_GlcNHglycan	99	102	PF01048	0.275
MOD_GSK3_1	189	196	PF00069	0.357
MOD_GSK3_1	32	39	PF00069	0.278
MOD_GSK3_1	366	373	PF00069	0.324
MOD_GSK3_1	505	512	PF00069	0.440
MOD_GSK3_1	593	600	PF00069	0.561
MOD_GSK3_1	646	653	PF00069	0.251
MOD_GSK3_1	662	669	PF00069	0.226
MOD_N-GLC_1	356	361	PF02516	0.454
MOD_NEK2_1	1	6	PF00069	0.661
MOD_NEK2_1	163	168	PF00069	0.230
MOD_NEK2_1	463	468	PF00069	0.256
MOD_NEK2_1	481	486	PF00069	0.256
MOD_NEK2_1	633	638	PF00069	0.378
MOD_NEK2_1	94	99	PF00069	0.314
MOD_PIKK_1	329	335	PF00454	0.241
MOD_PIKK_1	36	42	PF00454	0.269
MOD_PIKK_1	525	531	PF00454	0.344
MOD_PIKK_1	561	567	PF00454	0.451
MOD_PIKK_1	59	65	PF00454	0.256
MOD_PK_1	675	681	PF00069	0.275
MOD_PKA_1	367	373	PF00069	0.451
MOD_PKA_2	366	372	PF00069	0.307
MOD_PKA_2	424	430	PF00069	0.300
MOD_PKA_2	505	511	PF00069	0.502
MOD_PKA_2	667	673	PF00069	0.256
MOD_PKB_1	152	160	PF00069	0.275
MOD_Plk_1	134	140	PF00069	0.241
MOD_Plk_1	154	160	PF00069	0.386
MOD_Plk_1	252	258	PF00069	0.400
MOD_Plk_1	289	295	PF00069	0.241
MOD_Plk_1	359	365	PF00069	0.363
MOD_Plk_1	403	409	PF00069	0.256
MOD_Plk_1	675	681	PF00069	0.241
MOD_Plk_2-3	319	325	PF00069	0.275
MOD_Plk_2-3	535	541	PF00069	0.324
MOD_Plk_4	13	19	PF00069	0.365
MOD_Plk_4	189	195	PF00069	0.334
MOD_Plk_4	207	213	PF00069	0.291
MOD_Plk_4	255	261	PF00069	0.256
MOD_Plk_4	367	373	PF00069	0.308
MOD_Plk_4	403	409	PF00069	0.256
MOD_Plk_4	487	493	PF00069	0.297
MOD_Plk_4	633	639	PF00069	0.256
MOD_Plk_4	646	652	PF00069	0.237
MOD_Plk_4	662	668	PF00069	0.206
MOD_Plk_4	675	681	PF00069	0.253
MOD_ProDKin_1	2	8	PF00069	0.532
MOD_ProDKin_1	498	504	PF00069	0.409
MOD_SUMO_for_1	401	404	PF00179	0.414
MOD_SUMO_for_1	521	524	PF00179	0.345
MOD_SUMO_rev_2	231	239	PF00179	0.241
MOD_SUMO_rev_2	467	473	PF00179	0.305
TRG_DiLeu_BaEn_1	242	247	PF01217	0.386
TRG_DiLeu_BaEn_1	266	271	PF01217	0.386
TRG_DiLeu_BaEn_1	405	410	PF01217	0.241
TRG_ENDOCYTIC_2	125	128	PF00928	0.241
TRG_ENDOCYTIC_2	260	263	PF00928	0.241
TRG_ENDOCYTIC_2	585	588	PF00928	0.633
TRG_ENDOCYTIC_2	634	637	PF00928	0.256
TRG_ER_diArg_1	366	368	PF00400	0.464
TRG_ER_diArg_1	395	398	PF00400	0.486
TRG_ER_diArg_1	612	614	PF00400	0.241
TRG_ER_diArg_1	64	66	PF00400	0.256
TRG_ER_FFAT_1	467	475	PF00635	0.218
TRG_NLS_MonoCore_2	567	572	PF00514	0.557
TRG_NLS_MonoExtC_3	567	573	PF00514	0.505
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.275
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.300

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P437	Leptomonas seymouri	29%	69%
A0A0N0P5V0	Leptomonas seymouri	37%	99%
A0A0N0P8Y1	Leptomonas seymouri	36%	90%
A0A0N0P9D2	Leptomonas seymouri	85%	98%
A0A0N1IKA7	Leptomonas seymouri	39%	77%
A0A0N1PEU4	Leptomonas seymouri	35%	73%
A0A0S4IQ76	Bodo saltans	37%	98%
A0A0S4IR78	Bodo saltans	39%	79%
A0A0S4IS51	Bodo saltans	61%	90%
A0A0S4IWU8	Bodo saltans	39%	82%
A0A0S4J157	Bodo saltans	43%	100%
A0A0S4JCY8	Bodo saltans	42%	68%
A0A1X0NJ46	Trypanosomatidae	37%	98%
A0A1X0P0D7	Trypanosomatidae	71%	99%
A0A1X0P872	Trypanosomatidae	36%	79%
A0A1X0P9K6	Trypanosomatidae	34%	97%
A0A3Q8II71	Leishmania donovani	33%	87%
A0A3Q8IJ24	Leishmania donovani	36%	74%
A0A3Q8IWG4	Leishmania donovani	96%	100%
A0A3R7MA90	Trypanosoma rangeli	37%	97%
A0A3R7MM88	Trypanosoma rangeli	70%	100%
A0A3R7NT42	Trypanosoma rangeli	34%	98%
A0A3S7X3U3	Leishmania donovani	30%	68%
A0A3S7X433	Leishmania donovani	29%	76%
A0A3S7X8Z5	Leishmania donovani	38%	99%
A0A422N8L3	Trypanosoma rangeli	38%	68%
A0A422NK53	Trypanosoma rangeli	35%	100%
A4HAT8	Leishmania braziliensis	37%	92%
A4HIR4	Leishmania braziliensis	29%	68%
A4HME2	Leishmania braziliensis	37%	99%
A4HNU7	Leishmania braziliensis	35%	74%
A4HQ83	Leishmania braziliensis	90%	100%
A4I609	Leishmania infantum	30%	68%
A4I6B7	Leishmania infantum	29%	76%
A4IA06	Leishmania infantum	32%	86%
A4IB14	Leishmania infantum	38%	99%
A4ICP7	Leishmania infantum	36%	74%
A4IDY1	Leishmania infantum	96%	100%
C9ZMN0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	94%
C9ZNP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	95%
D0A2R5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	79%
D0A429	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	92%
D0A778	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	67%
D4A2Z8	Rattus norvegicus	29%	70%
E9AEU3	Leishmania major	37%	100%
E9ASK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	81%
E9AU01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B1A0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	68%
E9B1H5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	76%
E9B512	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	86%
E9B5Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	99%
F4IE66	Arabidopsis thaliana	37%	97%
F4IJV4	Arabidopsis thaliana	46%	67%
F4JMJ3	Arabidopsis thaliana	38%	79%
F4JRJ6	Arabidopsis thaliana	41%	100%
O22243	Arabidopsis thaliana	29%	69%
O22899	Arabidopsis thaliana	47%	96%
O35286	Mus musculus	44%	88%
O42945	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	95%
O43143	Homo sapiens	44%	88%
O45244	Caenorhabditis elegans	46%	69%
O51767	Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)	34%	85%
O60231	Homo sapiens	40%	67%
P0C9A2	African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)	26%	72%
P0C9A3	African swine fever virus (isolate Warthog/Namibia/Wart80/1980)	26%	72%
P0C9A4	African swine fever virus (isolate Pig/Kenya/KEN-50/1950)	25%	72%
P20095	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	80%
P36009	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	95%
P53131	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	91%
Q03319	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	97%
Q10752	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	66%
Q1EHT7	Oryza sativa subsp. japonica	27%	69%
Q20875	Caenorhabditis elegans	42%	94%
Q3ZBE0	Bos taurus	28%	97%
Q4Q1Y9	Leishmania major	35%	74%
Q4Q2X4	Leishmania major	33%	100%
Q4Q6W4	Leishmania major	29%	68%
Q54NJ4	Dictyostelium discoideum	38%	96%
Q5R864	Pongo abelii	36%	89%
Q5RAZ4	Pongo abelii	44%	88%
Q5RBD4	Pongo abelii	44%	97%
Q5UQ96	Acanthamoeba polyphaga mimivirus	28%	100%
Q5XH12	Xenopus laevis	30%	93%
Q5XI69	Rattus norvegicus	36%	89%
Q6PE54	Mus musculus	36%	89%
Q767K6	Sus scrofa	40%	67%
Q7K3M5	Drosophila melanogaster	46%	96%
Q7L7V1	Homo sapiens	32%	94%
Q7YR39	Pan troglodytes	40%	67%
Q80VY9	Mus musculus	42%	100%
Q89443	African swine fever virus (strain Badajoz 1971 Vero-adapted)	26%	72%
Q8BZS9	Mus musculus	28%	94%
Q8IX18	Homo sapiens	36%	89%
Q8TE96	Homo sapiens	31%	97%
Q8V9U2	African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983)	25%	72%
Q8VHK9	Mus musculus	28%	70%
Q8VY00	Arabidopsis thaliana	46%	67%
Q924H9	Mus musculus	30%	97%
Q93Y16	Arabidopsis thaliana	37%	100%
Q9BKQ8	Caenorhabditis elegans	41%	95%
Q9H5Z1	Homo sapiens	39%	99%
Q9H6R0	Homo sapiens	44%	99%
Q9HE06	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
Q9LZQ9	Arabidopsis thaliana	46%	96%
V5B3L7	Trypanosoma cruzi	70%	100%
V5BKH2	Trypanosoma cruzi	35%	91%
V5BPV3	Trypanosoma cruzi	38%	66%
V5BV22	Trypanosoma cruzi	36%	79%
V5C0I9	Trypanosoma cruzi	33%	89%
V5D886	Trypanosoma cruzi	37%	98%